The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
Recommended approaches for screening and early detection of lung cancer in the Middle East and Africa (MEA) region: a consensus statement
CONCLUSIONS: There is a great need for large-scale screening programs, preferably integrated with tobacco-control programs and awareness programs for physicians and patients, which may facilitate higher adherence to lung cancer screening and improve survival outcomes.PMID:38617789 | PMC:PMC11009596 | DOI:10.21037/jtd-23-1568 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Ahmed Allehebi Ameen Al-Omair Bassam Mahboub Coenraad F Koegelenberg Mohsen Mokhtar Ashraf Mokhtar Madkour Khaled Al-Asad Ugur Selek Humaid O Al-Shamsi Source Type: research
Prevalence and genetic characteristics of  Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
Predictors of Impairment and Self-Concept in Children and Adolescents with Persistent Tic Disorder
This study examined predictors of, and associations between, self-concept, demographic variables, and clinical measures in fifty-eight children and adolescents with Persistent Tic Disorder (PTD; 44 males, Mage = 11.9 years, SD = 2.74). Participants completed measures that assessed self-concept, tic severity, tic-related impairment, and comorbid psychological symptoms. Results showed that generalized anxiety disorder, major depressive disorder, persistent depressive disorder, total tic severity, number and complexity of tics, and total and social tic-related impairment were associated with self-concept. Tic-related social i...
Source: Child Psychiatry and Human Development - April 15, 2024 Category: Child Development Authors: Kirsten R Bootes Michael B Himle Jordan T Stiede Brianna C M Wellen Suzanne Mouton-Odum Douglas W Woods Source Type: research
Evaluation of the Patients with the Diagnosis of Pontocerebellar Hypoplasia: A Multicenter National Study
Cerebellum. 2024 Apr 15. doi: 10.1007/s12311-024-01690-1. Online ahead of print.ABSTRACTPontocerebellar hypoplasia (PCH) is a heterogeneous group of neurodegenerative disorders characterized by hypoplasia and degeneration of the cerebellum and pons. We aimed to identify the clinical, laboratory, and imaging findings of the patients with diagnosed PCH with confirmed genetic analysis. We collected available clinical data, laboratory, and imaging findings in our retrospective multicenter national study of 64 patients with PCH in Turkey. The genetic analysis included the whole-exome sequencing (WES), targeted next-generation s...
Source: Cerebellum - April 15, 2024 Category: Neuroscience Authors: Dilek Cavusoglu Gulten Ozturk Dilsad Turkdogan Semra Hiz Kurul Uluc Yis Mustafa Komur Faruk Incecik Bulent Kara Turkan Sahin Olcay Unver Cengiz Dilber Gulen Gul Mert Cagatay Gunay Gamze Sarikaya Uzan Ozlem Ersoy Yavuz Oktay Serdar Mermer Gokcen Oz Tuncer Source Type: research
Exploring the County Level Mortality Pattern Variations in Rural Areas of Iran (2006- 2016)
CONCLUSION: The findings indicate significant spatial and temporal variations in rural mortality rates in Iran. Policymakers can use this information to plan and enhance healthcare infrastructure in specific counties. The findings serve for evaluating the effectiveness of health policies, enabling policymakers to make informed decisions, allocate resources efficiently and design targeted interventions for improved public health outcomes.PMID:38618838 | DOI:10.34172/ijhpm.2024.8032 (Source: Rural Remote Health)
Source: Rural Remote Health - April 15, 2024 Category: Rural Health Authors: Mehrangiz Rezaee Nader Tavakoli Siamak Tahmasbi Source Type: research
Structure characterization and protective effect against UVB irradiation of polysaccharides isolated from the plateau plant Gentiana dahurica Fisch
Int J Biol Macromol. 2024 Apr 13:131551. doi: 10.1016/j.ijbiomac.2024.131551. Online ahead of print.ABSTRACTGentiana dahurica Fisch. (G. dahurica) is one of the legitimate sources of Qinjiao in Traditional Chinese Medicine (TCM) and grows on high-altitude plateaus. Plants develop unique biochemical accumulations to resist plateau conditions, especially the strong UV irradiation. Thus, this study aimed to investigate the polysaccharide of G. dahurica (GDP), its structure and its activity against UVB irradiation. Four GDPs were isolated and two of them were subjected to structural elucidation. The results suggested that GDP-...
Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Wen Ji Cuiyin Qian Xiaopeng Su Xiang Li Zhenqing Zhang Yonggui Ma Mingjin Zhang Duxin Li Source Type: research
ChatGPT and Corporations of Mega-journals Jeopardize the Norms That Underpin Academic Publishing
Arch Iran Med. 2024 Feb 1;27(2):110-112. doi: 10.34172/aim.2024.17.ABSTRACTThose who participate in and contribute to academic publishing are affected by its evolution. Funding bodies, academic institutions, researchers and peer-reviewers, junior scholars, freelance language editors, language-editing services, and journal editors are to enforce and uphold the ethical norms on which academic publishing is founded. Deviating from such norms will challenge and threaten the scholarly reputation, academic careers, and institutional standing; reduce the publishers' true impacts; squander public funding; and erode the public trus...
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Farid Rahimi Amin Talebi Bezmin Abadi Source Type: research
Impact of Implementing a Standard Operating Procedure to Reduce Blood Wastage in Blood Centers of Iran
CONCLUSION: This intervention effectively reduced waste and increased efficiency. Ongoing blood wastage reviews, auditing, and receiving feedback from the central headquarters were powerful tools in following the compliance of blood centers. Further studies are recommended, especially concerning blood wastage in hospital blood banks and various wards.PMID:38619032 | DOI:10.34172/aim.2024.14 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Hayedeh Javadzadeh Shahshahani Shahin Sharifi Soheila Nasizadeh Source Type: research
A New Model Including AMH Cut-off Levels to Predict Post-treatment Ovarian Function in Early Breast Cancer: A Prospective Cohort Study
CONCLUSION: This combination model can be used to withhold fertility preservation procedures in BC patients. Performing larger studies is suggested to further test this model.PMID:38619033 | DOI:10.34172/aim.2024.15 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Ramesh Omranipour Fatemeh Ahmadi-Harchegani Azin Saberi Ashraf Moini Mostafa Shiri Amirmohsen Jalaeefar Arvin Arian Akram Seifollahi Mahshad Madani Bita Eslami Sadaf Alipour Source Type: research
In Commemoration of Dr. Mostafa Pourtaghva Shahrestani, a Pioneer in Infectious Disease Research
Arch Iran Med. 2024 Feb 1;27(2):105-109. doi: 10.34172/aim.2024.16.ABSTRACTIt is important to honor the contributions of scientific leaders who have dedicated their lives to advancing knowledge and serving their country. One way is to document their experiences and personalities in a documentary format, which can serve as a historical record and an inspiration for future generations. Dr. Mostafa Pourtaghva Shahrestani, a renowned physician and specialist in infectious diseases and tropical medicine, has made significant contributions to public health in Iran. He has played a crucial role in controlling infectious diseases ...
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Fatemeh Bardestani Mohammad Ali Rad Mohammad Hossein Azizi Mohammad Mehdi Gouya Ehsan Mostafavi Source Type: research
The PERSIAN Cohort: Prevalence of Psychiatric Disorders Among Employees
CONCLUSION: Considering the relatively high prevalence of GAD and MDD among the employees of Tabriz University of Medical Sciences, strengthening counseling centers in the university and encouraging employees to participate in these centers, and examining them in terms of mental health help identify people at risk of mental disorders in time and provide counseling services to these people.PMID:38619030 | DOI:10.34172/aim.2024.12 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Mostafa Farahbakhsh Elnaz Faramarzi Ali Fakhari Mahshid Sadeghi Habibeh Barzegar Sanaz Norouzi Sepideh Harzand-Jadidi Source Type: research
Gut-Lung Microbiota Characterization in Patients with Non-Small Cell Lung Carcinoma and COVID-19 Coinfection
CONCLUSION: Eventually, it was found that compared to control groups, COVID-19 patients with NSCLC showed diminished gut bacteria diversity and increase in Lactobacillus spp., A. muciniphila, and Bifidobacterium spp. The overgrowth of Enterococcus spp., Streptococcus spp., and Prevotella spp. could be potential predictive biomarkers in the gut-lung axis of NSCLC patients with COVID-19.PMID:38619029 | DOI:10.34172/aim.2024.11 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Bahareh Vakili Parisa Shoaei Kiana Shahzamani Seyed Davar Siadat Hasan Shojaei Zahra Esfandiari Elahe Nasri Shiva Shabani Ali Zamani Moghadam Behrooz Ataei Source Type: research
Genetic Analysis of 27 Y-STR Haplotypes in 11 Iranian Ethnic Groups
CONCLUSION: The AMOVA analysis results explain that the close distance of Azeris and Turkmens may be the effect of male-dominant expansions across Central Asia that contributed to historical and demographics of populations in the region. Insignificant differences in network analysis could be the consequence of high mutation events that happened in the Y-STR regions over the years. Considering the ethnic group affiliations in medical research, our results provided an understanding and characterization of Iranian male population for future medical and population genetics studies.PMID:38619031 | DOI:10.34172/aim.2024.13 (Sour...
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Somayeh Alinaghi Marzieh Mohseni Zohreh Fattahi Maryam Beheshtian Fatemeh Ghodratpour Farzane Zare Ashrafi Sanaz Arzhangi Khadijeh Jalalvand Reza Najafipour Hamid Reza Khorram Khorshid Kimia Kahrizi Hossein Najmabadi Source Type: research
Epidemiology and Prevalence of Dyslipidemia Among Adult Population of Tehran: The Tehran Cohort Study
CONCLUSION: We found a high prevalence of dyslipidemia, mainly high LDL/HDL in the Tehran adult population. This dyslipidemia profiling provides important information for public health policy to improve preventive interventions and reduce dyslipidemiarelated morbidity and mortality in the future.PMID:38619028 | DOI:10.34172/aim.2024.10 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Akbar Shafiee Sina Kazemian Arash Jalali Farshid Alaeddini Soheil Saadat Farzad Masoudkabir Hamed Tavolinejad Ali Vasheghani-Farahani Vicente Artola Arita Saeed Sadeghian Mohamamdali Boroumand Abbasali Karimi Oscar H Franco Source Type: research
