YAP/TAZ-TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma
J Cell Mol Med. 2024 Apr;28(8):e18330. doi: 10.1111/jcmm.18330.ABSTRACTThe Hippo signalling pathway, a highly conserved signalling cassette, regulates organ size by controlling cell growth, apoptosis and stem cell self-renewal. The tumourigenic potential of this pathway is largely attributed to the activity of YAP/TAZ, which activate the TEAD1-4 transcription factors, leading to the expression of genes involved in cell proliferation and suppression of cell death. Aberrant regulation of the YAP/TAZ-TEAD signalling axis is commonly observed in malignant pleural mesothelioma (MPM), an insidious neoplasm of the pleural tissue ...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Kostas A Papavassiliou Amalia A Sofianidi Athanasios G Papavassiliou Source Type: research
Criteria for inpatient diagnostic and treatment of patients with lung cancer, mesothelioma or thymoma
Pneumologie. 2024 Apr;78(4):e1. doi: 10.1055/a-2278-4661. Epub 2024 Feb 28.NO ABSTRACTPMID:38608660 | DOI:10.1055/a-2278-4661 (Source: Pneumologie)
Source: Pneumologie - April 12, 2024 Category: Respiratory Medicine Authors: Nikolaj Frost Claas Wesseler Bernhard W örmann Wilfried Ernst Erich Eberhardt Source Type: research
Criteria for inpatient diagnostic and treatment of patients with lung cancer, mesothelioma or thymoma
Pneumologie. 2024 Apr;78(4):233-235. doi: 10.1055/a-2227-3775. Epub 2024 Jan 4.NO ABSTRACTPMID:38608657 | DOI:10.1055/a-2227-3775 (Source: Pneumologie)
Source: Pneumologie - April 12, 2024 Category: Respiratory Medicine Authors: Nikolaj Frost Claas Wesseler Bernhard W örmann Wilfried Ernst Erich Eberhardt Source Type: research
Criteria for inpatient diagnostic and treatment of patients with lung cancer, mesothelioma or thymoma
Pneumologie. 2024 Apr;78(4):e1. doi: 10.1055/a-2278-4661. Epub 2024 Feb 28.NO ABSTRACTPMID:38608660 | DOI:10.1055/a-2278-4661 (Source: Pneumologie)
Source: Pneumologie - April 12, 2024 Category: Respiratory Medicine Authors: Nikolaj Frost Claas Wesseler Bernhard W örmann Wilfried Ernst Erich Eberhardt Source Type: research
Criteria for inpatient diagnostic and treatment of patients with lung cancer, mesothelioma or thymoma
Pneumologie. 2024 Apr;78(4):233-235. doi: 10.1055/a-2227-3775. Epub 2024 Jan 4.NO ABSTRACTPMID:38608657 | DOI:10.1055/a-2227-3775 (Source: Pneumologie)
Source: Pneumologie - April 12, 2024 Category: Respiratory Medicine Authors: Nikolaj Frost Claas Wesseler Bernhard W örmann Wilfried Ernst Erich Eberhardt Source Type: research
YAP/TAZ-TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma
J Cell Mol Med. 2024 Apr;28(8):e18330. doi: 10.1111/jcmm.18330.ABSTRACTThe Hippo signalling pathway, a highly conserved signalling cassette, regulates organ size by controlling cell growth, apoptosis and stem cell self-renewal. The tumourigenic potential of this pathway is largely attributed to the activity of YAP/TAZ, which activate the TEAD1-4 transcription factors, leading to the expression of genes involved in cell proliferation and suppression of cell death. Aberrant regulation of the YAP/TAZ-TEAD signalling axis is commonly observed in malignant pleural mesothelioma (MPM), an insidious neoplasm of the pleural tissue ...
Source: J Cell Mol Med - April 12, 2024 Category: Molecular Biology Authors: Kostas A Papavassiliou Amalia A Sofianidi Athanasios G Papavassiliou Source Type: research
Criteria for inpatient diagnostic and treatment of patients with lung cancer, mesothelioma or thymoma
Pneumologie. 2024 Apr;78(4):e1. doi: 10.1055/a-2278-4661. Epub 2024 Feb 28.NO ABSTRACTPMID:38608660 | DOI:10.1055/a-2278-4661 (Source: Pneumologie)
Source: Pneumologie - April 12, 2024 Category: Respiratory Medicine Authors: Nikolaj Frost Claas Wesseler Bernhard W örmann Wilfried Ernst Erich Eberhardt Source Type: research
Criteria for inpatient diagnostic and treatment of patients with lung cancer, mesothelioma or thymoma
Pneumologie. 2024 Apr;78(4):233-235. doi: 10.1055/a-2227-3775. Epub 2024 Jan 4.NO ABSTRACTPMID:38608657 | DOI:10.1055/a-2227-3775 (Source: Pneumologie)
Source: Pneumologie - April 12, 2024 Category: Respiratory Medicine Authors: Nikolaj Frost Claas Wesseler Bernhard W örmann Wilfried Ernst Erich Eberhardt Source Type: research
Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis
CONCLUSION: Immunohistochemistry markers are essential in accurately diagnosing malignant pleural mesothelioma and its histological subtypes. This systematic review and meta-analysis provide a comprehensive insight into the diagnostic performance of these markers, facilitating their potential clinical utility in the discrimination of malignant pleural mesothelioma from other pleural pathologies and the differentiation of malignant pleural mesothelioma subtypes.PMID:38603842 | DOI:10.1016/j.prp.2024.155276 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 11, 2024 Category: Pathology Authors: Rafael Parra-Medina Juan Pablo Casta ñeda-González Viviana Chaves-Cabezas Juan Pablo Alzate Juan Jos é Chaves Source Type: research
Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis
CONCLUSION: Immunohistochemistry markers are essential in accurately diagnosing malignant pleural mesothelioma and its histological subtypes. This systematic review and meta-analysis provide a comprehensive insight into the diagnostic performance of these markers, facilitating their potential clinical utility in the discrimination of malignant pleural mesothelioma from other pleural pathologies and the differentiation of malignant pleural mesothelioma subtypes.PMID:38603842 | DOI:10.1016/j.prp.2024.155276 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 11, 2024 Category: Pathology Authors: Rafael Parra-Medina Juan Pablo Casta ñeda-González Viviana Chaves-Cabezas Juan Pablo Alzate Juan Jos é Chaves Source Type: research
A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe
(Source: Human Cell)
Source: Human Cell - April 10, 2024 Category: Cytology Source Type: research
Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment
Cancer Res Commun. 2024 Apr 8;4(4):1004-1015. doi: 10.1158/2767-9764.CRC-23-0423.ABSTRACTAsbestos and BAP1 germline mutations are risk factors for malignant mesothelioma (MM). While it is well accepted that amphibole asbestos is carcinogenic, the role of serpentine (chrysotile) asbestos in MM has been debated. To address this controversy, we assessed whether minimal exposure to chrysotile could significantly increase the incidence and rate of MM onset in germline Bap1-mutant mice. With either crocidolite or chrysotile, and at each dose tested, MMs occurred at a significantly higher rate and earlier onset time in Bap1-mutan...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Yuwaraj Kadariya Eleonora Sementino Maggie Ruan Mitchell Cheung Parham Hadikhani Hatice U Osmanbeyoglu Andres J Klein-Szanto Kathy Cai Joseph R Testa Source Type: research
Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research
Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research
Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research
