Questions and Answers: NDMA impurities in metformin products
Answers to questions about NDMA impurities found in metformin and FDA ’s actions to address the issue (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 28, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Apotex Corp. Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets 500mg Due to the Detection of N-nitrosodimethylamine (NDMA)
Apotex Corp is voluntarily recalling all lots of Metformin Hydrochloride Extended-Release Tablets, USP 500mg within expiry to retail level. Apotex was notified by the U.S. Food and Drug Administration (US FDA) that one lot of Metformin Hydrochloride Extended-Release Tablets, USP was tested and showe (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 28, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
U.S. FDA finds high levels of carcinogen in diabetes drug metformin
The U.S Food and Drug Administration said on Wednesday it had found high levels of a possible cancer-causing impurity in some versions of the popular diabetes drug metformin. (Source: Reuters: Health)
Source: Reuters: Health - May 27, 2020 Category: Consumer Health News Tags: healthNews Source Type: news
An exploratory study of metformin and rapamycin as maintenance therapy
(Impact Journals LLC) Volume 11, Number 21 of @Oncotarget reported that eligible patients with stable or responding mPDA after 6 months on chemotherapy were randomized 1:1 to metformin alone or with rapamycin, stratified by prior treatment with FOLFIRINOX. Metformin +/ rapamycin maintenance for mPDA was well-tolerated and several patients achieved stable disease associated with exceptionally long survival. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 27, 2020 Category: Cancer & Oncology Source Type: news
Improved adherence with extended-release metformin for T2DM in US
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - April 30, 2020 Category: Drugs & Pharmacology Source Type: news
Researchers discover a key to the survival of dormant breast cancer cells
(Dartmouth-Hitchcock Medical Center) Trying to understand why dormant breast cancer cells survive despite being starved of estrogen to prevent growth, researchers from Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center found that breakdown of fat to produce energy supports cancer cell survival. This type of fat metabolism is activated by metformin, an anti-diabetes drug being tested in clinical trials as an anti-cancer agent. Their findings suggest that metformin actually has context-dependent effects on cancer cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 22, 2020 Category: Cancer & Oncology Source Type: news
Could Preoperative Metformin Improve Major-Surgery Outcomes? Could Preoperative Metformin Improve Major-Surgery Outcomes?
An observational study hints that metformin may be ' an ideal pharmacologic prehabilitation agent, training patients ' bodies to better respond to the major stress of a surgical intervention. 'Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 17, 2020 Category: Surgery Tags: Diabetes & Endocrinology News Source Type: news
Preoperative Metformin Tied to Better Surgical Outcomes
WEDNESDAY, April 15, 2020 -- Preoperative metformin prescriptions may be associated with decreased postoperative mortality and readmission among patients with diabetes undergoing a major surgical procedure, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 15, 2020 Category: Pharmaceuticals Source Type: news
Examining association of preoperative metformin, surgical outcomes in patients with diabetes
(JAMA Network) Metformin is the most commonly prescribed noninsulin medication for type 2 diabetes and this observational study examined postoperative death and hospital readmission among adults with type 2 diabetes who had a prescription for metformin before major surgery with those who didn't. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 8, 2020 Category: International Medicine & Public Health Source Type: news
Safety of Metformin in Patients With Chronic Liver Disease Safety of Metformin in Patients With Chronic Liver Disease
The FDA advises against metformin use in hepatic impairment because of the risk of inducing lactic acidosis. Is this warning warranted?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 6, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Researchers Warn Possible Coronavirus Treatment Hydroxychloroquine May Be Toxic When Combined With Diabetes Drug
Pancreatic cancer researchers uncover worrying results in mice suggesting that hydroxychloroquine might be fatally toxic for people taking metformin for diabetes. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - April 5, 2020 Category: Pharmaceuticals Authors: Victoria Forster, Contributor Source Type: news
Metformin May Be of Benefit, Even in Advancing Kidney Disease Metformin May Be of Benefit, Even in Advancing Kidney Disease
In patients with type 2 diabetes and worsening kidney disease, use of metformin reduced mortality and progression to end-stage renal disease, without increasing the risk of lactic acidosis.Medscape Medical News (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - April 2, 2020 Category: Primary Care Tags: Diabetes & Endocrinology News Source Type: news
Metformin Could Reduce Obesity in Children
WEDNESDAY, March 18, 2020 -- Metformin treatment reduces some obesity measures in children, according to a review and meta-analysis published online Feb. 18 in Childhood Obesity.
Alireza Sadeghi, Ph.D., from the Tehran University of Medical Sciences... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 18, 2020 Category: Pharmaceuticals Source Type: news
Statins Associated with Lower All-Cause and Prostate Cancer Mortality
The use of statins, alone or in combination with metformin, was found to be associated with lower all-cause and prostate cancer mortality among high-risk patients, particularly in post-diagnostic settings. (Source: CancerNetwork)
Source: CancerNetwork - March 5, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news
Metformin-associated Lactic Acidosis Treated With Dialysis Metformin-associated Lactic Acidosis Treated With Dialysis
Lactic acidosis is a rare but potentially serious adverse effect of metformin therapy. Might continuous renal replacement therapy be advantageous in metformin-associated lactic acidosis?Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 3, 2020 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
