Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Developing a Recellularization Approach to Produce Thymic Tissue
The thymus produces the T cells that make up the adaptive immune system, but the organ atrophies with age, contributing to the age-related decline of immune function. A popular science article here comments on a new biotech company seeking to produce thymus tissue for transplantation from decellularized donor tissues. This builds upon work of recent years that improves the understanding of the stem cell and progenitor cell populations that give rise to thymic tissue. Given that understanding, it should be possible to take decellularized thymic tissue and repopulate it with patient-derived cells, or from novel universal cel...
Source: Fight Aging! - July 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Visible Examples of Progress in the Longevity Biotech Industry in 2022
Much of the progress that takes place year after year in any segment of the broader biotech industry is invisible, and the growing portion of that industry focused on aging and longevity is no exception. Biotech is not a high profile industry, particularly because of the heavy dependence on intellectual property and trade secrets as a basis for government-granted monopolies on particular treatments. Details are kept quiet least larger entities in the industry to decide replicate a therapy and call it their own, because the potential rewards are worth the near certainty of a lawsuit. Thus every visible presentation or press...
Source: Fight Aging! - February 22, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Ostium primum ASD and clinical findings of ASD
Ostium primum ASD
Ostium primum atrial septal defect is part of the AV canal defects. In partial AV canal defect, ostium primum ASD is often associated with cleft anterior mitral leaflet producing mitral regurgitation. Tricuspid regurgitation may also be noted. In complete AV canal defect, there is associated canal VSD or inlet VSD and sometimes a single AV valve.
Ostium primum ASD being part of the endocardial cushion defects, may be associated with Down syndrome. They are more likely to develop pulmonary hypertension and Eisenmenger syndrome earlier. DiGeorge syndrome and Ellis-Van Creveld syndrome are the other conditi...
Source: Cardiophile MD - October 10, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: HBC Wide fixed split of second heart sound Source Type: blogs
Spotlight on Special Interest Group 5, Craniofacial and Velopharyngeal Disorders
Peer support. Engaging exchanges on velopharyngeal surgery. Access to timely resources. SIG 5 offers all that and more.
What would you say to encourage other colleagues to join SIG 5?
Angela Dixon: For much of my career I was the only SLP in my state who specialized in cleft/craniofacial disorders. That was a lot of pressure and can be very isolating. It was difficult to not have an easy team of SLPs to learn from, bounce ideas off, etc. Joining SIG 5 provided that for me. I met a group of SLPs who had passions similar to mine, and SIG 5 allowed me an opportunity to network, learn, grow, and eventually even make friends. M...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - January 21, 2020 Category: Speech-Language Pathology Authors: Alison Scheer-Cohen Tags: Academia & Research Health Care Slider Speech-Language Pathology communication sciences and disorders craniofacial craniofacial disorders Speech Disorders Source Type: blogs
Polymicrogyria : MRI Teaching Case
Discussion -Polymicrogyria is one of the most common malformations of cortical developmentin which the process of normal cerebral cortical development is disturbed late in the stage of neuronal migration or early in the stage of cortical organization, thus considered a disorder of neuronal organization.1. Causes - Congenital infection (particularly cytomegalovirus infection). - Localized or diffuse in utero ischemia. - Mutations.2. Clinical profile - ranging f...
Source: Sumer's Radiology Site - October 19, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
DGCR8 Overexpression Attenuates the Accumulation of Senescent Cells with Age
Given the newfound acceptance of cellular senescence as an important cause of aging, many more research groups are assessing the impact of senescent cells in their research into aging. Here, the focus is on chromatin organization, a collection of nuclear structures and processes in the cell that appear to have some influence over the pace of aging over a lifetime. The researchers discover that the gene DGCR8 accelerates the appearance of senescent cells and dysfunction when mutated, and thus producing broken protein machinery, but slows the accumulation of lingering senescent cells when overexpressed in its correct form. T...
Source: Fight Aging! - August 8, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Index: Evolution's Clinical Guidebook
In the past few blogs, I ' ve been discussing the recent publication of my book,Evolution ’s Clinical Guidebook: Translating Ancient Genes Into Precision Medicine. The premise of this book is that modern medicine is based on an understanding of evolutionary processes. Evolution shows us the relationships between the subdisciplines of medicine that benefit directly from Precision Medicine (i.e., pathology, microbiology, clinical genetics, pharmacology, and bioinformatics). In Evolution ' s Clinical Guidebook, all of these diverse fields are brought together, under the subject of evolution. To illustrate, I have listed bel...
Source: Specified Life - May 11, 2019 Category: Information Technology Tags: bioinformatics clinical genetics evo-devo evolution precision medicine rare disease Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Fight Aging! Newsletter, September 5th 2016
This study is a good example of the degree to which the choice to remain active in later life makes a difference. That implies a range of other choices over the decades in order to raise the odds that you can in fact choose to remain active when older, such as avoiding weight gain.
Moderate physical activity is associated with a greater than 50% reduction in cardiovascular death in over-65s. The 12 year study in nearly 2500 adults aged 65 to 74 years found that moderate physical activity reduced the risk of an acute cardiovascular event by more than 30%. High levels of physical activity led to greater risk reducti...
Source: Fight Aging! - September 4, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Potential Use of Cell Therapies to Treat Immunosenescence
Immunosenescence is the name given to the decline of immune system effectiveness with aging, a large component of the frailty that arises in later life. This decline is partially a result of a failing supply of new immune cells, and partially a result of a growing misconfiguration of the immune system as a whole, driven by life-long exposure to infections. On this second front, persistent infection by herpesviruses such as cytomegalovirus appears to be particularly problematic, the cause of large fractions of the immune cell population in an old individual becoming specialized and unable to react to new threats. This open ...
Source: Fight Aging! - August 30, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How to Build Better Metrics: Focus on Physician Outcomes
By NIRAN AL-AGBA, MD
Quality measures began as tools to quantify the healthcare process, using outcomes, patient perceptions, and organizational structures associated with the provision of high-quality health care. Overall, the goals should focus on delivery of care that is effective, safe, efficient, and equitable. Did you notice a particular word missing? Yes, I missed the word physician too, because they have been left out of the conversation entirely.
Measuring quality healthcare by a patient lab result is like recording a patient’s temperature by waving the thermometer near their face. One has little to do wit...
Source: The Health Care Blog - August 8, 2016 Category: Consumer Health News Authors: John Irvine Tags: 2016 Town Hall Source Type: blogs
Metrics Should Be About Physician Outcomes
By NIRAN AL-AGBA, MD
Quality measures began as tools to quantify the healthcare process, using outcomes, patient perceptions, and organizational structures associated with the provision of high-quality health care. Overall, the goals should focus on delivery of care that is effective, safe, efficient, and equitable. Did you notice a particular word missing? Yes, I missed the word physician too, because they have been left out of the conversation entirely.
Measuring quality healthcare by a patient lab result is like recording a patient’s temperature by waving the thermometer near their face. One has little to do wit...
Source: The Health Care Blog - August 8, 2016 Category: Consumer Health News Authors: John Irvine Tags: 2016 Town Hall Source Type: blogs
Truncus arteriosus
is a cyanotic congenital heart disease in which one single great vessel with a single semilunar valve gives rise to the aorta, pulmonary arteries and the coronary arteries. There are three morphological types depending on the origin of pulmonary arteries from the truncus. In type I, a common pulmonary trunk arises from the truncus arteriosus and divides into left and right pulmonary arteries. In type II, the two pulmonary arteries arises separately, but adjacent to each other, from the truncus. In type III, the two pulmonary arteries arise separately from either side of the truncus. The older classification had a type IV ...
Source: Cardiophile MD - December 3, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: ECG / Electrophysiology General Cardiology Source Type: blogs
