Genes, Vol. 15, Pages 499: Proteomic Analysis of Lysine Acetylation and Succinylation to Investigate the Pathogenicity of Virulent Pseudomonas syringae pv. tomato DC3000 and Avirulent Line Pseudomonas syringae pv. tomato DC3000 avrRpm1 on Arabidopsis thaliana
In conclusion, this study provides an insightful profile of the lysine acetylome and succinylome in A. thaliana infected with virulent and avirulent lines of Pst DC3000. Our findings revealed the potential impact of these post-translational modifications (PTMs) on the physiological functions of the host plant during pathogen infection. This study offers valuable insights into the complex interactions between plant pathogens and their hosts, laying the groundwork for future research on disease resistance and pathogenesis mechanisms. (Source: Genes)
Source: Genes - April 16, 2024 Category: Genetics & Stem Cells Authors: Ding Liu Yang Zhao Wen Yang Zhang Tags: Article Source Type: research
Ethical and social implications of public–private partnerships in the context of genomic/big health data collection
In conclusion, this paper offers a set of minimum requirements for these partnerships within solidarity-based publicly funded healthcare systems. These include the necessity of public-private partnerships to (1) contribute to the public benefit and minimise harm produced by the use of publicly held data; (2) avoid prioritisation of commercial interests over robust governance structures to guarantee benefits to the public and protect donors, especially marginalised groups; (3) side-step the pitfalls of the rhetoric of solidarity and be transparent about the challenges to return the benefits to ‘all’. (Source: European J...
Source: European Journal of Human Genetics - April 16, 2024 Category: Genetics & Stem Cells Authors: Ruth Horn Jennifer Merchant Ruth Horn Jennifer Merchant Mark Bale Natalie Banner Anne Cambon-Thomsen Herve Chneiweiss Angus Clarke Yael Hashiloni-Dolev Angeliki Kerasidou Anneke Lucassen Michael Parker Christine Patch Barbara Prainsack Aviad Raz Gesine Ri Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
Recommended approaches for screening and early detection of lung cancer in the Middle East and Africa (MEA) region: a consensus statement
CONCLUSIONS: There is a great need for large-scale screening programs, preferably integrated with tobacco-control programs and awareness programs for physicians and patients, which may facilitate higher adherence to lung cancer screening and improve survival outcomes.PMID:38617789 | PMC:PMC11009596 | DOI:10.21037/jtd-23-1568 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Ahmed Allehebi Ameen Al-Omair Bassam Mahboub Coenraad F Koegelenberg Mohsen Mokhtar Ashraf Mokhtar Madkour Khaled Al-Asad Ugur Selek Humaid O Al-Shamsi Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
A Personal View: The Post-Captivity Condition
Isr Med Assoc J. 2024 Apr;26(4):266-268.NO ABSTRACTPMID:38616676 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Avi Ohry Source Type: research
Cardiac Tamponade: A Rare and Insidious Surgical Complication of Hiatal Hernia Repair
Isr Med Assoc J. 2024 Apr;26(4):251-253.NO ABSTRACTPMID:38616673 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Roy Apel Slava Bard Ari Naimark Nikolai Menasherov Nir Wasserberg Ory Wiesel Source Type: research
Es geht wohl anders [Things Turn Out Differently]
Isr Med Assoc J. 2024 Apr;26(4):254-258.NO ABSTRACTPMID:38616674 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Avi Ohry Esteban Gonz ález-López Source Type: research
The Healthcare System in Theresienstadt: Heroism and Challenges
Isr Med Assoc J. 2024 Apr;26(4):259-265.NO ABSTRACTPMID:38616675 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Philip J Hashkes Source Type: research
Volume Measurement of the Cavum Septi Pellucidi: Normative Values Between 20 and 40 Weeks of Gestation
CONCLUSIONS: The CSP volume had a poor correlation with gestational age; however, the volume did not exceed 2 ml regardless of gestational age. This information can be used to assess pathologies involving the CSP.PMID:38616669 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Ruba Tuma Marwan Odeh Maya Wolf Inshirah Sgayer Nicola Luigi Bragazzi Rola Khamisy-Farah Source Type: research
Diagnostic Yield of head Computed Tomography in Patients with Syncope: Sex Differences
CONCLUSIONS: Age had a more significant impact on diagnostic yield of syncope than head CT. The use of a head CT scan as a routine diagnosis tool in patients with syncope is unjustifiable unless there is an indication based on medical history or physical examination.PMID:38616670 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Raymond Farah Dvir Novak Rola Khamisy-Farah Source Type: research
Electrocautery-induced Inappropriate Implantable Cardiac Defibrillator Shock
Isr Med Assoc J. 2024 Apr;26(4):245-246.NO ABSTRACTPMID:38616671 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Dante Antonelli Vladimir Poletaev Vidal Essebag Alexander Feldman Source Type: research
Klatskin Signet Ring Cell Neuroendocrine Tumor of the Biliary Tree
Isr Med Assoc J. 2024 Apr;26(4):247-250.NO ABSTRACTPMID:38616672 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Eden Gerszman Esther Kazlow Victoria Vlasov Dvir Froylich Jacob Dickstein Riad Haddad Ahmad Mahamid Source Type: research
Exploring the Link Between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Retrospective Cohort Study
CONCLUSIONS: AS patients exhibit a markedly increased risk of developing IBD. These findings advocate for heightened clinical vigilance for IBD symptoms in AS patients and suggest the need for a multidisciplinary approach to patient care. Further research into the shared pathogenic pathways is needed to develop personalized treatment strategies and improve patient management.PMID:38616667 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Kassem Sharif Adi Lahat Yonatan Shneor Patt Niv Ben-Shabat Mahmud Omar Abdulla Watad Howard Amital Omer Gendelman Source Type: research
Group A Streptococcus Carriage in Adults in Southern Israel: A Prospective Study
CONCLUSIONS: Being an ultra-Orthodox Jew was the single variable associated with a GAS carriage, which may be related to having many children at home and living in overcrowded areas. Primary care physicians in Israel should recognize this situation when examining patients with sore throats, mainly ultra-Orthodox Jews.PMID:38616668 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Limor Adler Or Tzadok Zehavi Miriam Parizade Yair Hershkovitz Menashe Meni Amran Robert Hoffman Tal Hakmon Aronson Erela Rotlevi Bar Cohen Ilan Yehoshua Source Type: research
