Efficient magnetic solid-phase extraction, UPLC-MS/MS detection, and consumption assessment of five trace psychoactive substances
Environ Sci Pollut Res Int. 2024 Apr 18. doi: 10.1007/s11356-024-33284-z. Online ahead of print.ABSTRACTWastewater-based epidemiology (WBE) has become an objective and updated surveillance strategy for monitoring and estimating consumption trends of psychoactive substances (PSs) in the population. Firstly, magnetic shrimp shell biochar-based adsorbent (DZMBC) was synthesized and employed for extraction trace PSs from municipal wastewater. Proper pyrolysis temperature and increased KOH activator content favored the pore structure and surface area, thus facilitating extraction. DZMBC delivered exceptional extraction performa...
Source: Environmental Science and Pollution Research International - April 18, 2024 Category: Environmental Health Authors: Rong Zhu Shurui Cao Hongtao Su Dewang Ming Yao Tang Zhiqiong Chen Source Type: research
Chemsex and risk of sexually transmitted infections: a perspective from India
Introduction Chemsex, also called as party and play or intensive sex partying, is the intentional use of psychoactive drugs before or during sex, mostly by gay and bisexual men having sex with men (GBMSM) to enable, enhance and prolong sexual interaction.1 The practice is now becoming increasingly common among heterosexual individuals too.1 Various chemsex drugs have been described (table 1), the principal three that are commonly used include mephedrone, gamma-hydroxybutyrate/gamma-butyrolactone (GHB/GBL) and crystallised methamphetamine.1 The injectable use of these substances for similar purpose is called as slamming or ...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Juyal, D., Pal, S., Joshi, C., Dhawan, N., Rawre, J., Dhawan, B. Tags: Education Source Type: research
Point-of-care testing of methamphetamine and cocaine utilizing wearable sensors
Anal Biochem. 2024 Apr 13:115526. doi: 10.1016/j.ab.2024.115526. Online ahead of print.ABSTRACTThe imperative for the point-of-care testing of methamphetamine and cocaine in drug abuse prevention necessitates innovative solutions. To address this need, we have introduced a multi-channel wearable sensor harnessing CRISPR/Cas12a system. A CRISPR/Cas12a based system, integrated with aptamers specific to methamphetamine and cocaine, has been engineered. These aptamers function as signal-mediated intermediaries, converting methamphetamine and cocaine into nucleic acid signals, subsequently generating single-stranded DNA to acti...
Source: Analytical Biochemistry - April 15, 2024 Category: Biochemistry Authors: Ying Wang Ke Li Weijian Shen Xingxu Huang Lina Wu Source Type: research
Point-of-care testing of methamphetamine and cocaine utilizing wearable sensors
Anal Biochem. 2024 Apr 13:115526. doi: 10.1016/j.ab.2024.115526. Online ahead of print.ABSTRACTThe imperative for the point-of-care testing of methamphetamine and cocaine in drug abuse prevention necessitates innovative solutions. To address this need, we have introduced a multi-channel wearable sensor harnessing CRISPR/Cas12a system. A CRISPR/Cas12a based system, integrated with aptamers specific to methamphetamine and cocaine, has been engineered. These aptamers function as signal-mediated intermediaries, converting methamphetamine and cocaine into nucleic acid signals, subsequently generating single-stranded DNA to acti...
Source: Analytical Biochemistry - April 15, 2024 Category: Biochemistry Authors: Ying Wang Ke Li Weijian Shen Xingxu Huang Lina Wu Source Type: research
Point-of-care testing of methamphetamine and cocaine utilizing wearable sensors
Anal Biochem. 2024 Apr 13:115526. doi: 10.1016/j.ab.2024.115526. Online ahead of print.ABSTRACTThe imperative for the point-of-care testing of methamphetamine and cocaine in drug abuse prevention necessitates innovative solutions. To address this need, we have introduced a multi-channel wearable sensor harnessing CRISPR/Cas12a system. A CRISPR/Cas12a based system, integrated with aptamers specific to methamphetamine and cocaine, has been engineered. These aptamers function as signal-mediated intermediaries, converting methamphetamine and cocaine into nucleic acid signals, subsequently generating single-stranded DNA to acti...
Source: Analytical Biochemistry - April 15, 2024 Category: Biochemistry Authors: Ying Wang Ke Li Weijian Shen Xingxu Huang Lina Wu Source Type: research
Point-of-care testing of methamphetamine and cocaine utilizing wearable sensors
Anal Biochem. 2024 Apr 13:115526. doi: 10.1016/j.ab.2024.115526. Online ahead of print.ABSTRACTThe imperative for the point-of-care testing of methamphetamine and cocaine in drug abuse prevention necessitates innovative solutions. To address this need, we have introduced a multi-channel wearable sensor harnessing CRISPR/Cas12a system. A CRISPR/Cas12a based system, integrated with aptamers specific to methamphetamine and cocaine, has been engineered. These aptamers function as signal-mediated intermediaries, converting methamphetamine and cocaine into nucleic acid signals, subsequently generating single-stranded DNA to acti...
Source: Analytical Biochemistry - April 15, 2024 Category: Biochemistry Authors: Ying Wang Ke Li Weijian Shen Xingxu Huang Lina Wu Source Type: research
High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats
Translational Psychiatry, Published online: 15 April 2024; doi:10.1038/s41398-024-02895-yHigh frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats (Source: Translational Psychiatry)
Source: Translational Psychiatry - April 15, 2024 Category: Psychiatry Authors: Libo Zhang Shiqiu Meng Enze Huang Tianqi Di Zengbo Ding Shihao Huang Wenjun Chen Jiayi Zhang Shenghong Zhao Ting Yuwen Yang Chen Yanxue Xue Feng Wang Jie Shi Yu Shi Source Type: research
Police Harassment and Psychiatric, Sexual, and Substance Use Risk Among Black Sexual Minority Men and Black Transgender Women in the HIV Prevention Trials 061 Cohort
ConclusionPH may influence not only mental health but also behavioral risks that contribute to HIV/STI among BSMM/BTW, highlighting the potential wide-ranging and downstream effects of PH on health. Further research is required to confirm associations and elucidate pathways through which PH may influence HIV/STI among BSMM/BTW. (Source: Journal of Racial and Ethnic Health Disparities)
Source: Journal of Racial and Ethnic Health Disparities - April 12, 2024 Category: International Medicine & Public Health Source Type: research
Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity
This study aimed to assess whether brief recall of methamphetamine (MA) memory, when combined with ketamine (KE) treatment, may prevent stress-primed MA memory reinstatement. Combining 3-min recall and KE facilitated MA memory extinction and resistance to subsequent stress-primed reinstatement. Such combination also produced glutamate metabotropic receptor 5 (mGluR5) upregulation in animals' medial prefrontal cortex (mPFC) γ-amino-butyric acid (GABA) neuron. Accordingly, chemogenetic methods were employed to bi-directionally modulate mPFC GABA activity. Following brief recall and KE-produced MA memory extinction, intra-mP...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Li-Han Sun Lung Yu Ya-Hsuan Chan Min-Han Chin Chi-Pin Lee Yi-Han Liao Source Type: research
Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity
This study aimed to assess whether brief recall of methamphetamine (MA) memory, when combined with ketamine (KE) treatment, may prevent stress-primed MA memory reinstatement. Combining 3-min recall and KE facilitated MA memory extinction and resistance to subsequent stress-primed reinstatement. Such combination also produced glutamate metabotropic receptor 5 (mGluR5) upregulation in animals' medial prefrontal cortex (mPFC) γ-amino-butyric acid (GABA) neuron. Accordingly, chemogenetic methods were employed to bi-directionally modulate mPFC GABA activity. Following brief recall and KE-produced MA memory extinction, intra-mP...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Li-Han Sun Lung Yu Ya-Hsuan Chan Min-Han Chin Chi-Pin Lee Yi-Han Liao Source Type: research
IJERPH, Vol. 21, Pages 455: An Investigation into the Prevalence of Methamphetamine Related Enquiries to Local Government Environmental Health Officers
et Whiley
Methamphetamine contamination of residential properties remains a serious public health concern for members of the public. External stakeholders including Environmental Health Officers (EHOs) and testing and remediation technicians are engaged on investigating whether contamination has occurred from manufacturing or smoking processes. More specifically, local council EHOs are responsible for managing clandestine drug laboratories when notified by police and also for responding to public enquiries. However, the full scope of these contaminated properties is not seen by any single stakeholder, making it very ch...
Source: International Journal of Environmental Research and Public Health - April 8, 2024 Category: Environmental Health Authors: Emma J. Kuhn Kirstin E. Ross G. Stewart Walker Jackie Wright Harriet Whiley Tags: Article Source Type: research
Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
Biochem Pharmacol. 2024 Apr 3:116189. doi: 10.1016/j.bcp.2024.116189. Online ahead of print.ABSTRACTPrevious research has demonstrated therapeutic potential for VMAT2 inhibitors in rat models of methamphetamine use disorder. Here, we report on the neurochemical and behavioral effects of 1-(2-methoxyphenethyl)-4-phenethypiperazine (JPC-141), a novel analog of lobelane. JPC-141 potently inhibited (Ki = 52 nM) [3H]dopamine uptake by VMAT2 in striatal vesicles with 50 to 250-fold greater selectivity for VMAT2 over dopamine, norepinephrine and serotonin plasmalemma transporters. Also, JPC-141 was 57-fold more selective for inhi...
Source: Biochemical Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Cassie M Chandler Justin R Nickell A George Wilson John P Culver Peter A Crooks Michael T Bardo Linda P Dwoskin Source Type: research
Bilateral sequential nonarteritic anterior ischemic optic neuropathy associated with methamphetamine abuse
Can J Ophthalmol. 2024 Apr 2:S0008-4182(24)00066-8. doi: 10.1016/j.jcjo.2024.03.001. Online ahead of print.NO ABSTRACTPMID:38580216 | DOI:10.1016/j.jcjo.2024.03.001 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Caroline C Cotton Nancy F Vilar Source Type: research
Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
Biochem Pharmacol. 2024 Apr 3:116189. doi: 10.1016/j.bcp.2024.116189. Online ahead of print.ABSTRACTPrevious research has demonstrated therapeutic potential for VMAT2 inhibitors in rat models of methamphetamine use disorder. Here, we report on the neurochemical and behavioral effects of 1-(2-methoxyphenethyl)-4-phenethypiperazine (JPC-141), a novel analog of lobelane. JPC-141 potently inhibited (Ki = 52 nM) [3H]dopamine uptake by VMAT2 in striatal vesicles with 50 to 250-fold greater selectivity for VMAT2 over dopamine, norepinephrine and serotonin plasmalemma transporters. Also, JPC-141 was 57-fold more selective for inhi...
Source: Biochemical Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Cassie M Chandler Justin R Nickell A George Wilson John P Culver Peter A Crooks Michael T Bardo Linda P Dwoskin Source Type: research
Bilateral sequential nonarteritic anterior ischemic optic neuropathy associated with methamphetamine abuse
Can J Ophthalmol. 2024 Apr 2:S0008-4182(24)00066-8. doi: 10.1016/j.jcjo.2024.03.001. Online ahead of print.NO ABSTRACTPMID:38580216 | DOI:10.1016/j.jcjo.2024.03.001 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Caroline C Cotton Nancy F Vilar Source Type: research
