Isolation, structural properties, and bioactivities of polysaccharides from Althaea officinalis Linn.: A review
Int J Biol Macromol. 2023 May 26:125098. doi: 10.1016/j.ijbiomac.2023.125098. Online ahead of print.ABSTRACTAlthaea officinalis Linn. (AO) is a widely distributed herbaceous plant with a long history of medicinal and food functions in Europe and Western Asia. Althaea officinalis polysaccharide (AOP), as one of the main components and a crucial bioactive substance of AO, has a variety of pharmacological activities, including antitussive, antioxidant, antibacterial, anticancer, wound healing, immunomodulatory, and infertility therapy effects. Many polysaccharides have been successfully obtained in the last five decades from ...
Source: International Journal of Biological Macromolecules - May 28, 2023 Category: Biochemistry Authors: Taotao Xue Kaihua Ruan Zhishu Tang Jinao Duan Hongbo Xu Source Type: research

Isolation, structural properties, and bioactivities of polysaccharides from Althaea officinalis Linn.: A review
Int J Biol Macromol. 2023 May 26:125098. doi: 10.1016/j.ijbiomac.2023.125098. Online ahead of print.ABSTRACTAlthaea officinalis Linn. (AO) is a widely distributed herbaceous plant with a long history of medicinal and food functions in Europe and Western Asia. Althaea officinalis polysaccharide (AOP), as one of the main components and a crucial bioactive substance of AO, has a variety of pharmacological activities, including antitussive, antioxidant, antibacterial, anticancer, wound healing, immunomodulatory, and infertility therapy effects. Many polysaccharides have been successfully obtained in the last five decades from ...
Source: International Journal of Biological Macromolecules - May 28, 2023 Category: Biochemistry Authors: Taotao Xue Kaihua Ruan Zhishu Tang Jinao Duan Hongbo Xu Source Type: research

Phytohustil ® and root extract of Althaea officinalis L. exert anti-inflammatory and anti-oxidative properties and improve the migratory capacity of endothelial cells in vitro
Conclusion: Our data show that Phytohustil® and REA have anti-inflammatory/-oxidant properties and improve the migratory capacity of vascular endothelial cells. These properties may contribute to the healing characteristics of Phytohustil® and support the benefit of Phytohustil® in patient’s treatment of irritated oral mucosa. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 8, 2022 Category: Drugs & Pharmacology Source Type: research

High-efficiency removal of benzene vapor using activated carbon from Althaea officinalis L. biomass as a lignocellulosic precursor
This study aimed to evaluate biowaste material for activated carbon production from Althaea officinalis L. biomass by chemical activation (H2SO4, LiOH, and ZnCl2) at temperatures between 500 and 900 °C. Newly developed powdered activated carbons (Ao-ACs) are also tabulated as Ao-AC1-45 for easy reference. Benzene vapor was collected into Tenax TA® tubes by automatic thermal desorption in conjunction with a capillary gas chromatography-mass spectrometry (TD-GC/MS). The significant surface area and production yield of Ao-ACs were obtained at 1424 m2/g (Ao-AC43) and up to 40.32%, respectively. The maximum gas-phase benzene ...
Source: Environmental Science and Pollution Research International - May 4, 2022 Category: Environmental Health Authors: Kaan Isinkaralar Source Type: research

High-efficiency removal of benzene vapor using activated carbon from Althaea officinalis L. biomass as a lignocellulosic precursor
This study aimed to evaluate biowaste material for activated carbon production from Althaea officinalis L. biomass by chemical activation (H2SO4, LiOH, and ZnCl2) at temperatures between 500 and 900 °C. Newly developed powdered activated carbons (Ao-ACs) are also tabulated as Ao-AC1-45 for easy reference. Benzene vapor was collected into Tenax TA® tubes by automatic thermal desorption in conjunction with a capillary gas chromatography-mass spectrometry (TD-GC/MS). The significant surface area and production yield of Ao-ACs were obtained at 1424 m2/g (Ao-AC43) and up to 40.32%, respectively. The maximum gas-phase benzene ...
Source: Environmental Science and Pollution Research International - May 4, 2022 Category: Environmental Health Authors: Kaan Isinkaralar Source Type: research

Impact of copper treatment on phenylpropanoid biosynthesis in adventitious root culture of Althaea officinalis L.
(Source: Preparative Biochemistry)
Source: Preparative Biochemistry - March 15, 2022 Category: Biochemistry Authors: Park, Yun Ji Kim, Nam Su Sathasivam, Ramaraj Chung, Yong Suk Park, Sang Un Source Type: research

Study of Superoxide Dismutase Activity in Long-Term Cultivated Artemisia and Althaea "hairy" Roots
Curr Microbiol. 2021 Dec 14;79(1):14. doi: 10.1007/s00284-021-02709-0.ABSTRACTThe aim of the study was to evaluate the long-term effect of Agrobacterium rhizogenes genes transfer on plant antioxidant system by the study of superoxide dismutase (SOD) activity in "hairy" roots of Artemisia and Althaea spp plants. PCR analyses revealed stability of the transformation and presence of bacterial rol B and rol C genes in the "hairy" roots after 4-6 years from the transformation event. SOD activity in the roots of untransformed in vitro cultivated plants used for the initiation of "hairy" roots growth was in the range of 45.8 ± 8...
Source: Current Microbiology - December 14, 2021 Category: Microbiology Authors: Nadiia Matvieieva Anatolii Shakhovsky Hanna Tashyreva Yakiv Ratushnyak Volodymyr Duplij Taisa Bohdanovych Mykola Kuchuk Source Type: research

Study of Superoxide Dismutase Activity in Long-Term Cultivated Artemisia and Althaea "hairy" Roots
Curr Microbiol. 2021 Dec 14;79(1):14. doi: 10.1007/s00284-021-02709-0.ABSTRACTThe aim of the study was to evaluate the long-term effect of Agrobacterium rhizogenes genes transfer on plant antioxidant system by the study of superoxide dismutase (SOD) activity in "hairy" roots of Artemisia and Althaea spp plants. PCR analyses revealed stability of the transformation and presence of bacterial rol B and rol C genes in the "hairy" roots after 4-6 years from the transformation event. SOD activity in the roots of untransformed in vitro cultivated plants used for the initiation of "hairy" roots growth was in the range of 45.8 ± 8...
Source: Current Microbiology - December 14, 2021 Category: Microbiology Authors: Nadiia Matvieieva Anatolii Shakhovsky Hanna Tashyreva Yakiv Ratushnyak Volodymyr Duplij Taisa Bohdanovych Mykola Kuchuk Source Type: research

Polysaccharide extracted from Althaea officinalis L. root: New studies of structural, rheological and antioxidant properties
Carbohydr Res. 2021 Sep 10;510:108438. doi: 10.1016/j.carres.2021.108438. Online ahead of print.ABSTRACTA water-soluble acidic polysaccharide (AOP-2) from Althaea officinalis L. root was isolated by water extraction and purified by ion exchange chromatography (Cellulose DEAE-52) and gel filtration (Sephadex G-200). The structure characteristics of AOP-2 was determined by gel permeation chromatography (GPC), high performance liquid chromatography (HPLC), fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR) spectrum and gas chromatography-mass spectrometry (GC_MS). The results indicated that the AOP-2 was an ...
Source: Carbohydrate Research - October 1, 2021 Category: Genetics & Stem Cells Authors: Shafagh Karimi Babak Ghanbarzadeh Leila Roufegarinejad Pasquale M Falcone Source Type: research

Polysaccharide extracted from Althaea officinalis L. root: New studies of structural, rheological and antioxidant properties
Carbohydr Res. 2021 Sep 10;510:108438. doi: 10.1016/j.carres.2021.108438. Online ahead of print.ABSTRACTA water-soluble acidic polysaccharide (AOP-2) from Althaea officinalis L. root was isolated by water extraction and purified by ion exchange chromatography (Cellulose DEAE-52) and gel filtration (Sephadex G-200). The structure characteristics of AOP-2 was determined by gel permeation chromatography (GPC), high performance liquid chromatography (HPLC), fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR) spectrum and gas chromatography-mass spectrometry (GC_MS). The results indicated that the AOP-2 was an ...
Source: Carbohydrate Research - October 1, 2021 Category: Genetics & Stem Cells Authors: Shafagh Karimi Babak Ghanbarzadeh Leila Roufegarinejad Pasquale M Falcone Source Type: research

Polysaccharide extracted from Althaea officinalis L. root: New studies of structural, rheological and antioxidant properties
Carbohydr Res. 2021 Sep 10;510:108438. doi: 10.1016/j.carres.2021.108438. Online ahead of print.ABSTRACTA water-soluble acidic polysaccharide (AOP-2) from Althaea officinalis L. root was isolated by water extraction and purified by ion exchange chromatography (Cellulose DEAE-52) and gel filtration (Sephadex G-200). The structure characteristics of AOP-2 was determined by gel permeation chromatography (GPC), high performance liquid chromatography (HPLC), fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR) spectrum and gas chromatography-mass spectrometry (GC_MS). The results indicated that the AOP-2 was an ...
Source: Carbohydrate Research - October 1, 2021 Category: Genetics & Stem Cells Authors: Shafagh Karimi Babak Ghanbarzadeh Leila Roufegarinejad Pasquale M Falcone Source Type: research

Althaea officinalis improves wound healing in rats: a stereological study.
Authors: Mohsenikia M, Rafiee S, Rozei LS, Ebrahimi A, Zahmatkesh-Meimandi F, Aref NM, Nematollahi P, Mirlohi MS, Soleymani A, Zaree H, Ashkani-Esfahani S Abstract Althaea officinalis (AO) is reported to have the ability to activate fibroblasts as well as anti-inflammatory and antioxidative properties. Herein, we investigated the effects of this herbal medicine on wound healing in rat models by using stereological methods. In this experiment, 48 male Wistar rats were divided into four groups randomly (n = 12): the control group with no treatment, the gel-base treated group, 5% and 10% AO-gel treated groups...
Source: Drug Discoveries and Therapeutics - October 30, 2020 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
ConclusionsOur work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical discussion about their potential use as adjuvants in the treatment of early/mild common flu in otherwise healthy adults within the context of COVID-19. While these herbal medicines will not cure or prevent the flu, they may both improve general patient well-being and offer them an opportunity to personalize the therapeutic approaches. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 22, 2020 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and Anti-oxidative Effects of Phytohustil ® and Root Extract of Althaea officinalis L. on Macrophages in vitro
ConclusionThe present in vitro investigations indicate protective, i.e., anti-oxidative and anti-inflammatory effects of REAo and Phytohustil®, additionally improving the migratory capacity of MΦ. These antiinflammatory effects were similar or even better than diclofenac. Thus, our data support and may explain the positive effect of Phytohustil® observed in patients during the therapy of inflamed buccal mucosal membranes or treatment of cough. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

New infertility therapy effects of polysaccharides from Althaea officinalis leaf with emphasis on characterization, antioxidant and anti-pathogenic activity.
Abstract Characterization, antioxidant, anti-pathogenic and infertility therapy effects of polysaccharides from Althaea officinalis (marshmallow) leaf (AOLPS) were investigated. AOLPS was fractionated using ion-exchange chromatography, affording fractions of AOLPS-1, AOLPS-2, AOLPS-3 and AOLPS-4. The fractions were mainly composed of d-galactopyranose (α-(1 → 4)-glycosidic bond) with the average molecular weight of 1220, 2240, 998 and 2670 Da, respectively which means it was a pectin-like polysaccharide. Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FT-IR) te...
Source: International Journal of Biological Macromolecules - December 27, 2019 Category: Biochemistry Authors: Tahmouzi S, Nejat MRS Tags: Int J Biol Macromol Source Type: research