Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Higher Taurine Intake in the Diet Correlates with Some Measures of Strength in Middle Age
Taurine is a amino acid mainly found in fish and meat in the diet. It is not an essential amino acid, and can be synthesized in humans. Circulating taurine levels in the bloodstream decline with age by about 50% by middle age for reasons that have yet to be determined. Studies in aged mice and non-human primates have shown modestly improved function and slowed aging following taurine supplementation. Past human studies of taurine supplementation have produced entirely unimpressive outcomes, but given that they predated present aging clocks it may be that the researchers were evaluating the wrong metrics. Taurine may act on...
Source: Fight Aging! - April 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Culling in the name of …
If you have even a passing interest in the natural world, you will have most likely heard the phrase “invasive species”. By definition, a deliberate or accidental release of a species to an area beyond its natural environment where it then multiplies and causes damage to that environment and the native wildlife that relies on it. I discussed the UK issue of invasive species briefly last year and in the context of Muntjac and Black Hairstreak butterfly too.
Ecologist and conservationist Hugh Warwick tackles the issue in much more depth in his latest book – Cull of the Wild. Warwick is, as most of us are, ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - April 12, 2024 Category: Science Authors: David Bradley Tags: Biology Environment Science Source Type: blogs
Country life
As I may have mentioned from time to time, I live in a small town, a farming community. Like a lot of people here, I heat my house with wood. We do it because we can, basically. There are only three retail businesses in town: a liquor store, a seamstress (yes) and a chainsaw shop. In my case, between my own wooded property, and my neighbor who owns extensive forest land and is constantly having trees fall down across his roads, I get all the firewood I need by dint of my own efforts. I pretty much exclusively rely on deadfall, unless for some reason we ' re removing a tree anyway, so I ' m not angering the ents....
Source: Stayin' Alive - March 30, 2024 Category: American Health Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reporting on a Nine Month Self-Experiment in Taurine Supplementation
Today's post is a report from the community on the impact of taurine supplementation on a few biomarkers of interest. Taurine is a dietary amino acid, and circulating levels of taurine influence any number of biological processes. Taurine levels decrease with age in a variety of species; in humans circulating taurine is halved by age 50. You might recall that supplementation with taurine was demonstrated to modestly extend life in mice and improve health in old non-human primates. This may be largely due to enhanced performance of the antioxidant glutathione, and you might recall that other approaches to upregulation of gl...
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
History Lesson
Psalm 78 is, I believe, the third longest psalm. It ' s also one of three so-called " long history " psalms. It basically recounts events from Exodus and Numbers, in chronologically confused order, and then skips ahead to touch on the establishment of the reign of David. The listing of the plagues of Egypt does not exactly correspond to the canonical version of Exodus we have today -- there are no caterpillars or frost in Exodus. This may just be a fanciful addition, or it may be that it draws on a lost version of the story. Once again, keep in mind that there were no printing presses and any document would have existed in...
Source: Stayin' Alive - March 13, 2024 Category: American Health Source Type: blogs
Monopoly Money
First, let me acknowledge Chuck ' s comment on the previous Economics 101 post. I ' m going to get to public goods, it ' s extremely important, but I figured I ' d push it down the list because it ' s easier to deal with the rest of the assumptions first. (To put it formally, the ones having to do with public goods are that all good are non-exclusive and non-rivalrous, and also that there are no positive externalities. I will explain anon.)Today, I ' m going to deal with the Many sellers, Many buyers assumption. It ' s obviously impossible even for Milton Friedman to bamboozle people into thinking that this is somehow a na...
Source: Stayin' Alive - March 8, 2024 Category: American Health Source Type: blogs
Whole Roasted Squash With Tomato-Ginger Chickpeas & Za ’atar
I read myself the riot act about 6 months ago, when my cholesterol level reached a new high. My doctor seemed nonplussed, perhaps because my cardiac calcium score was a perfect zero. But I was not happy. Yes, I had lost weight and was exercising, but to be honest, my heart belonged to cheese. And eggs. And ice cream. Something had to change.
Breakfast was easy. The whole eggs (which I had been eating almost daily) were replaced by Starbucks Sous Vide Egg whites or oatmeal served with a side of chicken sausage. Lunches were yogurt or soup or vegan bean burritos or salad or tuna or peanut butter. I started snacking on nu...
Source: The Blog That Ate Manhattan - February 21, 2024 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Vegetables Butternut Squash Chickpeas vegetarian za'atar Source Type: blogs
Patient Advocates Argue Exercising Bayh-Dole " March-In " Rights Reasonable to Ensure Ongoing Supply of an Insulin Novo Nordisk Intends to Discontinue
Back in 2016 (when President Obama was still in office), the trade group known as the Pharmaceutical Research and Manufacturers of America (better known by the acronym PhRMA) claimed in an organization-published white paper (seehttps://web.archive.org/web/20161022175500/https://phrma.org/sites/default/files/pdf/bayh-dole-act-white-paper-summary.pdf for an archived copy of that paper from PhRMA; note that it has since been removed from PhRMA ' s website, hence I found a copy on the Internet Archive) that championed the Bayh-Dole Act of 1980. Understand that what PhRMA really wants to prevent a particular provision...
Source: Scott's Web Log - February 11, 2024 Category: Endocrinology Tags: march-in rights 2024 Alliance to Protect Insulin Choice APIC Bayh-Dole insulin detemir Levemir Novo Nordisk Source Type: blogs
Why lab-grown meat matters: USDA approval and environmental impact
In June of 2023, a release was buried in the cacophony of news stories that the USDA had approved two companies for selling lab-grown meat. This news followed the FDA’s conclusion that lab-grown meat was safe for human consumption. The two companies, GOOD Meat and UPSIDE Foods, have been working on various lab-grown types of
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Why lab-grown meat matters: USDA approval and environmental impact originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 10, 2024 Category: General Medicine Authors: Dinesh Arab, MD Tags: Conditions Nutrition Source Type: blogs
Chicken farming undergoes a radical shift: the rise of cell-cultivated meat
Following in his father’s footsteps, my son is a third-year medical student and by the time he completes his training, cell-cultivated chicken meat may be replacing meat from slaughtered birds. My home state of Alabama is one of the top chicken-producing states, but in the future, poultry production may take place in stainless steel tanks,
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Chicken farming undergoes a radical shift: the rise of cell-cultivated meat originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 16, 2024 Category: General Medicine Authors: R. Jason Newsom, MD, MPH Tags: Conditions Nutrition Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Twin Study to Assess Short Term Cardiometabolic Health Benefits of a Vegan Diet
If you're familiar with discussion of veganism as a lifestyle choice, nothing in this material will all that surprising. Vegans tend towards lower calorie intake and the benefits resulting from that, and that may be the dominant effect when looking at commonly measured health metrics in vegan study participants. It would be interesting to see more comparison studies in which the vegans were held to the same calorie intake as the omnivore control participants, but, alas, that is logistically harder and thus not the approach chosen by most study organizers.
Although it's well-known that eating less meat improves car...
Source: Fight Aging! - December 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
