Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons
We recently found a significant association between exonic copy-number variations in the Rho GTPase activating protein 10 (Arhgap10) gene and schizophrenia in Japanese patients. Special attention was paid to one ... (Source: Molecular Brain)
Source: Molecular Brain - January 22, 2021 Category: Neuroscience Authors: Kazuhiro Hada, Bolati Wulaer, Taku Nagai, Norimichi Itoh, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Daisuke Mori, Itaru Kushima, Toshitaka Nabeshima, Norio Ozaki and Kiyofumi Yamada Tags: Research Source Type: research

Surveillance by oral fluid of drugs subject to misuse among individuals under arrest.
Conclusion: The feasibility of collecting oral fluid from individuals under arrest in a jail setting to measure the prevalence of drugs subject to misuse was demonstrated. PMID: 33481634 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 22, 2021 Category: Addiction Authors: Magura S, Weller BE, Smith DR, Saxton MM, Amaratunga P Tags: Am J Drug Alcohol Abuse Source Type: research

Study Points to Methamphetamine Crisis Among American Indians, Alaska Natives
There was a fivefold increase in methamphetamine overdose deaths from 2011 to 2018 among U.S. adults aged 25 to 54, with American Indians and Alaska Natives experiencing the highest death rates, according to areport published Wednesday inJAMA Psychiatry.“While much attention is focused on the opioid crisis, a methamphetamine crisis has been quietly, but actively, gaining steam—particularly among American Indians and Alaska Natives, who are disproportionately affected by a number of health conditions,” said Nora D. Volkow, M.D., director of th e National Institute on Drug Abuse and a senior author of the r...
Source: Psychiatr News - January 21, 2021 Category: Psychiatry Tags: Alaska Natives American Indians JAMA Psychiatry methamphetamine NIDA Nora Volkow overdose death Source Type: research

Surface-enhanced Raman spectroscopy integrated with aligner mediated cleavage strategy for ultrasensitive and selective detection of methamphetamine.
Abstract New drugs and illicit synthesized mixtures detection at crime scenes is a great challenge for detection method, which requires anti-interference and ultrasensitive methods to detect methamphetamine (METH) in seized street samples and biological fluids. Herein, we constructed a surface-enhanced Raman sensing method based on aligner mediated cleavage (AMC) of nucleic acid for quantitative detection of METH for the first time. This method we proposed relied on AMC to achieve programmable sequence-specific cleavage of METH aptamer linked by gold nanoparticles (METH aptamer-Au NPs), the cleavage product-Au NPs...
Source: Analytica Chimica Acta - January 21, 2021 Category: Chemistry Authors: Mao J, Kang Y, Yu D, Zhou J Tags: Anal Chim Acta Source Type: research

Ovarian hormones prevent methamphetamine-induced anxiety-related behaviors and neuronal damage in ovariectomized rats
Publication date: Available online 19 January 2021Source: Neuroscience LettersAuthor(s): Hamed Ghazvini, Fatemeh Tirgar, Mehdi Khodamoradi, Zeinab Akbarnejad, Raheleh Rafaiee, Seyedeh Masoumeh Seyedhosseini Tamijani, Majid Asadi-Shekaari, Khadijeh Esmaeilpour, Vahid Sheibani (Source: Neuroscience Letters)
Source: Neuroscience Letters - January 20, 2021 Category: Neuroscience Source Type: research

Potential Contribution of the Intestinal Microbiome to Phenethylamine-Induced Hyperthermia
Phenethylamines (e.g., methamphetamine) are a common source of drug toxicity. Phenethylamine-induced hyperthermia (PIH) can activate a cascade of events that may result in rhabdomyolysis, coagulopathy, and even death. Here, we review recent evidence that suggests a potential link between the gut-brain axis and PIH. Within the preoptic area of the hypothalamus, phenethylamines lead to changes in catecholamine levels, that activate the sympathetic nervous system (SNS) and increase the peripheral levels of norepinephrine (NE), resulting in: (1) the loss of heat dissipation through α1 adrenergic receptor ( α1-AR)-m...
Source: Brain, Behavior and Evolution - January 20, 2021 Category: Neurology Source Type: research

Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?
This study has shown that several psychostimulants and hallucinogens are substrates for OCTs. Given the extensive cellular uptake of mescaline by the genetically highly polymorphic OCT1, strong interindividual variation in the pharmacokinetics of mescaline might be possible, which could be a reason for highly variable adverse reactions. The involvement of the polymorphic OCT2 in the renal excretion of several psychostimulants could be one reason for individual differences in toxicity. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Methamphetamine Overdose Deaths in the US by Sex and Race and Ethnicity
This cross-sectional study examines the extent to which methamphetamine overdose deaths vary by sex and race and ethnicity in the US. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - January 20, 2021 Category: Psychiatry Source Type: research

Harm Reduction and Adaptations Among PWUD in Rural Oregon During COVID-19
AbstractCoronavirus Disease 2019 (COVID-19) may influence HIV/HCV transmission risk behaviors in rural communities. We conducted semi-structured qualitative interviews with people who use drugs (PWUD) in five rural Oregon counties and asked about COVID-19 impact on substance use and harm reduction practices and their advice for improving public health responses. Participants (n  = 36) reported using only methamphetamine (52.8%), only heroin (16.7%), or both (30.6%); 75% of participants reported recent injection. Three thematic categories emerged: SSP adaptations and accessibility, PWUD harm reduction practice...
Source: AIDS and Behavior - January 20, 2021 Category: Infectious Diseases Source Type: research

Molecules, Vol. 26, Pages 516: Simultaneous Determination of Cortisol, Cortisone, and Multiple Illicit Drugs in Hair among Female Drug Addicts with LC-MS/MS
Huihua Deng Long-term dependence of illicit drugs impairs the function of the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the secretion of endogenous steroids, cortisol, and cortisone. Thus, the present study aimed to develop a sensitive method for simultaneous determination of the multiple illicit drugs and two steroids in hair to monitor the status of illicit drug exposure and the physiological and psychological health of drug addicts. The target analytes were extracted from hair by incubation with 1 mL methanol for 24 h at 40 °C and then determined with LC-APCI+-MS/MS. The validated method...
Source: Molecules - January 19, 2021 Category: Chemistry Authors: Cailing Duan Yan Wu Jin Yang Shenghuo Chen Yun Pu Huihua Deng Tags: Article Source Type: research

Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine
AbstractThis longitudinal study with 76 sexual minority men living with HIV who use methamphetamine examined whether dysregulation of essential amino acid precursors for neurotransmitters at baseline predicted positive and negative affect at 15  months. After controlling for covariates including baseline positive affect, a higher baseline kynurenine/tryptophan (K/T) ratio independently predicted lower positive affect at 15 months (β = − 18.31; 95% CI = − 35.35, − 1.27;p = 0.036). Future clinical research should examine whether bio-beh...
Source: Journal of NeuroVirology - January 18, 2021 Category: Neurology Source Type: research

Dynamic networks of psychotic symptoms in adults living in precarious housing or homelessness.
CONCLUSIONS: Past and current experiences contribute to the severity and dynamic relationships between psychotic symptoms. Interrupting the self-perpetuating severity of psychotic symptoms in a vulnerable group of people could contribute to reducing premature mortality. PMID: 33455593 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - January 18, 2021 Category: Psychiatry Authors: Jones AA, Gicas KM, Mostafavi S, Woodward ML, Leonova O, Vila-Rodriguez F, Procyshyn RM, Cheng A, Buchanan T, Lang DJ, MacEwan GW, Panenka WJ, Barr AM, Thornton AE, Honer WG Tags: Psychol Med Source Type: research

Public health challenges facing Environmental Health Officers during COVID-19: methamphetamine contamination of properties.
PMID: 33460218 [PubMed - as supplied by publisher] (Source: Australian and New Zealand Journal of Public Health)
Source: Australian and New Zealand Journal of Public Health - January 18, 2021 Category: International Medicine & Public Health Authors: Kuhn EJ, Walker GS, Wright J, Whiley H, Ross KE Tags: Aust N Z J Public Health Source Type: research

Wastewater analysis reveals urban, suburban, and rural spatial patterns of illicit drug use in Dalian, China.
Abstract Illicit drug use in rural and suburban areas of China has not been studied extensively, as most studies have focused on illicit drug use in urban areas. To compare the differences between urban, suburban, and rural drug use, we collected influent samples from 19 urban, 9 suburban, and 18 rural wastewater treatment plants in Dalian, respectively. A method using solid-phase extraction combined with derivatization for gas chromatography -mass spectrometry analysis was applied to detect biomarker concentrations. The concentrations of methamphetamine and morphine ranged from 3.12 to 605 ng/L and
Source: Environmental Science and Pollution Research International - January 18, 2021 Category: Environmental Health Authors: Cong ZX, Shao XT, Liu SY, Pei W, Wang DG Tags: Environ Sci Pollut Res Int Source Type: research

Brief Report: Syphilis Incidence and Effect on Viral Load, CD4, and CD4/CD8 Ratio in a Thai Cohort of Predominantly Men Who Have Sex With Men Living With HIV
Conclusion: Syphilis was common in the RV254 cohort, inducing a marginal but significant impact on HIV RNA and a temporary decline in CD4. Syphilis screening and behavioral risk reduction counseling should be implemented for MSM with AHI in Thailand. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - January 16, 2021 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Structural Imaging-Based Biomarkers for Detecting Craving and Predicting Relapse in Subjects With Methamphetamine Dependence
This study investigated whether IC abnormalities among MA users can detect craving state and predict relapse susceptibility.Methods: A total of 142 subjects with a history of MA dependence completed structural MRI (sMRI) scans, and 30 subjects (10 subjects relapsed) completed 4-month follow-up scans. MA craving was measured by the Visual Analog Scale for Craving. Abnormalities of IC gray matter volume (GMV) between the subjects with and without craving were investigated by voxel-based morphometry (VBM). The receiver operating characteristic (ROC) analysis was performed for the region-of-interest (ROI) of IC GMV to assess t...
Source: Frontiers in Psychiatry - January 15, 2021 Category: Psychiatry Source Type: research

Naltrexone-Bupropion Combination May Help People With Methamphetamine Use Disorder
A combination of naltrexone plus bupropion can reduce methamphetamine use in people with moderate to severe methamphetamine use disorder, reports astudy in theNew England Journal of Medicine. In a randomized clinical trial of over 400 adults, 13.6% of participants who took extended-release naltrexone/bupropion significantly reduced or stopped their methamphetamine use compared with 2.5% of those who took placebo.“Methamphetamine use disorder is a serious illness and is associated with medical conditions and mental health issues, marked functional impairment, and frequent relapses,” wrote Madhukar Trivedi, M.D.,...
Source: Psychiatr News - January 14, 2021 Category: Psychiatry Tags: bupropion methamphetamine methamphetamine use disorder naltrexone New England Journal of Medicine side effects substance use disorder Source Type: research

Long-term functioning to provide empirical support for the clinical relevance of treatment outcomes for methamphetamine use disorders
This study evaluated the association between different MA use outcomes and long-term life-functioning. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - January 14, 2021 Category: Addiction Authors: Andr é Q.C. Miguel, Crystal L. Smith, Ekaterina Burduli, John M. Roll, Sterling McPherson Source Type: research

Pediatric Methamphetamine Toxicity: Clinical Manifestations and Therapeutic Use of Antipsychotics-One Institution's Experience.
CONCLUSIONS: Pediatric patients with methamphetamine toxicity commonly manifest sympathomimetic signs. Antipsychotics were often used as an adjunct treatment in this cohort of patients, and no adverse events were reported. Clinicians should be aware of prominent gastrointestinal signs and abnormal motor activity and neurologic manifestations unique to pediatric patients that will assist in making the correct diagnosis in cases of suspected methamphetamine toxicity. PMID: 33442836 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - January 13, 2021 Category: Toxicology Authors: Malashock HR, Yeung C, Roberts AR, Snow JW, Gerkin RD, O'Connor AD Tags: J Med Toxicol Source Type: research

Deletion of VGLUT2 in Midbrain Dopamine Neurons Attenuates Dopamine and Glutamate Responses to Methamphetamine in Mice
Publication date: Available online 12 January 2021Source: Pharmacology Biochemistry and BehaviorAuthor(s): Hui Shen, Kai Chen, Rosa Anna M. Marino, Ross A. McDevitt, Zheng-Xiong Xi (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 12, 2021 Category: Biochemistry Source Type: research

mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving.
Abstract Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction-reinstatement animal models of addiction. Less is known about effects of mGlu5 NAMs in abstinence models, particularly for methamphetamine. We used the incubation of drug craving model, in which cue-induced craving progressively intensifies after withdrawal from drug self-administration, to conduct the first studies of the following aspects of mGlu5 function in the rat nucleus accumbens (NAc) core during abstinence from methamphetami...
Source: Neuropharmacology - January 11, 2021 Category: Drugs & Pharmacology Authors: Murray CH, Christian DT, Milovanovic M, Loweth JA, Hwang EK, Caccamise AJ, Funke JR, Wolf ME Tags: Neuropharmacology Source Type: research

The relationship between duration of abstinence and gray-matter brain structure in chronic methamphetamine users.
Abstract Background: Brain structural findings in chronic methamphetamine users have been inconsistent. Identifying contributing influences (e.g., sex, abstinence duration) can help clarify the clinical course of recovery. Objectives: We studied the effects of long-term methamphetamine abstinence on gray-matter volume. Our hypothesis was that smaller volume early in abstinence would precede long-term recovery. Methods: Individuals who used methamphetamine (≥100 g lifetime use, mandated to residential treatment for methamphetamine-positive urine; 40 men, 21 women), undergoing supervised abstinence (men...
Source: The American Journal of Drug and Alcohol Abuse - January 10, 2021 Category: Addiction Authors: Nie L, Ghahremani DG, Mandelkern MA, Dean AC, Luo W, Ren A, Li J, London ED Tags: Am J Drug Alcohol Abuse Source Type: research

Female rats display higher methamphetamine-primed reinstatement and c-Fos immunoreactivity than male rats
Publication date: Available online 8 January 2021Source: Pharmacology Biochemistry and BehaviorAuthor(s): Steven T. Pittenger, Shinnyi Chou, Nathen J. Murawski, Scott T. Barrett, Olivia Loh, Juan F. Duque, Ming Li, Rick A. Bevins (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 9, 2021 Category: Biochemistry Source Type: research

Smoking and drinking habits of women in subsequent pregnancies after specific advice about the dangers of these exposures during pregnancy.
CONCLUSIONS: Detailed information on the adverse effects of smoking and drinking during pregnancy was not effective in the population studied. Other methods to reduce or stop these toxic exposures should therefore be investigated. A short inter-pregnancy interval, as demonstrated by three enrolments in 7.5 years, is associated with preterm labour and fetal growth restriction, and is probably indicative of the role played by confounders such as poor socioeconomic conditions and drug exposure during pregnancy. PMID: 33403986 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

Substance use and depressive and anxiety symptoms among out-of-school adolescent girls and young women in Cape Town, South Africa.
CONCLUSIONS: Our findings highlight the need to address substance use, especially Mandrax use and its associated risk, and depression in an integrated, youth-friendly setting. PMID: 33404004 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - January 7, 2021 Category: African Health Tags: S Afr Med J Source Type: research

A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial.
CONCLUSIONS: This feasibility trial suggests that the locally adapted IDMI intervention is an acceptable and safe intervention as a brief treatment for MAUD in South Africa. Modifications to the study design should be considered in a fully powered, definitive controlled trial to assess this potentially effective intervention. Trial registration The trial is registered with the Pan African Clinical Trials Registry (Trial ID: PACTR201310000589295). PMID: 33413631 [PubMed - in process] (Source: Addiction Science and Clinical Practice)
Source: Addiction Science and Clinical Practice - January 7, 2021 Category: Addiction Authors: Sorsdahl K, Stein DJ, Pasche S, Jacobs Y, Kader R, Odlaug B, Richter S, Myers B, Grant JE Tags: Addict Sci Clin Pract Source Type: research

Methamphetamine exposures reported to United States poison control centers, 2000 –2019
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - January 6, 2021 Category: Toxicology Authors: Tiffany Chen Henry A. Spiller Jaahnavi Badeti Alexandra R. Funk Motao Zhu Gary A. Smith Source Type: research

New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders.
Abstract The abuse of illicit psychostimulants such as cocaine and methamphetamine continues to pose significant health and societal challenges. Despite considerable efforts to develop medications to treat psychostimulant use disorders, none have proven effective, leaving an underserved patient population and unanswered questions about what mechanism(s) of action should be targeted for developing pharmacotherapies. As both cocaine and methamphetamine rapidly increase dopamine (DA) levels in mesolimbic brain regions, leading to euphoria that in some can lead to addiction, targets in which this increased dopaminergi...
Source: Annual Review of Pharmacology and Toxicology - January 6, 2021 Category: Drugs & Pharmacology Authors: Newman AH, Ku T, Jordan CJ, Bonifazi A, Xi ZX Tags: Annu Rev Pharmacol Toxicol Source Type: research

6,7,4[Formula: see text]-Trihydroxyflavanone Prevents Methamphetamine-Induced T Cell Deactivation by Protecting the Activated T Cells from Apoptosis.
In this study, results showed that treatment with THF was not cytotoxic to Jurkat T cells but dose-dependently mitigated the cytotoxicity induced by exposure to METH. The Western blot results demonstrating pre-treatment with THF maintained the expression of anti-apoptotic proteins and phosphorylation of PI3K/Akt/mTOR downregulated by treatment with METH. Furthermore, we found that decreased expression of IL-2 and CD69 by METH exposure was partially restored, and viability was significantly prevented by pre-treatment with THF in activated T cells. These findings were involved in re-elevated expression of anti-apoptotic prot...
Source: The American Journal of Chinese Medicine - January 6, 2021 Category: Complementary Medicine Authors: Lee HS, Jeong GS Tags: Am J Chin Med Source Type: research

Inhibition of PLC β1 signaling pathway regulates methamphetamine self-administration and neurotoxicity in rats.
Inhibition of PLCβ1 signaling pathway regulates methamphetamine self-administration and neurotoxicity in rats. Food Chem Toxicol. 2021 Jan 06;:111970 Authors: Xu X, Fan R, Ruan Y, Xu M, He J, Cao M, Li X, Zhou W, Liu Y Abstract Studies have shown that the central renin-angiotensin system is involved in neurological disorders. Our previous studies have demonstrated that angiotensin II receptor type 1 (AT1R) in the brain could be a potential target against methamphetamine (METH) use disorder. The present study was designed to investigate the underlying mechanisms of the inhibitory effect of AT1R on...
Source: Food and Chemical Toxicology - January 6, 2021 Category: Food Science Authors: Xu X, Fan R, Ruan Y, Xu M, He J, Cao M, Li X, Zhou W, Liu Y Tags: Food Chem Toxicol Source Type: research

Hyperthermia associated with methamphetamine and cocaine use: A case series
Hyperthermia is defined as a core body temperature in excess of 40  °C (104 °F). It is distinguished from a fever, or pyrexia, which is body temperature greater than euthermia 38 °C (100.4 °F), and hyperpyrexia, defined as a core temperature greater than 41.5 °C (106.7 °F), by the lack of an alteration in the hypothalamic homeoregulatory set point from either severe infection or central nervous system hemorrhage [1]. This occurs when excess core energy needed to be dissipated to maintain euthermia exceeds the body's regulatory mechanisms, either through a significant increase in core hea...
Source: The American Journal of Emergency Medicine - January 4, 2021 Category: Emergency Medicine Authors: Catherine A. Marco, Kunal Gupta, Janet Lubov, Aisha Jamison, Brian Patrick Murray Source Type: research

Tracing consumption patterns of stimulants, opioids, and ketamine in China by wastewater-based epidemiology.
Abstract Illicit drug use has long been a key issue of international concern, and the true situation is unknown to the relevant authorities. To develop a profile of comprehensive consumption patterns of illicit drugs in China, data from 34 wastewater treatment plants in 25 cities were collected to analyze four classes of drugs, including amphetamine-type stimulants, opioids, ketamine, and cocaine. They were identified and quantified in samples using methods based on gas chromatography coupled to mass spectrometry. According to the wastewater-based epidemiology (WBE) approach, an analysis of the consumption pattern...
Source: Environmental Science and Pollution Research International - January 4, 2021 Category: Environmental Health Authors: Liu SY, Yu WJ, Wang YR, Shao XT, Wang DG Tags: Environ Sci Pollut Res Int Source Type: research

A randomized comparison of 4 vs. 16 weeks of psychosocial treatment for stimulant users
Controlled studies provide little empirical evidence to inform clinical recommendations for the optimal duration (i.e., “dosage”) of psychosocial treatment for substance use disorders (SUDs). The current study prospectively examined the relationships among treatment dosage, participant adherence to the treatment regimen, and treatment outcomes in a population of adults with stimulant use disorder (cocaine and/or methamphetamine). The study randomly assigned eighty-five participants to receive either 4 weeks or 16 weeks of standardized outpatient treatment. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - January 1, 2021 Category: Addiction Authors: Richard Rawson, Suzette Glasner Edwards, Mary-Lynn Brecht, David Farabee Source Type: research

A Systematic Review of the MDMA Model to Address Social Impairment in Autism.
CONCLUSION: MDMA and/or MDMA-like molecules appear to be an effective pharmacological treatment for the social impairments of autism, at least in animal models. Notably, clinical trials based on MDMA use are now in progress. Nevertheless, larger and more extended clinical studies are warranted to prove the assumption that MDMA and MDMA-like molecules have a role in the management of the social impairments of autism. PMID: 33388021 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - January 1, 2021 Category: Drugs & Pharmacology Authors: Chaliha D, Mamo JC, Albrecht M, Lam V, Takechi R, Vaccarezza M Tags: Curr Neuropharmacol Source Type: research

The Effect of Add-on Buprenorphine to Matrix Program in Reduction of Craving and Relapse Among People With Methamphetamine Use Disorder: A Randomized Controlled Trial
Background Methamphetamine addiction is a global issue. Buprenorphine might have beneficial roles in reducing craving to methamphetamine use via altering neurotransmission signaling and dopaminergic system-related reward mechanisms. Procedures This clinical trial was performed in 2019 to 2020 in Khorshid Hospital, Isfahan, Iran. The study was conducted on patients with methamphetamine use disorder. The intervention group received sublingual buprenorphine for 8 weeks, and the other group also received placebo tablets. Patients were followed up and visited every month for the next 4 months. Both groups were treate...
Source: Journal of Clinical Psychopharmacology - December 28, 2020 Category: Psychiatry Tags: Original Contributions Source Type: research

The transcranial Direct Current Stimulation over prefrontal cortex combined with the Cognitive Training reduced the cue-induced craving in female individuals with methamphetamine use disorder: A Randomized Controlled Trial
Publication date: Available online 22 December 2020Source: Journal of Psychiatric ResearchAuthor(s): Xiaomin Xu, Xinni Ding, Liyu Chen, Tianzhen Chen, Hang Su, Xiaotong Li, Yujian Ye, Wen Shi, Jie Ji, Min Zhao, Na Zhong, Haifeng Jiang (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - December 23, 2020 Category: Psychiatry Source Type: research

Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Abstract Methamphetamine (METH) is an addictive and illegal psychostimulant drug that can cause multiple organ dysfunction, especially in the central nervous system (CNS). Gut microbiota have been implicated in development of various CNS-related diseases, via the gut-brain axis (GBA). However, effect of METH in the alteration of gut microbiota and fecal metabolites is unclear, whereas the relationship with METH-induced neurotoxicity remains unknown. In the current study, we investigated effect of METH on neurotoxicity in striatum and colonic damage by exposing BALB/c mice to an escalating dose-multiple binge regim...
Source: Food and Chemical Toxicology - December 23, 2020 Category: Food Science Authors: Chen LJ, Zhi X, Zhang KK, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xie XL, Wang Q Tags: Food Chem Toxicol Source Type: research

Misuse of Prescription and Illicit Drugs in Middle Adulthood in the Context of the Opioid Epidemic.
Conclusions/Importance: Our analysis shows those misusing prescription opioids are at high risk of misusing other prescription and illicit drugs. Practitioners and researchers should consider concurrent drug misuse when treating and studying opioid misuse disorders. PMID: 33325317 [PubMed - as supplied by publisher] (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - December 18, 2020 Category: Addiction Tags: Subst Use Misuse Source Type: research

Macrophages and brown adipocytes cross-communicate to modulate a thermogenic program following methamphetamine exposure.
Authors: Sanchez-Alavez M, Bortell N, Basova L, Samad F, Marcondes MCG Abstract Hyperthermia is a potentially lethal side-effect of Methamphetamine (Meth), a stimulant drug. Activation of non-shivering thermogenesis in brown adipose tissue (BAT) is partly responsible for Meth-induced rise in temperature, with contributing sympathetic neurotransmitters, such as norepinephrine (NE), and reactive oxygen species (ROS). However, the mechanisms controlling the development of a molecular thermogenic program in brown adipocytes (BA) following Meth are unknown. We hypothesize that Meth and NE affect BAT cells, BA and macrop...
Source: International Journal of Hyperthermia - December 16, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Methamphetamine and social rewards interact to produce enhanced conditioned place preference in male adolescent rats
Publication date: Available online 14 December 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Nicole C. Reyna, John T. Madden, Kenneth J. Thiel, Nathan S. Pentkowski (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - December 15, 2020 Category: Biochemistry Source Type: research

The Relationship Between Polysubstance Injection Drug Use, HIV Risk Behaviors, and Interest in Pre-Exposure Prophylaxis (PrEP) Among People Who Inject Drugs in Rural West Virginia.
CONCLUSIONS: Patterns of polysubstance IDU have unique relationships with key HIV risk factors and protective behaviors. The expansion of harm reduction services in rural settings is warranted to prevent incident HIV infections. PMID: 33308403 [PubMed - in process] (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - December 15, 2020 Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research

Ventricular Preexcitation in a Patient Found to Have Wolff-Parkinson-White Pattern
This case report describes a man in his 30s with a history of methamphetamine and heroin use who presented with 30 minutes of exertional, sharp, left-sided chest pain. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - December 14, 2020 Category: Internal Medicine Source Type: research

Polyamide-coated wooden tips coupled to direct infusion mass spectrometry, a high throughput alternative for the determination of methadone, cocaine and methamphetamine in oral fluid
Publication date: Available online 11 December 2020Source: Microchemical JournalAuthor(s): Jaime Millán-Santiago, María Teresa García-Valverde, Rafael Lucena, Soledad Cárdenas (Source: Microchemical Journal)
Source: Microchemical Journal - December 13, 2020 Category: Chemistry Source Type: research

Persistence and Pervasiveness : Early Wave Opioid Overdose Death Rates Associated With Subsequent Overdose Death Rates.
CONCLUSION: These findings have important implications for continued surveillance to assist policy makers in deciding how to deploy resources to combat not just opioid use disorder but also polysubstance use disorder and broader problems of substance use disorder. PMID: 33301695 [PubMed - as supplied by publisher] (Source: Public Health Reports)
Source: Public Health Reports - December 12, 2020 Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Methamphetamine Use in Pregnancy: A Call for Action.
Authors: Graves L, Green C, Robert M, Cook J Abstract Substance use during pregnancy continues to be an area of concern in Canada. Rates of substance use appear to be increasing among women of childbearing age, and use during pregnancy may effect maternal and fetal outcomes. Little is known of the prevalence of methamphetamine use during pregnancy and its impact, but maternity care providers are encountering patients who use methamphetamines in their practices. These health care providers are asking for evidence-based recommendations for management and treatment. There is an immediate and urgent need to address thi...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - December 12, 2020 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Methamphetamine seeking after prolonged abstinence is associated with activated projections from anterior intralaminar nucleus of thalamus to dorsolateral striatum in female rats
Publication date: Available online 11 December 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ian R. Davis, Sydney A. Coldren, Xuan Li (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - December 11, 2020 Category: Biochemistry Source Type: research

The Relationship Between Serum Cytokine Levels and the Degree of Psychosis and Cognitive Impairment in Patients With Methamphetamine-Associated Psychosis in Chinese Patients
Background: Cytokine levels can be changed in methamphetamine (METH) use disorders (MUDs) and primary psychosis. The present study assessed serum levels of some kinds of interleukins (ILs) in METH-associated psychosis (MAP) and their relationships with psychotic symptoms and cognitive dysfunction.Methods: Serum IL-2R, IL-6, IL-8, and IL-10 levels were examined by chemiluminescence assays in MAP patients (n = 119) and healthy controls (n = 108). The Positive and Negative Syndrome Scale (PANSS) and Montreal Cognitive Assessment (MOCA) were administered.Results: Serum levels of IL-6 and IL-8 were significantly increased in MAP patients (all p
Source: Frontiers in Psychiatry - December 11, 2020 Category: Psychiatry Source Type: research

Increasing Heroin-Methamphetamine (Goofball) Use and Related Morbidity Among Seattle Area People Who Inject Drugs.
Abstract BACKGROUND AND OBJECTIVES: Methamphetamine use is increasing in the United States, potentially including the simultaneous injection of methamphetamine with heroin (goofball). We compared demographic, behavioral, contextual, and health factors among people who inject drugs (PWID) in the Seattle area and who reported that their main drug was goofball, heroin, or methamphetamine. METHODS: We used data from 2017 and 2019 cross-sectional surveys of clients at Public Health-Seattle & King County's syringe services program (N = 792). RESULTS: Among PWID participants, 55.3% reported us...
Source: American Journal on Addictions - December 10, 2020 Category: Addiction Authors: Glick SN, Klein KS, Tinsley J, Golden MR Tags: Am J Addict Source Type: research

Probabilistic Reversal Learning Deficits in Patients With Methamphetamine Use Disorder —A Longitudinal Pilot Study
Methamphetamine use disorder (MUD) is increasing worldwide and commonly associated with learning deficits. Little is known the about underlying trajectories, i.e., how the affected higher-order cognitive functions develop over time and with respect to abstinence and relapse. A probabilistic reversal learning (PRL) paradigm was implemented to uncover the microstructure of impulsive choice and maladaptive learning strategies in 23 patients with MUD in comparison with 24 controls. Baseline data revealed fewer optimal choices and a pattern of altered learning behavior from negative and positive feedback in patients suggesting ...
Source: Frontiers in Psychiatry - December 9, 2020 Category: Psychiatry Source Type: research

Slam Practice: A Review of the Literature
Conclusion: The data we found in international literature were very heterogeneous and from poorly reproducible studies. The definition of slamming in the international literature is not always clear, which limits the completeness of the collected data. This topic has been open to studies only recently; however, health professionals must be trained in the management of this practice, considering its risks in the short and medium terms and its addictive potential. We provided and discussed recommendations and potential future directions.Eur Addict Res (Source: European Addiction Research)
Source: European Addiction Research - December 4, 2020 Category: Addiction Source Type: research