Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Methamphetamine-Dependent Individuals After Six Months Abstinence
ConclusionThe present study suggests that cerebellar dysfunction, in particular aberrant cerebellar-cerebral functional connectivity, might involve in neurobiological mechanism of MA dependence, which supply a potential target for therapeutic interventions in the future. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 31, 2020 Category: Psychiatry Source Type: research

Recent Partner Violence, Sexual Relationship Power, and STIs among Women Who Use Methamphetamine: Does Type of Sexual Partner Matter?
The objective of our study was to examine the association of recent PV and SRP on STIs by partner type among HIV-negative, heterosexual women who use methamphetamine in San Diego, CA. Using baseline survey data from 209 women enrolled in FASTLANE II, an HIV behavioral intervention trial, we conducted logistic regression analyses to examine associations between PV, SRP, and self-reported lifetime STIs (e.g., chlamydia, gonorrhea). Models focused on PV perpetrated within the past 2  months by: (1) spouse, live-in, or steady sexual partners and (2) casual or anonymous sexual partners. Seventy-eight percent of women repor...
Source: Journal of Urban Health - March 30, 2020 Category: Health Management Source Type: research

Genes, Vol. 11, Pages 364: Differential Responses of LINE-1 in the Dentate Gyrus, Striatum and Prefrontal Cortex to Chronic Neurotoxic Methamphetamine: A Study in Rat Brain
a Methamphetamine (METH) is a widely abused psychostimulant with the potential to cause a broad range of severe cognitive deficits as well as neurobehavioral abnormalities when abused chronically, particularly at high doses. Cognitive deficits are related to METH neurotoxicity in the striatum and hippocampus. The activation of transposable Long INterspersed Nuclear Element 1 (LINE-1) is associated with several neurological diseases and drug abuse, but there are very limited data regarding the effects of high-dose METH on the activity of LINE-1 in the adult brain. Using real-time quantitative PCR, the present study demo...
Source: Genes - March 28, 2020 Category: Genetics & Stem Cells Authors: Anna Moszczynska Tags: Article Source Type: research

Methamphetamine alters the TLR4 signaling pathway, NF-κB activation, and pro-inflammatory cytokine production in LPS-challenged NR-9460 microglia-like cells
Publication date: May 2020Source: Molecular Immunology, Volume 121Author(s): Ana M. Vargas, Dormarie E. Rivera-Rodriguez, Luis R. Martinez (Source: Molecular Immunology)
Source: Molecular Immunology - March 27, 2020 Category: Allergy & Immunology Source Type: research

[ASAP] Astrocyte-Derived Lipocalin-2 Is Involved in Mitochondrion-Related Neuronal Apoptosis Induced by Methamphetamine
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.9b00559 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - March 27, 2020 Category: Neuroscience Authors: Xuebing Chen †¶, Feng Qiu‡¶, Xu Zhao†, Jiancong Lu†, Xiaohui Tan†, Jingtao Xu†, Chuanxiang Chen†, Fu Zhang§, Chao Liu?, Dongfang Qiao*†, and Huijun Wang*†‡ Source Type: research

Patterns and Characteristics of Methamphetamine Use Among Adults - United States, 2015-2018.
This report uses data from the 2015-2018 National Surveys on Drug Use and Health (NSDUHs) to estimate methamphetamine use rates in the United States and to identify characteristics associated with past-year methamphetamine use. Rates (per 1,000 adults aged ≥18 years) for past-year methamphetamine use were estimated overall, by demographic group, and by state. Frequency of past-year use and prevalence of other substance use and mental illness among adults reporting past-year use were assessed. Multivariable logistic regression examined characteristics associated with past-year use. During 2015-2018, the estimated rate of...
Source: MMWR Morb Mortal Wkl... - March 27, 2020 Category: Epidemiology Authors: Jones CM, Compton WM, Mustaquim D Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Methamphetamine-induced Acute Esophagitis in a 16-Year-old Girl
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - March 24, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Methamphetamine exposure during the first, but not the second half of prenatal development, affects social play behavior.
ková I, Šlamberová R Abstract Methamphetamine (MA), as a psychostimulant drug that crosses the placental barrier, may disrupt the development of social play. The present study aims to examine the effect of prenatal MA (5 mg/kg) exposure during the first (gestational day (GD) 1-11) or second (GD 12-22) halves of prenatal development of rats on social play behavior. To investigate an acute effect of MA on social play in adulthood, juvenile rats were exposed to a dose of 1 mg/kg MA or saline on the test day and tested for social play for 15 min. Prenatal exposure to MA during GD 1-11 increased so...
Source: Physiological Research - March 23, 2020 Category: Physiology Authors: Ševčíková M, Petríková I, Šlamberová R Tags: Physiol Res Source Type: research

Increasing Methamphetamine Detection in Cases of Early Childhood Fatalities.
Abstract Age and organ maturity can influence drug toxicity in children; however, most clinical data and literature are based on drug concentrations in adults. Therefore, the interpretation of drugs detected in children is often difficult or not possible. Retrospective reviewing of pathology and toxicology information from postmortem cases may assist in future interpretations or identify drug trends. A search of the Forensic Science SA case files was undertaken over 15 years from January 2002 to December 2016 for all children (
Source: Journal of Forensic Sciences - March 23, 2020 Category: Forensic Medicine Authors: Kenneally M, Byard RW Tags: J Forensic Sci Source Type: research

IJERPH, Vol. 17, Pages 2084: Cardiac and Locomotor Responses to Acute Stress in Signal Crayfish Pacifastacus leniusculus Exposed to Methamphetamine at an Environmentally Relevant Concentration
ák Petr Císař Pavel Kozák Methamphetamine (METH), a central nervous system stimulant used as a recreational drug, is frequently found in surface waters at potentially harmful concentrations. To determine effects of long-term exposure to environmentally relevant levels on nontarget organisms, we analysed cardiac and locomotor responses of signal crayfish Pacifastacus leniusculus to acute stress during a 21-day exposure to METH at 1 μg L−1 followed by 14 days depuration. Heart rate and locomotion were recorded over a period of 30 min before and 30 min after exposure to h...
Source: International Journal of Environmental Research and Public Health - March 21, 2020 Category: Environmental Health Authors: Filip Lo žek Iryna Kuklina Kate řina Grabicová Jan Kubec Milo š Buřič Tom áš Randák Petr C ísař Pavel Koz ák Tags: Article Source Type: research

Testing Unconventional Matrices to Monitor for Prenatal Exposure to Heroin, Cocaine, Amphetamines, Synthetic Cathinones, and Synthetic Opioids
Conclusions: Maternal hair testing is the most sensitive alternative matrix for identifying drug use during pregnancy, while drug concentrations in the meconium, placenta, and umbilical cord offer the identification of prenatal drug exposure at birth. Adverse developmental outcomes for the infant make it critical to promptly identify maternal drug use to limit fetal exposure or, if determined at birth, to provide resources to the exposed child and family. Alternative matrices offer choices for monitoring and challenge laboratories to deliver highly sensitive and specific analytical methods for detection. (Source: Therape...
Source: Therapeutic Drug Monitoring - March 20, 2020 Category: Drugs & Pharmacology Tags: Focus Series: Therapeutic Drug Monitoring During Pregnancy and Lactation Source Type: research

National Toxic Substances Incidents Program - Nine States, 2010-2014.
Abstract PROBLEM/CONDITION: Every year in the United States, thousands of toxic substance incidents harm workers, first responders, and the public with the potential for catastrophic consequences. Surveillance data enable public health and safety professionals to understand the patterns and causes of these incidents, which can improve prevention efforts and preparation for future incidents. PERIOD COVERED: 2010-2014. DESCRIPTION OF SYSTEM: In 2010, the Agency for Toxic Substances and Disease Registry (ATSDR) initiated the National Toxic Substance Incidents Program (NTSIP), and it was retired in 2014. Nin...
Source: MMWR Surveill Summ - March 20, 2020 Category: Epidemiology Authors: Melnikova N, Wu J, Ruiz P, Orr MF Tags: MMWR Surveill Summ Source Type: research

A revised excretion factor for estimating ketamine consumption by wastewater-based epidemiology - Utilising wastewater and seizure data.
Abstract The rate of drug excretion (excretion factor) is a critical parameter for monitoring drug consumption in the population by wastewater-based epidemiology (WBE). Previous studies have refined excretion factors for common illicit drugs, such as cocaine, amphetamine, methamphetamine, heroin, to improve the accuracy and reduce uncertainty in back-calculating consumption. Nevertheless, for ketamine, one of the most prevalent psychoactive substances, a careful review of its excretion factors has not been performed due to limited pharmacokinetic data. Here we review WBE studies and seizure data to refine and vali...
Source: Environment International - March 20, 2020 Category: Environmental Health Authors: Du P, Zheng Q, Thomas KV, Li X, Thai PK Tags: Environ Int Source Type: research

Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice.
Abstract Methamphetamine (METH) has been reported to induce endoplasmic reticulum (ER) stress and neuronal apoptosis in the central nervous system (CNS) during the development of addiction. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays an important role in inhibiting apoptosis and protects neurons from cytotoxicity through ER and mitochondria-mediated pathways. Our previous study has been reported that Trx-1 protects mice from METH-induced rewarding effect. However, whether Trx-1 plays the role in resisting METH injury is still unclear. Here, we aim to investigate whether Trx-1 participates in the ...
Source: Neurotoxicology - March 20, 2020 Category: Neurology Authors: Yang L, Guo N, Fan W, Ni C, Huang M, Bai L, Zhang L, Zhang X, Wen Y, Li Y, Zhou X, Bai J Tags: Neurotoxicology Source Type: research

Minocycline May be Useful to Prevent or Treat Methamphetamine-Induced Neural Cell Death: Hypothetic Role of Autophagia and Apoptosis Signaling Pathway.
PMID: 32181231 [PubMed] (Source: Biomed Res)
Source: Biomed Res - March 18, 2020 Category: Research Authors: Sepehr A, Motaghinejad M, Heysieattalab S, Safari S Tags: Adv Biomed Res Source Type: research

Dark Times: The Role of Negative Reinforcement in Methamphetamine Addiction
Methamphetamine use is associated with substantial adverse outcomes including poor mental and physical health, financial difficulties, and societal costs. Despite deleterious long-term consequences associated with methamphetamine, many people use drugs for short-term reduction of unpleasant physical or emotional sensations. By removing these aversive states, drug use behaviors are negatively reinforced. Abstinence from methamphetamine can then result in a return to previous aversive emotional states linked to withdrawal and craving, often contributing to an increased likelihood for relapse. This negative reinforcement cycl...
Source: Frontiers in Psychiatry - March 17, 2020 Category: Psychiatry Source Type: research

Sex Work as a Mediator Between Female Gender and Incident HIV Infection Among People Who Inject Drugs in Tijuana, Mexico
AbstractWe studied mechanisms driving gender differences in HIV incidence among 651 women and men who inject drugs (PWID) in Tijuana, Mexico, hypothesizing that sex work  will mediate the association between female gender and HIV incidence. Of 43 HIV seroconversions occurring between 2011 and 2018, 8.8% were among females and 5.2% among males. HIV incidence density was significantly higher among females versus males (1.75 per 100 person years [PY], 95% CI 1.16–2. 66, vs. 0.95 per 100 PY, 95% CI 0.62–1.47). Factors significantly associated with HIV seroconversion were: sex work (adjusted hazard ratio [aHR]&...
Source: AIDS and Behavior - March 17, 2020 Category: Infectious Diseases Source Type: research

Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review
ConclusionsNo pharmacotherapy yielded convincing results for the treatment of AMPH/MA dependence; mostly studies were underpowered and had low treatment completion rates. However, there were positive signals from several agents that warrant further investigation in larger scale studies; agonist therapies show promise. Common outcome measures should include change in use days. Future research must address the heterogeneity of AMPH/MA dependence (e.g. coexisting conditions, severity of disorder, differences between MA and AMPH dependence) and the role of psychosocial intervention. (Source: CNS Drugs)
Source: CNS Drugs - March 17, 2020 Category: Neurology Source Type: research

Reduction of dopaminergic transmission in the globus pallidus increases anxiety-like behavior without altering motor activity.
Abstract The globus pallidus (GP) has an important role in the flow of information between input and output structures of the basal ganglia (BG) circuit. For example, the GP participates in motor control symptoms of Parkinson's disease (PD). Since the GP receives dopaminergic innervation from the substantia nigra pars compacta (SNc), a local dopamine (DA) deficit could possibly be related to the cognitive and emotional alterations of PD as well. The aim of this study was to examine the effects of lesions in the GP (induced by 6-OHDA) on anxiety, depression and ambulation in rats. Such lesions are known to reduce d...
Source: Behavioural Brain Research - March 16, 2020 Category: Neurology Authors: G A, O P, E CM, M GR Tags: Behav Brain Res Source Type: research

Pre-exposure Prophylaxis Awareness and Use Among Cisgender Men Who Have Sex With Men and Use Methamphetamine in 3 Western US Cities
Conclusions These results highlight the need for continued efforts to educate and promote PrEP uptake among MSM, particularly those who use methamphetamine. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - March 13, 2020 Category: Sexual Medicine Tags: Original Studies Source Type: research

Addressing overdose risk among unstably housed women in San Francisco, California: an examination of potential fentanyl contamination of multiple substances
Numerous reports have led to concerns that fentanyl is added to many street drugs as an adulterant, including to stimulants like cocaine and methamphetamine, and could increase risks for negative health outcomes. (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - March 10, 2020 Category: Drugs & Pharmacology Authors: Meredith C. Meacham, Kara L. Lynch, Phillip O. Coffin, Amanda Wade, Eliza Wheeler and Elise D. Riley Tags: Brief report Source Type: research

Effect of Parkin on methamphetamine ‐induced α‐synuclein degradation dysfunction in vitro and in vivo
ConclusionsBy establishing stable cell lines and animal models that overexpress Parkin, we confirmed Parkin as an important factor in METH ‐induced α‐syn degradation dysfunction in vitro and in vivo. Parkin may be a promising target for the treatment of METH‐induced neurotoxicity. (Source: Brain and Behavior)
Source: Brain and Behavior - March 5, 2020 Category: Neurology Authors: Yunle Meng, Honghua Qiao, Jiuyang Ding, Yitong He, Haoling Fan, Chen Li, Pingming Qiu Tags: ORIGINAL RESEARCH Source Type: research

Differential effects of performance-enhancing drugs 'Methamphetamine' and 'hCG' on ex-vivo cultured primary blood mononuclear cells of male athletes.
CONCLUSION: This study demonstrated the differential effects of Meth and hCG on immune cells of athlete's blood. Meth acted as an inflammation and T cell dysfunction inducing agent, while hCG acted as an anti-inflammatory immunosuppressive molecule. PMID: 32124391 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Pramanik A, Das S, Khanna GL Tags: Pharmacol Rep Source Type: research

A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens
AbstractThe transition from occasional to escalated psychostimulant use is accelerated by prior drug exposure. These behavioral observations may be related to long-lasting transcriptional and/or epigenetic changes induced by the drug pre-exposure. Herein, we investigated if a single methamphetamine (METH) injection would enhance METH self-administration (SA) and impact any METH SA-induced epigenetic or transcriptional alterations. We thus injected a single METH dose (10  mg/kg) or saline to rats before training them to self-administer METH or saline. There were three experimental groups in SA experiments: (1) a single...
Source: Molecular Neurobiology - March 1, 2020 Category: Neurology Source Type: research

Investigating the New Zealand policy response to methamphetamine ‐contaminated houses
AbstractThe contamination of houses from clandestine methamphetamine manufacture emerged as an issue in New Zealand in the early 2000s. This perspective reviews and discusses the series of policies developed to address methamphetamine contamination in New Zealand houses over a 15 ‐year period, ending with the reversal of the established policy approach in 2018.The policies addressing methamphetamine contamination of New Zealand properties were influenced by a range of sources including overseas scientific guidelines, local scientific reviews, public housing agency policies, and the local methamphetamine testing industry....
Source: Drug Testing and Analysis - February 28, 2020 Category: Drugs & Pharmacology Authors: Claudia Denisse Sanchez Lozano, Chris Wilkins, Marta Rychert Tags: PERSPECTIVE Source Type: research

Psychopathy and Corticostriatal Connectivity: The Link to Criminal Behavior in Methamphetamine Dependence
This study shows that psychopathic traits contribute to weaker corticostriatal connectivity in methamphetamine dependence and contributes to an increase in criminal behavior. As the propensity to engage in criminal activity is dependent on a number of factors, a hierarchical regression identifies the contribution of the impulsive antisocial domain of psychopathy, anxiety, years of methamphetamine use and corticostriatal connectivity on different types of criminal offenses. Methamphetamine use and psychopathic traits reduce treatment responsiveness and increase the likelihood of recidivism, and it is therefore important to ...
Source: Frontiers in Psychiatry - February 28, 2020 Category: Psychiatry Source Type: research

Effectiveness of the First German-Language Group Psychotherapy Manual to Accompany Short-Term Treatment in Methamphetamine Dependence
Conclusions: This freely available therapy manual can help counter the shortfall in available psychotherapeutic interventions for patients with methamphetamine dependence in German-speaking countries. The routinely assessed parameters duration of regular methamphetamine use and abstinence before treatment were associated with outcome and may be used to personalize therapeutic strategies. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - February 28, 2020 Category: Psychiatry Source Type: research

Effect of Parkin on methamphetamine ‐induced α‐synuclein degradation dysfunction in vitro and in vivo
ConclusionsBy establishing stable cell lines and animal models that overexpress Parkin, we confirmed Parkin as an important factor in METH ‐induced α‐syn degradation dysfunction in vitro and in vivo. Parkin may be a promising target for the treatment of METH‐induced neurotoxicity. (Source: Brain and Behavior)
Source: Brain and Behavior - February 27, 2020 Category: Neurology Authors: Yunle Meng, Honghua Qiao, Jiuyang Ding, Yitong He, Haoling Fan, Chen Li, Pingming Qiu Tags: ORIGINAL RESEARCH Source Type: research

Motivations for crystal methamphetamine-opioid co-injection/co-use amongst community-recruited people who inject drugs: a qualitative study
We report on motivations for crystal methamphetamine-opioid co-use/co-injection through narratives of people who inject drugs during a period of increased crystal methamphetamine use reporting in Australia. (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - February 27, 2020 Category: Drugs & Pharmacology Authors: Anna Palmer, Nick Scott, Paul Dietze and Peter Higgs Tags: Research Source Type: research

Determination of structural factors affecting binding to mu, kappa and delta opioid receptors.
Abstract Addiction is a complex behavioral phenomenon in which naturally occurring or synthetic chemicals modulate the response of the reward system through their binding to a variety of neuroreceptors, resulting in compulsive substance-seeking and use despite harmful consequences to the individual. Among these, the opioid receptor (OR) family and more specifically, the mu-opioid receptor (MOR) subtype plays a critical role in the addiction to powerful prescription and illicit drugs such as hydrocodone, oxycodone, fentanyl, cocaine, and methamphetamine (Contet et al. in Curr Opin Neurobiol 14(3):370-378, 2004). Co...
Source: Archives of Toxicology - February 27, 2020 Category: Toxicology Authors: Slavov S, Mattes W, Beger RD Tags: Arch Toxicol Source Type: research

Preventive Effects of Duloxetine Against Methamphetamine Induced Neurodegeneration and Motor Activity Disorder in Rat: Possible Role of CREB/BDNF Signaling Pathway
Conclusions:We conclude that P ‑CREB/BDNF signaling pathways might have critical role in duloxetine neuroprotective effects againstmethamphetamine induced neurodegeneration.Keyword:Duloxetine, methamphetamine, motor activity, neurodegeneration, P ‑CREB/BDNFpathway (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - February 25, 2020 Category: International Medicine & Public Health Source Type: research

Age-dependent effects of repeated methamphetamine exposure on locomotor activity and attentional function in rats
Publication date: Available online 21 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Azadeh Nazari, Cristian Perez-Fernandez, Pilar Flores, Margarita Moreno, Fernando Sánchez-SantedAbstractMany adolescents use amphetamines which are the second most common abused illegal drugs. Methamphetamine (Meth), as a potent amphetamine affects attentional functions. However, the most significant factor for susceptibility to Meth is the age of exposure, most studies have examined the effects of Meth after early adolescence stage. The present experiment was aimed to investigate some possible short- and long...
Source: Pharmacology Biochemistry and Behavior - February 21, 2020 Category: Biochemistry Source Type: research

Use of a newly-developed portable capillary electrophoresis analyser to detect drugs of abuse in oral fluid: A case study.
kar J Abstract The aim of the current study was to develop and validate an analytical method to determine whether drugs of abuse (DOA) were present in oral fluid (OF) using a newly-developed, portable capillary electrophoresis (CE) instrument coupled to a deep ultra-violet fluorescence detector (FD). The performance of this portable CE-FD DOA analyser was tested at the Weekend Festival Baltic (Pärnu, Estonia) between 2016 and 2018 as well as on the roadside OF samples collected by the police. The study reported 128 analysed cases in which persons were allegedly found to have been under the influence of DOA. T...
Source: Talanta - February 21, 2020 Category: Chemistry Authors: Saar-Reismaa P, Brilla CA, Leiman K, Kaljurand M, Vaher M, Kulp M, Mazina-Šinkar J Tags: Talanta Source Type: research

The neurotoxicity of psychoactive phenethylamines “2C series” in cultured monoaminergic neuronal cell lines
ConclusionThe 2,5-dimethoxy-substitution of “2C series” induced severe neurotoxicity in both dopaminergic and serotonin-containing neurons. The non-toxic dose of MDMA or METH synergistically enhanced its neurotoxicity in serotonergic neurons. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 21, 2020 Category: Forensic Medicine Source Type: research

Frontocingulate Dysfunction Is Associated with Depression and Decreased Serum PON1 in Methamphetamine-Dependent Patients
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - February 19, 2020 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Acupuncture inhibits reinstatement of intravenous methamphetamine self-administration via gamma aminobutyric acid pathway
Methamphetamine is one of the widely abused drugs. Nevertheless, there is little predominant therapy for the abuse. In the previous study, acupuncture had shown to attenuate methamphetamine self-administration behavior, and based on, the present study investigated whether acupuncture inhibits the reinstatement of methamphetamine self-administration. As well, a possible neuronal mechanism was investigated. Male Sprague–Dawley rats weighing 270–300 g were trained to intravenously self-administer methamphetamine (0.1 mg/kg) for 3 weeks. Following training, rats who administered stable amount o...
Source: NeuroReport - February 18, 2020 Category: Neurology Tags: Integrative Systems Source Type: research

Decision-Making by Patients With Methamphetamine Use Disorder Receiving Contingency Management Treatment: Magnitude and Frequency Effects
ConclusionsA predilection for choices based on the size and immediacy of reward may reflect a cognitive strategy that works against CM. Pretesting with a decision-making task, such as the IGT, may help in matching cognitive therapies to clients with MA Use Disorder. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - February 18, 2020 Category: Psychiatry Source Type: research

Synthetic psychoactive cathinones: Hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine
ConclusionsThese data indicate that, under the conditions studied here: (1) SPCs exhibit less lethality than MA and MDMA; (2) SPCs impair thermoregulation; (3) effects of SPCs on temperature appear to be independent of effects on lethality. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 13, 2020 Category: Biochemistry Source Type: research

Ex –Henderson State University professors plead not guilty to making methamphetamine
Court documents allege the chemists made the drug and its precursors in a university laboratory (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - February 13, 2020 Category: Chemistry Authors: Bethany Halford Source Type: research

The experiences of pregnant women attending a specialist service and using methamphetamine
Pregnant women attending the Specialist Drug and Alcohol Service in Perth use methamphetamine as their primary drug of choice. This is the only tertiary service for pregnant and postnatal women with complex Alcohol and Other Drug Use in Western Australia. It is a midwifery-led multidisciplinary team. Many of the women struggle with addiction, polysubstance use, co-occurring mental health, family and domestic violence, complex trauma and fear of Child Protection and infant removal. Therefore, the aim of this study was to understand the impact of methamphetamine use of pregnant women attending the service and explore and hig...
Source: Women and Birth - February 13, 2020 Category: Midwifery Authors: Angela O ’Connor, Emma Harris, Dale Hamilton, Colleen Fisher, Mark Sachmann Source Type: research

Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
Molecular Psychiatry, Published online: 12 February 2020; doi:10.1038/s41380-020-0676-xGlial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - February 12, 2020 Category: Psychiatry Authors: Jason Dang Shashi Kant Tiwari Kriti Agrawal Hui Hui Yue Qin Tariq M. Rana Source Type: research

The experiences of pregnant women attending a specialist service and using methamphetamine.
CONCLUSION: We conclude that understanding the experiences of women and the impact methamphetamine use has on their life is paramount to providing effective and appropriate care to support pregnant women in a trauma-informed and woman-centred approach. Poor engagement in pregnancy care for women with methamphetamine use has significant impacts on mother and infant. PMID: 32061546 [PubMed - as supplied by publisher] (Source: Women Birth)
Source: Women Birth - February 12, 2020 Category: Midwifery Authors: O'Connor A, Harris E, Hamilton D, Fisher C, Sachmann M Tags: Women Birth Source Type: research

Prolonged methamphetamine exposure during a critical period in neonatal Sprague-Dawley rats does not exacerbate egocentric and allocentric learning deficits but increases reference memory impairments.
Abstract Children exposed to methamphetamine (MA) in utero have cognitive deficits. MA administration in rats for 5-10 days between postnatal day (P)6-20 produces cognitive deficits. The purpose of this study was to determine if extending MA administration by 5 days within P6-20 would exacerbate allocentric (Morris water maze) and egocentric (Cincinnati water maze) learning deficits. Sprague-Dawley female and male offspring (split-litter design) were administered saline (SAL) or MA (10 mg/kg) four times daily from P6-20 to create four groups: (1) SAL from P6-20, (2) MA from P6-20 (MA6-20), (3) MA from P6-15 (MA6-1...
Source: International Journal of Developmental Neuroscience - February 11, 2020 Category: Neuroscience Authors: Williams MT, Amos-Kroohs RM, Vorhees CV Tags: Int J Dev Neurosci Source Type: research

A four-channel paper microfluidic device with gold nanoparticles and aptamers for seized drugs.
Abstract In this note we describe a four-channel paper microfluidic device (μPAD) that utilizes gold nanoparticles (AuNPs) as colorimetric sensors and specifically tailored aptamers to capture a set of targeted drugs, including cocaine, codeine and methamphetamine. The design utilizes salt-induced aggregation of AuNPs to produce a color change that indicates the presence of target analytes. In the absence of the targets, the aptamers bind to AuNPs, preventing aggregation. This μPAD was developed by optimizing the concentrations of aggregating agents, AuNPs and aptamers. The resultant device is sensitive and ...
Source: Analytical Biochemistry - February 11, 2020 Category: Biochemistry Authors: Wang L, McCord B Tags: Anal Biochem Source Type: research

On-site testing of multiple drugs of abuse in urine by a miniature dual-LIT mass spectrometer.
Abstract There is an increasing need for rapid and on-site detection of emerging drugs of abuse. In this work, we developed a method using a miniature dual-LIT (linear ion trap) mass spectrometer recently developed with comprehensive tandem mass spectrometry analysis capability, for qualitative and quantitative analysis of multiple drugs of abuse. Paper-capillary spray cartridges were used with related workflow established to simplify overall analysis procedure. Quantitation of ketamine and methamphetamine was achieved by beam-type collision-induced dissociation on the miniature dual-LIT mass spectrometer and a li...
Source: Analytica Chimica Acta - February 9, 2020 Category: Chemistry Authors: Kang M, Zhang W, Dong L, Ren X, Zhu Y, Wang Z, Liang L, Xue J, Zhang Y, Zhang W, Ouyang Z Tags: Anal Chim Acta Source Type: research

Potential of the zebrafish model for the forensic toxicology screening of NPS: a comparative study of the effects of APINAC and Methiopropamine on the behavior of zebrafish larvae and mice.
In conclusion, the present study highlighted the impairment of spontaneous motor and sensorimotor behavior induced by MPA and APINAC administration in both species, thus confirming the usefulness of ZL as a model for a rapid behavioural-based drug screening. PMID: 32050087 [PubMed - as supplied by publisher] (Source: Neurotoxicology)
Source: Neurotoxicology - February 9, 2020 Category: Neurology Authors: Morbiato E, Bilel S, Tirri M, Arfè R, Fantinati A, Savchuk S, Appolonova S, Frisoni P, Tagliaro F, Neri M, Grignolio S, Bertolucci C, Marti M Tags: Neurotoxicology Source Type: research

Characteristics of analytically confirmed illicit substance-using patients in the Emergency Department
This study aimed to describe clinical presentations of patients who visited the ED because of acute illicit substance-related complications.MethodsWe performed a retrospective study between May 2017 and August 2018 on patients presenting to the ED with positive urine illicit substance analysis by LC-MS/MS.ResultsOf 203 patients with at least one illicit substance detected in their urine, 162 (79.8%) showed traditional illicit substances, and 56 (32.0%) showed new psychoactive substances (NPS). Methamphetamine was the most common illicit substance (67.9%). The most common NPS was ketamine (21.7%), followed by synthetic cath...
Source: Journal of the Formosan Medical Association - February 8, 2020 Category: General Medicine Source Type: research

Association Analysis Between the rs1899663 Polymorphism of HOTAIR and Risk of Psychiatric Conditions in an Iranian Population
AbstractRecent studies have shown contribution of long non-coding RNAs (lncRNAs) in the pathogenesis of a number of psychiatric disorders. In the current study, we investigated the association between a single nucleotide polymorphism in the lncRNAHOX transcript antisense intergenic RNA (HOTAIR) and risk of diverse neuropsychiatric conditions in Iranian population. The selected polymorphism (rs1899663) is an intronic variant of this lncRNA which has been associated with several cancers in different populations. This SNP was genotyped in 323 individuals with methamphetamine addiction, 55 children with attention-deficit hyper...
Source: Journal of Molecular Neuroscience - February 8, 2020 Category: Neuroscience Source Type: research

Altered serum microRNA expression profile in subjects with heroin and methamphetamine use disorder
ConclusionsOur study raises the possibility that the altered serum miRNAs could potentially be used as an auxiliary tool to identify individuals in drug abuse and addiction.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 7, 2020 Category: Drugs & Pharmacology Source Type: research

Ex-Henderson State University professors plead not guilty to making methamphetamine
Court documents allege the chemists made the drug and its precursors in a university laboratory (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - February 7, 2020 Category: Chemistry Authors: Bethany Halford Source Type: research