Unveiling the molecular networks underlying cellular impairment in Saccharomyces cerevisiae: investigating the effects of magnesium oxide nanoparticles on cell wall integrity and endoplasmic reticulum stress response
This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae, with a focus on cell wall integrity, endoplasmic reticulum (ER) stress response, mitochondrial function, lipid metabolism, autophagy, and epigenetic alterations. MgO-NPs were synthesized through a chemical reduction method, characterized for morphology, size distribution, and elemental composition. Concentration-dependent toxicity assays were conducted to evaluate the inhibitory effect on yeast growth, accompanied by propidium iodide (PI) staining to assess membrane damage. Int...
Source: Environmental Science and Pollution Research International - April 11, 2024 Category: Environmental Health Authors: Shraddha Chauhan Raghuvir Singh Tomar Source Type: research
Unveiling the molecular networks underlying cellular impairment in Saccharomyces cerevisiae: investigating the effects of magnesium oxide nanoparticles on cell wall integrity and endoplasmic reticulum stress response
This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae, with a focus on cell wall integrity, endoplasmic reticulum (ER) stress response, mitochondrial function, lipid metabolism, autophagy, and epigenetic alterations. MgO-NPs were synthesized through a chemical reduction method, characterized for morphology, size distribution, and elemental composition. Concentration-dependent toxicity assays were conducted to evaluate the inhibitory effect on yeast growth, accompanied by propidium iodide (PI) staining to assess membrane damage. Int...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Shraddha Chauhan Raghuvir Singh Tomar Source Type: research
Oral application of magnesium-L-threonate alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats
CONCLUSIONS: Oral application of L-TAMS alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats.PMID:38604557 | DOI:10.1016/j.brainres.2024.148910 (Source: Brain Research)
Source: Brain Research - April 11, 2024 Category: Neurology Authors: Siyuan Li Hongjian Yi Fuli Yuan Xuejuan Zhang Yi Zhong Yangliang Huang Source Type: research
Unveiling the molecular networks underlying cellular impairment in Saccharomyces cerevisiae: investigating the effects of magnesium oxide nanoparticles on cell wall integrity and endoplasmic reticulum stress response
This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae, with a focus on cell wall integrity, endoplasmic reticulum (ER) stress response, mitochondrial function, lipid metabolism, autophagy, and epigenetic alterations. MgO-NPs were synthesized through a chemical reduction method, characterized for morphology, size distribution, and elemental composition. Concentration-dependent toxicity assays were conducted to evaluate the inhibitory effect on yeast growth, accompanied by propidium iodide (PI) staining to assess membrane damage. Int...
Source: Environmental Science and Pollution Research International - April 11, 2024 Category: Environmental Health Authors: Shraddha Chauhan Raghuvir Singh Tomar Source Type: research
Oral application of magnesium-L-threonate alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats
CONCLUSIONS: Oral application of L-TAMS alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats.PMID:38604557 | DOI:10.1016/j.brainres.2024.148910 (Source: Brain Research)
Source: Brain Research - April 11, 2024 Category: Neurology Authors: Siyuan Li Hongjian Yi Fuli Yuan Xuejuan Zhang Yi Zhong Yangliang Huang Source Type: research
Isochemical crystallization in condensed borate LaMgB_5O_10 glass-ceramics doped with optical probe Eu^3+
The isochemical glass-ceramics doped with Eu^3+ were prepared by the heat treatment of lanthanum magnesium borate glass. The crystalline ... (Source: Optics Letters)
Source: Optics Letters - April 11, 2024 Category: Physics Authors: Bartosz Bondzior Source Type: research
Peri-articular elbow fracture fixations with magnesium implants and a review of current literature: A case series
CONCLUSION: Although there is still a paucity of literature available on the subject and further studies are required, magnesium implants appear to be a feasible tool for fixation of peri-articular elbow fractures with promising results in our series.PMID:38596190 | PMC:PMC10999966 | DOI:10.5312/wjo.v15.i3.215 (Source: World Journal of Orthopaedics)
Source: World Journal of Orthopaedics - April 10, 2024 Category: Orthopaedics Authors: Christopher Fang Antony Xavier Rex Premchand Derek Howard Park Dong Hao Toon Source Type: research
Associations Among Diabetes Medication Use, Serum Magnesium, and Insulin Resistance in a Cohort of Older Puerto Rican Adults
CONCLUSIONS: Diabetes medication, especially metformin, was associated with elevated odds of hypomagnesemia, which may weaken the association between metformin and lowering of HOMA-IR. The causal inference needs to be confirmed in further studies.PMID:38599521 | DOI:10.1016/j.ajcnut.2024.04.005 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 10, 2024 Category: Nutrition Authors: Fan Chen Kelsey M Mangano Mahdi Garelnabi Kellee Cardaleen Katherine L Tucker Source Type: research
Associations Among Diabetes Medication Use, Serum Magnesium, and Insulin Resistance in a Cohort of Older Puerto Rican Adults
CONCLUSIONS: Diabetes medication, especially metformin, was associated with elevated odds of hypomagnesemia, which may weaken the association between metformin and lowering of HOMA-IR. The causal inference needs to be confirmed in further studies.PMID:38599521 | DOI:10.1016/j.ajcnut.2024.04.005 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 10, 2024 Category: Nutrition Authors: Fan Chen Kelsey M Mangano Mahdi Garelnabi Kellee Cardaleen Katherine L Tucker Source Type: research
Peri-articular elbow fracture fixations with magnesium implants and a review of current literature: A case series
CONCLUSION: Although there is still a paucity of literature available on the subject and further studies are required, magnesium implants appear to be a feasible tool for fixation of peri-articular elbow fractures with promising results in our series.PMID:38596190 | PMC:PMC10999966 | DOI:10.5312/wjo.v15.i3.215 (Source: World Journal of Orthopaedics)
Source: World Journal of Orthopaedics - April 10, 2024 Category: Orthopaedics Authors: Christopher Fang Antony Xavier Rex Premchand Derek Howard Park Dong Hao Toon Source Type: research
Electrochemical Microplastic Detection using Chitosan-Magnesium Oxide Nanosheet
Environ Res. 2024 Apr 8:118894. doi: 10.1016/j.envres.2024.118894. Online ahead of print.ABSTRACTMicroplastics, an invisible threat, are emerging as serious pollutants that continuously affect health by interrupting/contaminating the human cycle, mainly involving food, water, and air. Such serious scenarios raised the demand for developing efficient sensing systems to detect them at an early stage efficiently and selectively. In this direction, the proposed research reports an electrochemical hexamethylenetetramine (HMT) sensing utilizing a sensing platform fabricated using chitosan-magnesium oxide nanosheets (CHIT-MgO NS)...
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Ashab Noumani Damini Verma Ajeet Kaushik Ajit Khosla Pratima R Solanki Source Type: research
Metabolomic profiling of embryo culture media in patients with repeated implantation failure during assisted reproductive technology cycles
CONCLUSION: The metabolic profile of the culture medium of the embryos in the RIF group differed from that of the control group. These findings suggest potential factors that may affect implantation capacity in RIF patients and provide a new perspective on embryo selection.PMID:38599889 | DOI:10.5653/cerm.2023.06429 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Sheyda Nami Azam Govahi Nabaa Najjar Samaneh Ghasemi Farshid Rezaei Fatemehsadat Amjadi Gholamreza Taheripak Source Type: research
Associations Among Diabetes Medication Use, Serum Magnesium, and Insulin Resistance in a Cohort of Older Puerto Rican Adults
CONCLUSIONS: Diabetes medication, especially metformin, was associated with elevated odds of hypomagnesemia, which may weaken the association between metformin and lowering of HOMA-IR. The causal inference needs to be confirmed in further studies.PMID:38599521 | DOI:10.1016/j.ajcnut.2024.04.005 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 10, 2024 Category: Nutrition Authors: Fan Chen Kelsey M Mangano Mahdi Garelnabi Kellee Cardaleen Katherine L Tucker Source Type: research
Associations Among Diabetes Medication Use, Serum Magnesium, and Insulin Resistance in a Cohort of Older Puerto Rican Adults
CONCLUSIONS: Diabetes medication, especially metformin, was associated with elevated odds of hypomagnesemia, which may weaken the association between metformin and lowering of HOMA-IR. The causal inference needs to be confirmed in further studies.PMID:38599521 | DOI:10.1016/j.ajcnut.2024.04.005 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 10, 2024 Category: Nutrition Authors: Fan Chen Kelsey M Mangano Mahdi Garelnabi Kellee Cardaleen Katherine L Tucker Source Type: research
Electrochemical Microplastic Detection using Chitosan-Magnesium Oxide Nanosheet
Environ Res. 2024 Apr 8:118894. doi: 10.1016/j.envres.2024.118894. Online ahead of print.ABSTRACTMicroplastics, an invisible threat, are emerging as serious pollutants that continuously affect health by interrupting/contaminating the human cycle, mainly involving food, water, and air. Such serious scenarios raised the demand for developing efficient sensing systems to detect them at an early stage efficiently and selectively. In this direction, the proposed research reports an electrochemical hexamethylenetetramine (HMT) sensing utilizing a sensing platform fabricated using chitosan-magnesium oxide nanosheets (CHIT-MgO NS)...
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Ashab Noumani Damini Verma Ajeet Kaushik Ajit Khosla Pratima R Solanki Source Type: research
