Protocol of a multicenter, single-blind, randomized, parallel controlled trial evaluating the effect of microbiological rapid on-site evaluation (M-ROSE) guiding anti-infection treatment in patients with severe hospital-acquired pneumonia
AbstractIntroductionThe mortality rate of hospitalized patients with severe hospital-acquired pneumonia (SHAP) remains high. Empirical broad-spectrum antibiotic coverage and the misuse of high-grade antibiotics could lead to the emergence of multi-drug and even pandrug-resistant bacteria. In addition to metagenomic next-generation sequencing (mNGS), microbiological rapid on-site evaluation (M-ROSE) might be a useful technique to identify the pathogens in the early stage; however, the effect of M-ROSE guiding anti-infection treatment on prognostic outcomes of SHAP patients is still unclear.Methods/designThis is a multicente...
Source: Trials - August 23, 2023 Category: Research Source Type: clinical trials
What is the role of randomised trials in implementation science?
ConclusionPolicy-makers and researchers should avoid prematurely discarding trial designs when evaluating implementation strategies and work to enhance the conditions for their conduct. (Source: Trials)
Source: Trials - August 16, 2023 Category: Research Source Type: clinical trials
A response to Al et al. Trials 2023;24:233
AbstractIn their recent paper, Al and colleagues (Trials 2023;24:233) argue that manipulation of the methods of recruitment using well-known techniques in order to increase enrollment can be ethically acceptable. This brief response challenges that notion as an affront to voluntariness and a devolution of the ethics of human subjects research to the “ethics” of the marketplace. (Source: Trials)
Source: Trials - August 13, 2023 Category: Research Source Type: clinical trials
Impact of an Online Program in Ethics in Physiotherapy
Condition: Ethics, Narrative Intervention: Other: Online learning Sponsor: University of Valencia Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 9, 2023 Category: Research Source Type: clinical trials