Antiviral compound protects nonhuman primates against Marburg virus
(US Army Medical Research Institute of Infectious Diseases) An experimental drug that protected monkeys from the deadly Marburg virus appears to have potential for treating people who have been exposed to the virus, according to a study published in the July 23 edition of The New England Journal of Medicine. Marburg virus is closely related to Ebola virus and also causes a severe hemorrhagic fever. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 22, 2015 Category: Infectious Diseases Source Type: news

Medical News Today: New antibody treatment may protect against Marburg and Ebola viruses
Scripps researchers have designed proteins that elicit an effective antibody response in a mouse model against Marburg virus and its viral cousin, Ebola virus. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 29, 2015 Category: Consumer Health News Tags: Ebola Source Type: news

TSRI and Biotech partners find new antibody weapons against Marburg virus
(Scripps Research Institute) A new study led by scientists at The Scripps Research Institute identifies new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus. The research provides ingredients needed to develop treatments for future Marburg outbreaks. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 29, 2015 Category: Global & Universal Source Type: news

New antibody weapons against Marburg virus
New immune molecules that protect against deadly Marburg virus, a relative of Ebola virus, have been identified by researchers. The research provides ingredients needed to develop treatments for future Marburg outbreaks, they say. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 27, 2015 Category: Science Source Type: news

A First Responder's Guide to Ebola
"Filoviridae is the only known virus family about which we have such profound ignorance." -- C.J. Peters & J.W. LeDuc, National Center for Infectious Diseases, CDC Learning Objectives Identify the signs and symptoms of Ebola. Learn the pathogenesis of Ebola. Understand how Ebola is transmitted and how to protect yourself when caring for an infected patient. KEY Terms Cytokine: Proteins important in cell signaling in immune response. Dendritic cells: Immune cells that encourage T-cell response. Macrophages: White blood cells that engulf foreign cells and assist in inflammation and immune processes. Tissue f...
Source: JEMS Patient Care - May 4, 2015 Category: Emergency Medicine Authors: James F. Goss, MHA, MICP Tags: Infectious Diseases Operations Provider Wellness & Safety Patient Care Source Type: news

GeoVax and NIH to develop vaccines against Ebola and Marburg viruses
Biotechnology firm GeoVax Labs has signed a research collaboration agreement with the National Institutes of Health’s (NIH) National Institute of Allergy and Infectious Diseases (NIAID) to develop its vaccines against Ebola and Marburg viruses. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - April 16, 2015 Category: Pharmaceuticals Source Type: news

West Africa: Potential Ebola Treatment Mechanism Discovered
[SciDev.Net] A possible mechanism to treat infection by the deadly Marburg and Ebola viruses has been uncovered by scientists working in the United States. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 5, 2015 Category: African Health Source Type: news

Potential Ebola treatment mechanism discovered
Antibody research set out in two papers shows a possible way to tackle Ebola and Marburg viruses. (Source: SciDev.Net)
Source: SciDev.Net - March 4, 2015 Category: Global & Universal Source Type: news

Researchers identify how humans can develop immunity to deadly Marburg virus
(University of Texas Medical Branch at Galveston) A collaborative team from The University of Texas Medical Branch at Galveston, Vanderbilt University and The Scripps Research Institute have identified mechanisms involved in antibody response to the deadly Marburg virus by studying the blood of a Marburg survivor. Using blood samples from a Marburg survivor, the researchers were able to determine how a person's immune system can fight against the virus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2015 Category: Global & Universal Source Type: news

Human antibodies target Marburg, Ebola viruses; 1 step closer to vaccine
(Vanderbilt University Medical Center) Researchers at Vanderbilt University, the University of Texas Medical Branch at Galveston and The Scripps Research Institute for the first time have shown how human antibodies can neutralize the Marburg virus, a close cousin to Ebola. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 26, 2015 Category: Infectious Diseases Source Type: news

Airport screening for viruses misses half of infected travelers but can be improved, says UCLA-led study
In the past decade, the H1N1 virus and Ebola are just two of the diseases whose spread was spurred by international airline travel. Screening passengers at airports, therefore, could be one key method for slowing the global spread of infectious diseases. And although a team lead by UCLA researchers has found that airport screening misses at least half of infected travelers, the scientists say that rate could be improved. Their research was published in eLife, a highly regarded open-access online science journal. The life scientists used a mathematical model to analyze screening for six viruses: the SARS coronavirus, the Eb...
Source: UCLA Newsroom: Health Sciences - February 25, 2015 Category: Universities & Medical Training Source Type: news

Airport screening for viruses misses half of infected travelers but can be improved
(University of California - Los Angeles) Airport screening for diseases often misses at least half of infected travelers, but can be improved, scientists reported Feb. 19 in eLife, a highly regarded open-access online science journal. The life scientists used a mathematical model to analyze screening for six viruses: SARS coronavirus, Ebola virus, Middle East respiratory syndrome coronavirus, Marburg virus, Influenza H1N1 and Influenza H7N9. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 24, 2015 Category: Infectious Diseases Source Type: news

Airport screening for diseases like Ebola and swine flu misses around HALF of infected travellers because people 'lie about exposure to avoid delays'
Scientists in California and London examined screening programmes for six viruses, including Ebola, Marburg virus swine and avian flu. They found questionnaires most effective in early stages. (Source: the Mail online | Health)
Source: the Mail online | Health - February 19, 2015 Category: Consumer Health News Source Type: news

Experimental Ebola Drug From Sarepta Protects 75 Percent Of Monkeys In Study
By Sharon Begley NEW YORK, Feb 10 (Reuters) - An experimental Ebola drug from Sarepta Therapeutics Inc protected 75 percent of lab monkeys injected with the virus, scientists from the company and the U.S. Army reported on Tuesday. The drug, called AVI-7537, joins ZMapp from Mapp Biopharmaceutical and a compound from Tekmira Pharmaceuticals Corp as the agents shown to cure non-human primates given otherwise-lethal injections of Ebola virus. The ZMapp and Tekmira drugs protected 100 percent of lab monkeys in studies, giving them a possible edge. But, unlike those drugs, Sarepta's drug has been formally t...
Source: Healthy Living - The Huffington Post - February 10, 2015 Category: Consumer Health News Source Type: news

Nigeria: Trial Confirms Ebola Vaccine Candidate Safe
[Guardian]TWO experimental DNA vaccines to prevent Ebola virus and the closely related Marburg virus are safe, and generated a similar immune response in healthy Ugandan adults as reported in healthy US adults earlier this year. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 8, 2015 Category: African Health Source Type: news

Promising results from new Ebola vaccine trial
In an early human trial, experimental vaccines for Ebola and the Marburg virus were shown to be safe and relatively effective (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - December 23, 2014 Category: Consumer Health News Source Type: news

Trial confirms Ebola vaccine candidate safe, equally immunogenic in Africa
Two experimental DNA vaccines to prevent Ebola virus and the closely related Marburg virus are safe, and generated a similar immune response in healthy Ugandan adults as reported in healthy US adults earlier this year. The findings are from the first trial of filovirus vaccines in Africa. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 23, 2014 Category: Science Source Type: news

Scientists report on trial of early-generation Ebola, Marburg vaccine candidates
(NIH/National Institute of Allergy and Infectious Diseases) esults of an early-stage clinical trial of two experimental vaccines against Ebola and Marburg viruses -- the first to be completed in an African country -- showed that they were safe and induced immune responses in healthy Ugandan adult volunteers. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 23, 2014 Category: Infectious Diseases Source Type: news

Study confirms Ebola and Marburg virus DNA vaccines are safe and immunogenic in Africa
(The U.S. Military HIV Research Program (MHRP)) Results from the first Ebola vaccine clinical trial conducted in Africa (in 2009-2010) reveal a vaccine candidate produces the same immune response seen in the United States in an African setting. The findings of this 2009-2010 study, published online today in The Lancet, describe the successful execution and analysis of a Phase 1 clinical trial of two DNA vaccine candidates, one for the Ebola virus and the other for the closely related Marburg virus. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 23, 2014 Category: Infectious Diseases Source Type: news

City Life May Be To Blame For Rising Diabetes Rates
Aesop's fable about the dangers of urban life goes something like this: A City Mouse visits his cousin in the country and is shocked at the humble meal they eat. The City Mouse invites the Country Mouse to his home in town, where he promises to serve a delicious feast. But when the Country Mouse comes calling, dangerous and stressful interruptions from dogs and cats prevent them from digging into their meal in peace. Returning to his simple home, the Country Mouse thinks, “Better beans and bacon in peace than cakes and ale in fear.” The results of new study published in The Journal of Clinical Endocrinology &...
Source: Science - The Huffington Post - December 19, 2014 Category: Science Source Type: news

City Life May Be To Blame For Rising Diabetes Rates
Aesop's fable about the dangers of urban life goes something like this: A City Mouse visits his cousin in the country and is shocked at the humble meal they eat. The City Mouse invites the Country Mouse to his home in town, where he promises to serve a delicious feast. But when the Country Mouse comes calling, dangerous and stressful interruptions from dogs and cats prevent them from digging into their meal in peace. Returning to his simple home, the Country Mouse thinks, “Better beans and bacon in peace than cakes and ale in fear.” The results of new study published in The Journal of Clinical Endocrinology &...
Source: Healthy Living - The Huffington Post - December 19, 2014 Category: Consumer Health News Source Type: news

Ebola Vaccines: Why Clinical Trials Are Just the First Step
With clinical trials for Ebola vaccines now under way, and with governments and manufacturers stepping up to fund them, there is an almost palpable sense that the panic is over and the problem solved. The reality, however, is that even if a safe and effective vaccine emerges and the epidemic is brought under control, we are still in many ways no better prepared for future outbreaks than we were a year ago. So how is it that we can spend billions of dollars every year keeping fleets of nuclear-armed submarines permanently patrolling our oceans, to protect us from a threat that will almost certainly never happen, and yet i...
Source: Science - The Huffington Post - December 5, 2014 Category: Science Source Type: news

CDC Looks Ahead To The Next Epidemic
WASHINGTON (AP) -- The next Ebola or the next SARS. Maybe even the next HIV. Even before the Ebola epidemic in West Africa is brought under control, public health officials are girding for the next health disaster. "It's really urgent that we address the weak links and blind spots around the world," Dr. Tom Frieden, director of the Centers for Disease Control and Prevention, told The Associated Press. "Ebola is a powerful reminder that a health threat anywhere can affect us." Ebola sprang from one of those blind spots, in an area that lacks the health systems needed to detect an outbreak before it bec...
Source: Science - The Huffington Post - November 24, 2014 Category: Science Source Type: news

Marburg virus disease - Uganda
On 11 November 2014, the Government of Uganda declared that Uganda was free of the Marburg virus. This declaration was made at the National Media Centre by the Minister of State for Primary Health Care, Hon. Sarah Achieng Opendi. On 4 October 2014, WHO was notified by the Government of Uganda of a case of Marburg virus disease. The case was a male health professional that developed symptoms on 11 September. On 17 September, the patient was admitted to a district health facility in Mpigi. He was later transferred to a hospital in Kampala. On 28 September, the case passed away and was buried on 30 September in Kasese distri...
Source: WHO Disease Outbreaks - November 13, 2014 Category: Infectious Diseases Tags: marburg [subject], marburg haemorrhagic fever, marburg [subject], marburg haemorrhagic fever, Disease outbreak news [doctype] Source Type: news

Virus Study May Help Doctors Detect Ebola Earlier
By: Rachael Rettner Published: 11/12/2014 10:36 AM EST on LiveScience Tests for Ebola virus currently cannot identify the disease until after people show symptoms, and so individuals exposed to the virus have to wait to see if they are infected. But a new study has found potential early markers of diseases similar to Ebola, suggesting it may be possible to test for these viruses much earlier. In the study, researchers infected monkeys with either Lassa virus or Marburg virus, which is a "cousin" of Ebola virus. Like Ebola, both Lassa and Marburg can cause hemorrhagic fevers, meaning fever accompanied by damage...
Source: Science - The Huffington Post - November 12, 2014 Category: Science Source Type: news

Sascha Haverfield
VP, Scientific and Regulatory AffairsSascha Haverfield is the Vice President for Scientific and Regulatory Affairs at PhRMA. He leads PhRMA's activities on global regulatory policy issues and is the architect of our engagement on the implementation of the Prescription Drug User Fee Act (PDUFA).  He previously worked in the biopharmaceutical industry on drug discovery, translational medicine and regulatory affairs with a focus on global drug development issues.  Sascha completed his undergraduate studies in biological sciences at the University of Marburg, Germany and received a doctorate in genetics and cell ...
Source: PHRMA - November 12, 2014 Category: Pharmaceuticals Authors: Emily Source Type: news

Uganda: Uganda Declared Marburg Free!
[Independent (Kampala)]Today, the Ministry of Health wishes to inform the Public that the country is officially declared free of the Marburg Virus Epidemic. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 12, 2014 Category: African Health Source Type: news

Uganda says free of Ebola-like Marburg after outbreak in September
KAMPALA (Reuters) - Ugandan authorities said the east African country was free of Marburg, a virus similar to Ebola, after no new cases had been reported more than a month after a hospital worker died of the disease in the capital. (Source: Reuters: Health)
Source: Reuters: Health - November 11, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Pre-symptomatic markers for hemorrhagic viruses like Ebola identified
This study will allow for the development of better diagnostics, especially during the early stages of disease, when treatments have a greater chance of being effective. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 10, 2014 Category: Science Source Type: news

Study identifies pre-symptomatic markers for hemorrhagic viruses like Ebola
(Boston University Medical Center) A new study has found it is possible to distinguish between different hemorrhagic fevers, including Marburg (Ebola cousin) and Lassa before the person becomes symptomatic. The study, which appears in the journal BMC Genomics, will allow for the development of better diagnostics, especially during the early stages of disease, when treatments have a greater chance of being effective. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 10, 2014 Category: Global & Universal Source Type: news

Ebola modifies genes as it kills infected hosts
(NaturalNews) The mechanism by which Ebola and other filoviruses attack and kill their hosts has been identified as what we now know to be genetic modification, according to shocking new research published in the journal mBio. Upon entry, Ebola and the related Marburg viruses demonstrably... (Source: NaturalNews.com)
Source: NaturalNews.com - November 9, 2014 Category: Consumer Health News Source Type: news

Ebola, Marburg viruses edit genetic material during infection
(American Society for Microbiology) Filoviruses like Ebola 'edit' genetic material as they invade their hosts, according to a study published this week in mBio, the online open-access journal of the American Society for Microbiology. The work, by researchers at the Icahn School of Medicine at Mount Sinai, the Galveston National Laboratory, and the J. Craig Venter Institute, could lead to a better understanding of these viruses, paving the way for new treatments down the road. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 4, 2014 Category: Infectious Diseases Source Type: news

Hermit thrush or humans: Who sets the tone?
(University of Vienna) The songs of the hermit thrush, a common North American songbird, follow principles found in much human music -- namely the harmonic series. Researchers from the University of Vienna, Austria, the Cornish College of the Arts, USA, and the Philipps University of Marburg, Germany, are the first to demonstrate note selection from the harmonic series in a non-human animal using rigorous analytical methods. The study is published in the scientific journal Proceedings of the National Academy of Sciences. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 4, 2014 Category: Biology Source Type: news

Tanzania: Relief As Mwanza Samples Test Ebola Virus Negative
[Daily News]Mwanza -THE results of the specimen collected from the late Salome Richard and brought to the special laboratory for specialised screening of Ebola, Marburg and Rift Valley Fever (RFV) have all tested negative. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 28, 2014 Category: African Health Source Type: news

Evolutionary Roots of the Ebola Virus
The family of viruses housing Ebola and Marburg is ancient, and the two viruses last shared a common ancestor millions of years ago, scientists say... (Source: Disabled World)
Source: Disabled World - October 24, 2014 Category: Disability Tags: Ebola Virus Source Type: news

Ebola's evolutionary roots more ancient than previously thought
A new study is helping to rewrite Ebola’s family history. It shows that Ebola and Marburg are each members of ancient evolutionary lines, and that these two viruses last shared a common ancestor sometime prior to 16-23 million years ago. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 24, 2014 Category: Science Source Type: news

Ebola's evolutionary roots are more ancient than previously thought, study finds
(University at Buffalo) A new study is helping to rewrite Ebola's family history. The research shows that Ebola and Marburg are each members of ancient evolutionary lines, and that these two viruses last shared a common ancestor sometime prior to 16-23 million years ago. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 24, 2014 Category: Infectious Diseases Source Type: news

What Can Africa's Ebola Containment Successes Teach Other Nations?
As Nigeria is declared free of active transmission of Ebola virus disease, Uganda's Director-General for Health Affairs reiterates that unified public and political support ? and a responsible press ? have been crucial to stopping their Ebola and Marburg outbreaks. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - October 20, 2014 Category: Pharmaceuticals Authors: David Kroll Source Type: news

An Ebola Outbreak Contained: What U.S. And Other Nations Can Learn From Nigeria
As Nigeria is declared free of active transmission of Ebola virus disease, Uganda's Director-General for Health Affairs reiterates that unified public and political support – and a responsible press – have been crucial to stopping their Ebola and Marburg outbreaks. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - October 20, 2014 Category: Pharmaceuticals Authors: David Kroll Source Type: news

Clear Questions and Answers About Ebola
National Institutes of Health (NIH) Risk factors  By Mayo Clinic Staff For most people, the risk of getting Ebola or Marburg viruses (hemorrhagic fevers) is low. The risk increases if you: Travel to Africa. You're at increased risk if you visit or work in areas where Ebola virus or Marburg virus outbreaks have occurred. Conduct [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - October 17, 2014 Category: Databases & Libraries Source Type: news

Kenya: Marburg Team Sent to Uganda Border
[The Star]HEALTH officials in Turkana have told residents that they are monitoring the Kenya- Uganda border for Marburg fever after a medic died in the neigbouring country. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 14, 2014 Category: African Health Source Type: news

See How Ebola’s Spread Compares to Other Deadly Outbreaks
When the director of the Centers for Disease Control and Prevention (CDC) compared Ebola to AIDS last week, he introduced a new note of urgency to the outbreak. As was the case in the early days of HIV, there are currently no approved drugs to treat Ebola, and the virus carries the potential to cause untold devastation—not to mention a lot of panic. But as an epidemic, Ebola has far more in common with other diseases. Here’s a comparison of Ebola’s impact over the past 19 weeks to other recent outbreaks that, like Ebola, have no known cure or vaccine. Middle East Respiratory Syndrome (MERS) MERS is a vira...
Source: TIME.com: Top Science and Health Stories - October 13, 2014 Category: Consumer Health News Authors: davejohndc Tags: Uncategorized Source Type: news

Kenya: Health Ministry Orders Screening for Ebola-Like Virus
[The Star]THE Ministry of Health has put all facilities and ports of entry on high alert for the Marburg fever. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 13, 2014 Category: African Health Source Type: news

MSF Responds to Marburg Hemorrhagic Fever in Uganda
MSF is responding to a confirmed case of Marburg hemorrhagic fever in Kampala. Language English (Source: MSF News)
Source: MSF News - October 10, 2014 Category: Global & Universal Authors: Elias Primoff Source Type: news

MSF Responds to Marburg Hemorrhagic Fever in Uganda
Field newsMSF Responds to Marburg Hemorrhagic Fever in Uganda October 09, 2014 MSF is responding to a confirmed case of Marburg hemorrhagic fever in Uganda. (Source: MSF News)
Source: MSF News - October 10, 2014 Category: Global & Universal Authors: Elias Primoff Source Type: news

Marburg virus disease - Uganda
On 5 October 2014, the Ministry of Health (MoH) of Uganda notified WHO of a confirmed case of Marburg virus disease (MVD) in Kampala, Uganda. The confirmed case was a healthcare worker who had onset of disease on 11 September 2014 while working at Mengo Hospital, Kampala. The case presented to Mpigi District Health Center on 17 September 2014, and transferred to Mengo Hospital, Kampala, on 23 September 2014. On admission the case presented with symptoms including fever, headache, abdominal pain, vomiting and diarrhoea and died on 28 September 2014. (Source: WHO Disease Outbreaks)
Source: WHO Disease Outbreaks - October 10, 2014 Category: Infectious Diseases Tags: marburg [subject], marburg haemorrhagic fever, marburg [subject], marburg haemorrhagic fever, African Region [region], Disease outbreak news [doctype], Uganda [country] Source Type: news

In 2005 Marburg virus outbreak, some lessons for Ebola crisis
WASHINGTON (Reuters) - When I see the footage of health workers in protection suits taking up the fight against Ebola in west Africa, memories come flooding back. (Source: Reuters: Health)
Source: Reuters: Health - October 10, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Uganda: Uganda - Update On Marburg Hemorrhagic Fever Outbreak
[MSF]On 29 September, a Ugandan man, aged about thirty and presenting symptoms of hemorrhagic fever, died in a hospital in the Ugandan capital, Kampala. On 4th October, the Centre for Disease Control and Prevention (CDC) announced that the man's blood tests had revealed contamination by Marburg fever. MSF, which has been working in Uganda since 1986, is currently mobilising its teams in preparation for a response. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 10, 2014 Category: African Health Source Type: news

99 in Uganda quarantined after Marburg virus death
Three days after a fatal case of Marburg hemorrhagic fever was diagnosed in Uganda, 99 people are under isolation in four different locations across the East African country, as field epidemiologists and surveillance officers continue to closely monitor all people who got into contact with only victim. (Source: CNN.com - Health)
Source: CNN.com - Health - October 8, 2014 Category: Consumer Health News Source Type: news