Attitudes to Decisions to Withdraw or Withhold Life-sustaining Treatments in Critically Ill Children
Conditions: Pediatric Disorder; Critical Illness; Ethics, Narrative Interventions: Other: Survey Sponsors: G öteborg University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials
HIP-STITCH (Wound Recovery After THA)
Conditions: Wound Healing Disturbance of Interventions: Device: Ethicon Monocryl Smooth Suture; Device: Ethicon Vicryl Rapide Braided Suture; Device: Flexifuze Indermil Topical Skin Adhesive; Device: Dermabond Prineo Skin Closure System; Device: Stryker Zip Skin Closure System Sponsors: Reinier Haga Orthopedisch Centrum Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials
Obesity Treatments to Improve Type 1 Diabetes (OTID): a randomized controlled trial of the combination of glucagon-like peptide 1 analogues and sodium-glucose cotransporter 2 inhibitors —protocol for Obesity Treatments to Improve Type 1 Diabetes (the OTID trial)
This study addresses the current gap in the evidence base regarding the combination of these two drugs, which is particularly relevant given the American Diabetes Association and European Association for the Study of Diabetes guidelines recommending their combined use for patients with obesity, type 2 diabetes, and chronic kidney disease who do not achieve metabolic control with either drug alone.Trial registrationClinicalTrials.gov Identifier: NCT05390307 Trial registration date - 25th May 2022 (Source: Trials)
Source: Trials - February 16, 2024 Category: Research Source Type: clinical trials
Ethical Attitude and Humanistic Acting Skills of Intensive Care Nurses
Conditions: Humanistic Care Skills Sponsors: Bilecik Seyh Edebali Universitesi Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 15, 2024 Category: Research Source Type: clinical trials
Ethical Crossroads in Nursing Education
Conditions: Ethics, Narrative; Professional Identity Formation Interventions: Other: No intervention Sponsors: Mansoura University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials
Defining usual care comparators when designing pragmatic trials of complex health interventions: a methodology review
DiscussionWhen deciding the content of a usual care arm, researchers need to understand the context in which a trial will be implemented and what the trial needs to achieve to address its aim and remain ethical. This is a complex decision-making process and trade-offs might need to be made. It also requires research and engagement with stakeholders, and therefore time and funding during the trial ’s design phase.Trial registrationPROSPERO CRD42022307324. (Source: Trials)
Source: Trials - February 12, 2024 Category: Research Source Type: clinical trials
Preventing Respiratory Viral Illness Invisibly (PRiVII): protocol for a pragmatic cluster randomized trial evaluating far-UVC light devices in long-term care facilities to reduce infections
DiscussionThis trial aims to inform decisions about whether to implement far-UVC light in LTC facilities for RVI prevention. The trial design features align with this pragmatic intent. Appropriate additional ethical protections have been implemented to mitigate participant vulnerabilities that arise from conducting this study. Knowledge dissemination will be supported through media engagement, peer-reviewed presentations, and publications.Trial registrationClinicalTrials.gov NCT05084898. October 20, 2021. (Source: Trials)
Source: Trials - January 26, 2024 Category: Research Source Type: clinical trials
Improving the inclusion of an under-served group in trials: development and implementation of the INCLUDE Impaired Capacity to Consent Framework
ConclusionsThe INCLUDE Impaired Capacity to Consent Framework and implementation toolkit can support researchers to design more inclusive trials and other types of research studies. Further engagement, including with funders who are key to ensuring uptake, and evaluation is needed. (Source: Trials)
Source: Trials - January 25, 2024 Category: Research Source Type: clinical trials
Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9 —Pragmatic Research and Innovation through Multinational Experimentation
AbstractIn an era focused on value-based healthcare, the quality of healthcare and resource allocation should be underpinned by empirical evidence. Pragmatic clinical trials (pRCTs) are essential in this endeavor, providing randomized controlled trial (RCT) insights that encapsulate real-world effects of interventions. The rising popularity of pRCTs can be attributed to their ability to mirror real-world practices, accommodate larger sample sizes, and provide cost advantages over traditional RCTs. By harmonizing efficacy with effectiveness, pRCTs assist decision-makers in prioritizing interventions that have a substantial ...
Source: Trials - January 23, 2024 Category: Research Source Type: clinical trials
Increasing transcultural competence in clinical psychologists through a web-based training: study protocol for a randomized controlled trial
DiscussionThis randomized controlled trial tests the efficacy of and satisfaction with a web-based training on transcultural competence for German-speaking clinical psychologists. If validated successfully, the training can represent a time- and place-flexible training opportunity that could be integrated into the continuing education of clinical psychologists in the long term.Trial registrationDRKS00031105. Registered on 21 February 2023. (Source: Trials)
Source: Trials - January 20, 2024 Category: Research Source Type: clinical trials
Efficacy of ultrasound-guided erector spinae plane block on analgesia and quality of recovery after minimally invasive direct coronary artery bypass surgery: protocol for a randomized controlled trial
DiscussionThis is a novel randomized controlled study evaluating a preoperative ultrasound-guided single-shot unilateral ESPB on analgesia and quality of patient recovery in MIDCAB surgery. The results of this study will characterize the degree of acute postoperative pain and clinical outcomes following MIDCAB. Our study may help optimizing analgesia regimen selection and improving patient comfort in this specific population.Trial registrationThe study was prospectively registered with the Chinese Clinical Trial Registry (trial identifier: ChiCTR2100052810). Date of registration: November 5, 2021. (Source: Trials)
Source: Trials - January 19, 2024 Category: Research Source Type: clinical trials
Social Emotional and Ethical Development (SEED) Video Curriculum
Conditions: Development, Child; Mindfulness Interventions: Behavioral: Social, Emotional, and Ethical Development (SEED) curriculum videos Sponsors: Chinese University of Hong Kong Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 18, 2024 Category: Research Source Type: clinical trials
Determining the effects of targeted high-definition transcranial direct current stimulation on reducing post-stroke upper limb motor impairments —a randomized cross-over study
DiscussionWe hypothesize that anodal stimulation to the ipsilesional primary motor cortex will increase the excitability of the damaged cortico-spinal tract, reducing the UE flexion synergy and enhancing UE motor function. We further hypothesize that targeted cathodal stimulation to the contralesional premotor cortex will decrease activation of the cortico-reticulospinal tract (CRST) and the expression of the upper extremity (UE) flexion synergy and spasticity. Finally, we hypothesize bilateral stimulation will achieve both results simultaneously. Results from this study could improve understanding of the mechanism behind ...
Source: Trials - January 9, 2024 Category: Research Source Type: clinical trials
Improving access to family planning for women with disabilities in Kaduna city, Nigeria: study protocol for a pragmatic cluster-randomized controlled trial with integrated process evaluation
DiscussionDefining access to services is complex, as it is not a single variable that can be measured directly and need for family planning is subjectively defined. Consequently, we have conceptualized ‘access to family planning’ based on a composite of beliefs about using services if needed.Trial registrationISRCTN registry ISRCTN12671153. Retrospectively registered on 17/04/2023. (Source: Trials)
Source: Trials - January 5, 2024 Category: Research Source Type: clinical trials
Ethics and Research in Anaesthesia
Conditions: Anesthesia; Ethics, Narrative; Surgery Sponsors: Centre Hospitalier Universitaire de N īmes Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 3, 2024 Category: Research Source Type: clinical trials
