How Do You Treat Adrenal Crisis?
Discussion
Septo-optic dysplasia (SOD) is a disorder of midline prosencephalic development early in gestation. It causes agenesis of the septum pellucidum and/or thinning or absence of the corpus callosum and pituitary hormone deficiencies. It has an incidence of 1:10,000 live births. Most cases appear to be due to a combination of genetic and environmental factors but there are rare familial cases which are most often autosomal recessive.
The phenotype is variable and diagnosis can occur at birth with more severe problems or later with milder ones. Patients must have at least 2 of 3 problems for diagnosis including uni- ...
Source: PediatricEducation.org - May 4, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Rituximab May Be Helpful in Graves' OrbitopathyRituximab May Be Helpful in Graves' Orbitopathy
Compared to IV methylprednisolone for Graves' orbitopathy, rituximab offers a number of advantages, Italian researchers say. Reuters Health Information (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - January 6, 2015 Category: Opthalmology Tags: Diabetes & Endocrinology News Source Type: news
ACC: Steroids Hike MIs After Heart Surgery
WASHINGTON (MedPage Today) -- Giving methylprednisolone to patients undergoing cardiac surgery with cardiopulmonary bypass heightened the risk of myocardial infarction, a large randomized trial showed. (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - April 1, 2014 Category: Surgery Source Type: news
Impact of High-Dose Methylprednisolone in Acute SCI PatientsImpact of High-Dose Methylprednisolone in Acute SCI Patients
Methylprednisolone is commonly administered to acute spinal cord injury patients, but safety concerns remain. Emergency Medicine Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2014 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news
Improved anti-inflammatory therapy for acute MS relapses
Last week, the First-in-Human study with 2B3- 201, to-BBB's second product, was initiated at the Centre for Human Drug Research (CHDR) in Leiden, the Netherlands. This Phase I trial is designed to determine the safety profile, and will also give a first glance at the pharmacological profile. In this double-blind crossover study, 18 healthy volunteers are assigned to three cohorts in which they will receive an ascending single dose of 2B3-201, as well as placebo and standard of care methylprednisolone. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 19, 2013 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news
Exserohilum rostratum: Anatomy of a national outbreak of fungal meningitis
This article reviews (i) the development and handling of the outbreak; (ii) the clinical manifestations and management of the infections; (iii) the detection, identification, and characteristics of E. rostratum, including the factors that might enhance its virulence; (iv) the regulatory concerns for microbiological quality control; and (v) what we have learned from this experience. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - November 25, 2013 Category: Microbiology Authors: Davise H. Larone, Thomas J. Walsh Source Type: news
Updated Details on Contaminated Methylprednisolone-Related Fungal Infections (FREE)
By Joe Elia
Two papers in the New England Journal of Medicine offer further clinical and epidemiologic findings a year after the 2012 outbreak of fungal infections associated with contaminated … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 24, 2013 Category: Primary Care Source Type: news
Immunotherapy Helps ID Epilepsy Type
NEW ORLEANS (MedPage Today) -- A few weeks of intravenous immunoglobulin or methylprednisolone was useful in determing whether epilepsy not responding to conventional drugs had an autoimmune origin. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - October 14, 2013 Category: Pediatrics Source Type: news
Cyclophosphamide Effective, Not Well Tolerated in SPMSCyclophosphamide Effective, Not Well Tolerated in SPMS
Results of a randomized comparison show that cyclophosphamide reduced progression vs methylprednisolone in secondary progressive MS, but a high dropout rate may limit its usefulness. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 4, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Methylprednisolone injections significantly improve carpel tunnel symptoms, but surgery still likely
Methylprednisolone injections significantly reduce pain and improve function in carpal tunnel syndrome (CTS) in the short term, but only slightly reduce the rate of surgery after one year. CTS is a common condition in which there is excessive pressure on the nerve in the wrist that allows feeling and movement to parts of the hand. Patients are initially treated with wrist splinting, but many go on to have surgery. While surgery often produces good outcomes, recovery can last several weeks and includes lost work time. Thus, finding an effective nonsurgical treatment is desirable... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 5, 2013 Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news
High-Dose Steroids for Hantavirus Cardiopulmonary SyndromeHigh-Dose Steroids for Hantavirus Cardiopulmonary Syndrome
High-dose IV methylprednisolone is not helpful against hantavirus cardiopulmonary syndrome (HCPS), researchers from Chile report. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 24, 2013 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
MRI Screening May Help Identify Spinal Infections From Contaminated Drug Injections
Magnetic resonance imaging (MRI) at the site of injection of a contaminated lot of a steroid drug to treat symptoms such as back pain resulted in earlier identification of patients with probable or confirmed fungal spinal or paraspinal infection, allowing early initiation of medical and surgical treatment, according to a study in the June 19 issue of JAMA. "Fungal contamination of methylprednisolone [a steroid] prepared by a compounding pharmacy resulted in an unprecedented multistate outbreak of meningitis in the fall of 2012," according to background information in the article... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 20, 2013 Category: Consumer Health News Tags: MRI / PET / Ultrasound Source Type: news
MRI May Identify Fungal Infections From Tainted Steroids
People who may have been injected with contaminated steroids can undergo an MRI scan to check for signs of infection, even if they do not have symptoms, according to a new study published in JAMA. A group of researchers examined 172 people who were injected with methylprednisolone from a New England Compounding Center (NECC) lot that may have been tainted with meningitis and fungi, and identified 36 unusual test results in these subjects - including 13 subjects who had no new or worsening symptoms such as pain or weakness near the injection site... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 19, 2013 Category: Consumer Health News Tags: MRI / PET / Ultrasound Source Type: news
MRI May Detect Meningitis From Tainted Steroids
People who may have been injected with contaminated steroids can undergo an MRI scan to check for signs of infection, even if they do not have symptoms, according to a new study published in JAMA. A group of researchers examined 172 people who were injected with methylprednisolone from a New England Compounding Center (NECC) lot that may have been tainted with meningitis and fungi, and identified 36 unusual test results in these subjects - including 13 subjects who had no new or worsening symptoms such as pain or weakness near the injection site... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 19, 2013 Category: Consumer Health News Tags: MRI / PET / Ultrasound Source Type: news
MRI Spots Indolent Spinal Infections From Contaminated MPAMRI Spots Indolent Spinal Infections From Contaminated MPA
Some patients exposed to contaminated methylprednisolone found to have asymptomatic fungal spinal or paraspinal infection on MRI, clinicians on the front-line of the outbreak say. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 18, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
