Inhibition of pannexin ‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice
AbstractMutations inPKD1 andPKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid-filled cysts in the kidney. In a subset of ADPKD patients, reduced blood calcium (Ca2+) and magnesium (Mg2+) concentrations are observed. As cystic fluid contains increased ATP concentrations and purinergic signaling reduces electrolyte reabsorption, we hypothesized that inhibiting ATP release could normalize blood Ca2+ and Mg2+ levels in ADPKD. Inducible kidney-specificPkd1 knockout mice (iKsp-Pkd1−/−) exhibit hypocalcemia and hypomagnesemia in a precystic stage and show increas...
Source: Physiological Reports - April 2, 2024 Category: Physiology Authors: Wouter H. van Megen,
Teun J. van Houtert,
Caro Bos,
Dorien J. M. Peters,
Jeroen H. F. de Baaij,
Joost G. J. Hoenderop Tags: ORIGINAL ARTICLE Source Type: research
A comprehensive characterization of indoor ambient microplastics in households during the COVID-19 pandemic
This study investigated the composition of indoor airborne MPs by active sampling in seven houses in the city center of northwestern Turkey (Eski şehir) during the COVID-19 pandemic. The visual identification showed the presence of different colored MPs, white, red, orange, green, and yellow, with different shapes (fibers, fragments, films, lines, foam, and pellets). The size of the identified MPs was between 2.5 and 327.36 μm. The polymer ic composition analysis showed the presence of 123 MPs in all the samples with 22 different polymeric compositions. Residents in these houses are exposed to airborne MPs, with inhalat...
Source: Air Quality, Atmosphere and Health - April 2, 2024 Category: Environmental Health Source Type: research
Cymbopogon proximus and Petroselinum crispum seed ethanolic extract/Gum Arabic nanogel emulsion: Preventing ethylene glycol and ammonium chloride-induced urolithiasis in rats
This study aimed to assess the anti-urolithic effects ofCymbopogon proximus (Halfa Bar) andPetroselinum crispum (parsley) seed ethanolic extract /Gum Arabic (GA) emulsion, and its nanogel form against ethylene glycol (EG) and ammonium chloride (AC)-induced experimental urolithiasis in rats. Rats were divided into four groups: group 1 served as the normal control, group 2 received EG with AC in drinking water for 14 days to induce urolithiasis, groups 3 and 4 were orally administered emulsion (600 mg/kg/day) and nanogel emulsion (600 mg/kg/day) for 7 days, followed by co-administration with EG and AC in drinking water fo...
Source: Urolithiasis - April 2, 2024 Category: Urology & Nephrology Source Type: research
Magnesium supplementation therapy to prevent cisplatin-induced acute nephrotoxicity in pediatric cancer: a randomized phase-2 trial
ConclusionsThe study design, which treated a single chemotherapy course as a study object, failed to detect a statistically significant benefit of Mg supplementation for preventing CIN in pediatric cancer patients.Trial registrationJRCT (https://jrct.niph.go.jp/) Identifier UMIN000029215 jRCTs031180251. UMIN-CTR (http://www.umin.ac.jp/icdr/index.html) Identifier UMIN000029215. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Magnesium sulfate and risk of hypoxic ischemic encephalopathy in a high-risk cohort
Hypoxic ischemic encephalopathy contributes to morbidity and mortality among neonates ≥ 360 weeks’ gestation. Evidence of preventative antenatal treatment is limited. Magnesium sulfate has neuroprotective properties among preterm fetuses. Hypertensive disorders of pregnancy are a risk factor for hypoxic ischemic encephalopathy and magnesium sulfate is recommended for maternal sei zure prophylaxis among patients with pre-eclampsia with severe features. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 2, 2024 Category: OBGYN Authors: Kathleen C. MINOR, Jessica LIU, Maurice L. DRUZIN, Yasser Y. EL-SAYED, Susan R. HINTZ, Sonia L. BONIFACIO, Stephanie A. LEONARD, Henry C. LEE, Jochen PROFIT, Scarlett D. KARAKASH Tags: Original Research: Obstetrics Source Type: research
Cymbopogon proximus and Petroselinum crispum seed ethanolic extract/Gum Arabic nanogel emulsion: Preventing ethylene glycol and ammonium chloride-induced urolithiasis in rats
This study aimed to assess the anti-urolithic effects ofCymbopogon proximus (Halfa Bar) andPetroselinum crispum (parsley) seed ethanolic extract /Gum Arabic (GA) emulsion, and its nanogel form against ethylene glycol (EG) and ammonium chloride (AC)-induced experimental urolithiasis in rats. Rats were divided into four groups: group 1 served as the normal control, group 2 received EG with AC in drinking water for 14 days to induce urolithiasis, groups 3 and 4 were orally administered emulsion (600 mg/kg/day) and nanogel emulsion (600 mg/kg/day) for 7 days, followed by co-administration with EG and AC in drinking water fo...
Source: Urolithiasis - April 2, 2024 Category: Urology & Nephrology Source Type: research
5-year Follow-up of Reimplanted Parathyroid Glands in Forearm Subcutaneous Tissue During Thyroidectomy. A Confirmation of Graft Vitality in a Large Series of Patients
CONCLUSIONS: Parathyroid reimplantation using the PR-FaST technique is a viable option for patients undergoing thyroidectomy and has been shown to be a reproducible and effective technique in most patients, with sustained graft functionality and parathyroid hormone production over a 5-year follow-up period.PMID:38557257 | DOI:10.1177/00031348241244631 (Source: The American Surgeon)
Source: The American Surgeon - April 1, 2024 Category: Surgery Authors: Giulio Lelli Alessandra Micalizzi Angela Gurrado Marco Bononi Angelo Iossa Francesco De Angelis Diletta Di Meo Alessia Fassari Mario Testini Giuseppe Cavallaro Source Type: research
Efficient synthesis of rare sugars from galactose in hot compressed water using eggshells as an environmentally friendly catalyst
Bioresour Technol. 2024 Mar 30;399:130642. doi: 10.1016/j.biortech.2024.130642. Online ahead of print.ABSTRACTAqueous galactose solutions containing eggshell was heated at 120 °C to produce calcium supplements containing rare sugars. Galactose was isomerized to rare sugars with improving rare sugar yields compared to those without eggshell. Organic acids were also formed as byproducts during the reaction. These acids were neutralized by dissolving eggshells with increasing the calcium ion concentration in the solution. When eggshell components (calcium carbonate, magnesium carbonate, or calcium phosphate) were used for th...
Source: Bioresource Technology - April 1, 2024 Category: Biotechnology Authors: Shin Futamata Yuichiro Onishi Shuji Adachi Pramote Khuwijitjaru Yoshiyuki Watanabe Fumito Tani Takashi Kobayashi Source Type: research
Water and sediment chemistry drivers of chlorophyll-a dynamics within a Ramsar declared floodplain pan wetland system
Environ Sci Pollut Res Int. 2024 Apr 1. doi: 10.1007/s11356-024-33052-z. Online ahead of print.ABSTRACTFloodplain pans are hydrologically dynamic in nature and characterised by variables such as chlorophyll-a (chl-a), water, and sediment chemistry over their hydroperiods. The present study investigated the spatio-temporal variations in water and sediment physico-chemical, and chlorophyll-a concentration characteristics of six floodplain pans found in the Ramsar declared Makuleke wetlands, Kruger National Park, South Africa. The water and sediment physico-chemical variable values were generally elevated during the high-wate...
Source: Environmental Science and Pollution Research International - April 1, 2024 Category: Environmental Health Authors: Linton F Munyai Lutendo Mugwedi Ryan J Wasserman Farai Dondofema Eddie Riddell Chad Keates Tatenda Dalu Source Type: research
Efficient synthesis of rare sugars from galactose in hot compressed water using eggshells as an environmentally friendly catalyst
Bioresour Technol. 2024 Mar 30;399:130642. doi: 10.1016/j.biortech.2024.130642. Online ahead of print.ABSTRACTAqueous galactose solutions containing eggshell was heated at 120 °C to produce calcium supplements containing rare sugars. Galactose was isomerized to rare sugars with improving rare sugar yields compared to those without eggshell. Organic acids were also formed as byproducts during the reaction. These acids were neutralized by dissolving eggshells with increasing the calcium ion concentration in the solution. When eggshell components (calcium carbonate, magnesium carbonate, or calcium phosphate) were used for th...
Source: Bioresource Technology - April 1, 2024 Category: Biotechnology Authors: Shin Futamata Yuichiro Onishi Shuji Adachi Pramote Khuwijitjaru Yoshiyuki Watanabe Fumito Tani Takashi Kobayashi Source Type: research
Restoration of gut dysbiosis through Clostridium butyricum and magnesium possibly balance blood glucose levels: an experimental study
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by an elevated level of blood glucose due to the absence of insulin secretion, ineffectiveness, or lack of uptake of secreted insulin in the... (Source: BMC Microbiology)
Source: BMC Microbiology - April 1, 2024 Category: Microbiology Authors: Hafiz Muhammad Ubaid Tayyib, Amjed Ali, Shaista Jabeen, Habib-ur-Rehman, Hafsa Kamran, Majed A. Bajaber, Muhammad Usman and Xiao Zhang Tags: Research Source Type: research
