The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance
AbstractWe assessed the value of cytokeratin 17 (CK17) expression for the differential diagnosis between primary ovarian mucinous tumors and metastases from the gastrointestinal tract (GIT) and the significance of CK17 expression in a broad spectrum of primary ovarian tumors with respect to their prognosis. The sample set consisted of 554 primary ovarian tumors and 255 GIT tumors. In the primary ovarian tumors, a higher CK17 expression (in  >  10% of tumors cells) was present only in 0–11.4% of all tumors (including mucinous tumors, micropapillary serous borderline tumors, clear cell, endometrioid, and high-grade ...
Source: Virchows Archiv - May 13, 2022 Category: Pathology Source Type: research

Cell Polarity Reversal Distinguishes True Micropapillary Growth From Retraction Artifact in Invasive Urothelial Carcinoma
Focal micropapillary features in invasive urothelial carcinoma is sometimes difficult to distinguish from retraction artifact morphologically. Cell polarity reversal has been demonstrated in micropapillary tumors by epithelial membrane antigen (EMA) immunostaining. We have previously described the use of E-cadherin as a cell polarity marker in ovarian micropapillary serous borderline tumors. The aim of this study was to evaluate the utility of immunohistochemistry for EMA and E-cadherin in differentiating micropapillary urothelial carcinoma from retraction artifact. We identified 29 invasive urothelial carcinomas with micr...
Source: Applied Immunohistochemistry and Molecular Morphology - January 1, 2018 Category: Chemistry Tags: Online Articles: Research Articles Source Type: research

Principles of Treatment for Borderline, Micropapillary Serous, and Low-Grade Ovarian Cancer.
This article reviews the particulars of BOTs and LG-EOCs, their similarities and differences, and how they are best managed and treated, and emphasizes the major role of surgery and the controversial role of chemotherapy. Because these tumors disproportionately affect younger women, this review addresses ovarian preservation in circumstances when fertility or hormonal preservation is desired. PMID: 27587627 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - September 4, 2016 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Cell Polarity Reversal in Ovarian Low ‐Grade Serous Carcinomas and Micropapillary Serous Borderline Tumours: Immunohistochemical Observations
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - June 6, 2016 Category: Pathology Authors: Yiang Hui, Joyce J. Ou, C. James Sung, W. Dwayne Lawrence, M. Ruhul Quddus Tags: Correspondence Source Type: research

Cell Polarity Reversal in Ovarian Low‐Grade Serous Carcinomas and Micropapillary Serous Borderline Tumours: Immunohistochemical Observations
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - May 31, 2016 Category: Pathology Authors: Yiang Hui, Joyce J. Ou, C. James Sung, W. Dwayne Lawrence, M. Ruhul Quddus Tags: Correspondence Source Type: research

Is Invasive Micropapillary Serous Carcinoma a Low-grade Carcinoma?
“Invasive micropapillary serous carcinoma” has been proposed as a synonym for low-grade serous carcinoma by some expert pathologists. In contrast, Singer and colleagues reported that some serous carcinomas with conspicuous invasive micropapillary pattern (SC-IMPs) can show high-grade nuclear atypia. However, the molecular features of such tumors have not been well documented. The aim of this study was to demonstrate and emphasize the fact that high-grade serous carcinoma confirmed by immunohistochemistry and molecular analysis can show conspicuous invasive micropapillary pattern. We selected 24 “SC-IMPs” and invest...
Source: International Journal of Gynecological Pathology - December 8, 2015 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research