The pharmacology and neurotoxicology of synthetic cathinones
Adv Pharmacol. 2024;99:61-82. doi: 10.1016/bs.apha.2023.12.001. Epub 2023 Dec 26.ABSTRACTThe synthetic cathinones are man-made compounds derived from the naturally occurring drug cathinone, which is found in the khat plant. The drugs in this pharmacological class that will be the focus of this chapter include mephedrone, MDPV, methcathinone and methylone. These drugs are colloquially known as "bath salts". This misnomer suggests that these drugs are used for health improvement or that they have legitimate medical uses. The synthetic cathinones are dangerous drugs with powerful pharmacological effects that include high abus...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Mariana Angoa-Perez Donald M Kuhn Source Type: research
The pharmacology and neurotoxicology of synthetic cathinones
Adv Pharmacol. 2024;99:61-82. doi: 10.1016/bs.apha.2023.12.001. Epub 2023 Dec 26.ABSTRACTThe synthetic cathinones are man-made compounds derived from the naturally occurring drug cathinone, which is found in the khat plant. The drugs in this pharmacological class that will be the focus of this chapter include mephedrone, MDPV, methcathinone and methylone. These drugs are colloquially known as "bath salts". This misnomer suggests that these drugs are used for health improvement or that they have legitimate medical uses. The synthetic cathinones are dangerous drugs with powerful pharmacological effects that include high abus...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Mariana Angoa-Perez Donald M Kuhn Source Type: research
Immunity on ice: The impact of methamphetamine on peripheral immunity
Adv Pharmacol. 2024;99:217-250. doi: 10.1016/bs.apha.2023.09.003. Epub 2023 Oct 24.ABSTRACTMethamphetamine (METH) regulation of the dopamine transporter (DAT) and central nervous system (CNS) dopamine transmission have been extensively studied. However, our understanding of how METH influences neuroimmune communication and innate and adaptive immunity is still developing. Recent studies have shed light on the bidirectional communication between the CNS and the peripheral immune system. They have established a link between CNS dopamine levels, dopamine neuronal activity, and peripheral immunity. Akin to dopamine neurons in ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Emily J Miller Habibeh Khoshbouei Source Type: research
Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences
Adv Pharmacol. 2024;99:145-168. doi: 10.1016/bs.apha.2023.08.002. Epub 2024 Feb 9.ABSTRACTMethamphetamine (METH) is the most commonly misused amphetamine-type stimulant throughout the globe. METH is very rewarding, and its misuse can lead to a diagnosis of METH use disorder (MUD). Although METH use is observed in both sexes, there are, however, reported differences in the clinical manifestations of METH use and its consequences. These observations indicate the need for more research on the long-term sex-dependent consequences of METH taking in both preclinical and clinical settings. In effect, sex is a biological variable ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Atul P Daiwile Jean Lud Cadet Source Type: research
The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines
Adv Pharmacol. 2024;99:125-144. doi: 10.1016/bs.apha.2023.09.002. Epub 2023 Oct 20.ABSTRACTUse of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are long-lasting. Similarly, female users may be uniquely vulnerable to certain aspects of drug use. A recognition of the role of use during adolescence and sex on outcomes of amphetamine and methamphetamine exposure are of critical importance in understanding and treating substance use disorders. This chapter highlights what human research, which has been largely epidemiological, suggests ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Lauren K Carrica Joshua M Gulley Source Type: research
Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences
Adv Pharmacol. 2024;99:145-168. doi: 10.1016/bs.apha.2023.08.002. Epub 2024 Feb 9.ABSTRACTMethamphetamine (METH) is the most commonly misused amphetamine-type stimulant throughout the globe. METH is very rewarding, and its misuse can lead to a diagnosis of METH use disorder (MUD). Although METH use is observed in both sexes, there are, however, reported differences in the clinical manifestations of METH use and its consequences. These observations indicate the need for more research on the long-term sex-dependent consequences of METH taking in both preclinical and clinical settings. In effect, sex is a biological variable ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Atul P Daiwile Jean Lud Cadet Source Type: research
The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines
Adv Pharmacol. 2024;99:125-144. doi: 10.1016/bs.apha.2023.09.002. Epub 2023 Oct 20.ABSTRACTUse of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are long-lasting. Similarly, female users may be uniquely vulnerable to certain aspects of drug use. A recognition of the role of use during adolescence and sex on outcomes of amphetamine and methamphetamine exposure are of critical importance in understanding and treating substance use disorders. This chapter highlights what human research, which has been largely epidemiological, suggests ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Lauren K Carrica Joshua M Gulley Source Type: research
The pharmacology and neurotoxicology of synthetic cathinones
Adv Pharmacol. 2024;99:61-82. doi: 10.1016/bs.apha.2023.12.001. Epub 2023 Dec 26.ABSTRACTThe synthetic cathinones are man-made compounds derived from the naturally occurring drug cathinone, which is found in the khat plant. The drugs in this pharmacological class that will be the focus of this chapter include mephedrone, MDPV, methcathinone and methylone. These drugs are colloquially known as "bath salts". This misnomer suggests that these drugs are used for health improvement or that they have legitimate medical uses. The synthetic cathinones are dangerous drugs with powerful pharmacological effects that include high abus...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Mariana Angoa-Perez Donald M Kuhn Source Type: research
Immunity on ice: The impact of methamphetamine on peripheral immunity
Adv Pharmacol. 2024;99:217-250. doi: 10.1016/bs.apha.2023.09.003. Epub 2023 Oct 24.ABSTRACTMethamphetamine (METH) regulation of the dopamine transporter (DAT) and central nervous system (CNS) dopamine transmission have been extensively studied. However, our understanding of how METH influences neuroimmune communication and innate and adaptive immunity is still developing. Recent studies have shed light on the bidirectional communication between the CNS and the peripheral immune system. They have established a link between CNS dopamine levels, dopamine neuronal activity, and peripheral immunity. Akin to dopamine neurons in ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Emily J Miller Habibeh Khoshbouei Source Type: research
The pharmacology and neurotoxicology of synthetic cathinones
Adv Pharmacol. 2024;99:61-82. doi: 10.1016/bs.apha.2023.12.001. Epub 2023 Dec 26.ABSTRACTThe synthetic cathinones are man-made compounds derived from the naturally occurring drug cathinone, which is found in the khat plant. The drugs in this pharmacological class that will be the focus of this chapter include mephedrone, MDPV, methcathinone and methylone. These drugs are colloquially known as "bath salts". This misnomer suggests that these drugs are used for health improvement or that they have legitimate medical uses. The synthetic cathinones are dangerous drugs with powerful pharmacological effects that include high abus...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Mariana Angoa-Perez Donald M Kuhn Source Type: research
The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines
Adv Pharmacol. 2024;99:125-144. doi: 10.1016/bs.apha.2023.09.002. Epub 2023 Oct 20.ABSTRACTUse of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are long-lasting. Similarly, female users may be uniquely vulnerable to certain aspects of drug use. A recognition of the role of use during adolescence and sex on outcomes of amphetamine and methamphetamine exposure are of critical importance in understanding and treating substance use disorders. This chapter highlights what human research, which has been largely epidemiological, suggests ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Lauren K Carrica Joshua M Gulley Source Type: research
Immunity on ice: The impact of methamphetamine on peripheral immunity
Adv Pharmacol. 2024;99:217-250. doi: 10.1016/bs.apha.2023.09.003. Epub 2023 Oct 24.ABSTRACTMethamphetamine (METH) regulation of the dopamine transporter (DAT) and central nervous system (CNS) dopamine transmission have been extensively studied. However, our understanding of how METH influences neuroimmune communication and innate and adaptive immunity is still developing. Recent studies have shed light on the bidirectional communication between the CNS and the peripheral immune system. They have established a link between CNS dopamine levels, dopamine neuronal activity, and peripheral immunity. Akin to dopamine neurons in ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Emily J Miller Habibeh Khoshbouei Source Type: research
Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences
Adv Pharmacol. 2024;99:145-168. doi: 10.1016/bs.apha.2023.08.002. Epub 2024 Feb 9.ABSTRACTMethamphetamine (METH) is the most commonly misused amphetamine-type stimulant throughout the globe. METH is very rewarding, and its misuse can lead to a diagnosis of METH use disorder (MUD). Although METH use is observed in both sexes, there are, however, reported differences in the clinical manifestations of METH use and its consequences. These observations indicate the need for more research on the long-term sex-dependent consequences of METH taking in both preclinical and clinical settings. In effect, sex is a biological variable ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Atul P Daiwile Jean Lud Cadet Source Type: research
The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines
Adv Pharmacol. 2024;99:125-144. doi: 10.1016/bs.apha.2023.09.002. Epub 2023 Oct 20.ABSTRACTUse of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are long-lasting. Similarly, female users may be uniquely vulnerable to certain aspects of drug use. A recognition of the role of use during adolescence and sex on outcomes of amphetamine and methamphetamine exposure are of critical importance in understanding and treating substance use disorders. This chapter highlights what human research, which has been largely epidemiological, suggests ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Lauren K Carrica Joshua M Gulley Source Type: research
Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences
Adv Pharmacol. 2024;99:145-168. doi: 10.1016/bs.apha.2023.08.002. Epub 2024 Feb 9.ABSTRACTMethamphetamine (METH) is the most commonly misused amphetamine-type stimulant throughout the globe. METH is very rewarding, and its misuse can lead to a diagnosis of METH use disorder (MUD). Although METH use is observed in both sexes, there are, however, reported differences in the clinical manifestations of METH use and its consequences. These observations indicate the need for more research on the long-term sex-dependent consequences of METH taking in both preclinical and clinical settings. In effect, sex is a biological variable ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Atul P Daiwile Jean Lud Cadet Source Type: research
