Guidelines on melatonin usage
Chronic administration of melatonin should be restricted to nighttime and doses tailored to the patient, according to new guidelines published inEndocrine Reviews.Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 12, 2018 Category: Endocrinology Source Type: news

Researchers propose guidelines for the therapeutic use of melatonin
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) In an article published in Endocrine Reviews, Brazilian professors discuss the general criteria to be considered when prescribing the pineal hormone as a health supplement. The guidelines will help health professionals to analyze, understand and interpret the effects of melatonin. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2018 Category: International Medicine & Public Health Source Type: news

Look Up From Your Screen
One of the best things about being in the emergency services is the freedom we enjoy from a traditional office setting. Increasingly, though, our mobile devices are infiltrating our space and chewing up our time and attention. We can be sitting in the cab of an emergency vehicle anywhere, but still be tethered by our phone and tablets, unless we make a conscious choice not to be ruled by techno-diversions. As a member of the healthcare world, why not set an example to others and choose to heed the advice of experts to look up from the screens to which we all seem addicted? Here are three good reasons: 1. ...
Source: JEMS Special Topics - December 4, 2018 Category: Emergency Medicine Authors: Kate Dernocoeur, NREMT Tags: Exclusive Articles Columns Operations Source Type: news

Arrestin activity during light exposure linked to regulation of melatonin
Research, published inCell Reports, suggests that arrestins allow melanopsin in the rentina to regenerate during exposure to light, affecting melatonin levels and the circadian rhythm.  Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - November 28, 2018 Category: Endocrinology Source Type: news

Medical News Today: Is melatonin safe for children?
Melatonin supplements are a popular treatment for children with sleeping problems. Although some research suggests that melatonin may be safe and effective for children, there are no clear guidelines on a suitable dosage. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 27, 2018 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news

As Melatonin Use Rises, So Do Safety Concerns As Melatonin Use Rises, So Do Safety Concerns
Although the use of melatonin offers benefits, calls to poison centers about melatonin have increased, and it can make some drugs less effective, including antihypertensive medications.WebMD Health News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 13, 2018 Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news

As Melatonin Use Rises, So Do Safety Concerns
One review of 15 studies involving 284 otherwise healthy subjects found that those who took melatonin before bed fell asleep 3.9 minutes faster on average and slept 13 minutes longer. Another, of 19 studies involving 1,700 people, found that melatonin users fell asleep 7 minutes faster on average and slept 8 minutes longer. (Source: WebMD Health)
Source: WebMD Health - November 12, 2018 Category: Consumer Health News Source Type: news

Melatonin: the body's natural sleep-promoting hormone
Prescriptions for short periods are considered safe, but there is little research into the long-term effectsIn daylight hours there is so little melatonin in the bloodstream that it is barely detectable. But when the sun goes down, the eyes sense the failing light, and part of the hippocampus signals the pineal gland, a pea-sized lump of tissue near the centre of the brain, to ramp up production of the sleep-promoting hormone. Levels of melatonin rise sharply from 9pm, inducing feelings of sleepiness, and remain high until the following morning.Much of the research on prescribing melatonin for children with sleep problems ...
Source: Guardian Unlimited Science - November 2, 2018 Category: Science Authors: Ian Sample Tags: Science Sleep Child protection Health & wellbeing Children Social care Society UK news Source Type: news

Is My Teenager Depressed or Just Moody? 8 Questions to Consider Before Getting Help
Teenagers are supposed to be moody, right? One moment they are happy and laughing about a silly Youtube video and the next they are slamming their door to their room and crying into their pillow.  You tell yourself “Its just hormones,” and try to brush it off. Chances are you are right. Most teenagers do fluctuate in mood to some extent and that is normal. I have a friend who even nicknamed her teen the “Threen-ager” because her daughter resorted to teen meltdowns when she didn’t get her way. But how do you know if your teen is just moody or if he or she is depressed or even anxious? Knowing the difference coul...
Source: Psych Central - October 5, 2018 Category: Psychiatry Authors: Amy Topelson, MA, MA, LPC, NCC Tags: Children and Teens Depression Parenting School Issues Students Suicide Source Type: news

Melatonin may reduce diabetes risk in men
According to a study, published inClinical Endocrinology, higher levels of melatonin are associated with a reduced incidence of type-2 diabetes in men.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - September 24, 2018 Category: Endocrinology Source Type: news

The Scientific Secrets to Preventing Jet Lag
Traveling abroad can be exhilarating. But sometimes it’s easy to discount the crippling jet leg that can set in after traversing multiple time zones—leaving you exhausted, disoriented and possibly causing you to miss out on your vacation. Jet lag is “something that can ruin a vacation or plague athletes and musicians or have a businessman or woman not perform at their peak,” explains Charmane Eastman, a professor in the Department of Behavioral Sciences and the founding director of the Biological Rhythms Research Laboratory at Rush University Medical Center in Chicago. The number of passengers flyin...
Source: TIME: Health - September 18, 2018 Category: Consumer Health News Authors: Melissa Locker Tags: Uncategorized health jet lag Living sleep Travel Source Type: news

Charity calls on the NHS to give all children with cancer a £1 jetlag supplement
Children with Cancer UK is urging the health service to provide melatonin on top of youngsters' existing chemo or radiotherapy. The supplement also eases chemo's side effects. (Source: the Mail online | Health)
Source: the Mail online | Health - September 13, 2018 Category: Consumer Health News Source Type: news

Melatonin meets diabetes
(Source: ScienceNOW)
Source: ScienceNOW - August 30, 2018 Category: Science Authors: Foley, J. F. Tags: twis Source Type: news

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling
Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-function variants in MTNR1B, which encodes the melatonin receptor MT2, a G protein–coupled receptor (GPCR), are associated with an increased risk of type 2 diabetes (T2D). To identify specific T2D-associated signaling pathway(s), we profiled the signaling output of 40 MT2 variants by monitoring spontaneous (ligand-independent) and melatonin-induced activation of multiple signaling effectors. Genetic association analysis showed that defects in the melatonin-induced activation of Gαi1 and Gαz proteins and in spontaneou...
Source: Signal Transduction Knowledge Environment - August 28, 2018 Category: Science Authors: Karamitri, A., Plouffe, B., Bonnefond, A., Chen, M., Gallion, J., Guillaume, J.-L., Hegron, A., Boissel, M., Canouil, M., Langenberg, C., Wareham, N. J., Le Gouill, C., Lukasheva, V., Lichtarge, O., Froguel, P., Bouvier, M., Jockers, R. Tags: STKE Research Articles Source Type: news