Maternal inulin supplementation ameliorates prenatal methamphetamine exposure-induced hepatotoxicity and restores gut microbiota in mouse offspring
Ecotoxicol Environ Saf. 2023 Nov 30;269:115769. doi: 10.1016/j.ecoenv.2023.115769. Online ahead of print.ABSTRACTPrenatal exposure to methamphetamine (METH) is an issue of global concern due to its adverse effects on offspring, particularly its impact on liver health, an area still not fully understood. Inulin, a recognized prebiotic, is thought to potentially ameliorate these developmental disorders and toxic injuries in progeny. To investigate the effects of prenatal METH exposure on the liver and the role of gut microbiota, we established a murine model, the subjects of which were exposed to METH prenatally and subseque...
Source: Ecotoxicology and Environmental Safety - December 1, 2023 Category: Environmental Health Authors: Jia-Hao Li Jia-Li Liu Xiu-Wen Li Yi Liu Jian-Zheng Yang Hong-Sheng Ma Li-Jian Chen Kai-Kai Zhang Xiao-Li Xie Qi Wang Source Type: research

Maternal inulin supplementation ameliorates prenatal methamphetamine exposure-induced hepatotoxicity and restores gut microbiota in mouse offspring
Ecotoxicol Environ Saf. 2023 Nov 30;269:115769. doi: 10.1016/j.ecoenv.2023.115769. Online ahead of print.ABSTRACTPrenatal exposure to methamphetamine (METH) is an issue of global concern due to its adverse effects on offspring, particularly its impact on liver health, an area still not fully understood. Inulin, a recognized prebiotic, is thought to potentially ameliorate these developmental disorders and toxic injuries in progeny. To investigate the effects of prenatal METH exposure on the liver and the role of gut microbiota, we established a murine model, the subjects of which were exposed to METH prenatally and subseque...
Source: Ecotoxicology and Environmental Safety - December 1, 2023 Category: Environmental Health Authors: Jia-Hao Li Jia-Li Liu Xiu-Wen Li Yi Liu Jian-Zheng Yang Hong-Sheng Ma Li-Jian Chen Kai-Kai Zhang Xiao-Li Xie Qi Wang Source Type: research

EPH72 Polysubstance Use of Psychoactive Stimulants, Suicidal Behavior, and Mental Health Disability Among Women of Reproductive Age
Polysubstance use (PSU) is defined as the ingestion of more than one drug of abuse within a defined period with specific motivations driven by anticipated drug effect(s). Prenatal stimulant use in the US, including cocaine/crack, methamphetamine, and amphetamine-related compounds, is more common than opioids with detrimental health effects on both the mother and her infant. PSU is becoming increasingly prevalent among women of reproductive age. The purpose of this study was to examine associations between PSU of stimulants and mental health disability (MHD), measured by the World Health Organization Disability Assessment S...
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: S. Kim, P. Kitsantas Source Type: research

Quantitative analysis of drugs of abuse and cognitive enhancers in influent wastewater by means of two chromatographic methods
Two methods for qualitative and quantitative analysis of selected drugs of abuse and a cognitive enhancer in wastewater samples were successfully developed and validated. A two-column setup was necessary for the analysis of all analytes included in this method. Evaluation of proof-of-concept samples enabled quantification of several analytes in wastewater grab samples, allowing the method to be used for monitoring trends in the consumption of the included analytes in wastewater. AbstractSewage-based epidemiology using influent wastewater is used to estimate the consumption trends of (illicit) drugs over a short or long per...
Source: Drug Testing and Analysis - November 28, 2023 Category: Drugs & Pharmacology Authors: Fabian Frankenfeld, Lea Wagmann, Cathy M. Jacobs, Markus R. Meyer Tags: RESEARCH ARTICLE Source Type: research

Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1 α, and CCL5 levels
In conclusion, long-term MA use and dependency severely undermine immune homeostasis, whereas MAP may be the consequence of increased IL-1α - CCL5 signaling superimposed on strongly depleted CIRS and Th-1 functions. The widespread immunosuppression established in longstanding MA use may increase the likelihood of infectious and immune illness or exacerbate disorders such as hepatitis and AIDS. Furthermore, elevated levels of CCL5, CCL11, CCL27, IL-1α, and/or IL-12p70 may play a role in the peripheral (atherosclerosis, cutaneous inflammation, immune aberrations, hypospermatogenesis) and central (neuroinflammation, neuroto...
Source: Atherosclerosis - November 23, 2023 Category: Cardiology Authors: Rasmon Kalayasiri Kanokwan Dadwat Supaksorn Thika Sunee Sirivichayakul Michael Maes Source Type: research

Basolateral Amygdala Corticotropin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory in Males
Neurobiol Learn Mem. 2023 Nov 21:107865. doi: 10.1016/j.nlm.2023.107865. Online ahead of print.ABSTRACTPreclinical studies show that inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory in male and female adult and adolescent rodents. The effect is highly selective, as NMII inhibition has no effect in other relevant brain regions (e.g., dorsal hippocampus [dPHC], nucleus accumbens [NAc]), nor does it interfere with associations for o...
Source: Neurobiology of Learning and Memory - November 23, 2023 Category: Neurology Authors: Madalyn Hafenbreidel Surya Pandey Sherri B Briggs Meghana Arza Shalakha Bonthu Cadence Fisher Annika Tiller Alice B Hall Shayna Reed Natasha Mayorga Li Lin Susan Khan Michael D Cameron Gavin Rumbaugh Courtney A Miller Source Type: research

Basolateral Amygdala Corticotropin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory in Males
Neurobiol Learn Mem. 2023 Nov 21:107865. doi: 10.1016/j.nlm.2023.107865. Online ahead of print.ABSTRACTPreclinical studies show that inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory in male and female adult and adolescent rodents. The effect is highly selective, as NMII inhibition has no effect in other relevant brain regions (e.g., dorsal hippocampus [dPHC], nucleus accumbens [NAc]), nor does it interfere with associations for o...
Source: Neurobiology of Learning and Memory - November 23, 2023 Category: Neurology Authors: Madalyn Hafenbreidel Surya Pandey Sherri B Briggs Meghana Arza Shalakha Bonthu Cadence Fisher Annika Tiller Alice B Hall Shayna Reed Natasha Mayorga Li Lin Susan Khan Michael D Cameron Gavin Rumbaugh Courtney A Miller Source Type: research

Design of smart nanoparticles for the electrochemical detection of 3,4 ‐methylenedioxymethamphetamine to allow in field screening by law enforcement officers
A highly sensitive and portable sensor has been developed to detect MDMA in street samples. It uses electroactive molecularly imprinted polymer nanoparticles computationally designed to recognize MDMA, which were immobilized on screen-printed carbon electrodes with chitosan and graphene. The sensor showed good sensitivity and satisfactory recoveries (92 –99%), confirmed with UPLC-MS/MS validation. This technology has the potential to be used in forensic analysis. AbstractA portable and highly sensitive sensor was designed for the specific detection of 3,4-methyl-enedioxy-methamphetamine (MDMA), in a range of field-testin...
Source: Drug Testing and Analysis - November 23, 2023 Category: Drugs & Pharmacology Authors: Florina Maria Truta, Alvaro Garcia Cruz, Ana ‐Maria Dragan, Mihaela Tertis, Todd Cowen, Maria‐Geogia Stefan, Tamara Topala, Amorn Slosse, Elena Piletska, Filip Van Durme, Bela Kiss, Karolien De Wael, Sergey A. Piletsky, Cecilia Cristea Tags: RESEARCH ARTICLE Source Type: research

Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α, and CCL5 levels
Translational Psychiatry, Published online: 23 November 2023; doi:10.1038/s41398-023-02645-6Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α, and CCL5 levels (Source: Translational Psychiatry)
Source: Translational Psychiatry - November 23, 2023 Category: Psychiatry Authors: Rasmon Kalayasiri Kanokwan Dadwat Supaksorn Thika Sunee Sirivichayakul Michael Maes Source Type: research

Design of smart nanoparticles for the electrochemical detection of 3,4 ‐methylenedioxymethamphetamine to allow in field screening by law enforcement officers
A highly sensitive and portable sensor has been developed to detect MDMA in street samples. It uses electroactive molecularly imprinted polymer nanoparticles computationally designed to recognize MDMA, which were immobilized on screen-printed carbon electrodes with chitosan and graphene. The sensor showed good sensitivity and satisfactory recoveries (92 –99%), confirmed with UPLC-MS/MS validation. This technology has the potential to be used in forensic analysis. AbstractA portable and highly sensitive sensor was designed for the specific detection of 3,4-methyl-enedioxy-methamphetamine (MDMA), in a range of field-testin...
Source: Drug Testing and Analysis - November 22, 2023 Category: Drugs & Pharmacology Authors: Florina Maria Truta, Alvaro Garcia Cruz, Ana ‐Maria Dragan, Mihaela Tertis, Todd Cowen, Maria‐Geogia Stefan, Tamara Topala, Amorn Slosse, Elena Piletska, Filip Van Durme, Bela Kiss, Karolien De Wael, Sergey A. Piletsky, Cecilia Cristea Tags: RESEARCH ARTICLE Source Type: research

IJERPH, Vol. 20, Pages 7090: Association of Public Works Disasters with Substance Use Difficulties: Evidence from Flint, Michigan, Five Years after the Water Crisis Onset
on Reuben Public works environmental disasters such as the Flint water crisis typically occur in disenfranchised communities with municipal disinvestment and co-occurring risks for poor mental health (poverty, social disconnection). We evaluated the long-term interplay of the crisis and these factors with substance use difficulties five years after the crisis onset. A household probability sample of 1970 adults living in Flint during the crisis was surveyed about their crisis experiences, use of substances since the crisis, and risk/resilience factors, including prior potentially traumatic event exposure and current so...
Source: International Journal of Environmental Research and Public Health - November 21, 2023 Category: Environmental Health Authors: Tuviere Onookome-Okome Angel Hsu Dean G. Kilpatrick Angela Moreland Aaron Reuben Tags: Article Source Type: research

Melatonin enhances the restoration of neurological impairments and cognitive deficits during drug withdrawal in methamphetamine-induced toxicity and endoplasmic reticulum stress in rats
This study aimed to investigate the restorative effect of Mel on behavioral flexibility in METH-induced cognitive deficits. Male Sprague-Dawley rats were randomly assigned to be intraperitoneally injected with saline (control) or Meth at 5mg/kg for 7 consecutive days. Then, METH injection was withdrawn and rats in each group were subcutaneously injected with saline or Mel at 10mg/kg for 14 consecutive days. The stereotypic behavioral test and attentional set-shifting task (ASST) were used to evaluate neurological functions and cognitive flexibility, respectively. Rats developed abnormal features of stereotyped behaviors an...
Source: Neurotoxicology - November 18, 2023 Category: Neurology Authors: Pongphat Komlao Natcharee Kraiwattanapirom Kitipong Promyo Zaw Myo Hein Banthit Chetsawang Source Type: research

Implementing Heart Plus: Design and Early Results of a Novel Co-Management Clinic for Patients with Stimulant-Associated Cardiomyopathy
The national prevalence of heart failure (HF) and stimulant use – notably methamphetamine and cocaine – is rising, and there is increasing recognition of the connection between the two in the form of stimulant-associated cardiomyopathy (SA-CMP).1–5 Mortality and acute care utilization (e.g., Emergency Department [ED] visits, hospital admissions) rates are disproportionately elevated in people with SA-CMP, while consistent outpatient care engagement rates are lower than matched controls.6 In California, methamphetamine-associated HF admissions increased 600%, from 1.2% of all hospitalizations in 2008 to 8% in 2018. (S...
Source: Journal of Cardiac Failure - November 18, 2023 Category: Cardiology Authors: Jonathan Davis, Lurit Bepo, Leslie W. Suen, Megan M. McLaughlin, Meredith Adamo, Elizabeth Abbs, Grace Lemke, Soraya Azari Source Type: research

Implementing Heart Plus: Design and Early Results of a Novel Comanagement Clinic for Patients With Stimulant-associated Cardiomyopathy
The national prevalence of heart failure (HF) and stimulant use —notably methamphetamine and cocaine—is increasing, and there is increasing recognition of the connection between the two in the form of stimulant-associated cardiomyopathy (SA-CMP).1–5 Mortality and acute care use (eg, emergency department visits, hospital admissions) rates are disproportiona tely elevated in people with SA-CMP, whereas consistent outpatient care engagement rates are lower than matched controls.6 In California, methamphetamine-associated HF admissions increased 600%, from 1.2% of all hospitalizations in 2008 to 8.0% in 2018. (Source: Jo...
Source: Journal of Cardiac Failure - November 18, 2023 Category: Cardiology Authors: Jonathan D. Davis, Lurit Bepo, Leslie W. Suen, Megan M. Mclaughlin, Meredith Adamo, Elizabeth Abbs, Grace Lemke, Soraya Azari Source Type: research