The New MCAT Exam and the Continuing Imperative of Holistic Review in the Selection of Medical Students
No abstract available (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: From the Editor Source Type: research

Leveraging the Medical School Admissions Process to Foster a Smart, Humanistic, and Diverse Physician Workforce
An excellent physician has a range of talents, including the knowledge and critical thinking abilities to work with the rapidly changing biomedical and social science content of the profession as well as the interpersonal and communication skills to build meaningful relationships with patients and families. The Medical College Admission Test (MCAT) was revised in 2015 to focus more on analytical reasoning skills and behavioral and social sciences knowledge to ensure that future physicians have the capabilities needed to care for patients in the 21st century and to allow admissions committees to identify applicants who have...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Invited Commentaries Source Type: research

The Diversity and Success of Medical School Applicants With Scores in the Middle Third of the MCAT Score Scale
Admissions officers assemble classes of medical students with different backgrounds and experiences who can contribute to their institutions’ service, leadership, and research goals. While schools’ local interests vary, they share a common goal: meeting the health needs of an increasingly diverse population. Despite the well-known benefits of diversity, the physician workforce does not yet reflect the nation’s diversity by socioeconomic status, race/ethnicity, or other background characteristics. (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Perspectives Source Type: research

The Consequences of Structural Racism on MCAT Scores and Medical School Admissions: The Past Is Prologue
Those in medical education have a responsibility to prepare a physician workforce that can serve increasingly diverse communities, encourage healthy changes in patients, and advocate for the social changes needed to advance the health of all. The authors of this Perspective discuss many of the likely causes of the observed differences in mean Medical College Admission Test (MCAT) scores between students from groups well represented in medicine and those from groups underrepresented in medicine. The lower mean MCAT scores of underrepresented groups can present challenges to diversifying the physician workforce if medical sc...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Perspectives Source Type: research

Investigating Group Differences in Examinees’ Preparation for and Performance on the New MCAT Exam
In 2015, the Medical College Admission Test (MCAT) was redesigned to better assess the concepts and reasoning skills students need to be ready for the medical school curriculum. During the new exam’s design and rollout, careful attention was paid to the opportunities examinees had to learn the new content and their access to free and low-cost preparation resources. The design committee aimed to mitigate possible unintended effects of the redesign, specifically increasing historical mean group differences in MCAT scores for examinees from lower socioeconomic status (SES) backgrounds and races/ethnicities underrepresen...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Articles Source Type: research

The Validity of Scores From the New MCAT Exam in Predicting Student Performance: Results From a Multisite Study
Conclusions This study provides early evidence that scores from the new MCAT exam predict student performance in M1. Future research will examine the validity of MCAT scores in predicting performance in later years. (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Research Reports Source Type: research

A Study of the Validity of the New MCAT Exam
Purpose To conduct a study of the validity of the new Medical College Admission Test (MCAT). Method Deidentified data for first- and second-year medical students (185 women, 54.3%; 156 men, 45.7%) who matriculated in 2016 and 2017 to the University of Minnesota Medical School–Twin Cities were included. Of those students, 220 (64.5%) had taken the new MCAT exam and 182 (53.4%) had taken the old MCAT exam (61 [17.9%] had taken both). The authors calculated descriptive statistics and Pearson product moment correlations (r) between new and old MCAT section scores. They conducteda regression analysis of MCAT section ...
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Research Reports Source Type: research

Exploring the Socialization Experiences of Medical Students From Social Science and Humanities Backgrounds
Conclusions The existing hidden curriculum inadvertently marginalizes SSH medical students; their experiences likely reflect the socialization experiences of other students from underrepresented backgrounds. Curricular and institutional reforms are imperative to shift the hidden curriculum toward one of epistemological inclusion that better supports students from nontraditional backgrounds. (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: Research Reports Source Type: research

How to Help Students Strategically Prepare for the MCAT Exam and Learn Foundational Knowledge Needed for Medical School
No abstract available (Source: Academic Medicine)
Source: Academic Medicine - February 27, 2020 Category: Universities & Medical Training Tags: AM Last Page Source Type: research

Exploring the Predictors of Post-Clerkship USMLE Step 1 Scores.
Abstract Theory: We used two theoretical frameworks for this study: a) experiential learning, whereby learners construct new knowledge based on prior experience, and learning grows out of a continuous process of reconstructing experience, and b) deliberate practice, whereby the use of testing (test-enhanced learning) promotes learning and produces better long-term retention. Hypothesis: We hypothesized that moving the USMLE Step 1 exam to follow the clerkship year would provide students with a context for basic science learning that may enhance exam performance. We also hypothesized that examination performance va...
Source: Teaching and Learning in Medicine - February 19, 2020 Category: Universities & Medical Training Authors: Torre DM, Dong T, Schreiber-Gregory D, Durning SJ, Pangaro L, Pock A, Hemmer PA Tags: Teach Learn Med Source Type: research

Synthetic psychoactive cathinones: Hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine
ConclusionsThese data indicate that, under the conditions studied here: (1) SPCs exhibit less lethality than MA and MDMA; (2) SPCs impair thermoregulation; (3) effects of SPCs on temperature appear to be independent of effects on lethality. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 13, 2020 Category: Biochemistry Source Type: research

Treatment of Multiple Mandibular Gingival Recession Defects Using MCAT Technique and SCTG With and Without rhPDGF-BB: A Randomized Controlled Clinical Trial.
Authors: Parween S, George JP, Prabhuji M Abstract The aim of this randomized controlled trial was to compare the clinical outcomes of modified coronally advanced tunnel technique (MCAT) with subepithelial connective tissue graft (SCTG) with and without recombinant human platelet-derived growth factor-BB (rhPDGF-BB) for mandibular multiple recessions. Twenty-four Miller Class I and III recessions were randomly assigned to a group: test (MCAT+SCTG+rhPDGF-BB) or control (MCAT+SCTG). After 6 months, mean recession-depth reduction was higher in the test group (2.08 ± 0.90 mm) than the control (1.83 ± 0.93...
Source: International Journal of Periodontics and Restorative Dentistry - February 9, 2020 Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research

Effects of Moving the United States Medical Licensing Examination Step 1 After Core Clerkships on Step 2 Clinical Knowledge Performance
Conclusions Moving Step 1 after core clerkships appears to have had no significant impact on Step 2 CK scores or failure rates, supporting the argument that such a change is noninferior to the traditional model. Students with lower MCAT scores benefit most from the change. (Source: Academic Medicine)
Source: Academic Medicine - December 24, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

How Postbaccalaureate Career Changer and Traditional Medical Students Differ Academically.
CONCLUSIONS: Career changer medical students show a small, persistent academic lag in the first 2 years of medical school and on USMLE Step 1 scores. By USMLE Step 2 the difference disappears. Similar undergraduate grade point averages and Medical College Admission Test scores suggest that science exposure, not ability may explain these differences. An unexpected finding is the number of career changer students is not increasing proportional to the proliferation of postbaccalaureate programs in the United States. This study may benefit student advisors and residency directors, and, it is hoped, provide reassurance to caree...
Source: Southern Medical Journal - December 6, 2019 Category: General Medicine Tags: South Med J Source Type: research

Reactive Oxygen Species-Dependent Regulation of PDK4 in White Adipose Tissue.
CONCLUSIONS: Genetic and nutritional approaches that attenuate redox signaling prevent exercise and b-agonist induced gene expression within WAT. Combined, these data suggest ROS represent important mediators of gene expression within WAT. PMID: 31721616 [PubMed - as supplied by publisher] (Source: Am J Physiol Cell Ph...)
Source: Am J Physiol Cell Ph... - November 13, 2019 Category: Cytology Authors: Townsend LK, Weber AJ, Barbeau PA, Holloway GP, Wright DC Tags: Am J Physiol Cell Physiol Source Type: research

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress
Publication date: Available online 5 November 2019Source: Redox BiologyAuthor(s): Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. SantosAbstractA hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical li...
Source: Redox Biology - November 6, 2019 Category: Biology Source Type: research

Patient Shadowing: A Useful Research Method, Teaching Tool, and Approach to Student Professional Development for Premedical Undergraduates
Problem Questions have been raised about whether undergraduate institutions are effectively preparing premedical students in the sociobehavioral and cognitive reasoning content found on the revised Medical College Admission Test, providing opportunities to understand and apply these sociobehavioral and cognitive reasoning concepts in real-world scenarios, and offering career exploration opportunities. Approach The Research in Physician–Patient Interactions course is a 15-week course designed for premedical students and taught through the collaboration of an emergency medicine physician and an applied medical ant...
Source: Academic Medicine - October 30, 2019 Category: Universities & Medical Training Tags: Innovation Reports Source Type: research

Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice
AbstractMoment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via the homeostatic mechanism known as neurovascular coupling (NVC) has an essential role in maintenance of normal brain function. In advanced age cerebromicrovascular endothelial dysfunction impairs NVC responses, which contribute to age-related cognitive decline. Recently, we have shown that pharmacological treatments that attenuate mitochondrial production of reactive oxygen species (ROS) provide significant neurovascular protection, improving NVC responses in aged mice. Transgenic mice that overexpress human catalase localized to the ...
Source: AGE - October 23, 2019 Category: Geriatrics Source Type: research

Reliance on Multiple-Choice Board Examinations Will Have Trade-Offs
With regard to predicting success on the Core Examination [1], it should come as no surprise that good multiple-choice test-takers (ie, those with high scores on the SAT, Medical College Admission Test, and United States Medical Licensing Examination [USMLE]) will perform well on subsequent multiple-choice tests. But translating that test-taking performance to professional work performance is not straightforward. In the field of human resources, review of actual “work samples” are generally deemed to be the most valid metric for evaluating the performance of workplace candidates [2]. (Source: Journal of the Ame...
Source: Journal of the American College of Radiology : JACR - October 19, 2019 Category: Radiology Authors: Seth M. Hardy, Edmin F. Donnelly, Michael A. Bruno Tags: Letter to the editor Source Type: research

Branched chain fatty acid composition of yak milk and manure during full-lactation and half-lactation
ConclusionsBCFA in yak manure especially anteiso BCFA are positively correlated with yak milk from the same animal, indicating that these BCFA come from dietary sources. Yak milk delivers 777 mg BCFA compared to 158 mg per cup of whole U.S. dairy milk. QTP herders known to consume up to 2 kg of yak yogurt take in an estimated 3,500-5,000 mg BCFA per day. We conclude that BCFA intake for yak milk consumers is among the highest known in the world, higher when drawn from half lactating yaks. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA))
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - September 5, 2019 Category: Lipidology Source Type: research

Dynamic Measurement in Health Professions Education: Rationale, Application, and Possibilities
Dynamic measurement modeling (DMM) is a psychometric paradigm that uses longitudinal data to estimate individual students’ growth in measured skills over the course of an educational program (i.e., growth scores). DMM represents a more formal way of assessing learning progress across the health professions education continuum. In this article, the authors provide justification for this approach in health professions education and demonstrate its proof-of-concept use with three time points of United States Medical Licensing Examination Step exams to generate growth scores for 454 current and recent medical learners. T...
Source: Academic Medicine - August 29, 2019 Category: Universities & Medical Training Tags: Articles Source Type: research

Addressing the Diversity–Validity Dilemma Using Situational Judgment Tests
Conclusions The inclusion of an SJT in the admissions process has the potential to widen access to medical education for a number of UIM groups. (Source: Academic Medicine)
Source: Academic Medicine - August 1, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

A novel mindful-compassion art therapy (MCAT) for reducing burnout and promoting resilience for end-of-life care professionals: a waitlist RCT protocol
End-of-life (EoL) care professionals are prone to burnout given the intense emotional nature of their work. Previous research supports the efficacy of art therapy in reducing work-related stress and enhancing ... (Source: Trials)
Source: Trials - July 8, 2019 Category: General Medicine Authors: Andy Hau Yan Ho, Geraldine Tan-Ho, Thuy Anh Ngo, Grace Ong, Poh Heng Chong, Dennis Dignadice and Jordan Potash Tags: Study protocol Source Type: research

Identifying Students at Risk of Failing the USMLE Step 2 Clinical Skills Examination.
CONCLUSIONS: Certain medical student performance metrics are associated with risk of failing Step 2 CS. It is important to clarify these and advise students accordingly. PMID: 31184761 [PubMed - in process] (Source: Famly Medicine)
Source: Famly Medicine - June 1, 2019 Category: Primary Care Authors: Rosenthal S, Russo S, Berg K, Majdan J, Wilson J, Grinberg C, Veloski J Tags: Fam Med Source Type: research

Medical Student Leader Performance in an Applied Medical Field Practicum.
CONCLUSION: With the guidance of a conceptual framework, the assessment tool was used to assess leader performance in a relevant, applied, medical teaching setting. The findings of this study indicate that leader performance can be measured. Additionally, leader performance appears to be a separate skillset from medical academic performance and both types of performance can be taught and developed. This was a retrospective correlation study and was conducted during a military medical field practicum at a single institution. Gathering additional validity evidence of the assessment tool is needed. With additional validity ev...
Source: Military Medicine - May 22, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

A Reflection Upon the Impact of Early 21st-Century Technological Innovations on Medical School Admissions
The authors describe influences associated with the incorporation of modern technologies into medical school admissions processes. Their purpose is not to critique or support specific technologies but, rather, to prompt reflection on the evolution that is afoot. Technology is now integral to the administration of multiple admissions tools, including the Medical College Admission Test, situational judgment tests, and standardized video interviews. Consequently, today’s admissions landscape is transforming into an online, globally interconnected marketplace for health professions admissions tools. Academic capitalism a...
Source: Academic Medicine - April 25, 2019 Category: Universities & Medical Training Tags: Perspectives Source Type: research

Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 24, 2019 Category: Cancer & Oncology Source Type: research

para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter.
HH Abstract The transporters for dopamine (DAT) and serotonin (SERT) are important targets in the treatment of psychiatric disorders including major depression, anxiety and attention-deficit hyperactivity disorder. Drugs acting at these transporters can act as inhibitors or as releasers. In addition, it has been recently appreciated that some compounds are less efficacious releasers than amphetamine. Thus, they are classified as partial releasers. Compounds can act on both SERT and DAT or display exquisite selectivity for either SERT or DAT, but the structural basis for selectivity is poorly understood. The trifl...
Source: Neuropharmacology - April 24, 2019 Category: Drugs & Pharmacology Authors: Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH Tags: Neuropharmacology Source Type: research

Comprehensive Medical College Admission Test Preparatory Course as a Strategy to Encourage Premedical Students to Pursue Osteopathic Medicine in Rural Areas.
Conclusion: Participant knowledge and attitudes about practicing osteopathic medicine were enhanced after they completed the comprehensive MCAT preparatory course. These results suggest that offering similar courses in osteopathic medical schools throughout the country may improve the outlook of creating a diverse physician workforce that provides health care in rural areas. PMID: 30907963 [PubMed - in process] (Source: Journal of the American Osteopathic Association)
Source: Journal of the American Osteopathic Association - March 26, 2019 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

Longitudinal Assessment of Medical Student Emotional Intelligence Over Preclinical Training.
Authors: Mintle LS, Greer CF, Russo LE Abstract Context: Given the importance of emotional intelligence (EI) in physician leadership and success, the possible decline of EI over the course of training is a concern in medical education. Objectives: To assess the EI of osteopathic medical students as they progress through the preclinical years of medical school, to discover the course of EI over time, and to identify specific core EI competencies to be enhanced or coached. Methods: This exploratory, longitudinal study used survey data to assess the course and competencies of EI in the incoming 2019 class of m...
Source: Journal of the American Osteopathic Association - March 26, 2019 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

Gastrointestinal effects of ivermectin treatment in rats infected with Strongyloides venezuelensis.
Américo MF Abstract We aimed to evaluate the effects of ivermectin treatment on gastrointestinal morphology and function after Strongyloides venezuelensis infection. Male rats composed Control (C), Parasitized (Sv), Ivermectin (IVM) and Parasitized and treated with Ivermectin (Sv/IVM) groups. IVM and Sv/IVM groups were subdivided according to IVM: single dose of 200 µg/kg (IVM1 and Sv/IVM1) or three repeated doses of 200 µg/kg at 24 h intervals (IVM3 and Sv/IVM3). First dose of IVM was administered after peak of infection. Eggs per gram (EPG), mean gastric emptying time (MGE...
Source: Acta Tropica - March 23, 2019 Category: Infectious Diseases Authors: Mendonça JC, Gama LA, Hauschildt AT, Corá LA, Américo MF Tags: Acta Trop Source Type: research

Small molecules as therapeutic drugs for Alzheimer's disease
This article discusses advantages and disadvantages of small molecules, their ability to mitigate Aβ induced damage, and ability to ameliorate synaptic dysfunction and cognitive loss. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - March 12, 2019 Category: Neuroscience Source Type: research

Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice.
Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice. Biochem Biophys Res Commun. 2019 Mar 11;: Authors: Gao T, Qian S, Shen S, Zhang X, Liu J, Jia W, Chen Z, Ye J Abstract LA (alpha-Lipoic acid) deficiency represents a risk factor in the pathogenesis of diabetic complications as synthetic LA is routinely used in the treatment of the complications in patients. The mechanism underlying LA deficiency remains elusive in the diabetic conditions. In the present study, we investigated the s...
Source: Biochemical and Biophysical Research communications - March 11, 2019 Category: Biochemistry Authors: Gao T, Qian S, Shen S, Zhang X, Liu J, Jia W, Chen Z, Ye J Tags: Biochem Biophys Res Commun Source Type: research

Examining Demographics, Prior Academic Performance, and United States Medical Licensing Examination Scores
Conclusions Demographic differences in USMLE performance were tempered by previous examination performance and undergraduate performance. Additional research is required to identify factors that contribute to demographic differences, can aid educators’ identification of students who would benefit from assistance preparing for USMLE, and can assist residency program directors in assessing performance measures while meeting diversity goals. (Source: Academic Medicine)
Source: Academic Medicine - March 1, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

Moving the United States Medical Licensing Examination Step 1 After Core Clerkships: An Outcomes Analysis
This study provides a psychometric investigation of the impact on United States Medical Licensing Examination Step 1 scores of changing the timing of Step 1 from after completion of the basic science curricula to after core clerkships. Method Data from four schools that recently moved the examination were analyzed in a pre–post format using examinee scores from three years before and after the change. The sample included scores from 2008 through 2016. Several confounders were addressed, including rising national scores and potential differences in cohort abilities using deviation scores and analysis of covariance ...
Source: Academic Medicine - March 1, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

Examining Demographics, Prior Academic Performance, and United States Medical Licensing Examination Scores
Conclusions Demographic differences in USMLE performance were tempered by previous examination performance and undergraduate performance. Additional research is required to identify factors that contribute to demographic differences, can aid educators’ identification of students who would benefit from assistance preparing for USMLE, and can assist residency program directors in assessing performance measures while meeting diversity goals. (Source: Academic Medicine)
Source: Academic Medicine - February 28, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

Moving the United States Medical Licensing Examination Step 1 After Core Clerkships: An Outcomes Analysis
This study provides a psychometric investigation of the impact on United States Medical Licensing Examination Step 1 scores of changing the timing of Step 1 from after completion of the basic science curricula to after core clerkships. Method Data from four schools that recently moved the examination were analyzed in a pre–post format using examinee scores from three years before and after the change. The sample included scores from 2008 through 2016. Several confounders were addressed, including rising national scores and potential differences in cohort abilities using deviation scores and analysis of covariance ...
Source: Academic Medicine - February 28, 2019 Category: Universities & Medical Training Tags: Research Reports Source Type: research

Nelson-Denny Reading Test Scores as a Predictor of Student Success in Osteopathic Medical Education.
Conclusion: The reasoning skills section of the new MCAT could serve as a good proxy for a reading test. There were no correlations between the Nelson-Denny Reading Test and performance in the first 2 years of medical school or COMLEX-USA Level 1 performance. Further research can strengthen the findings and determine whether correlations exist with clinical performance. PMID: 30801115 [PubMed - in process] (Source: Journal of the American Osteopathic Association)
Source: Journal of the American Osteopathic Association - February 27, 2019 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

GSE124130 Expression data from adult mouse brain astrocytes
Contributors : Juan P Bolanos ; Carlos Vicente-GutierrezSeries Type : Expression profiling by arrayOrganism : Mus musculusWe aimed to investigate whether reduction of mitochondrial reactive oxygen species (mROS) in adult astrocytes altered the transcriptional profile in vivo. To do so, we used a genetic approach expressing a version of the catalase enzyme within the mitochondria of astrocytes. Astrocytes were acutely isolated from the brains of adult GFAP-mCAT and control mice by the immunomagnetic approach and subjected to a whole-genome transcriptomics array analysis.We used microarrays to detail the whole genome changes...
Source: GEO: Gene Expression Omnibus - February 4, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Tobacco Smoking Induces Cardiovascular Mitochondrial Oxidative Stress, Promotes Endothelial Dysfunction and Enhances Hypertension.
Abstract Tobacco smoking is a major risk factor for cardiovascular disease and hypertension. It is associated with the oxidative stress and induces metabolic reprograming altering mitochondrial function. We hypothesized that cigarette smoke induces cardiovascular mitochondrial oxidative stress which contributes to endothelial dysfunction and hypertension. To test this hypothesis, we studied if scavenging of mitochondrial H2O2 in transgenic mice expressing mitochondria-targeted catalase (mCAT) attenuates the development of cigarette smoke/angiotensin II-induced mitochondrial oxidative stress and hypertension compar...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 4, 2019 Category: Physiology Authors: Dikalov S, Itani HA, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova AE Tags: Am J Physiol Heart Circ Physiol Source Type: research

Late Breaking Abstract - Safety and immunogenicity of non-typeable H. influenzae (NTHi) and M. catarrhalis (Mcat) adjuvanted vaccines in adults
Conclusion: NTHi-Mcat vaccines have an acceptable reactogenicity/safety profile and are immunogenic.Funding: GlaxoSmithKline Biologicals SA (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Van Damme, P., Leroux-Roels, G., Vandermeulen, C., De Ryck, I., Tasciotti, A., Dozot, M., Moraschini, L., Testa, M., Arora, A. K. Tags: Clinical Problems Source Type: research

MCAT: Motif Combining and Association Tool
Journal of Computational Biology, Ahead of Print. (Source: Journal of Computational Biology)
Source: Journal of Computational Biology - November 10, 2018 Category: Biology Authors: Yanshen Yang Jeffrey A. Robertson Zhen Guo Jake Martinez Christy Coghlan Lenwood S. Heath Source Type: research

Differences in Medical Students' Academic Performance between a Pass/Fail and Tiered Grading System.
CONCLUSIONS: Overall academic performance was similar. The potential for an enhanced learning environment associated with pass/fail grading does not create an important decrement in academic performance. PMID: 30392003 [PubMed - in process] (Source: Southern Medical Journal)
Source: Southern Medical Journal - November 6, 2018 Category: General Medicine Tags: South Med J Source Type: research

Clinical evaluation of Miller class I and II recessions treatment with use of modified coronally advanced tunnel technique with either collagen matrix (CM) or subepithelial connective tissue graft (SCTG): a randomized clinical study.
CONCLUSIONS: MCAT leads to reduction of gingival recession both when combined CM and SCTG, of which the latter is more efficient as far as root coverage and aesthetic parameters are concerned. This article is protected by copyright. All rights reserved. PMID: 30362599 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - October 26, 2018 Category: Dentistry Authors: Pietruska M, Skurska A, Podlewski Ł, Milewski R, Pietruski J Tags: J Clin Periodontol Source Type: research

Plastic surgery or primary care? Altruistic preferences and expected specialty choice of U.S. medical students
This study examines experimentally measured altruistic preferences of medical students from schools around the U.S., and whether these preferences predict those students’ expected medical specialty choice. The experimental design consists of a set of computer-based revealed preference decision problems, which ask the experimental subjects to allocate real money between themselves and an anonymous person. These data are used to derive an innovative measure of altruism for each participant. I then examine the association between altruism and expected specialty choice, after controlling for an extensive set of covariate...
Source: Journal of Health Economics - October 5, 2018 Category: Health Management Source Type: research

Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers
This study aimed to review a large population based database to evaluate prognostic factors that could impact survival.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify patients with MCAT of the head and neck. Both overall and disease specific survival were the main outcome measures for the study. Univariate and multivariate analyses were performed to evaluate the association of suspected prognostic factors with survival.ResultsThe five-year OS and DSS were 72.6 and 95.5%, respectively. A favorable factor for OS was surgical resection ([HR] 0.324; P = 0.001), while unfavora...
Source: American Journal of Otolaryngology - October 5, 2018 Category: Endocrinology Source Type: research

Academic and Professional Admission Tools and Outcomes on National Licensure
National licensure scores act as surrogates for subsequent endpoints in medical practice. For national licensure, strong pre-interview screening tests predictive of  future cognitive performance exist – that of Grade Point Average (GPA), Medical College Admission Test (MCAT) (Tamblyn, Abrahamowicz, Dauphinee, Wenghofer, Jacques, Klass, et al. 2007). The same does not hold true for national licensure endpoints reflective of personal/professional characterist ics. To the same extent, GPA and MCAT does not adequately address the need for prediction of outcomes associated with personal/professional characterist...
Source: Journal of Oral and Maxillofacial Surgery - October 1, 2018 Category: ENT & OMF Authors: K.L. Dore Tags: Dental Implant Abstract Session Source Type: research

Mitochondrial-derived reactive oxygen species influence ADP sensitivity, but not CPT-I substrate sensitivity
The mechanisms regulating oxidative phosphorylation during exercise remain poorly defined; however, key mitochondrial proteins, including carnitine palmitoyltransferase-I (CPT-I) and adenine nucleotide translocase, have redox-sensitive sites. Interestingly, muscle contraction has recently been shown to increase mitochondrial membrane potential and reactive oxygen species (ROS) production; therefore, we aimed to determine if mitochondrial-derived ROS influences bioenergetic responses to exercise. Specifically, we examined the influence of acute exercise on mitochondrial bioenergetics in WT (wild type) and transgenic mice (M...
Source: Biochemical Journal - September 28, 2018 Category: Biochemistry Authors: Barbeau, P.-A., Miotto, P. M., Holloway, G. P. Tags: Research Articles Source Type: research

[ASAP] Arene Ruthenium Catalyst MCAT-53 for the Synthesis of Heterobiaryl Compounds in Water through Aromatic C –H Bond Activation
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.8b00141 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - August 31, 2018 Category: Chemistry Authors: Anita Mehta, Biswajit Saha, Ali Aiden Koohang, Mukund S. Chorghade Source Type: research

Assessing the Big Five with bifactor computerized adaptive testing.
In this study, MCAT-B was compared with a short fixed-length scale and computerized adaptive testing based on unidimensional (UCAT) and multidimensional (correlated-factors) models (MCAT) to measure the Big Five model of personality. The sample comprised 826 respondents who completed a pool with 360 personality items measuring the Big Five domains and facets. The dimensionality of the Big Five domains was also tested. With only 12 items per domain, the MCAT and MCAT-B procedures were more efficient to assess highly multidimensional constructs (e.g., Agreeableness), whereas no differences were found with UCAT and the short ...
Source: Psychological Assessment - August 30, 2018 Category: Psychiatry & Psychology Source Type: research