Field Evaluations of Innovative Tools for Vector-borne Disease Control in Conflict-affected Communities
Conditions: Malaria; Childhood ALL; Vector Borne Diseases Interventions: Combination Product: Mesh - spatial repellent impregnated with transfluthrin (2500mg); Behavioral: Information and Education Campaigns (IEC); Diagnostic Test: test and treat malaria cases Sponsors: The Mentor Initiative; Liverpool School of Tropical Medicine; University of Maiduguri; US government; SCJohnson Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 22, 2023 Category: Research Source Type: clinical trials

In-vivo Transmission Model in Semi-immune Adults
Conditions: Controlled Human Malaria Infection; Induced Blood Stage Malaria Infection; Malaria Transmission; Malaria Challenge Interventions: Drug: Piperaquine tablets , which will be administered orally as a single dose of 480mg (320mg+160mg).; Drug: Doxycycline (100mg tablets strength as Doxycycline Hyclate) will also be administered orally and will be given as 1 tablet (100mg) Once daily for 7 days. Sponsors: Ifakara Health Institute; University of Oxford Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials

Parasite Clearance and Protection From Infection (PCPI) in Cameroon
Conditions: Malaria Interventions: Drug: SP (Macleods Pharmaceuticals Ltd); Drug: SPAQ (Guilin Pharmaceuticals); Drug: AS (Guilin Pharmaceuticals) Sponsors: London School of Hygiene and Tropical Medicine Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials

A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants
Conditions: Malaria, Falciparum Interventions: Drug: GSK4024484C; Drug: Placebo Sponsors: GlaxoSmithKline Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 14, 2023 Category: Research Source Type: clinical trials

Parasite Clearance and Protection From Infection (PCPI) in Zambia
Conditions: Malaria Interventions: Drug: SP (Macleods Pharmaceuticals Ltd); Drug: AS (Guilin Pharmaceuticals) Sponsors: London School of Hygiene and Tropical Medicine Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 12, 2023 Category: Research Source Type: clinical trials

Malaria Burden in Pregnant Women and the Incidence of Pregnancy in a Cohort of Nulligravida
Conditions: Maternal Malaria During Pregnancy - Baby Not Yet Delivered Sponsors: Groupe de Recherche Action en Sante Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials

Perennial Malaria Chemoprevention (PMC) Effect Study
Conditions: Malaria Interventions: Other: Perennial Malaria Chemoprevention effect Sponsors: Malaria Consortium; Nigerian Institute of Medical Research; London School of Hygiene and Tropical Medicine; Northwestern University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 4, 2023 Category: Research Source Type: clinical trials

Africa Ready Malaria Screening
Conditions: Malaria Interventions: Diagnostic Test: Immuno analytical assay Sponsors: University of Ghana; Shai-Osudoku District Hospital; Kumasi Technical University; University of Rostock; University of Applied Sciences Bonn-Rhein-Sieg; Hochschule Aalen Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 1, 2023 Category: Research Source Type: clinical trials

Master statistical analysis plan: attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
AbstractThis manuscript is a master statistical analysis plan for each of three-cluster randomized controlled trials to evaluate the efficacy of attractive targeted sugar baits (ATSB) described in an already published protocol. The master SAP contains an overarching plan for all three trials, which can be adapted to trial-specific circumstances. The primary objective of the trials is to evaluate the efficacy of ATSB in the presence of universal vector control coverage with insecticide-treated nets (ITN) or indoor residual spraying (IRS) after two transmission seasons on clinical malaria incidence as compared with universal...
Source: Trials - November 29, 2023 Category: Research Source Type: clinical trials

A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria
Conditions: Vivax Malaria Interventions: Drug: Tafenoquine; Drug: Primaquin Sponsors: Menzies School of Health Research; University of Melbourne; Funda ção de Medicina Tropical Dr. Heitor Vieira Dourado; Arba Minch University; Addis Ababa University; Papuan Community Health and Development Foundation, Indonesia; Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Indonesia; Curtin University; Papua New Guinea I nstitute of Medical Research Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 28, 2023 Category: Research Source Type: clinical trials

A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
Conditions: Malaria; Malaria,Falciparum; Protozoan Infections; Parasitic Disease; Infections; Vector Borne Diseases Interventions: Biological: Matrix M with RH5.1 Sponsors: University of Oxford Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 21, 2023 Category: Research Source Type: clinical trials

Statistical analysis plan for the LAKANA trial: a cluster-randomized, placebo-controlled, double-blinded, parallel group, three-arm clinical trial testing the effects of mass drug administration of azithromycin on mortality and other outcomes among 1 –11-month-old infants in Mali
ConclusionThe SAP written prior to data collection completion will help avoid reporting bias and data-driven analysis for the primary and secondary aims of the trial. If there are deviations from the analysis methods described here, they will be described and justified in the publications of the trial results.Trial registrationClinicalTrials.gov IDNCT04424511. Registered on 11 June 2020. (Source: Trials)
Source: Trials - November 15, 2023 Category: Research Source Type: clinical trials

Spatial Repellents for Malaria Control
Conditions: Malaria Interventions: Device: Transfluthrin Sponsors: University of Notre Dame; SC Johnson, A Family Company; Catholic Relief Services; Infectious Diseases Research Collaboration, Uganda Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 8, 2023 Category: Research Source Type: clinical trials

EaveTubes for control of vector-borne diseases in C ôte d’Ivoire: study protocol for a cluster randomized controlled trial
DiscussionFindings will serve as an efficacy trial of ETs and will be submitted to the WHO Vector Control Advisory Group (VCAG) for assessment of public health value. Entomological outcomes will also be measured as proxies of malaria transmission to help develop guidelines for the evaluation of future In2Care ® ETs products.Trial registrationClinicalTrials.gov NCT05736679. Registered on 10 February 2023. (Source: Trials)
Source: Trials - November 2, 2023 Category: Research Source Type: clinical trials

Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
Conditions: Malaria,Falciparum; Anemia in Children Interventions: Drug: Dihydroartemisinin-Piperaquine; Drug: Chloroquine; Drug: Sulfadoxine pyrimethamine; Drug: Sulfadoxine-pyrimethamine-amodiaquine Sponsors: Liverpool School of Tropical Medicine; Kamuzu University of Health Sciences Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials