Molecular understanding of drug interactions suggests pathway to better malaria treatments
(University of Houston) Researchers have for the first time demonstrated what happens at the molecular level when two compounds known to inhibit crystal growth were combined, yielding new insights into malaria treatments and, more broadly, improving the process of drug development. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 15, 2020 Category: Infectious Diseases Source Type: news

Infectious disease defenses among ancient hominid contributions to adaptation of modern humans
(Molecular Biology and Evolution (Oxford University Press)) In a new study published in the advanced online edition of Molecular Biology and Evolution, scientists Alexandre Gouy and Laurent Excoffier have developed new computational tools to better analyze human genome datasets, and found more evidence of a legacy of ancient hominid adaptation, particularly to help fight off infectious diseases like malaria. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 14, 2020 Category: Infectious Diseases Source Type: news

Zimbabwe: Bulawayo Needs U.S.$15 Million to Fight Mosquitoes
[New Zimbabwe] The city of Bulawayo has been hit by an unprecedented outbreak of mosquito which has become a menace to the city. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - January 13, 2020 Category: Infectious Diseases Source Type: news

Kenya: Global Fund Gives U.S.$413,739,805 to Fund Fight Against Aids, TB
[Nation] The Global Fund -- the agency that helps Kenya fight HIV/Aids, tuberculosis and malaria -- has given the country Sh42 billion to be used up to 2024. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - January 13, 2020 Category: Infectious Diseases Source Type: news

New grant enables Clemson researcher to further combat widespread parasitic disease
(Clemson University) Clemson University faculty member Zhicheng Dou received new funding from the National Institutes of Health to better understand the molecular mechanisms of the parasite that causes toxoplasmosis, which is the second-leading cause of death among food-borne illnesses in the United States. His findings may someday pave the way for a cure for the disease, while having an important impact on the treatment of malaria, a mosquito-borne disease that is caused by a related parasite. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 13, 2020 Category: Biology Source Type: news

Rwanda: Rwanda to Distribute First Locally Made Mosquito Nets
[New Times] The Ministry of Health has announced that it will this year start to distribute the first mosquito nets that are made in Rwanda. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - January 11, 2020 Category: Infectious Diseases Source Type: news

Nigeria: Business Mogul Flags Off Malaria-Free Africa Campaign in Antarctica
[Vanguard] Renowned billionaire, entrepreneur, public health environmentalist, and Chairman, Ned Nwoko Foundation, Dr Ned Nwoko, has landed in Antarctica for the symbolic flag-off of his multi-billion naira malaria eradication in Africa project. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 10, 2020 Category: African Health Source Type: news

Nigeria: Politician Takes Malaria Eradication Campaign to Antarctica
[Premium Times] A Nigerian politician, Ned Nwoko, has taken a malaria eradication campaign to Antarctica. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - January 10, 2020 Category: Infectious Diseases Source Type: news

Africa: Ned Nwoko Flags Off Malaria-Free Africa Campaign in Antarctica
[Vanguard] Renowned billionaire, entrepreneur, public health environmentalist, and Chairman, Ned Nwoko Foundation, Dr Ned Nwoko, has landed in Antarctica for the symbolic flag-off of his multi-billion naira malaria eradication in Africa project. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - January 10, 2020 Category: Infectious Diseases Source Type: news

Malaria Antigen Shed in Breast Milk of Mothers in Region With Endemic Malaria Malaria Antigen Shed in Breast Milk of Mothers in Region With Endemic Malaria
Malaria antigen is shed in the breast milk of mothers with asymptomatic malaria who live in northeastern Uganda, where malaria is endemic, researchers report.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 9, 2020 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Liberia: Liberia Coordinating Mechanism Commences Regional Consultative Country Dialogue for TB/HIV Grant Proposal Development
[FrontPageAfrica] Bomi County -The Liberia Coordinating Mechanism (LCM) of the Global Fund (TGF) to fight AIDS, TB and Malaria has commenced a regional consultative prioritization country dialogue to develop a joint funding request for Tuberculosis and HIV, on behalf of the country, for submission to the Fund. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - January 8, 2020 Category: Infectious Diseases Source Type: news

Liberia: LMC Commences Regional Consultative Country Dialogue
[New Dawn] The Liberia Coordinating Mechanism (LCM) of the Global Fund (TGF) to fight AIDS, TB and Malaria has commenced a regional consultative prioritization country dialogue to develop a joint funding request for Tuberculosis and HIV, on behalf of the country, for submission to the Fund. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - January 8, 2020 Category: Infectious Diseases Source Type: news

New study reveals the origin of complex malaria infections
(Texas Biomedical Research Institute) New technology employing single cell genome sequencing of the parasite that causes malaria has yielded some surprising results and helps pave the way for possible new intervention strategies for this deadly infectious disease, according to Texas Biomedical Research Institute Assistant Professor Ian Cheeseman, Ph.D. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 8, 2020 Category: Infectious Diseases Source Type: news

Nigeria: World Bank, IDB, AfDB Offer $364m for Malaria Drug Production in Nigeria
[Daily Trust] The coordinator of the National Malaria Elimination Programme (NMEP), Audu Mohammed, says the Federal Government will empower local manufacturers to produce malaria drugs. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 7, 2020 Category: African Health Source Type: news

Nigeria: Road2MalariaEradication - Nigerian Military Partners Prince Ned Nwoko Foundation
[Vanguard] A high-level delegation from the Nigerian Armed Forces led by Rear Admiral OH Ngalabak- Chief of Defence Civil Military corporation and Rear Admiral N.J Bala paid a courtesy visit to Prince Ned Nwoko to promote Civilian-Military partnerships in their bid to eradicate malaria and upcoming projects which include the Unsung Heroes Concert scheduled for 11th January 2020 and the visit to military base at Maiduguri. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 6, 2020 Category: African Health Source Type: news

Tanzania: Zanzibar On Alert As Malaria Scare Rises
[Daily News] MALARIA is on the rise in some areas of Zanzibar including the outskirts of Stone Town, authorities revealed here yesterday, appealing to members of the public to seriously observe health precautions. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - January 5, 2020 Category: Infectious Diseases Source Type: news

How malaria parasites become resistant to artemisinin antimalarial drugs
(American Association for the Advancement of Science) Malaria parasite mutations that inhibit the endocytoic appetite for a host's red blood cells may render them resistant to artemisinin, a widely used frontline antimalarial drug, according to a new study, which reveals a key molecular mechanism of drug resistance. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 2, 2020 Category: Biology Source Type: news

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites
In this study, we identified proteins located at a Kelch13-defined compartment. Inactivation of eight of these proteins, including Kelch13, rendered parasites resistant to ART, revealing a pathway critical for resistance. Functional analysis showed that these proteins are required for endocytosis of hemoglobin from the host cell. Parasites with inactivated Kelch13 or a resistance-conferring Kelch13 mutation displayed reduced hemoglobin endocytosis. ARTs are activated by degradation products of hemoglobin. Hence, reduced activity of Kelch13 and its interactors diminishes hemoglobin endocytosis and thereby ART activation, re...
Source: ScienceNOW - January 2, 2020 Category: Science Authors: Birnbaum, J., Scharf, S., Schmidt, S., Jonscher, E., Hoeijmakers, W. A. M., Flemming, S., Toenhake, C. G., Schmitt, M., Sabitzki, R., Bergmann, B., Fröhlke, U., Mesen-Ramirez, P., Blancke Soares, A., Herrmann, H., Bartfai, R., Spielmann, T. Tags: Cell Biology, Microbiology r-articles Source Type: news

Kenya: Hope in the New Year As Malaria Vaccines Lined Up for Clinical Trials
[Nation] As this year comes to an end, we remain hopeful that malaria, an infectious disease that kills 1,200 children under five years every day, will be prevented using a vaccine. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 31, 2019 Category: African Health Source Type: news

A new breakthrough in developing effective antimalarial drugs
(Institut Pasteur) Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes. The parasites manage to acclimatize to these two completely different hosts because the plasticity of their genome enables them to adapt as necessary. Scientists decided to investigate the epigenetic mechanisms behind this plasticity, in particular DNA methylation. They identified molecules capable of inhibiting DNA methylation and effectively killing even the most resistant Plasmodium falciparum parasites. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 31, 2019 Category: Infectious Diseases Source Type: news

Africa: A Look At Ned Nwoko's Move Against Malaria in Africa
[Vanguard] From the unearthly terrain of the Antarctica, otherwise known as the White Desert, Prince Ned Nwoko, Nigerian-born lawyer and entrepreneur, plans to launch a final onslaught against mosquitoes and malaria in Africa. The husband of star actress Regina Daniels is a man used to rising above the parapet to help his country pull the chestnut out of fire. For those who might have forgotten, he is the national hero who doggedly played the pivotal role in securing the payment of billions of dollars refunds back to (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - December 30, 2019 Category: Infectious Diseases Source Type: news

Swaziland: Natural Weapons Put Malaria On Notice - Eco-Friendly Insecticides in Eswatini
[UNEP] Living atop a hill in Malindza, a tiny county in eSwatini's lush east, 56-year-old Ntombi Ndzimandze is the matriarch of her household of 11 women and children. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - December 27, 2019 Category: Infectious Diseases Source Type: news

Angola: Malaria Kills Over 100 People in Lunda Sul
[ANGOP] Saurimo -At least 174 people died of malaria in eastern Lunda Sul province from January to December this year. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - December 27, 2019 Category: Infectious Diseases Source Type: news

Researchers identify that mosquitoes can sense toxins through their legs
(Liverpool School of Tropical Medicine) Researchers at LSTM have identified a completely new mechanism by which mosquitoes that carry malaria are becoming resistant to insecticide. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 25, 2019 Category: International Medicine & Public Health Source Type: news

Researchers map malaria parasites proliferate in human blood cells
(Tohoku University) Malaria parasites transform healthy red blood cells into rigid versions of themselves that clump together, hindering the transportation of oxygen. The infectious disease affects more than 200 million people across the world and causes nearly half a million deaths every year, according to the World Health Organization's 2018 report on malaria. Until now, however, researchers did not have a strong understanding of how the parasite so effectively infiltrated a system's red blood cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 25, 2019 Category: Biology Source Type: news

Africa: Eradicating Malaria in Africa
[This Day] Abuja -Ned Nwoko is out with a campaign to free the continent of the debilitating disease. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - December 24, 2019 Category: Infectious Diseases Source Type: news

Nigeria: Malaria Kills 95,844 in Nigeria Annually - NMEP
[Vanguard] The National Coordinator of the National Malaria Elimination Programme, NMEP, Dr. Audu Bala Mohammed has disclosed that malaria kills an estimated 95,844 Nigerians and infects 57 million annually. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - December 24, 2019 Category: Infectious Diseases Source Type: news

Zimbabwe: Global Fund Gives U.S.$500 Million to Fight HIV, TB, Malaria
[The Herald] Zimbabwe is assured of an adequate supply of anti-retroviral drugs (ARVs) following the allocation of US$500 million for the next three years by the Global Fund to Fight Aids, Tuberculosis and Malaria. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - December 20, 2019 Category: Infectious Diseases Source Type: news

IKBFU Scientists study molecular elements effective in countering malaria
(Immanuel Kant Baltic Federal University) The scientists research a building block of organic molecules needed for medical chemistry development. Spirocycles in nature is an element, that chemists are crazy about. This element presents in artemisinin, the most effective group of drugs against malaria. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 20, 2019 Category: Infectious Diseases Source Type: news

Ten Big Moments in Global Health from the 2010s
By Margarite Nathe, Principal Editor/Writer, IntraHealth International A nurse provides antiretroviral medicines to an HIV-positive client in Guatemala. Photo by Anna Watts for IntraHealth International. (Banner: Felicia, a 29 year old Liberian nurse, prepares to go inside an Ebola patient ward to draw blood. Photo by Morgana Wingard for USAID, used underCC BY-NC 2.0.)December 19, 2019As the 2010s come to a close, we’re looking back on the past decade in global health. Here are ten big moments that will stick with us—and could continue to shape the future of health for us all.2010: We worried about a global...
Source: IntraHealth International - December 19, 2019 Category: International Medicine & Public Health Authors: mnathe Tags: Family Planning & Reproductive Health HIV AIDS Infectious Diseases Maternal, Newborn, Child Health Noncommunicable Diseases Policy Advocacy Gender Equality Global Health Security Health Workforce Systems Nursing Midwifery Source Type: news

Africa: Highest-Ever Funding Allocations Announced to Fight Aids, TB and Malaria
[Global Fund] Geneva -Following a record-breaking Replenishment in October 2019, the Global Fund today announced its largest-ever funding allocations for eligible countries to fight AIDS, tuberculosis and malaria and build systems for health over the next three years. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - December 19, 2019 Category: Infectious Diseases Source Type: news

Nigeria: Ned Nwoko Flags Off Malaria Eradication Programme
[Vanguard] Billionaire businessman and politician, Ned Nwoko, has flagged off a malaria eradication program to overcome the recurring tragedy of hundreds of thousands of avoidable health complications and deaths as a result of the deadly disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 19, 2019 Category: African Health Source Type: news

Gene drives work faster than non-drive approaches to control problem insects
(PLOS) When controlling mosquitoes that spread malaria, gene drives, which force genetic changes to proliferate in a population, are faster and more efficient than simply releasing mosquitoes that are immune to the parasite, according to a new study published Dec. 19, 2019 in PLOS Genetics by Anthony James at University of California, Irvine and colleagues. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 19, 2019 Category: Infectious Diseases Source Type: news

Nigeria: Ned Nwoko, Malaria Challenge and Nigerians
[Vanguard] Malaria fever is one medical challenge that confronts millions of Nigerians and when it strikes, it hangs precariously like a sword of Damocles and poses some of the most disturbing disruptions to virtually all of our economic, social, religious and cultural activities. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - December 18, 2019 Category: Infectious Diseases Source Type: news

East Africa: Malaria Remains a Threat Despite Gains
[East African] Uganda is among six countries that accounted for more than half of all malaria cases last year, according to the World Malaria Report 2019. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 18, 2019 Category: African Health Source Type: news

East Africa: Donors Reduce Funding for Malaria Programmes
[East African] Malaria remains a big risk in East Africa despite the gains in the fight against the disease, the World Report has warned, turning the spotlight on reduction on donor funding, low domestic funding and prevention campaigns. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 18, 2019 Category: African Health Source Type: news

Nigeria: Meet Your Match - J Blood Artificial Intelligence Connects Blood Donors to Receivers in the FCT
[Nigeria Health Watch] Is there an alternative to blood for humans? The answer is no.One of the most vital requirements for a woman experiencing severe bleeding during childbirth is a blood transfusion. It is also the most essential need of a child suffering from severe anaemia due to chronic malnutrition or malaria. Accident victims, organ transplant patients and others often require blood transfusions to keep them alive, and blood transfusion is only possible with the availability of safe blood at the point of need. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 17, 2019 Category: African Health Source Type: news

Malaria under arrest: New drug target prevents deadly transmission
(Walter and Eliza Hall Institute) Australian researchers have found a new drug target for stopping the spread of malaria, after successfully blocking the world's deadliest malaria parasite -- Plasmodium falciparum -- from completing the 'transmission stage' of its lifecycle. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 17, 2019 Category: Infectious Diseases Source Type: news

Kenya: Clueless Officials Are Watching As KPL Deteriorates Further
[Nation] A Mombasa-based miraa dealer whose name I do not care to mention was just a few months ago admitted at the coast Provincial General Hospital with malaria raging through his veins. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 16, 2019 Category: African Health Source Type: news

Tanzania: Malaria Tops Ncd in 16.59m/ - Annual Budget Fund
[Daily News] AS some Malaria drugs' cases becoming resistant in treatment in the public, certain Non-Communicable Diseases have been cited as also milking the State where national health insurance sets aside at least 16.59m/- annually to fund their cures to the locals. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 16, 2019 Category: African Health Source Type: news

Sudan: Malaria Breached Epidemic Threshold in 2019
[Radio Dabanga] Khartoum -More than 1.8 million cases of malaria were reported from across Sudan so far in 2019, a sharp increase compared to previous years, the UN Office for the Coordination of Humanitarian Affairs (OCHA) reported on Thursday. Cases of diphtheria, dengue fever, rift valley fever, chikungunya, and cholera continue to be recorded across the country, according to the Sudanese Ministry of Health. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 16, 2019 Category: African Health Source Type: news

Africa: We Are Using Computer Models to Fight Drug Resistance
[The Conversation Africa] The infectious disease burden in Africa is very high, particularly for tuberculosis (TB), malaria and HIV/AIDS. In 2018, nearly a quarter (24%) of TB cases in the world were in Africa. The region accounted for 93% of malaria cases. The continent also bears the brunt of the HIV epidemic: 20.6 million of the 37.9 million people living with HIV are in eastern and southern Africa. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - December 13, 2019 Category: Infectious Diseases Source Type: news

Nigeria: Malaria - EU/Unicef Programme Treats 16,992 Children in Adamawa
[Premium Times] No fewer than 16,992 children below the age of five were treated of malaria under the EU/UNICEF Maternal, New-born and Child Health and Nutrition (MNCHN) project in Adamawa. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - December 10, 2019 Category: Infectious Diseases Source Type: news

Tafenoquine for Prevention and Antirelapse Therapy for Malaria Tafenoquine for Prevention and Antirelapse Therapy for Malaria
Learn the indications for and proper administration of tafenoquine, a newly approved option for malaria chemoprophylaxis and antirelapse therapy.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 9, 2019 Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news

Minestrone Meets Malaria, And Wins
While chicken soup has often been considered as effective as penicillin to treat many illnesses, or at least bad colds, a new study looks at different kinds of soups (yes, soups) to battle a more serious infection —malaria. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - December 9, 2019 Category: Pharmaceuticals Authors: Nina Shapiro, Contributor Source Type: news

Progress in malaria prevention questioned by experts
Call for inquiry into pace of improvement amid statistical inconsistencies (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - December 6, 2019 Category: Pharmaceuticals Source Type: news

Uganda: Uganda Among Six States With Half of World's Malaria Cases
[Monitor] Uganda has again been named one of six African countries that account for more than half of all malaria cases in the world, according to the 2019 World Malaria report released yesterday. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 5, 2019 Category: African Health Source Type: news

Birth Control Breakthrough At MIT: Once-A-Month Pill Shows Promise
By Eric Cheung, CNN (CNN) — Scientists say they have made a breakthrough on developing a contraceptive pill that only needs to be taken once a month. The star-shaped capsule could help reduce unintended pregnancies that arise from users forgetting to take their daily dose of the pill, according to a news release from the Massachusetts Institute of Technology (MIT). The capsule is coated with gelatin that can remain in the stomach for weeks after being swallowed, the researchers said. From there, it slowly releases hormones to prevent pregnancy. Tests conducted on pigs showed that the capsule could provide t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 5, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health birth control CNN MIT Source Type: news

Nigeria: Nigeria Accounted for 25% of Malaria Cases Worldwide in 2018 - WHO
[Premium Times] Nigeria accounted for about 25 per cent of the global burden of malaria in 2018, a new malaria report by the World Health Organisation has shown. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 5, 2019 Category: African Health Source Type: news

Researchers Make Progress Toward a Monthly Birth Control Pill
Birth control pills are among the most effective ways to prevent pregnancy, but only if women faithfully take them every day. Human nature being what it is, nearly half of women admit to missing a pill at least once every three months, and, as a result, about 9% of women on oral contraception become pregnant every year. That number would almost certainly fall if women only had to remember to take the pill once a month or so. That’s why researchers at MIT and Brigham and Women’s Hospital (with support from the Gates Foundation) are trying to create a once-a-month birth control pill. In a paper published today (...
Source: TIME: Health - December 4, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Birth Control embargoed study Reproductive Health Source Type: news