The Cost Avoidance Of Switching From Iv Chlorothiazide To Metolazone For Dual Nephron Blockade Using Clinical Use Criteria: A Single-center Experience
Intravenous (IV) bolus or continuous use loop diuretics are considered first line for volume overload in patients with heart failure (HF). If maximal loop diuretic therapy is insufficient, addition of a thiazide-type diuretic is needed for dual nephron blockade (DNB). Unfortunately, chlorothiazide, the only available IV thiazide, is expensive compared to metolazone (chlorothiazide 500 mg vial: $35.00 vs metolazone 5mg: $0.60). While studies suggest no statistically significant differences in safety or efficacy between the two thiazides exists for DNB, we have observed inappropriate overuse of chlorothiazide within the ICU ...
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Lydia Ganaden, Courtney Shakowski, David Raymer, Robert L. Page Tags: 133 Source Type: research
Use Of Metolazone And Tolvaptan As Adjuvant Diuretic Therapy In Patients With Acute Heart Failure Exacerbation: A Systematic Literature Review And Meta-analysis Of Randomized Controlled Trials
Hospitalization rates for acute decompensated heart failure (ADHF) continue to rise. Current guidelines recommend adequate diuresis as a cornerstone of ADHF treatment, with loop diuretics often used as first-line therapy. Diuretic resistance is common among patients with heart failure and portends a poorer prognosis. In these patients, combination therapy with two or more diuretic agents may be required. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Matthew G. Kaye, Mohamad A. Kalot, Ronak Bahuva, Ronak Bharucha, Cody Elkhechen, Anna Jacquinot, Mohamad Kaki, Paras Mehmood, Kristie Nasr, Rohan Pandey, Danny Ram Tags: 313 Source Type: research
Letter to the Editor: Effects of Add-On Metolazone to High-Dose Oral Frusemide on Refractory Fluid Overload in Patients with End-Stage Kidney Disease Opting for Conservative Management
Journal of Palliative Medicine,Volume 26, Issue 2, Page 163-164, February 2023. (Source: Journal of Palliative Medicine)
Source: Journal of Palliative Medicine - January 27, 2023 Category: Palliative Care Authors: Ho Yan Au Kwok Ying Chan Desmond Y.H. Yap Terence Yip Chi Yan Wong Source Type: research
Molecules, Vol. 28, Pages 1191: Establishment of LC-MS/MS Method for Determination of GMDTC in Rat Plasma and Its Application in Preclinical Pharmacokinetics
-Jiang Tang
Sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-4(methylthio)butanoate (GMDTC) is the first compound to use cadmium repellent as an indication. In this paper, we established and validated a bioanalytical method for the determination of GMDTC in rat plasma, and used it to determine the drug concentrations in the plasma of rats after intravenous dosing in different genders and dosages. After pretreating the plasma samples with an acetonitrile–water–ammonia solution (70:30:1.25, v/v/v), liquid chromatographic separations were efficiently achieved wit...
Source: Molecules - January 25, 2023 Category: Chemistry Authors: Wei Hu Zhi-Yong Zhong Yu-Ting Gao Xue-Feng Ren Hai-Yang Liu Xiao-Jiang Tang Tags: Article Source Type: research
A novel case of drug reaction with eosinophilia and systemic symptoms (dress) after metolazone use
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially lethal delayed hypersensitivity reaction often triggered by high-risk drugs such as antiepileptics and antibiotics containing sulfonamides. To our knowledge, there are no reported cases of metolazone, a sulfonamide containing, thiazide diuretic as the causative agent of DRESS. Here we present a case of DRESS after metolazone usage. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: A. Ayyash Tags: M055 Source Type: research
Efficacy of pharmacologic therapies in patients with acute heart failure: A network meta-analysis
Conclusion: No drug was superior to the other drugs for the secondary outcomes and safety outcomes. Current drugs for AHF show similar efficacy and safety. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 23, 2022 Category: Drugs & Pharmacology Source Type: research
Diuretic-resistant pretricuspid shunt: what is the missing link?
Clinical introduction A man in his 70s presented with dyspnoea and oedema. He had a background of chronic kidney disease stage III and atrial fibrillation (AF). The working diagnosis was heart failure (HF). On admission to the local hospital, 12 lead ECG demonstrated rate controlled AF and transthoracic echocardiography (TTE) demonstrated preserved left ventricular (LV) function with a dilated right ventricle (RV). Cardiac MRI (cMR) demonstrated a sinus venosus atrial septal defect (ASD). Despite receiving intravenous furosemide and oral metolazone, his symptoms and weight remained unchanged. Due to a suspicion the pretric...
Source: Heart - September 12, 2022 Category: Cardiology Authors: Camfield, D., Iveson, R., Warriner, D. Tags: Image challenges Source Type: research
Diabetes and Cardiorenal Complications: A Clinical Review of Existing Therapies and Novel Combinations, Focusing on SGLT2 Inhibitors
Curr Diabetes Rev. 2022 Aug 16. doi: 10.2174/1573399819666220816145907. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) is a set of metabolic disorders specified by hyperglycemia as a result of abnormalities in insulin secretion or sensitivity. Chronic kidney disease (CKD) and cardiovascular disease (CVD) are the widespread co-morbidities of T2DM and share risk factors for onset and progression. Despite numerous mono- and combination therapies exist, the progression of diabetes complications remains a global health concern. Treatment options for diabetic- CKD and CVD include drugs targeting hyperglycemia, hyp...
Source: Current Diabetes Reviews - August 17, 2022 Category: Endocrinology Authors: Ajinath Kale Anshima Sharma Hans-Joachim Anders Anil Bhanudas Gaikwad Source Type: research
Metolazone versus intravenous chlorothiazide for decompensated heart failure sequential nephron blockade: A retrospective cohort study
The objective of this study was to determine whether IV chlorothiazide is superior to metolazone in increasing net urine output (UOP) of hospitalized patients with ADHF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - June 7, 2022 Category: Cardiology Authors: Tamara Cisowska, Irene Z. Pan, Joseph Biskupiak, Kevin S. Shah, James C. Fang, Joshua A. Jacobs Source Type: research
Formulation, Characterization, and the Diuretic Effects of a New
Intravenous Metolazone Emulsion
Conclusion This metolazone emulsion was capable of increasing urine volume
output and demonstrated both natriuretic and kaliuretic properties. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - May 10, 2022 Category: Drugs & Pharmacology Authors: Ahlschwede, Kristen M. Ofori, Edward Andey, Terrick Osei, Anita Somberg, John S Tags: Original Article Source Type: research
Metolazone Add-On Therapy in Heart Failure: A Cohort Study from Persian Registry of Cardiovascular Disease/Heart Failure (PROVE/HF)
CONCLUSION: Our findings revealed that adding metolazone in patients with furosemide resistance is not associated with higher morbidity and mortality. Therefore, usage of these two therapeutic agents could be a helpful strategy for severe HF patients.PMID:34721901 | PMC:PMC8556116 | DOI:10.1155/2021/3820292 (Source: Critical Care Research and Practice)
Source: Critical Care Research and Practice - November 1, 2021 Category: Intensive Care Authors: Farzad Rahimi Mehrbod Vakhshoori Maryam Heidarpour Fatemeh Nouri Kiyan Heshmat-Ghahdarijani Mohammad Fakhrolmobasheri Davood Shafie Source Type: research
