Lyme borreliosis: diagnosis and management
(Source: BMJ Education)
Source: BMJ Education - May 27, 2020 Category: General Medicine Source Type: research

The Lyme Disease Biobank: Characterization of 550 Patient and Control Samples from the East Coast and Upper Midwest of the United States [Immunoassays]
Lyme disease (LD) is an increasing public health problem. Current laboratory testing is insensitive in early infection, the stage at which appropriate treatment is most effective in preventing disease sequelae. The Lyme Disease Biobank (LDB) collects samples from individuals with symptoms consistent with early LD presenting with or without erythema migrans (EM) or an annular, expanding skin lesion and uninfected individuals from areas of endemicity. Samples were collected from 550 participants (298 cases and 252 controls) according to institutional review board-approved protocols and shipped to a centralized biorepository....
Source: Journal of Clinical Microbiology - May 26, 2020 Category: Microbiology Authors: Horn, E. J., Dempsey, G., Schotthoefer, A. M., Prisco, U. L., McArdle, M., Gervasi, S. S., Golightly, M., De Luca, C., Evans, M., Pritt, B. S., Theel, E. S., Iyer, R., Liveris, D., Wang, G., Goldstein, D., Schwartz, I. Tags: Immunoassays Source Type: research

Expanding Access to Biospecimens for Lyme Disease Test Development [Commentary]
The laboratory diagnosis of Lyme disease relies upon serologic testing. A standard or modified two-tiered testing algorithm is used to enhance the accuracy of antibody detection. However, this approach suffers from a lack of sensitivity in early Lyme disease. Ongoing efforts to develop more sensitive antibody detection technologies and other diagnostic approaches are dependent upon the availability of quality-assured biospecimens linked to reliable clinical data. In this issue of the Journal of Clinical Microbiology, Horn et al. (E. J. Horn, G. Dempsey, A. M. Schotthoefer, U. L. Prisco, et al., J Clin Microbiol 58:e00032-2...
Source: Journal of Clinical Microbiology - May 26, 2020 Category: Microbiology Authors: Schmitz, J. L. Tags: Commentary Source Type: research

IJERPH, Vol. 17, Pages 3607: Local Population Structure and Seasonal Variability of Borrelia garinii Genotypes in Ixodes ricinus Ticks, Slovakia
In this study, multilocus sequence typing (MLST) was employed to investigate the local population structure of B. garinii in Ixodes ricinus ticks. The study took place in a natural wetland in Slovakia, temporally encompassing spring and autumn bird migration periods as well as the breeding period of resident birds. In total, we examined 369 and 255 ticks collected from 78 birds and local vegetation, respectively. B. burgdorferi s.l. was detected in 43.4% (160/369) of ticks recovered from birds and in 26.3% (67/255) of questing ticks, respectively. Considering the ticks from bird hosts, the highest prevalence was found for ...
Source: International Journal of Environmental Research and Public Health - May 21, 2020 Category: Environmental Health Authors: Zuzana Mtierov á Mark éta Derdáková Michal Chvost áč Yuliya M. Didyk Barbara Mangov á Veronika Rus ňáková Tarageľová Diana Selyemov á Al žbeta Šujanová Radovan V áclav Tags: Article Source Type: research

The Lon-1 Protease Is Required by Borrelia burgdorferi To Infect the Mammalian Host [Molecular Pathogenesis]
Borrelia burgdorferi encodes a functional homolog of canonical Lon protease termed Lon-2. In addition, B. burgdorferi encodes a second Lon homolog called Lon-1. Recent studies suggest that Lon-1 may function differently from the prototypical Lon protease. However, the function of Lon-1 in B. burgdorferi biology remains virtually unknown. Particularly, the contribution of Lon-1 to B. burgdorferi fitness and infection remains hitherto unexplored. Herein, we show that Lon-1 plays a critical role for the infection of B. burgdorferi in a mammalian host. We found that lon-1 was highly expressed during animal infection, implying ...
Source: Infection and Immunity - May 20, 2020 Category: Infectious Diseases Authors: Thompson, C., Mason, C., Parrilla, S., Ouyang, Z. Tags: Molecular Pathogenesis Source Type: research

Immunoserological Diagnosis of Human Borrelioses: Current Knowledge and Perspectives
Spirochetes of the genus Borrelia are divided into relapsing fever borreliae and Lyme disease borreliae. Immunoserological assays have been poorly developed for relapsing fever borreliae, where direct detection methods are more adapted to the pathophysiology of these infections presenting with massive bacteraemia. However, emergence of the novel agent of relapsing fever B. miyamotoi has renewed interest in serology in this context. In Lyme disease, because direct detection methods show low sensitivity, serology plays a central role in the diagnostic strategy. This diagnostic strategy is based on a two-tier methodology invo...
Source: Frontiers in cellular and infection microbiology - May 19, 2020 Category: Microbiology Source Type: research

Opinion du comit é No 399 : Prise en charge des morsures de tiques et de la maladie de Lyme pendant la grossesse: (In English: Management of Tick Bites and Lyme Disease During Pregnancy).
Opinion du comité No 399 : Prise en charge des morsures de tiques et de la maladie de Lyme pendant la grossesse: (In English: Management of Tick Bites and Lyme Disease During Pregnancy). J Obstet Gynaecol Can. 2020 May;42(5):654-664 Authors: Smith GN, Moore KM, Hatchette TF, Nicholson J, Bowie W, Langley JM PMID: 32414480 [PubMed - as supplied by publisher] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - May 18, 2020 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy: (En fran çais : Prise en charge des morsures de tiques et de la maladie de Lyme pendant la grossesse).
Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy: (En français : Prise en charge des morsures de tiques et de la maladie de Lyme pendant la grossesse). J Obstet Gynaecol Can. 2020 May;42(5):644-653 Authors: Smith GN, Moore KM, Hatchette TF, Nicholson J, Bowie W, Langley JM Abstract OBJECTIVE: Lyme disease is an emerging infection in Canada caused by the bacterium belonging to the Borrelia burgdorferi sensu lato species complex, which is transmitted via the bite of an infected blacklegged tick. Populations of blacklegged ticks continue to expand and are now es...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - May 18, 2020 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Bacterial infection and non-Hodgkin's lymphoma.
ult D Abstract One quarter of all cancers are linked to infectious diseases. The link between viral infection and cancer has been widely studied, but few reports have focused on the carcinogenic role of bacterial infection. Nonetheless, Helicobacter pylori, Chlamydia psittaci, Coxiella burnetii, Borrelia burgdorferi and Campylobacter jejuni are bacteria that can be associated with non-Hodgkin's lymphoma (NHL), the most common haematologic malignancy. Here, we review the evidence in favour of a link between these bacterial infections and NHL. Sero-epidemiological observation makes it possible to identify a link bet...
Source: Critical Reviews in Microbiology - May 15, 2020 Category: Microbiology Authors: Melenotte C, Mezouar S, Mège JL, Gorvel JP, Kroemer G, Raoult D Tags: Crit Rev Microbiol Source Type: research

Refining an Approach to Lyme Carditis
Publication date: Available online 11 May 2020Source: IDCasesAuthor(s): Cynthia Yeung, Naomi Gazendam, Adrian Baranchuk (Source: IDCases)
Source: IDCases - May 12, 2020 Category: Infectious Diseases Source Type: research

"Candidatus Borrelia ibitipoquensis," a Borrelia valaisiana-Related Genospecies Characterized from Ixodes paranaensis in Brazil.
"Candidatus Borrelia ibitipoquensis," a Borrelia valaisiana-Related Genospecies Characterized from Ixodes paranaensis in Brazil. Microb Ecol. 2020 May 04;: Authors: Muñoz-Leal S, Ramirez DG, Luz HR, Faccini JLH, Labruna MB Abstract Borrelia burgdorferi sensu lato (Bbsl) spirochetes include the agents of Lyme borreliosis in temperate regions of the Northern Hemisphere, and merge their transmission cycles mainly with ticks of the Ixodes ricinus complex. Twenty genospecies compose Bbsl currently, and with the exception of Borrelia chilensis, and Borrelia garinii, all have been described ...
Source: Microbial Ecology - May 4, 2020 Category: Microbiology Authors: Muñoz-Leal S, Ramirez DG, Luz HR, Faccini JLH, Labruna MB Tags: Microb Ecol Source Type: research

Tickborne Diseases: Diagnosis and Management.
Abstract Tickborne diseases that affect patients in the United States include Lyme disease, Rocky Mountain spotted fever (RMSF), ehrlichiosis, anaplasmosis, babesiosis, tularemia, Colorado tick fever, and tickborne relapsing fever. Tickborne diseases are increasing in incidence and should be suspected in patients presenting with flulike symptoms during the spring and summer months. Prompt diagnosis and treatment can prevent complications and death. Location of exposure, identification of the specific tick vector, and evaluation of rash, if present, help identify the specific disease. Lyme disease presents with an ...
Source: American Family Physician - May 1, 2020 Category: Primary Care Authors: Pace EJ, O'Reilly M Tags: Am Fam Physician Source Type: research

Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.
Authors: Rauer S, Kastenbauer S, Hofmann H, Fingerle V, Huppertz HI, Hunfeld KP, Krause A, Ruf B, Dersch R, Consensus group Abstract Lyme borreliosis is the most common tick-borne infectious disease in Europe. A neurological manifestation occurs in 3-15% of infections and can manifest as polyradiculitis, meningitis and (rarely) encephalomyelitis. This S3 guideline is directed at physicians in private practices and clinics who treat Lyme neuroborreliosis in children and adults. Twenty AWMF member societies, the Robert Koch Institute, the German Borreliosis Society and three patient organisations participated in its ...
Source: GMS German Medical Science - April 30, 2020 Category: General Medicine Tags: Ger Med Sci Source Type: research

Chapter 3 - Immunologic detection of Lyme disease and the related borrelioses
Publication date: 2020Source: Methods in Microbiology, Volume 47Author(s): Charles S. Pavia (Source: Methods in Microbiology)
Source: Methods in Microbiology - April 29, 2020 Category: Microbiology Source Type: research

A Fully Automated Multiplex Assay for Diagnosis of Lyme Disease with High Specificity and Improved Early Sensitivity [Immunoassays]
Lyme borreliosis is a tick-borne disease caused by the Borrelia burgdorferi sensu lato complex. Bio-Rad Laboratories has developed a fully automated multiplex bead-based assay for the detection of IgM and IgG antibodies to B. burgdorferi. The BioPlex 2200 Lyme Total assay exhibits an improved rate of seropositivity in patients with early Lyme infection. Asymptomatic subjects from endemic and nonendemic origins demonstrated a seroreactivity rate of approximately 4% that was similar to other commercial assays evaluated in this study. Coupled to this result was the observation that the Lyme Total assay retained a high first-t...
Source: Journal of Clinical Microbiology - April 23, 2020 Category: Microbiology Authors: Hahm, J. B., Breneman, J. W., Liu, J., Rabkina, S., Zheng, W., Zhou, S., Walker, R. P., Kaul, R. Tags: Immunoassays Source Type: research

Featured Cover
The cover image is based on the Original Research Patient ‐reported outcome after treatment for definite Lyme neuroborreliosis by Randi Eikeland et al.,https://doi.org/10.1002/brb3.1595 (Source: Brain and Behavior)
Source: Brain and Behavior - April 23, 2020 Category: Neurology Tags: FEATURED COVER Source Type: research

A Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits Borrelia burgdorferi Sensu Lato Species and Isolate Differentiation
In this study, we developed a new filter-based chemical extraction technique that allows measurement of high quality Borrelia spp. spectra from less than 100,000 bacteria per spot in MALDI-TOF MS. We used 49 isolates of 13 different species to produce the largest mass-library for Borrelia spp. so far and to validate the protocol. The library was successfully established and identifies>96% of used isolates correctly to species level. Cluster analysis on the sum spectra was applied to all the different isolates, which resulted in tight cluster generation for most species. Comparative analysis of the generated cluster to a...
Source: Frontiers in Microbiology - April 21, 2020 Category: Microbiology Source Type: research

The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease [Microbial Immunity and Vaccines]
In this study, we demonstrated that immunization with CspZ-YA, a CspZ mutant protein with no FH-binding activity, protected mice from infection by several spirochete genotypes introduced via tick feeding. We found that the sera from CspZ-YA-vaccinated mice more efficiently eliminated spirochetes and blocked CspZ FH-binding activity than sera from CspZ-immunized mice. We also found that vaccination with CspZ, but not CspZ-YA, triggered the production of anti-FH antibodies, justifying CspZ-YA as an LD vaccine candidate. The mechanistic and efficacy information derived from this study provides insights into the development of...
Source: Infection and Immunity - April 20, 2020 Category: Infectious Diseases Authors: Marcinkiewicz, A. L., Lieknina, I., Yang, X., Lederman, P. L., Hart, T. M., Yates, J., Chen, W.-H., Bottazzi, M. E., Mantis, N. J., Kraiczy, P., Pal, U., Tars, K., Lin, Y.-P. Tags: Microbial Immunity and Vaccines Source Type: research

Assessment of Borrelia miyamotoi in febrile patients and ticks in Alsace, an endemic area for Lyme borreliosis in France
Borrelia miyamotoi is a relapsing fever Borrelia species transmitted by ticks of the Ixodes ricinus complex. Human disease caused by B. miyamotoi was first described in Russia and later in the USA and Japan. Addi... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 17, 2020 Category: Microbiology Authors: Pierre H. Boyer, Joris Koetsveld, Laurence Zilliox, Hein Sprong, Émilie Talagrand-Reboul, Yves Hansmann, Sylvie Josiane de Martino, Nathalie Boulanger, Joppe W. Hovius and Benoît Jaulhac Tags: Short report Source Type: research

A descriptive epidemiological study of the incidence of newly diagnosed Lyme disease cases in a UK primary care cohort, 1998 –2016
Primary care is likely to see the highest number of Lyme disease patients. Despite this, there is limited published data regarding Lyme disease patients accessing primary care in the UK. We aim to describe tre... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 16, 2020 Category: Infectious Diseases Authors: John S. P. Tulloch, Robert M. Christley, Alan D. Radford, Jenny C. Warner, Mike B. J. Beadsworth, Nick J. Beeching and Roberto Vivancos Tags: Research article Source Type: research

A painless erythematous swelling of the external ear as a manifestation of Lyme disease: a case report
ConclusionsBorrelial lymphocytoma is a rare manifestation of Lyme disease in North America, although not uncommon in Europe. Diagnosis is made by the presence of a painless erythematous swelling typically found on the ear lobe, nipples, or testes. Laboratory tests are available but with low sensitivity, therefore, a high index of suspicion is necessary for a clinical diagnosis to be made. Treatment for isolated borrelial lymphocytoma is doxycycline 4  mg/kg up to 100 mg twice daily, whereas for children less than 8 years of age amoxicillin 50 mg/kg divided three times daily, for 3–4&thinsp...
Source: Journal of Medical Case Reports - April 16, 2020 Category: General Medicine Source Type: research

Sensitivity and specificity of cerebrospinal fluid CXCL13 for diagnosing Lyme neuroborreliosis - a study on 1410 patients and review of the literature
The B-cell chemoattractant CXCL13 has been suggested as a cerebrospinal fluid (CSF) biomarker for Lyme neuroborreliosis (LNB). Our aim was to substantiate the value of CXCL13 in a large unselected cohort and determine a practical cut-off value to diagnose LNB. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 16, 2020 Category: Neurology Authors: Hannes Lintner, Petra Hochgatterer-Rechberger, Barbara Pischinger, Josef Seier, Peter Vollmann, Alexander Haushofer, Heike Rittner, Claudia Sommer, Raffi Topakian Source Type: research

Borrelia burgdorferi mimicking central nervous system relapse in diffuse large B cell lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - April 15, 2020 Category: Hematology Source Type: research

Posttreatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses
(Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - April 14, 2020 Category: Biomedical Science Authors: Allen C. Steere Source Type: research

About modeling long-term cardiac manifestations of Lyme disease
This study compared 113 patients with AF to 109 patients without AF from a convenience sample of routine ambulatory care patients treated in one outpatient cardiology clinic. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 13, 2020 Category: Cardiology Authors: Cynthia Yeung, Wilma M. Hopman, Adrian Baranchuk Source Type: research

Telephone versus web panel National Survey for monitoring adoption of preventive behaviors to climate change in populations: a case study of Lyme disease in Qu ébec, Canada
To monitor the adoption of climate change adaptive behaviors in the population, public health authorities have to conduct national surveys, which can help them target vulnerable subpopulations. To ensure relia... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - April 10, 2020 Category: Research Authors: Gr âce Ngambo Domche, Pierre Valois, Magalie Canuel, Denis Talbot, Maxime Tessier, Cécile Aenishaenslin, Catherine Bouchard and Sandie Briand Tags: Research article Source Type: research

Possible Lyme Carditis with Sick Sinus Syndrome
Publication date: Available online 8 April 2020Source: IDCasesAuthor(s): Brian Cheung, Larry Lutwick, Michelle Cheung (Source: IDCases)
Source: IDCases - April 8, 2020 Category: Infectious Diseases Source Type: research

Sharing the Ride: Ixodes scapularis Symbionts and Their Interactions
The deer tick Ixodes scapularis transmits a variety of disease agents in the United States, spreading the bacteria that causes Lyme borreliosis, the protozoan agent of babesiosis, and viruses such as Powassan. However, a variety of other organisms have also evolved symbiotic relationships with this tick species, and it seems likely that some of these microbes have simultaneously coevolved mechanisms to impact each other and their tick host. The number of organisms identified as I. scapularis symbionts has increased seemingly exponentially with the advent of PCR and next generation sequencing technologies, but convincing ar...
Source: Frontiers in cellular and infection microbiology - April 8, 2020 Category: Microbiology Source Type: research

Transovarial transmission of Borrelia spp., Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus under field conditions extrapolated from DNA detection in questing larvae
Ixodes ricinus constitutes the main European vector tick for the Lyme borreliosis pathogen Borrelia burgdorferi (sensu lato), the relapsing fever borrelia Borrelia miyamotoi, as well as Anaplasma phagocytophilum ... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 7, 2020 Category: Microbiology Authors: Daniela Hauck, Daniela Jordan, Andrea Springer, Bettina Schunack, Stefan Pachnicke, Volker Fingerle and Christina Strube Tags: Research Source Type: research

Reader response: Functional neurologic disorders: Bringing the informal and hidden curriculum to light
I read with interest the editorial by Strom1 about functional neurologic disorders (FNDs). As a treating physician, I have struggled with the multiple diagnostic labels attached to these patients by physicians of different medical specialties during the course of their clinical disease presentation. A neurologist may assign a patient who presents with chronic fatigue the diagnostic labels of narcolepsy, idiopathic hypersomnia, or chronic Lyme disease. A rheumatologist may assign the label of collagen vascular disease, and a psychiatrist may diagnose depression. This diagnostic ambiguity is troublesome for patients and clin...
Source: Neurology Clinical Practice - April 6, 2020 Category: Neurology Authors: Sethi, N. K. Tags: The Nerve! Readers Speak Source Type: research

Research status and perspectives for pathogenic spirochete vaccines.
Abstract Leptospira interrogans, Borrelia burgdorferi, and Treponema pallidum are important pathogenic spirochetes. The incidence of human diseases caused by pathogenic spirochetes, e.g., leptospirosis, Lyme disease, and syphilis, has been recently increasing, posing a threat to public health. Mechanisms of spirochete pathogenicity are not yet fully understood, and no safe and effective vaccine to prevent and control the infection by pathogenic spirochetes is currently available.In this article, we review the progress of research into the pathogenic spirochete vaccine, mainly in terms of vaccine types.The developm...
Source: International Journal of Clinical Chemistry - April 6, 2020 Category: Chemistry Authors: Duan J, Zhao Y, Zhang X, Jiang H, Xie B, Zhao T, Zhao F Tags: Clin Chim Acta Source Type: research

GSE145974 Global transcriptome analysis identifies a signature for early disseminated Lyme disease and its resolution
We examined gene expression patterns in the blood of individuals with early disseminated LD at the time of diagnosis (Acute LD) and also at approximately 1 month and 6 months following antibiotic treatment. A distinct acute LD profile was observed that was sustained during early convalescence (1 month) but returned to control levels six months after treatment. Using a computer learning algorithm, we identified sets of 20 classifier genes that discriminate LD from other bacterial and viral infections. In addition, these novel LD biomarkers are highly acurate in distinvuishing patients with acute LD from healthy subjects and...
Source: GEO: Gene Expression Omnibus - April 3, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research

Lyme disease: diagnosis and treatment
Purpose of review Lyme disease is an important, vector-borne infection found throughout the temperate Northern hemisphere. The disease causes rash, acute systemic illness, and in some untreated patients, inflammatory arthritis. This review examines the emergence, clinical features and management of early Lyme disease and Lyme arthritis. Recent findings There has been continuing progress in characterizing the clinical manifestations, diagnostic testing and treatment of Lyme disease. Almost all patients with early Lyme disease can be cured with antibiotic treatment. In most cases, Lyme arthritis also responds to antibio...
Source: Current Opinion in Rheumatology - March 28, 2020 Category: Rheumatology Tags: CLINICAL THERAPEUTICS AND HEMATOLOGIC COMPLICATIONS: Edited by W. Joseph McCune Source Type: research

Development of a Pediatric Lyme Meningitis Symptom Measurement instrument using a Delphi technique
Publication date: Available online 23 March 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Aris Garro, Miriam Dash, John M. VanBuren, Lise E. Nigrovic, for Pedi Lyme Net (Source: Ticks and Tick borne Diseases)
Source: Ticks and Tick borne Diseases - March 25, 2020 Category: Zoology Source Type: research

Broadly Protective Multivalent OspA Vaccine against Lyme Borreliosis, Developed Based on Surface Shaping of the C-Terminal Fragment [Microbial Immunity and Vaccines]
This article presents the proof-of-concept study for a multivalent OspA vaccine targeting a wide range of pathogenic LB Borrelia species with a single recombinant antigen for prevention of Lyme borreliosis. (Source: Infection and Immunity)
Source: Infection and Immunity - March 23, 2020 Category: Infectious Diseases Authors: Nayak, A., Schüler, W., Seidel, S., Gomez, I., Meinke, A., Comstedt, P., Lundberg, U. Tags: Microbial Immunity and Vaccines Source Type: research

Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family [Cellular Microbiology: Pathogen-Host Cell Molecular Interactions]
Borrelia burgdorferi sensu lato, the causative agent of tick-borne Lyme borreliosis (LB), has a limited metabolic capacity and needs to acquire nutrients, such as amino acids, fatty acids, and nucleic acids, from the host environment. Using X-ray crystallography, liquid chromatography-mass spectrometry, microscale thermophoresis, and cellular localization studies, we show that basic membrane protein D (BmpD) is a periplasmic substrate-binding protein of an ABC transporter system binding to purine nucleosides. Nucleosides are essential for bacterial survival in the host organism, and these studies suggest a key role for Bmp...
Source: Infection and Immunity - March 23, 2020 Category: Infectious Diseases Authors: Cuellar, J., Astrand, M., Elovaara, H., Pietikäinen, A., Siren, S., Liljeblad, A., Guedez, G., Salminen, T. A., Hytönen, J. Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research

The Borrelia burgdorferi VlsE Lipoprotein Prevents Antibody Binding to an Arthritis-Related Surface Antigen
Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Abdul G. Lone, Troy Bankhead (Source: Cell Reports)
Source: Cell Reports - March 19, 2020 Category: Cytology Source Type: research

Cerebrospinal fluid cytokines and chemokines in children with Lyme neuroborreliosis; pattern and diagnostic utility.
CONCLUSIONS: The intrathecal immune reaction in LNB is characterized by B cell associated chemokines. Whether the combination CXCL13/CCL19 further improves discrimination between LNB and NLAM beyond the diagnostic improvements by CXCL13 alone needs to be tested in new studies. PMID: 32199247 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - March 18, 2020 Category: Molecular Biology Authors: Barstad B, Henningsson AJ, Tveitnes D, Ushakova A, Noraas S, Ask IS, Bosse FJ, Øymar K Tags: Cytokine Source Type: research

EliSpot assays and their diagnostic potential in Lyme disease and Lyme Neuroborreliosis.
Abstract We have read the research article entitled "Prospective comparison of two enzyme-linked immunosorbent spot assays for the diagnosis of Lyme neuroborreliosis" by van Gorkom T, Voet W, Sankatsing SUC, Nijhuis CDM, Ter Haak E, Kremer K and Thijsen SFT published in Clinical and Experimental Immunology (2019 Oct 30. https://doi.org/10.1111/cei.13393) (1). We want to congratulate the authors for the publishing of this article, and make some remarks and contributions. PMID: 32180218 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 17, 2020 Category: Allergy & Immunology Authors: Ettischer-Schmid N, Preyer R Tags: Clin Exp Immunol Source Type: research

The Value of the Surface ECG for the Diagnosis and Management of Lyme Carditis.
Authors: Yeung C, Al-Turki M, Baranchuk A Abstract Lyme carditis (LC) is an early-disseminated manifestation of Lyme disease, most commonly presenting as high-degree atrioventricular block (AVB). The degree of AVB can fluctuate rapidly within minutes, and progression to third-degree AVB is potentially fatal if not recognized and managed promptly. However, the AVB in LC is often transient, and usually resolves with appropriate antibiotic therapy. LC should be on the differential diagnosis in young patients presenting with new high-degree AVB and factors that increase the index of suspicion for Lyme disease. The Susp...
Source: Current Cardiology Reviews - March 15, 2020 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research

Untreated neuroborreliosis presenting with somatic delusions and subjective memory impairment
Lyme disease is a tick-borne spirochete illness with multi-system involvement. Although neurological manifestations of Lyme disease are becoming increasingly well recognized, its psychiatric presentations are not well known. Physicians need to be aware of its neuropsychiatric symptoms that may present months to years later. Endemic areas to Borellia Burgdorferi also have higher rates of schizophrenia. Prompt diagnosis and effective treatment is need to to avoid irreversible neuropsychiatric complications. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - March 14, 2020 Category: Geriatrics Authors: Setare Eslami, Michael Serna Tags: Poster Number: EI-12 Source Type: research

The predictive value of CXCL13 in suspected Lyme neuroborreliosis: a retrospective cross-sectional study
AbstractThe role of CXCL13 as a marker of Lyme neuroborreliosis (LNB) is under investigation, and CXCL13 is not part of routine diagnostics in suspicion of LNB. Our aim was to find the optimal cut-off value of CXCL13 for LNB in a Danish population and to investigate the role of CXCL13 both in early LNB and as a discriminatory marker between LNB and other neuroinflammatory disorders. We conducted a retrospective cross-sectional study including all patients with a cerebrospinal CXCL13 test performed at the Department of Clinical Immunology, Odense University Hospital, Denmark, between 1 January 2015 and 31 December 2018. We ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 14, 2020 Category: Microbiology Source Type: research

History of Lyme Disease as a Predictor of Atrial Fibrillation
This study aimed to assess whether the serological history of Borrelia infection was associated with the risk of AF. The study included 113 AF patients and 109 patients in sinus rhythm. All patients underwent a clinical evaluation, echocardiography and had t heir blood taken for the assessment of anti-Borrelia IgG antibodies. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 13, 2020 Category: Cardiology Authors: Anna Szymanska, Anna E. Platek, Miroslaw Dluzniewski, Filip M. Szymanski Source Type: research

Serological testing for Lyme Borreliosis in general practice: A qualitative study among Dutch general practitioners.
Conclusion: Both diagnosis and ruling out of disseminated Lyme Borreliosis can be difficult for general practitioners. General practitioners use serological tests to reassure patients and rule out Lyme Borreliosis, thereby deviating from the national guideline. Interpretation of test results in these cases can be difficult. PMID: 32157944 [PubMed - in process] (Source: European Journal of General Practice)
Source: European Journal of General Practice - March 12, 2020 Category: Primary Care Tags: Eur J Gen Pract Source Type: research

IJERPH, Vol. 17, Pages 1830: Management Options for Ixodes ricinus-Associated Pathogens: A Review of Prevention Strategies
Rudenko Libor Grubhoffer Ticks are important human and animal parasites and vectors of many infectious disease agents. Control of tick activity is an effective tool to reduce the risk of contracting tick-transmitted diseases. The castor bean tick (Ixodes ricinus) is the most common tick species in Europe. It is also a vector of the causative agents of Lyme borreliosis and tick-borne encephalitis, which are two of the most important arthropod-borne diseases in Europe. In recent years, increases in tick activity and incidence of tick-borne diseases have been observed in many European countries. These increases are lin...
Source: International Journal of Environmental Research and Public Health - March 12, 2020 Category: Environmental Health Authors: Ji ří Černý Geoffrey Lynn Johana Hrnkov á Maryna Golovchenko Natalia Rudenko Libor Grubhoffer Tags: Review Source Type: research

Cost analysis of vaccination in tick-mouse transmission of Lyme disease
Publication date: Available online 10 March 2020Source: Journal of Theoretical BiologyAuthor(s): Daniel Carrera-Pineyro, Harley Hanes, Adam Litzler, Andrea McCormack, Josean Velazquez-Molina, Anuj Mubayi, Karen Ríos-Soto, Christopher Kribs (Source: Journal of Theoretical Biology)
Source: Journal of Theoretical Biology - March 11, 2020 Category: Biology Source Type: research

Patient ‐reported outcome after treatment for definite Lyme neuroborreliosis
ConclusionsResults on validated PROM questionnaires measuring fatigue, anxiety, depression, self ‐reported somatic symptom burden, and physical health‐related quality did not differ between persons treated for definite NB 1–10 years earlier and reference scores. NB‐treated persons tended to report a slightly poorer mental health‐related quality of life than found in normative data, b ut when adjusting for confounders the causative connection is questionable. Overall, the long‐term prognosis of definite NB seems to be good. (Source: Brain and Behavior)
Source: Brain and Behavior - March 10, 2020 Category: Neurology Authors: Randi Eikeland, Unn Lj østad, Geir Helgeland, Geir Sand, Heidi Øyen Flemmen, Margrete Halvorsen Bø, Ludmila Nordaa, Jone Furulund Owe, Åse Mygland, Åslaug Rudjord Lorentzen Tags: ORIGINAL RESEARCH Source Type: research

Dorsal Root Ganglion Stimulation for Post ‐Lyme Disease Chronic Peripheral Neuropathic Pain
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - March 9, 2020 Category: Biotechnology Authors: Jay Karri, Brian Bruel Tags: Letter to the Editor Source Type: research

Borrelia burgdorferi and Anaplasma phagocytophilum Genospecies in Northern California
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - March 9, 2020 Category: Infectious Diseases Authors: Kathleen Sholty Emily L. Pascoe Janet Foley Nicole Stephenson Greg Hacker Mary Straub Austin Roy Richard Brown Source Type: research

Epidemiology of Lyme Disease in a Highly Endemic European Zone.
Conclusions: This study found a high incidence of Lyme disease in Lithuania. We elucidated the baseline characteristics regarding the infected Lithuanian population which may ease medical clinicians' work on new Lyme diagnoses. PMID: 32151097 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 5, 2020 Category: Universities & Medical Training Authors: Petrulionienė A, Radzišauskienė D, Ambrozaitis A, Čaplinskas S, Paulauskas A, Venalis A Tags: Medicina (Kaunas) Source Type: research