Holistic Admissions and the MCAT as Predictors of Competence
No abstract available (Source: Academic Medicine)
Source: Academic Medicine - November 30, 2020 Category: Universities & Medical Training Tags: Letters to the Editor Source Type: research

Once in the Door, Grit May Matter More: An Evaluation of Grit in Medical Students.
This study evaluates relationships between Grit and medical student performance measures. We gather validity evidence for Grit scale use among medical students and, subsequently, use this data to evaluate for differences in Grit score by gender and assess whether there is a relationship between Grit and standardized exam scores. We hypothesize that Grit will not vary with gender and that it will be positively associated with standardized examination scores. METHODS: Enrolled students receive the 12-item Grit survey. An exploratory factor analysis evaluates validity evidence of Grit. Descriptive statistical analysis, Pe...
Source: Military Medicine - October 3, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

What Influences the Decision to Interview a Candidate for Medical School?
CONCLUSIONS: The use of holistic review generated a class with a composition different from that which would be predicted by Medical College Admission Test and grade point average alone. Further, holistic review produced an interview pool and class more representative of the wider Military Health Service beneficiary population. In the case of USU, holistic review allowed the school to better meet its mission to create a representative class able to "care for those in harm's way." PMID: 32909602 [PubMed - as supplied by publisher] (Source: Military Medicine)
Source: Military Medicine - September 12, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Screening for Candidate Genes Associated with Biocontrol Mechanisms of Bacillus pumilus DX01 Using Tn5 Transposon Mutagenesis and a 2-DE-Based Comparative Proteomic Analysis.
Abstract A total of 1467 mutants of the biocontrol bacterium Bacillus pumilus DX01 were obtained by Tn5 insertional mutagenesis and subjected to the determination of antagonistic capabilities. Compared with the wild-type strain DX01, the mutant M25 was identified to have the most significant reduction in antagonistic capability against the phytopathogen Bipolaris maydis and extracellular proteinase activity. The integration site of the exogenous T-DNA in the genome of mutant M25 was revealed in the coding region of malony CoA-ACP transacylase (MCAT) gene (mcat), which belongs to a polyketide synthase (PKS) gene cl...
Source: Current Microbiology - September 10, 2020 Category: Microbiology Authors: Chen Y, Liu T, Li Q, Ma Y, Cheng J, Xu L Tags: Curr Microbiol Source Type: research

Treatment of multiple adjacent recessions with the modified coronally advanced tunnel or laterally closed tunnel in conjunction with cross-linked hyaluronic acid and subepithelial connective tissue graft: a report of 15 cases
Lanzrein, Carla / Guldener, Kevin / Imber, Jean-Claude / Katsaros, Christos / St ähli, Alexandra / Sculean, AntonPage 710 - 719Objectives: To evaluate the healing of multiple adjacent type 1 and 2 gingival recessions (RT1 and RT2) treated with the modified coronally advanced tunnel (MCAT) or the laterally closed tunnel (LCT) in conjunction with a cross-linked hyaluronic acid and subepithelial palatal connective tissue grafts.Method and materials: Fifteen healthy patients exhibiting multiple adjacent mandibular or maxillary RT1 and RT2 of a depth of ≥ 2 mm, were treated with the MCAT or LCT in conjunction with cross...
Source: Quintessence International - September 8, 2020 Category: Dentistry Source Type: research

Associations Between Medical Education Assessments and American Board of Family Medicine Certification Examination Score and Failure to Obtain Certification
Conclusions For family medicine residents, more recent assessments generally have stronger associations with board certification score and status than earlier assessments. Solely using medical school admissions (grade point average and MCAT) and licensure (USMLE) scores for resident selection may not adequately predict ultimate board certification. (Source: Academic Medicine)
Source: Academic Medicine - August 27, 2020 Category: Universities & Medical Training Tags: Research Reports Source Type: research

MCAT Testing During the COVID-19 Pandemic
No abstract available (Source: Academic Medicine)
Source: Academic Medicine - August 27, 2020 Category: Universities & Medical Training Tags: Letters to the Editor Source Type: research

Time Is Now for Addressing Racism in Medical Education
As APA leaders continue to work toeliminate systemic racism within psychiatry, a group of psychiatry resident leaders recognized with APA/APA Foundation Minority Fellowshipsdescribed an action plan they believe will reduce racism in medical education in the most recent issue ofPsychiatric News.“Many health care institutions and medical schools, including the AMA, have released statements condemning police brutality and racism. However, such statements ring hollow without action,” the APA/APAF Minority Fellows wrote. “We believe that one of the first steps in combating systemic racis m in the medical field...
Source: Psychiatr News - August 21, 2020 Category: Psychiatry Tags: APA/APA Foundation Minority Fellows diversity graduate medical education health disparities mentorship Psychiatric News racism research scholarship standardized testing Source Type: research

Skeletal tissue regulation by catalase over-expression in mitochondria.
Abstract Accumulation of oxidative damage from excess reactive oxygen species (ROS) may contribute to skeletal aging and mediate adverse responses to physiological challenges. Wildtype (WT) and transgenic mice (male, 16 weeks of age) with human catalase targeted to the mitochondria (mCAT) were analyzed for skeletal responses to the remodeling stimuli of combined hindlimb unloading and exposure to ionizing radiation (137Cs, 2 Gy). Treatment for 2wk caused lipid peroxidation in WT bones but not mCAT, showing that transgene expression mitigated oxidative stress. Ex vivo osteoblast colony growth rate was 95% greater i...
Source: Am J Physiol Cell Ph... - August 11, 2020 Category: Cytology Authors: Schreurs AS, Torres S, Truong T, Moyer EL, Kumar A, Tahimic CGT, Alwood JS, Globus RK Tags: Am J Physiol Cell Physiol Source Type: research

Gender dependent differences in lipid metabolism in individuals with type 2 diabetes mellitus
ConclusionInsulin resistance adversely affects lipid profile, adipocytokines in males with type 2 diabetes. Expression of genes involved in lipid metabolism and inflammation is found to be undesirably and differentially altered in both the genders. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - July 14, 2020 Category: Endocrinology Source Type: research

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochondrial ROS in cardiomyocytes from old mice, accompanied by reduced protein oxidation and a shift towards a more reduced protein thiol redox state in old hearts. Improved diastolic function was concordant with increased phosphorylation of cMyBP-C Ser282 but was independent of titin isoform shift. Late-life viral expression of mito...
Source: eLife - July 10, 2020 Category: Biomedical Science Tags: Human Biology and Medicine Source Type: research

Beyond High-Stakes Testing: Learner Trust, Educational Commodification, and the Loss of Medical School Professionalism
With ever-growing emphasis on high-stakes testing in medical education, such as the Medical College Admission Test and the United States Medical Licensing Examination Step 1, there has been a recent surge of concerns on the rise of a “Step 1 climate” within U.S. medical schools. The authors propose an alternative source of the “climate problem” in current institutions of medical education. Drawing on the intertwined concepts of trust and professionalism as organizational constructs, the authors propose that the core problem is not hijacking-by-exam but rather a hijackable learning environment weaken...
Source: Academic Medicine - May 28, 2020 Category: Universities & Medical Training Tags: Invited Commentaries Source Type: research

Treatment of single mandibular recessions with the modified coronally advanced tunnel or laterally closed tunnel, hyaluronic acid, and subepithelial connective tissue graft: a report of 12 cases
Guldener, Kevin / Lanzrein, Carla / Eliezer, Meizi / Katsaros, Christos / St ähli, Alexandra / Sculean, AntonPage 456 - 463Objectives: To clinically evaluate the healing of mandibular Miller Class I and II isolated gingival recessions treated with the modified coronally advanced tunnel (MCAT) or laterally closed tunnel (LCT) combined with hyaluronic acid (HA) and subepithelial connective tissue graft (SCTG).Method and materials: Twelve healthy patients exhibiting one isolated mandibular Miller Class I or II (Cairo Class 1) gingival recession of a depth of ≥ 3 mm, were consecutively treated with the MCAT or LCT in c...
Source: Quintessence International - May 18, 2020 Category: Dentistry Source Type: research

Tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: a randomized clinical trial
ConclusionsBoth treatment modalities were equally effective in treatment of multiple GR and led to similar improvements in clinical parameters. However, the application of EMD as an adjunct resulted in less post-operative pain and better professionally assessed esthetic outcomes.Clinical relevancePatients ’ early morbidity and 6-month esthetic outcomes following GR coverage with MCAT might be influenced by means of EMD utilization. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 6, 2020 Category: Dentistry Source Type: research

Lipoic acid alleviates schistosomiasis-induced liver fibrosis by upregulating Drp1 phosphorylation.
This study provides a new insight into the mechanism of the protective effect of LA against schistosomiasis-induced liver fibrosis, which demonstrates that LA is required for the maintenance of mitochondrial function by upregulating p-Drp1 expression to inhibit mitochondrial fission. PMID: 32194067 [PubMed - as supplied by publisher] (Source: Acta Tropica)
Source: Acta Tropica - March 15, 2020 Category: Infectious Diseases Authors: Luo J, Shen S Tags: Acta Trop Source Type: research

Medical Education with 3-Year Regional Campuses: Do They Attract a Different Type of Applicant?
Abstract BACKGROUND: In response to calls to increase class sizes, the Medical College of Wisconsin (MCW) opened two new 3-year community-based regional campuses in 2016 and 2017. The goal of this study was to analyze whether the applicants and accepted student pools differed for the school's 3-year and 4-year campuses. METHODS: Deidentified data from Wisconsin applicants to MCW for the class enrolling in 2017 were categorized based on their preference for the Milwaukee or a regional campus. Applicants and admitted student data were compared on Medical College Admissions Test (MCAT) score, undergraduate schoo...
Source: WMJ - February 29, 2020 Category: General Medicine Authors: Hueston WJ, Treat R Tags: WMJ Source Type: research

Leveraging the Medical School Admissions Process to Foster a Smart, Humanistic, and Diverse Physician Workforce
An excellent physician has a range of talents, including the knowledge and critical thinking abilities to work with the rapidly changing biomedical and social science content of the profession as well as the interpersonal and communication skills to build meaningful relationships with patients and families. The Medical College Admission Test (MCAT) was revised in 2015 to focus more on analytical reasoning skills and behavioral and social sciences knowledge to ensure that future physicians have the capabilities needed to care for patients in the 21st century and to allow admissions committees to identify applicants who have...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Invited Commentaries Source Type: research

The New MCAT Exam and the Continuing Imperative of Holistic Review in the Selection of Medical Students
No abstract available (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: From the Editor Source Type: research

The Diversity and Success of Medical School Applicants With Scores in the Middle Third of the MCAT Score Scale
Admissions officers assemble classes of medical students with different backgrounds and experiences who can contribute to their institutions’ service, leadership, and research goals. While schools’ local interests vary, they share a common goal: meeting the health needs of an increasingly diverse population. Despite the well-known benefits of diversity, the physician workforce does not yet reflect the nation’s diversity by socioeconomic status, race/ethnicity, or other background characteristics. (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Perspectives Source Type: research

The Consequences of Structural Racism on MCAT Scores and Medical School Admissions: The Past Is Prologue
Those in medical education have a responsibility to prepare a physician workforce that can serve increasingly diverse communities, encourage healthy changes in patients, and advocate for the social changes needed to advance the health of all. The authors of this Perspective discuss many of the likely causes of the observed differences in mean Medical College Admission Test (MCAT) scores between students from groups well represented in medicine and those from groups underrepresented in medicine. The lower mean MCAT scores of underrepresented groups can present challenges to diversifying the physician workforce if medical sc...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Perspectives Source Type: research

Investigating Group Differences in Examinees’ Preparation for and Performance on the New MCAT Exam
In 2015, the Medical College Admission Test (MCAT) was redesigned to better assess the concepts and reasoning skills students need to be ready for the medical school curriculum. During the new exam’s design and rollout, careful attention was paid to the opportunities examinees had to learn the new content and their access to free and low-cost preparation resources. The design committee aimed to mitigate possible unintended effects of the redesign, specifically increasing historical mean group differences in MCAT scores for examinees from lower socioeconomic status (SES) backgrounds and races/ethnicities underrepresen...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Articles Source Type: research

The Validity of Scores From the New MCAT Exam in Predicting Student Performance: Results From a Multisite Study
Conclusions This study provides early evidence that scores from the new MCAT exam predict student performance in M1. Future research will examine the validity of MCAT scores in predicting performance in later years. (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Research Reports Source Type: research

A Study of the Validity of the New MCAT Exam
Purpose To conduct a study of the validity of the new Medical College Admission Test (MCAT). Method Deidentified data for first- and second-year medical students (185 women, 54.3%; 156 men, 45.7%) who matriculated in 2016 and 2017 to the University of Minnesota Medical School–Twin Cities were included. Of those students, 220 (64.5%) had taken the new MCAT exam and 182 (53.4%) had taken the old MCAT exam (61 [17.9%] had taken both). The authors calculated descriptive statistics and Pearson product moment correlations (r) between new and old MCAT section scores. They conducteda regression analysis of MCAT section ...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Research Reports Source Type: research

How to Help Students Strategically Prepare for the MCAT Exam and Learn Foundational Knowledge Needed for Medical School
No abstract available (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: AM Last Page Source Type: research

Exploring the Socialization Experiences of Medical Students From Social Science and Humanities Backgrounds
Conclusions The existing hidden curriculum inadvertently marginalizes SSH medical students; their experiences likely reflect the socialization experiences of other students from underrepresented backgrounds. Curricular and institutional reforms are imperative to shift the hidden curriculum toward one of epistemological inclusion that better supports students from nontraditional backgrounds. (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Research Reports Source Type: research

Exploring the Predictors of Post-Clerkship USMLE Step 1 Scores.
Abstract Theory: We used two theoretical frameworks for this study: a) experiential learning, whereby learners construct new knowledge based on prior experience, and learning grows out of a continuous process of reconstructing experience, and b) deliberate practice, whereby the use of testing (test-enhanced learning) promotes learning and produces better long-term retention. Hypothesis: We hypothesized that moving the USMLE Step 1 exam to follow the clerkship year would provide students with a context for basic science learning that may enhance exam performance. We also hypothesized that examination performance va...
Source: Teaching and Learning in Medicine - February 18, 2020 Category: Universities & Medical Training Authors: Torre DM, Dong T, Schreiber-Gregory D, Durning SJ, Pangaro L, Pock A, Hemmer PA Tags: Teach Learn Med Source Type: research

Synthetic psychoactive cathinones: Hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine
ConclusionsThese data indicate that, under the conditions studied here: (1) SPCs exhibit less lethality than MA and MDMA; (2) SPCs impair thermoregulation; (3) effects of SPCs on temperature appear to be independent of effects on lethality. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 13, 2020 Category: Biochemistry Source Type: research

Treatment of Multiple Mandibular Gingival Recession Defects Using MCAT Technique and SCTG With and Without rhPDGF-BB: A Randomized Controlled Clinical Trial.
Authors: Parween S, George JP, Prabhuji M Abstract The aim of this randomized controlled trial was to compare the clinical outcomes of modified coronally advanced tunnel technique (MCAT) with subepithelial connective tissue graft (SCTG) with and without recombinant human platelet-derived growth factor-BB (rhPDGF-BB) for mandibular multiple recessions. Twenty-four Miller Class I and III recessions were randomly assigned to a group: test (MCAT+SCTG+rhPDGF-BB) or control (MCAT+SCTG). After 6 months, mean recession-depth reduction was higher in the test group (2.08 ± 0.90 mm) than the control (1.83 ± 0.93...
Source: International Journal of Periodontics and Restorative Dentistry - February 9, 2020 Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research

Effects of Moving the United States Medical Licensing Examination Step 1 After Core Clerkships on Step 2 Clinical Knowledge Performance
Conclusions Moving Step 1 after core clerkships appears to have had no significant impact on Step 2 CK scores or failure rates, supporting the argument that such a change is noninferior to the traditional model. Students with lower MCAT scores benefit most from the change. (Source: Academic Medicine)
Source: Academic Medicine - December 24, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

How Postbaccalaureate Career Changer and Traditional Medical Students Differ Academically.
CONCLUSIONS: Career changer medical students show a small, persistent academic lag in the first 2 years of medical school and on USMLE Step 1 scores. By USMLE Step 2 the difference disappears. Similar undergraduate grade point averages and Medical College Admission Test scores suggest that science exposure, not ability may explain these differences. An unexpected finding is the number of career changer students is not increasing proportional to the proliferation of postbaccalaureate programs in the United States. This study may benefit student advisors and residency directors, and, it is hoped, provide reassurance to caree...
Source: Southern Medical Journal - December 6, 2019 Category: General Medicine Tags: South Med J Source Type: research

Reactive Oxygen Species-Dependent Regulation of PDK4 in White Adipose Tissue.
CONCLUSIONS: Genetic and nutritional approaches that attenuate redox signaling prevent exercise and b-agonist induced gene expression within WAT. Combined, these data suggest ROS represent important mediators of gene expression within WAT. PMID: 31721616 [PubMed - as supplied by publisher] (Source: Am J Physiol Cell Ph...)
Source: Am J Physiol Cell Ph... - November 12, 2019 Category: Cytology Authors: Townsend LK, Weber AJ, Barbeau PA, Holloway GP, Wright DC Tags: Am J Physiol Cell Physiol Source Type: research

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress
Publication date: Available online 5 November 2019Source: Redox BiologyAuthor(s): Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. SantosAbstractA hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical li...
Source: Redox Biology - November 6, 2019 Category: Biology Source Type: research

Patient Shadowing: A Useful Research Method, Teaching Tool, and Approach to Student Professional Development for Premedical Undergraduates
Problem Questions have been raised about whether undergraduate institutions are effectively preparing premedical students in the sociobehavioral and cognitive reasoning content found on the revised Medical College Admission Test, providing opportunities to understand and apply these sociobehavioral and cognitive reasoning concepts in real-world scenarios, and offering career exploration opportunities. Approach The Research in Physician–Patient Interactions course is a 15-week course designed for premedical students and taught through the collaboration of an emergency medicine physician and an applied medical ant...
Source: Academic Medicine - October 30, 2019 Category: Universities & Medical Training Tags: Innovation Reports Source Type: research

Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice
AbstractMoment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via the homeostatic mechanism known as neurovascular coupling (NVC) has an essential role in maintenance of normal brain function. In advanced age cerebromicrovascular endothelial dysfunction impairs NVC responses, which contribute to age-related cognitive decline. Recently, we have shown that pharmacological treatments that attenuate mitochondrial production of reactive oxygen species (ROS) provide significant neurovascular protection, improving NVC responses in aged mice. Transgenic mice that overexpress human catalase localized to the ...
Source: AGE - October 22, 2019 Category: Geriatrics Source Type: research

Reliance on Multiple-Choice Board Examinations Will Have Trade-Offs
With regard to predicting success on the Core Examination [1], it should come as no surprise that good multiple-choice test-takers (ie, those with high scores on the SAT, Medical College Admission Test, and United States Medical Licensing Examination [USMLE]) will perform well on subsequent multiple-choice tests. But translating that test-taking performance to professional work performance is not straightforward. In the field of human resources, review of actual “work samples” are generally deemed to be the most valid metric for evaluating the performance of workplace candidates [2]. (Source: Journal of the Ame...
Source: Journal of the American College of Radiology : JACR - October 18, 2019 Category: Radiology Authors: Seth M. Hardy, Edmin F. Donnelly, Michael A. Bruno Tags: Letter to the editor Source Type: research

Branched chain fatty acid composition of yak milk and manure during full-lactation and half-lactation
ConclusionsBCFA in yak manure especially anteiso BCFA are positively correlated with yak milk from the same animal, indicating that these BCFA come from dietary sources. Yak milk delivers 777 mg BCFA compared to 158 mg per cup of whole U.S. dairy milk. QTP herders known to consume up to 2 kg of yak yogurt take in an estimated 3,500-5,000 mg BCFA per day. We conclude that BCFA intake for yak milk consumers is among the highest known in the world, higher when drawn from half lactating yaks. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 5, 2019 Category: Lipidology Source Type: research

Dynamic Measurement in Health Professions Education: Rationale, Application, and Possibilities
Dynamic measurement modeling (DMM) is a psychometric paradigm that uses longitudinal data to estimate individual students’ growth in measured skills over the course of an educational program (i.e., growth scores). DMM represents a more formal way of assessing learning progress across the health professions education continuum. In this article, the authors provide justification for this approach in health professions education and demonstrate its proof-of-concept use with three time points of United States Medical Licensing Examination Step exams to generate growth scores for 454 current and recent medical learners. T...
Source: Academic Medicine - August 29, 2019 Category: Universities & Medical Training Tags: Articles Source Type: research

Addressing the Diversity–Validity Dilemma Using Situational Judgment Tests
Conclusions The inclusion of an SJT in the admissions process has the potential to widen access to medical education for a number of UIM groups. (Source: Academic Medicine)
Source: Academic Medicine - August 1, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

A novel mindful-compassion art therapy (MCAT) for reducing burnout and promoting resilience for end-of-life care professionals: a waitlist RCT protocol
End-of-life (EoL) care professionals are prone to burnout given the intense emotional nature of their work. Previous research supports the efficacy of art therapy in reducing work-related stress and enhancing ... (Source: Trials)
Source: Trials - July 8, 2019 Category: General Medicine Authors: Andy Hau Yan Ho, Geraldine Tan-Ho, Thuy Anh Ngo, Grace Ong, Poh Heng Chong, Dennis Dignadice and Jordan Potash Tags: Study protocol Source Type: research

Identifying Students at Risk of Failing the USMLE Step 2 Clinical Skills Examination.
CONCLUSIONS: Certain medical student performance metrics are associated with risk of failing Step 2 CS. It is important to clarify these and advise students accordingly. PMID: 31184761 [PubMed - in process] (Source: Famly Medicine)
Source: Famly Medicine - May 31, 2019 Category: Primary Care Authors: Rosenthal S, Russo S, Berg K, Majdan J, Wilson J, Grinberg C, Veloski J Tags: Fam Med Source Type: research

Medical Student Leader Performance in an Applied Medical Field Practicum.
CONCLUSION: With the guidance of a conceptual framework, the assessment tool was used to assess leader performance in a relevant, applied, medical teaching setting. The findings of this study indicate that leader performance can be measured. Additionally, leader performance appears to be a separate skillset from medical academic performance and both types of performance can be taught and developed. This was a retrospective correlation study and was conducted during a military medical field practicum at a single institution. Gathering additional validity evidence of the assessment tool is needed. With additional validity ev...
Source: Military Medicine - May 22, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

A Reflection Upon the Impact of Early 21st-Century Technological Innovations on Medical School Admissions
The authors describe influences associated with the incorporation of modern technologies into medical school admissions processes. Their purpose is not to critique or support specific technologies but, rather, to prompt reflection on the evolution that is afoot. Technology is now integral to the administration of multiple admissions tools, including the Medical College Admission Test, situational judgment tests, and standardized video interviews. Consequently, today’s admissions landscape is transforming into an online, globally interconnected marketplace for health professions admissions tools. Academic capitalism a...
Source: Academic Medicine - April 25, 2019 Category: Universities & Medical Training Tags: Perspectives Source Type: research

Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter.
HH Abstract The transporters for dopamine (DAT) and serotonin (SERT) are important targets in the treatment of psychiatric disorders including major depression, anxiety and attention-deficit hyperactivity disorder. Drugs acting at these transporters can act as inhibitors or as releasers. In addition, it has been recently appreciated that some compounds are less efficacious releasers than amphetamine. Thus, they are classified as partial releasers. Compounds can act on both SERT and DAT or display exquisite selectivity for either SERT or DAT, but the structural basis for selectivity is poorly understood. The trifl...
Source: Neuropharmacology - April 23, 2019 Category: Drugs & Pharmacology Authors: Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH Tags: Neuropharmacology Source Type: research

Longitudinal Assessment of Medical Student Emotional Intelligence Over Preclinical Training.
Authors: Mintle LS, Greer CF, Russo LE Abstract Context: Given the importance of emotional intelligence (EI) in physician leadership and success, the possible decline of EI over the course of training is a concern in medical education. Objectives: To assess the EI of osteopathic medical students as they progress through the preclinical years of medical school, to discover the course of EI over time, and to identify specific core EI competencies to be enhanced or coached. Methods: This exploratory, longitudinal study used survey data to assess the course and competencies of EI in the incoming 2019 class of m...
Source: Journal of the American Osteopathic Association - March 26, 2019 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

Comprehensive Medical College Admission Test Preparatory Course as a Strategy to Encourage Premedical Students to Pursue Osteopathic Medicine in Rural Areas.
Conclusion: Participant knowledge and attitudes about practicing osteopathic medicine were enhanced after they completed the comprehensive MCAT preparatory course. These results suggest that offering similar courses in osteopathic medical schools throughout the country may improve the outlook of creating a diverse physician workforce that provides health care in rural areas. PMID: 30907963 [PubMed - in process] (Source: Journal of the American Osteopathic Association)
Source: Journal of the American Osteopathic Association - March 26, 2019 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

Gastrointestinal effects of ivermectin treatment in rats infected with Strongyloides venezuelensis.
Américo MF Abstract We aimed to evaluate the effects of ivermectin treatment on gastrointestinal morphology and function after Strongyloides venezuelensis infection. Male rats composed Control (C), Parasitized (Sv), Ivermectin (IVM) and Parasitized and treated with Ivermectin (Sv/IVM) groups. IVM and Sv/IVM groups were subdivided according to IVM: single dose of 200 µg/kg (IVM1 and Sv/IVM1) or three repeated doses of 200 µg/kg at 24 h intervals (IVM3 and Sv/IVM3). First dose of IVM was administered after peak of infection. Eggs per gram (EPG), mean gastric emptying time (MGE...
Source: Acta Tropica - March 22, 2019 Category: Infectious Diseases Authors: Mendonça JC, Gama LA, Hauschildt AT, Corá LA, Américo MF Tags: Acta Trop Source Type: research

Small molecules as therapeutic drugs for Alzheimer's disease
This article discusses advantages and disadvantages of small molecules, their ability to mitigate Aβ induced damage, and ability to ameliorate synaptic dysfunction and cognitive loss. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - March 12, 2019 Category: Neuroscience Source Type: research

Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice.
Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice. Biochem Biophys Res Commun. 2019 Mar 11;: Authors: Gao T, Qian S, Shen S, Zhang X, Liu J, Jia W, Chen Z, Ye J Abstract LA (alpha-Lipoic acid) deficiency represents a risk factor in the pathogenesis of diabetic complications as synthetic LA is routinely used in the treatment of the complications in patients. The mechanism underlying LA deficiency remains elusive in the diabetic conditions. In the present study, we investigated the s...
Source: Biochemical and Biophysical Research communications - March 10, 2019 Category: Biochemistry Authors: Gao T, Qian S, Shen S, Zhang X, Liu J, Jia W, Chen Z, Ye J Tags: Biochem Biophys Res Commun Source Type: research

Examining Demographics, Prior Academic Performance, and United States Medical Licensing Examination Scores
Conclusions Demographic differences in USMLE performance were tempered by previous examination performance and undergraduate performance. Additional research is required to identify factors that contribute to demographic differences, can aid educators’ identification of students who would benefit from assistance preparing for USMLE, and can assist residency program directors in assessing performance measures while meeting diversity goals. (Source: Academic Medicine)
Source: Academic Medicine - March 1, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research