Glenmark gets USFDA nod to begin trials for potential cancer drug
The USFDA approval paves the way for Glenmark's subsidiary Glenmark Specialty to proceed with a Phase 1/2, first-in-human, clinical study of GRC 54276 for the treatment of patients with advanced solid tumors and lymphomas. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 16, 2023 Category: Pharmaceuticals Source Type: news
FDA Panel Endorses New First-Line Lymphoma Regimen
(MedPage Today) -- Despite the concerns of FDA staff, agency advisors endorsed the inclusion of polatuzumab vedotin (Polivy) in a modified version of R-CHOP for adults with previously untreated large B-cell lymphoma.
By a vote of 11-2 on Thursday... (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - March 10, 2023 Category: American Health Source Type: news
FDA Advisory Committee votes in favour of the clinical benefit of Roche ’s Polivy combination for people with previously untreated diffuse large B-cell lymphoma
U.S. FDA ’s Oncologic Drugs Advisory Committee voted 11 to 2 in favour of the clinical benefit of the phase III POLARIX study of Polivy in combination with R-CHP for people with previously untreated diffuse large B-cell lymphoma (DLBCL)This is the first treatment in 20 years to show a significant and clinically meaningful improvement in progression-free survival over the standard of care for first-line DLBCLDLBCL is an aggressive, hard-to-treat disease and the most common form of non-Hodgkin lymphoma in the USBasel, 10 March 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the U.S. Food and Drug Administrat...
Source: Roche Investor Update - March 10, 2023 Category: Pharmaceuticals Source Type: news
FDA Advisory Committee votes in favour of the clinical benefit of Roche ’s Polivy combination for people with previously untreated diffuse large B-cell lymphoma
U.S. FDA ’s Oncologic Drugs Advisory Committee voted 11 to 2 in favour of the clinical benefit of the phase III POLARIX study of Polivy in combination with R-CHP for people with previously untreated diffuse large B-cell lymphoma (DLBCL)This is the first treatment in 20 years to show a significant and clinically meaningful improvement in progression-free survival over the standard of care for first-line DLBCLDLBCL is an aggressive, hard-to-treat disease and the most common form of non-Hodgkin lymphoma in the USBasel, 10 March 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the U.S. Food and Drug Administrat...
Source: Roche Media News - March 10, 2023 Category: Pharmaceuticals Source Type: news
CLL Treatment: More Infections Among Real-World Patients CLL Treatment: More Infections Among Real-World Patients
A high rate of severe infections was seen in patients with chronic lymphocytic leukemia (CLL) or B-cell lymphoma who were taking ibrutinib (Imbruvica), idelalisib (Zydelig), or venetoclax (Venclexta).MDedge News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 9, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Lymphadenopathy resolves relatively quickly after a COVID-19 booster
Ultrasound shows that axillary lymphadenopathy after a COVID-19 vaccine booste...Read more on AuntMinnie.comRelated Reading:
PET tracer uptake related to COVID-19 vaccines detected in lymphoma patients
ECR: Don't fear lymphadenopathy after vaccination
AI of ultrasound predicts lymph node reactions to COVID vax
Lymphadenopathy on breast ultrasound lasts longer than reported
COVID-19 posed myriad challenges to breast imagers (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 9, 2023 Category: Radiology Source Type: news
FDA Not Quite Sold on Polivy in Frontline Large B-Cell Lymphoma Regimen
(MedPage Today) -- The FDA's Oncologic Drugs Advisory Committee (ODAC) will meet Thursday to consider whether results from the POLARIX trial support a favorable benefit-risk assessment for adult patients with previously untreated large B-cell lymphoma... (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - March 7, 2023 Category: American Health Source Type: news
Cases of Breast Implant-Associated Lymphoma Continue to Accumulate
(MedPage Today) -- MIAMI BEACH -- As more cases of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) emerge, clinical experience has shown the disease to be heterogeneous and that multidisciplinary management provides the best... (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - March 7, 2023 Category: Hematology Source Type: news
Atorvastatin Cut Anthracycline Cardiac Dysfunction Atorvastatin Cut Anthracycline Cardiac Dysfunction
A daily 40-mg dose of atorvastatin for 12 months significantly cut incident cardiac dysfunction in patients with lymphoma receiving anthracycline treatment.MDedge News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 5, 2023 Category: Cancer & Oncology Tags: Cardiology News Source Type: news
Atorvastatin Tied to Cardioprotection for Lymphoma Patients on Anthracyclines
(MedPage Today) -- NEW ORLEANS -- Patients with lymphoma on anthracycline-based chemotherapy who took atorvastatin (Lipitor) for a year were less likely to experience cardiac dysfunction, according to the STOP-CA trial.
The trial's primary endpoint... (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 4, 2023 Category: Cardiology Source Type: news
FDG-PET/CT reveals sites of COVID-19 brain infection
FDG-PET/CT imaging shows metabolic neurologic changes due to COVID-19 in patient...Read more on AuntMinnie.comRelated Reading:
PET tracer uptake related to COVID-19 vaccines detected in lymphoma patients
F-18 FDG lymph node uptake assessed in vaccinated COVID-19 patients
Total-body PET/CT tested in COVID-19 patients
Myocarditis induced by COVID-19-vaccine milder than that caused by other factors
SNMMI warns of omicron's impact on PET/CT scans (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 3, 2023 Category: Radiology Source Type: news
FDA Accepts for Priority Review ADX-2191 New Drug Application for the Treatment of Primary Vitreoretinal Lymphoma
LEXINGTON, Mass.--(BUSINESS WIRE) March 2, 2023 --Aldeyra Therapeutics, Inc. (Nasdaq: ALDX) (Aldeyra) today announced that the U.S. Food and Drug Administration (FDA) accepted for Priority Review the New Drug Application (NDA) for ADX-2191... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - March 2, 2023 Category: Drugs & Pharmacology Source Type: news
What Causes Mediastinal Masses?
Discussion
The mediastinum resides in the chest and is the space bounded by the thoracic inlet cephalically, diaphragm caudally, sternum anteriorly and transverse process of the spine posteriorly, and mediastinal pleura and lungs laterally. It is divided into various compartments:
Superior mediastinum
Bounded by the thoracic inlet cephalically and a horizontal plane passing from the manubriosternal joint to the junction of T4/T5 vertebrae horizontally.
Structures include: esophagus, trachea, parts of great vessels and first branches, great veins and initial branches, thymus, vagus, phrenic and other nerves, thoracic duct...
Source: PediatricEducation.org - February 20, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
How did radiographers in Singapore handle the COVID-19 pandemic?
Radiographers in Singapore hospitals were well equipped and trained to manag...Read more on AuntMinnie.comRelated Reading:
COVID-19-dampened lung cancer screening rates have recovered, sort of
PET tracer uptake related to COVID-19 vaccines detected in lymphoma patients
FAPI-PET detects rare tumor in COVID-19 patient
Bone scan capacity increased to meet COVID-19 backlog
COVID, Damadian, and quick reads topped AuntMinnie's 2022 top 10 list (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 16, 2023 Category: Radiology Source Type: news
Netherlands Cancer Institute Tests New Mesothelioma Therapy
Research for a new type of mesothelioma treatment is underway at the Netherlands Cancer Institute. Scientists are exploring a novel combination of existing medications for patients with BAP1 genetic mutations.
More than half of all mesothelioma patients show alterations in the BAP1 tumor-suppressor gene. An altered BAP1 gene allows for vulnerabilities that make specific treatments more effective. The combination treatment led to about a four-week increase in median survival.
Researchers have previously only explored the combination of zoledronic acid and tazemetostat in single cells and animal models. This late...
Source: Asbestos and Mesothelioma News - February 15, 2023 Category: Environmental Health Authors: Amy Edel Tags: Clinical Trials/Research/Emerging Treatments Mesothelioma Source Type: news
