Combining BNCT with carbonic anhydrase inhibition for mesothelioma treatment: Synthesis, in vitro, in vivo studies of ureidosulfamido carboranes
Eur J Med Chem. 2024 Mar 26;270:116334. doi: 10.1016/j.ejmech.2024.116334. Online ahead of print.ABSTRACTMesothelioma is a malignant neoplasm of mesothelial cells caused by exposure to asbestos. The average survival time after diagnosis is usually nine/twelve months. A multi-therapeutic approach is therefore required to treat and prevent recurrence. Boronated derivatives containing a carborane cage, a sulfamido group and an ureido functionality (CA-USF) have been designed, synthesised and tested, in order to couple Boron Neutron Capture Therapy (BNCT) and the inhibition of Carbonic Anhydrases (CAs), which are overexpressed...
Source: European Journal of Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alberto Lanfranco Sahar Rakhshan Diego Alberti Polyssena Renzi Ayda Zarechian Nicoletta Protti Saverio Altieri Simonetta Geninatti Crich Annamaria Deagostino Source Type: research
Establishing mesothelioma patient-derived organoid models from malignant pleural effusions
Pleural mesothelioma is an aggressive cancer arising in the mesothelial cells that line the lungs and the chest wall. Mesothelioma is characterized by mutations in tumor suppressor genes, including cyclin-dependent kinase inhibitor 2A (CDKN2A) and BRAC1-associated protein (BAP1), that, at present, are difficult to target therapeutically [1]. First-line treatment for unresectable mesothelioma is combination chemotherapy of cisplatin plus pemetrexed. Unfortunately, approximately 60 % of mesothelioma patients do not respond significantly to chemotherapy, and those that do eventually become resistant [2]. (Source: Lung Cancer)
Source: Lung Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Ashleigh J. Hocking, Lauren A. Mortimer, Alexandra L. Farrall, Prudence A. Russell, Sonja Klebe Source Type: research
The mental health and well-being implications of a mesothelioma diagnosis: A mixed methods study
CONCLUSIONS: Healthcare professionals delivering a mesothelioma diagnosis require regular training in communication skills plus updating in current treatment options, so they provide an appropriate mix of realism and hope. Better signposting to mental health support is needed for patients and carers. Our introduction of posttraumatic growth into the mesothelioma literature is novel. We recommend specialist nurses are trained to recognise, understand, and foster posttraumatic growth.PMID:38522172 | DOI:10.1016/j.ejon.2024.102545 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - March 24, 2024 Category: Nursing Authors: Virginia Sherborne Emily Wood Catriona R Mayland Clare Gardiner Caitlin Lusted Anna Bibby Angela Tod Bethany Taylor Stephanie Ejegi-Memeh Source Type: research
The mental health and well-being implications of a mesothelioma diagnosis: A mixed methods study
CONCLUSIONS: Healthcare professionals delivering a mesothelioma diagnosis require regular training in communication skills plus updating in current treatment options, so they provide an appropriate mix of realism and hope. Better signposting to mental health support is needed for patients and carers. Our introduction of posttraumatic growth into the mesothelioma literature is novel. We recommend specialist nurses are trained to recognise, understand, and foster posttraumatic growth.PMID:38522172 | DOI:10.1016/j.ejon.2024.102545 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - March 24, 2024 Category: Nursing Authors: Virginia Sherborne Emily Wood Catriona R Mayland Clare Gardiner Caitlin Lusted Anna Bibby Angela Tod Bethany Taylor Stephanie Ejegi-Memeh Source Type: research
