Overexpression of Mitochondrial Catalase in Adipose Tissue Improves Survival and Cardiac Cachexia in AOM-DSS Model of Colitis-associated Colorectal Cancer
A debilitating result of colorectal cancer (CRC) is cachexia, involving fat/muscle wasting, leading to cardiac atrophy and heart failure. Adipose tissue (AT) undergoes extensive remodelling, including enhanced resting energy expenditure, inflammation, oxidative stress, and lipolysis that promote cardiac cachexia and predict overall survival in CRC patients. Here, we hypothesised that improving adipose tissue health by adipose-targeted overexpression of mitochondrial catalase (mCAT) can prevent cardiac cachexia and overall survival in an animal model of colitis-induced CRC. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: A. Croft, C. Kelly, D. Chen, L. Murtha, S. Sugito, T. Haw, A. Boyle, A. Sverdlov, D. Ngo Source Type: research
Digitally measured exposed root surface area for predicting the effectiveness of modified coronally advanced tunnel combined de-epithelialized gingival grafting in the treatment of multiple adjacent gingival recessions
ConclusionsDigitally measured ERSA may provide strong predictive values for RT1 and RT2 defects treated with MCAT + DGG.Clinical relevanceThis study demonstrates that digitally measured ERSA is a valid outcome predictor for root coverage surgery, especially applicable for predicting RT2 MAGRs. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 25, 2023 Category: Dentistry Source Type: research
Evaluating Intersite Consistency Across 11 Geographically Distinct Pediatric Clerkship Training Sites: Providing Assurance That Educational Comparability Is Possible
CONCLUSIONS: Over the ensuing 5-year period after a curriculum overhaul to an 18-month, integrated module pre-clerkship curriculum, we found that student pediatric clerkship performance in clinical knowledge and skills did not differ significantly across 11 varied geographic teaching sites when controlling for students' pre-clerkship achievement. Specialty-specific curriculum resources, faculty development tools, and assessment of learning objectives may provide a framework for maintaining intersite consistency when faced with an expanding network of teaching facilities and faculty.PMID:37201493 | DOI:10.1093/milmed/usad04...
Source: Military Medicine - May 18, 2023 Category: International Medicine & Public Health Authors: Courtney A Judd Ting Dong Christopher Foster Steven J Durning Patrick W Hickey Source Type: research
Undergraduate Medical Education Leader Performance Predicts Postgraduate Military Leader Performance
CONCLUSIONS: The findings of this study indicate that a positive relationship exists between leader performance at the end of medical school and leader performance in PGY1 and 3 years of residency. These correlations were stronger in PGY3 compared to PGY1. During PGY1, learners may be more focused on being a physician and an effective team member compared to PGY3 where they have a deeper understanding of their roles and responsibilities and can take on more leadership roles. Additionally, this study also found that MCAT and USMLE Step exams performance was not predictive of PGY1 or PGY3 leader performance. These findings p...
Source: Military Medicine - May 18, 2023 Category: International Medicine & Public Health Authors: Erin S Barry Steven J Durning Deanna Schreiber-Gregory Neil E Grunberg Angela M Yarnell Ting Dong Source Type: research
Blinding of Admissions Committee to MCAT Scores: Is There a Difference in Subsequent Medical School Performance Between Cohorts?
CONCLUSION: This study found similar medical school performance between the MCAT-blinded and MCAT-revealed cohorts. The research team plans to continuously follow these two cohorts to understand their performance further down their education path, including step 1 and step 2 examinations.PMID:37201485 | DOI:10.1093/milmed/usad010 (Source: Military Medicine)
Source: Military Medicine - May 18, 2023 Category: International Medicine & Public Health Authors: Yating Teng Ting Dong Steven J Durning Eulho Jung Aaron Saguil Robert Liotta Source Type: research
Surveying the Middle Ground: A Thematic Analysis of the Medical School Applications of Standard Performers
CONCLUSIONS: This study suggests that the diversity and frequency of exceptional performing themes in a medical school application may be useful in distinguishing between exceptional performers and other performers, though the small sample size limits quantitative conclusions. Low performing themes may be specific to low performers and thus could be useful to admissions committees. Future studies should include a larger sample size and could assess for predictive validity evidence of these exceptional performing and low performing themes through a blinded protocol.PMID:37201484 | DOI:10.1093/milmed/usad073 (Source: Military Medicine)
Source: Military Medicine - May 18, 2023 Category: International Medicine & Public Health Authors: Joseph M Maciuba Yating Teng Matthew Pflipsen Mary A Andrews Steven J Durning Source Type: research
