What do you think of this elderly man with " possible seizure " ?
Written by Pendell Meyers(with really great and thorough explanation of this finding by Ken Grauer).At my hospital, patients with any symptoms which could be vaguely interpreted as a possible stroke during the triage process are brought to the high acuity area and a provider is asked to do a " neuro check " , which involves a quick H and P and exam to determine if we should activate our stroke protocol.A man in his 70s was brought to me for a neuro check, and the triage providers commented that they were worried about a possible seizure as well. The patient was alert and oriented with normal vitals at triage. He ...
Source: Dr. Smith's ECG Blog - May 24, 2020 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ASC Specks in the Inflammatory Microglial Response to Amyloid- β Aggregation in Alzheimer's Disease
The Alzheimer's disease research community is nowadays ever more strongly considering chronic inflammation in the brain as a vital part of the progression of the condition. In the amyloid cascade hypothesis, a slow aggregation of amyloid-β over decades (for reasons that are debated) causes ever greater inflammatory dysfunction in microglia, the immune cells of the brain responsible for clearing up metabolic waste such as protein aggregates. That inflammation in turn sets the stage for tau aggregation to take place to a significant degree, causing cell death and severe neural dysfunction. Today's open access res...
Source: Fight Aging! - March 31, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Answer to Case 585
Answer toParasite Case of the Week 585: Hard tick,Ixodes scapularis,unengorged adult female with intact mouth parts.As several of you mentioned, it would be important to know the location for where this tick was obtained. This particular tick was obtained in Florida, although similar-appearing ticks are found on the west coast of the United States (Ixodes pacificus) and Europe (Ixodes ricinus). All three of these ticks serve as the vector for members of theBorrelia burgdorferisensu lato species complex that cause human Lyme disease (Lyme borreliosis).There are a couple of features which can get you to the genus level prett...
Source: Creepy Dreadful Wonderful Parasites - March 28, 2020 Category: Parasitology Source Type: blogs

A 40-something with chest pain. Is this inferior MI?
This was sent by a Saleh Hatem, an avid reader of the blog.The patient presented with chest pain:There is a narrow complex tachycardia.Is there inferior ST Elevation?Here was my interpretation:What appears to be ST Elevation in inferior leads is really a P-wave that is contiguous with the QRS. (The next bump over is a T-wave that looks like a P-wave!).Since the P-wave is not inverted, it is NOT retrograde, and therefore it is a native sinus beat.  This sinus beat does conduct, but there is severely prolonged PR interval (severe first degree AV block), with a PR interval of over 400 ms.So: Sinus tachycardia with severe...
Source: Dr. Smith's ECG Blog - March 4, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs

Fight Aging! Newsletter, February 24th 2020
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve. A Comparison of Biological Age Measurement Approaches https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/ Researchers here assess the performance of a range of approaches to measuring biological...
Source: Fight Aging! - February 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Evidence for Bacterial DNA to Promote Tau Aggregation in Neurodegeneration
The field of Alzheimer's disease research is in the midst of a slow-moving and consequential debate over the role of infection in the development of the condition. The fundamental question is this: in the absence of genetic variants that raise risk, why do only some people progress to full blown Alzheimer's disease? The presence - in only some people - of sufficient degrees of persistent infection is one possible answer to that question. Candidates include herpesviruses, oral bacteria such as P. gingivalis, lyme disease spirochetes, and others. Alzheimer's is a condition characterized by amyloid-β aggregation i...
Source: Fight Aging! - February 21, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Credit Card Sized Diagnostic Lab Plugs into Smartphone
Researchers at the University of Cincinnati have developed a tiny portable diagnostic device that can detect the presence of specific pathogens in a saliva sample, and relay the results to a doctor when plugged into a smartphone. The device can potentially diagnose a wide array of diseases, including malaria, HIV and Lyme disease, and could be useful for point-of-care testing and even self-testing. A custom app can relay the results of tests to one’s doctor for nearly instant diagnostic results. The technology includes single-use plastic chips that a user places in their mouth to load a saliva sample before pluggi...
Source: Medgadget - February 7, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Pathology Psychiatry Source Type: blogs

Microfluidic Device for Rapid Lyme Disease Diagnosis
Researchers at Columbia University have developed a microfluidic device that can diagnose Lyme disease in as little as 15 minutes. The device is particularly accurate in identifying antibody biomarkers that are present during early stage Lyme disease, raising hopes that it could be useful in detecting cases of early infection in a doctor’s office, leading to timely treatment. Lyme disease, which is spread by infected ticks, is incredibly common. Approximately 300,000 Americans are diagnosed with the disease each year, and if left untreated it can result in serious neurological and cardiac symptoms. The disease is ...
Source: Medgadget - October 14, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Neurology Pathology Public Health Source Type: blogs

Chronic Lyme arthritis: A mystery solved?
In 1975, researchers from Yale investigated an epidemic of 51 patients with arthritis who lived near the woodsy town of Lyme, Connecticut. The most common symptom was recurrent attacks of knee swelling. A few had pain in other joints, such as the wrist or ankle. Many had fever, fatigue, and headache. Some remembered a round skin rash before the onset of knee swelling. We now know that Lyme disease is an infection acquired from tick bites, caused by a spiral bacterium named Borrelia burgdorferi. After a tick bite, Borrelia bacteria wriggle through the skin away from the bite site. This leads to a circular red rash, known as...
Source: Harvard Health Blog - October 3, 2019 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Arthritis Bones and joints Infectious diseases Source Type: blogs

New Definition for DTC Lab Testing Prompted by EverlyWell Business Model
A recent article in Dark Daily convinced me that we need a new definition for direct-to-consumer (DTC) lab testing which has also been called direct-access-testing (DAT) (see:Direct-to-Consumer Lab Test Start-Up EverlyWell Puts Clinical Laboratory Tests on Shelves at CVS and Target). Below is an excerpt from the article:....Julia Taylor Cheek, Founder and CEO ofEverlyWell, a well-financed digital health company based in Austin —hopes to build a... disruptive business in the clinical laboratory industry....Cheek is talking about the same primary business strategy of letting consumers purchase their own lab tests....Th...
Source: Lab Soft News - July 17, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Diagnostics Direct Access Testing (DAT) Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Reference Laboratories Test Kits and H Source Type: blogs

Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - June 23, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Infection Induced Systemic Inflammation as a Contributing Cause of Alzheimer's Disease
The big question regarding Alzheimer's disease has always been why only some people suffer this form of dementia. While being overweight clearly increases the risk of dementia, and it is easy to argue that this is because of the chronic inflammation generated by visceral fat tissue, not every overweight individual progresses to the point of Alzheimer's disease. Some people who are not overweight suffer Alzheimer's disease. The condition starts with rising levels of amyloid-β aggregates forming in the brain, thought to be a progressive process occurring over a decade or more prior to any clinical symptoms, but why does...
Source: Fight Aging! - June 20, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What Was the Cause of the Excruciating Pain in His Shoulders and Hips? - The New York Times
As the physician prepared to leave the exam room, the patient's wife spoke up:"Doctor, my husband won't tell you this, but he is suffering," the woman said, her voice cracking. Dr. Timothy Quan, a rheumatologist in central Connecticut, looked at the 69-year-old man he'd been caring for over the past several months. The man gave a brisk nod. It was true. The past few weeks had been a nightmare of pain.Six months earlier, the patient woke up with a sore, swollen right hand. He figured he must have injured it a few days before when he cleared out a pile of wood in his backyard. He mentioned it to his pri...
Source: Psychology of Pain - June 5, 2019 Category: Anesthesiology Source Type: blogs

3D Printed ELISA Pipette Tips for Low Cost Medical Testing
Researchers at the University of Connecticut have developed a 3D printed enzyme-linked immunosorbent assay (ELISA) device, which fits onto a normal pipette and substantially reduces the time and cost of this common medical test. The device could allow for medical testing in remote or low-resource regions, where such tests would otherwise be unavailable. ELISA tests are routinely used to measure protein levels in biological samples – this includes antibodies, and a variety of pathogenic molecules. The test can reveal the presence of numerous diseases, including some cancers, HIV, and Lyme disease. However, performing ...
Source: Medgadget - May 23, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Pathology Source Type: blogs

‘ At Least You Don ’ t Have … ’ How to Be Supportive of Someone with Chronic Illness
I was speaking with someone recently who has a series of chronic and painful conditions; some of which are noticeable and some ‘invisible’. What is particularly distressful is that people sometimes say to her, “At least you don’t have cancer.” How dismissive is that? I know they are trying to help her feel better about what she does have and perhaps even attempt to minimize the impact, but it is not compassionate or helpful. There are diagnoses such as fibromyalgia, lupus, diabetes, arthritis or neuropathy which some people have to navigate. It might mean taking naps on an as-needed basis, en...
Source: World of Psychology - May 15, 2019 Category: Psychiatry & Psychology Authors: Edie Weinstein, MSW, LSW Tags: Chronic Pain Health-related Inspiration & Hope Personal Arthritis Chronic Illness Diabetes Fibromyalgia Lupus Lyme disease neuropathy peer support Source Type: blogs

Tick-Borne Diseases of Norway
Tick-borne encephalitis (TBE) is one of eight zoonoses carried by ticks in Norway (the others are Anaplasmosis, Babesiosis, Louping ill, Lyme borreliosis, Relapsing fever, Rickettsial spotted fever and Tularemia).  As displayed in the following graphs, rates of human TBE are considerably lower than those of other tick-borne diseases in Norway, and below TBE rates reported by neighboring countries. [1-3]     References: Berger S. Infectious Diseases of Norway, 2019. 387 pages , 138 graphs , 858 references. Gideon e-books,  https://www.gideononline.com/ebooks/country/infectious-diseases-of-norway/ Berg...
Source: GIDEON blog - April 1, 2019 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Ebooks Epidemiology Graphs ProMED Source Type: blogs

Should Mental Health Determine Pain Treatment Options?
Patients with a mental health condition might have a hard time accessing opioids for pain relief, while patients with unexplained pain are often referred to psychiatric care, which does little to alleviate their symptoms. Finding treatment can be frustrating and humiliating. Four years ago, Dez Nelson’s pain management clinic demanded that she complete a visit with a psychologist. Nelson was surprised, since she had no history of mental illness, but she didn’t feel that she could push back on the request. “Of course I said okay — I didn’t want to lose my treatment,” Nelson told The Fix. ...
Source: World of Psychology - March 26, 2019 Category: Psychiatry & Psychology Authors: Psych Central Guest Author Tags: Addiction Disorders Health-related Medications Mental Health and Wellness Publishers Substance Abuse The Fix Treatment Chronic Pain mental health and pain Opioids Pain Management pain management clinic Pain Relief pain treatm Source Type: blogs

Climate Crisis Call to Action: Major Obstacles but Hope for an “Energized Base”
  We have known for more than half a century that the earth is heating up and scientists have long foretold the consequences. Yet in these same decades, the earth’s population has increased dramatically; the demand for convenience, quality of life, and consumer goods has expanded; energy consumption and CO2 emissions have skyrocketed; and we are living in the hottest climate on record. So why aren’t we doing more to stop this catastrophe? One way to answer this question is by contrasting our inertia with the successful response to another public health crisis: the AIDS epidemic. Act Up, the political movem...
Source: Academic Medicine Blog - September 18, 2018 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective climate change medical education medical students physicians Source Type: blogs

Fight Aging! Newsletter, September 17th 2018
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - September 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Debating the Microbial Hypothesis for Alzheimer's Disease
Why do only some older people develop the elevated levels of amyloid-β that start the amyloid cascade of Alzheimer's disease, leading to tau aggregation and consequent death and dysfunction of brain cells? If amyloid-β is the result of persistent infection by pathogens such as herpesviruses and lyme spirochetes that are, collectively, only present in 20% or so of the population, then perhaps that is the answer. This is the core of the microbial hypothesis of Alzheimer's disease, that amyloid-β is a feature of the innate immune system, and thus persistent infection of brain tissue will result in higher levels...
Source: Fight Aging! - September 10, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 27th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - August 26, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Synapses of Some Individuals Appear Resilient to Age-Related Protein Aggregation
We all, to some degree, accumulate harmful protein aggregates in the brain with age, but only some people develop severe neurodegenerative disease as a result. The rest of the population remains mildly impaired. Why is this? Some have suggested that Alzheimer's disease and the like are to some degree lifestyle conditions, aggravated by the presence of excess visceral fat tissue and the abnormal metabolism that results. Alternatively the microbial hypothesis suggests that only some people have sufficient persistent infection by herpesviruses or lyme spirochetes to result in high levels of protein aggregates. Theories of imp...
Source: Fight Aging! - August 20, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 6th 2018
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly indiv...
Source: Fight Aging! - August 5, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Alzheimer's as the Endpoint of a Life-Long Burden of Infectious Disease
The long years of failure in Alzheimer's research, in which trial after trial of immunotherapies targeting amyloid-β produced no meaningful benefits in Alzheimer's patients, has sown the seeds of change in the research community. In the past couple of years, promising human data for amyloid-β clearance has finally arrived, but the damage is done. The amyloid hypothesis for Alzheimer's disease is now challenged, and alternative theories are thriving. One of particular note is built upon the point that generation of amyloid in the brain appears to be a defensive mechanism of the innate immune system, and thus its p...
Source: Fight Aging! - August 4, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Public input into gene-editing decisions
Lyme disease is caused by a type of bacteria that lives in mice, which are considered a “reservoir” for the disease-causing agent.  Ticks bite the mice, pick up the bacteria, and then infect people when they bite them.  (Ticks are called the “vector” for the disease.) If mice were immune to the bacteria, their immune … Continue reading "Public input into gene-editing decisions" (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 3, 2018 Category: Medical Ethics Authors: Jon Holmlund Tags: Genetics Health Care bioethics biotechnology Consent / Research syndicated Source Type: blogs

Crowdsourced Ticks Help to Create Maps of Lyme, Other Diseases
Perhaps the best way of stopping tick-borne diseases is public awareness campaigns, but these must be well targeted to achieve good results without wearing people out with unnecessary warnings. While ticks are widespread, the diseases they carry don’t travel quite as well, so knowing where tick-borne pathogens are found can be of great advantage. In addition, knowing how the diseases are distributed geographically in animal hosts can point to new ways of curtailing them. The Bay Area Lyme Foundation recently asked people from around the United States to send them ticks that they find around where they live. The found...
Source: Medgadget - July 25, 2018 Category: Medical Devices Authors: Editors Tags: Informatics Medicine Public Health Source Type: blogs

Answer to Case 502
Answer:Borreliaspp., relapsing fever group. Molecular studies are needed to definitively identify the causative agent. However, knowing the exposure history of the patient also helps narrow the differential. In this case, we later found out that the patient is from the northwestern part of North America, and therefore this is most likelyBorrelia hermsii,one of the tick-borne relapsing feverBorreliaspecies.The other tick-borneBorreliain North America areB. parkeriiandB. turicatae.These species are transmitted through the bite of a soft-bodied tick in the genusOrnithodoros,and are usually associated with exposure to'rustic's...
Source: Creepy Dreadful Wonderful Parasites - July 15, 2018 Category: Parasitology Source Type: blogs

Zoonotic Disease Deaths in the United States
With the exception of salmonellosis, deaths from Rocky Mountain spotted fever (RMSF) * have exceeded those of other reportable zoonoses in the United States for most of the past six decades. [1,2]    Rabies was the predominant cause of zoonotic death prior to 1950; Lyme disease and West Nile fever since 2000. * Since 2010, reporting of “Rocky Mountain spotted fever” has been broadened to include                            related diseases –  under the heading “Spotted fever rickettsiosis”   Refer...
Source: GIDEON blog - July 13, 2018 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Ebooks Epidemiology Graphs ProMED Source Type: blogs

Lyme disease: Resolving the “Lyme wars”
It’s finally getting warm here in New England, and most of us have plans to enjoy the beautiful weather. And that’s why the Centers for Disease Control and Prevention (CDC) recently released a report raising awareness about how to prevent the tickborne infections that typically occur during this time of the year. Lyme disease is probably the most well-known, and the one for which diagnosis and treatment are most controversial. What is Lyme disease? Several countries around the world, especially in the Northern Hemisphere, and all 50 states in the US have already reported cases of Lyme. The disease is caused by ...
Source: Harvard Health Blog - June 18, 2018 Category: Consumer Health News Authors: Marcelo Campos, MD Tags: Health Infectious diseases Source Type: blogs

Most common cause of acquired heart disease in children in developed countries – Cardiology MCQ
Most common cause of acquired heart disease in children in developed countries: a) Rheumatic heart disease b) Viral myocarditis c) Kawasaki disease d) Lyme disease Click here for the correct answer.   (Source: Cardiophile MD)
Source: Cardiophile MD - May 28, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

Study Finds Deer Tick Populations on the Rise in Indiana
Ticks that carry Lyme disease and other illnesses are spreading into Indiana and the Midwest states.Read more on sciencespacerobots.com (Source: HealthNewsBlog.com)
Source: HealthNewsBlog.com - May 25, 2018 Category: Consumer Health News Tags: ticks mice Source Type: blogs

Ticked off: America ’s quiet epidemic of tickborne diseases
For most of us, springtime marks the return of life to a dreary landscape, bringing birdsong, trees in bud, and daffodils in bloom. But if you work for the Centers for Disease Control and Prevention (CDC), the coming of spring means the return of nasty diseases spread by ticks and mosquitoes. The killjoys at CDC celebrated the end of winter with a bummer of a paper showing that infections spread by ticks doubled in the United States from 2004 to 2016. (Tick populations have exploded in recent decades, perhaps due to climate change and loss of biodiversity.) Lyme disease The most common infection spread by ticks in the US i...
Source: Harvard Health Blog - May 25, 2018 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Health Infectious diseases Source Type: blogs

4 things to know about ticks and Lyme
As the weather gets better and school vacations begin, along with sunburns and water safety there is something else parents need to think about: ticks and Lyme disease. Lyme disease is spread by the bite of the blacklegged tick. While there are cases in various parts of the country, it’s most common in the Northeast and mid-Atlantic states, as well as around the Great Lakes. The early symptoms of Lyme include fever, body aches, and a bull’s-eye rash. It’s very treatable with antibiotics, but if not caught and left untreated, it can lead to serious health problems. Here is information from the Centers for ...
Source: Harvard Health Blog - May 15, 2018 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Infectious diseases Parenting Source Type: blogs

Thriving with an Invisible Chronic Illness
You have a chronic illness that is debilitating and requires meticulous management. Which is hard enough. But you also have an invisible illness—like fibromyalgia, diabetes, Lyme disease, IBS, or something very rare. On the outside, on most days, you look fine, even perfectly healthy. But on the inside, you’re struggling with unbearable migraines, knock-you-off-your-feet fatigue, dangerous digestive issues, severe pain and much more. Because people don’t see these symptoms, they misunderstand what’s going on, which leads you to feel judged and lonely. And these people might include everyone from med...
Source: World of Psychology - May 13, 2018 Category: Psychiatry & Psychology Authors: Margarita Tartakovsky, M.S. Tags: Disorders General Health-related Inspiration & Hope Mental Health and Wellness Self-Help Chronic Illness Chronic Pain Coping Skills Resilience Source Type: blogs

Tick- and Mosquito-borne Diseases: Trends in the United States
The following data are abstracted from Gideon and the Gideon e-book series. [1]  Charts were created using an interactive tool driven by over 30,000 base graphs in the program. [2] Chart 1 contrasts trends for reported incidence of Lyme disease and Rocky Mountain spotted fever (RMSF).  Note that while rates of Lyme disease in 2016 are 15-fold those reported in 1987, those of RMSF increased by a factor of seven.  The number of fatal cases for both diseases have remained similar in recent years (i.e., the relative case-fatality rate of Lyme disease has decreased) Chart 2 summarizes incidence data for a variet...
Source: GIDEON blog - May 4, 2018 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Ebooks Epidemiology Graphs ProMED Source Type: blogs

Biomeme ’s Portable PCR System Expands Research Possibilities
Polymerase chain reaction (PCR) is one of the most widely used techniques in biological research and testing, allowing researchers to amplify and identify even small quantities of DNA or RNA. It serves a wide variety of uses, from genetic testing to infectious disease identification to forensics. Thermal cyclers, the machines that run PCR, are a staple in research laboratories. However, they are also large and expensive. Biomeme hopes to expand those limitations. The Philadelphia-based company started in 2013 with one simple but powerful idea. “We wanted to empower anyone, a lay person, a researcher, a clinician, who...
Source: Medgadget - January 22, 2018 Category: Medical Devices Authors: Cici Zhou Tags: Diagnostics Genetics Source Type: blogs

For “ chemobrain ” et alia: think “ brain fitness training ”
If you have this personal history of cancer and chemo- or radiation-therapy, or know someone or are treating someone who has lived it, you might seriously consider enrolling (them) in a serious “brain fitness program”. That is ESPECIALLY the case if memory or other cognitive losses have been noted after either chemotherapy and/or radiation therapy. Posit Science is now supporting a study that is designed to document improvements in cognitive function resulting from its “brain fitness training” strategy (see www.brainhq.com) in chemotherapy-treated breast cancer survivors. While initial findings in t...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - January 1, 2018 Category: Neuroscience Authors: Dr. Merzenich Tags: Aging and the Brain Brain Fitness Brain Trauma, Injury Chemobrain Source Type: blogs

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): MRI
Discussionby Dr MGK Murthy, Dr GA PrasadChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is characterized clinically by a progressive or relapsing course of many months to years of symptoms similar to compressive myelopathy.Etiology Remains unknown, but T-cell activation in nerves plays an important role in the pathogenesis of CIDP& antigens in Schwann cells have been identified.PathologicallyCIDP is characterized by mononuclear cell infiltrates, edema, segmental demyelination, and remyelination&“onion bulb formation” which describes enlarged fascicles with increased endoneural conn...
Source: Sumer's Radiology Site - December 12, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Cardiology MCQ Test 4
Time limit: 0 Quiz-summary 0 of 20 questions completed Questions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Information This test series requires login for attempting. You can login easily with your Facebook account (Use the CONNECT WITH icon on the upper part of right sidebar displaying t...
Source: Cardiophile MD - October 21, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Microbial Theories of Alzheimer's Disease are Gaining Support
The lack of concrete progress in the amyloid clearance approach to Alzheimer's disease, despite significant investment and many clinical trials over the past decade, has led to a great deal of theorizing in the research community. Is it that the dominant anti-amyloid strategy immunotherapy is intrinsically challenging when applied to the brain at this point in the progress of medical biotechnology, or is it that amyloid is not the best target? In the SENS view of aging, amyloid accumulation is a primary difference between old and young tissue, and it should be removed. But Alzheimer's is a very complicated condition, invol...
Source: Fight Aging! - September 8, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

MKSAP: 36-year-old man with history of fatigue
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 36-year-old man is evaluated for a 1-year history of fatigue, intermittent headaches, sore throat, and joint and muscle pain. He reports no difficulties falling asleep and gets 10 hours of uninterrupted but nonrestorative sleep each night. He has seen several physicians over the past year. Evaluation has included a complete blood count with differential, thyroid-stimulating hormone level, and plasma glucose level that were normal at the time of initial presentation and again 2 months ago. HIV testing p...
Source: Kevin, M.D. - Medical Weblog - August 19, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Endocrinology Infectious Disease Pain Management Primary Care Rheumatology Source Type: blogs

Ticks and the changing landscape of tick borne illnesses
Ticks and the diseases they carry have long been recognized as health concerns, especially in the warmer months when ticks (and humans) are more active. Ticks wait on grass tips or shrubs to latch onto new hosts when they brush by. Most of the hosts are animals, but a few tick species do bite and feed on humans. While doing so, they can transmit bacteria and viruses through their saliva. But here’s what’s changing: Tick species are being found in a wider geographic range. The number of case reports of tick-borne illnesses is increasing. Scientists continue to identify new pathogens (bacteria and viruses that c...
Source: Harvard Health Blog - August 11, 2017 Category: Consumer Health News Authors: Wynne Armand, MD Tags: Health Infectious diseases Prevention Safety Travel health Source Type: blogs

Ticks and the changing landscape of tick-borne illnesses
Ticks and the diseases they carry have long been recognized as health concerns, especially in the warmer months when ticks (and humans) are more active. Ticks wait on grass tips or shrubs to latch onto new hosts when they brush by. Most of the hosts are animals, but a few tick species do bite and feed on humans. While doing so, they can transmit bacteria and viruses through their saliva. But here’s what’s changing: Tick species are being found in a wider geographic range. The number of case reports of tick-borne illnesses is increasing. Scientists continue to identify new pathogens (bacteria and viruses that c...
Source: Harvard Health Blog - August 11, 2017 Category: Consumer Health News Authors: Wynne Armand, MD Tags: Health Infectious diseases Prevention Safety Travel health Source Type: blogs

More Theorizing on the Role of Pathogens in Alzheimer's Disease
The dominant approach to Alzheimer's research and the development of potential therapies involves finding ways to clear out aggregates of amyloid and tau that build up in the brain. This has proven challenging, however. It is too early to say in certainty whether lack of tangible progress on this front is because it is a hard problem, or because this isn't the most effective direction. The weight of evidence strongly suggests the former is the case, but that hasn't stopped delayed progress from spurring the development of a great many alternative hypotheses as to the cause of Alzheimer's disease. One line of thinking sugge...
Source: Fight Aging! - July 27, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Healthy 50-something with new dyspnea on exertion and an interesting ECG
This study was on asymptomatic patients.There are other longitudinal studies which did NOT show increased long term risk. (Source: Dr. Smith's ECG Blog)
Source: Dr. Smith's ECG Blog - July 25, 2017 Category: Cardiology Authors: Steve Smith Source Type: blogs

More awful reporting on the "poop doping" claimed by Dr. Lauren Peterson
UggBeen trying to stamp out the awful reporting on the poop doping claims of Dr. Lauren Peterson. SeeIrresponsible reporting on "poop doping" from the Washington PostKudos to Bicycling Magazine for pedaling so so so much overselling of the microbiomeBut the crap keeps flowing. Here is the last - in the NY Post: Poop transplants are the final frontier in athletic doping | New York PostHere are some quotes from the story and my comments about them."The treatment helped her battle Lyme Disease, however, there was a downside."No evidence exists that this treatment helped her battle Lyme disea...
Source: The Tree of Life - June 28, 2017 Category: Microbiology Authors: Jonathan Eisen Source Type: blogs

Deaths and complications due to treating the fake disease known as “ chronic Lyme disease ”
Alternative practitioners invent and treat fake diseases like adrenal fatigue and chronic Lyme disease. Unfortunately, as a recent CDC report on complications due to treating chronic Lyme disease with long term antibiotics shows, treating fake diseases can cause harm and, in some cases, even kill. (Source: Respectful Insolence)
Source: Respectful Insolence - June 21, 2017 Category: Surgery Authors: Orac Tags: Clinical trials Complementary and alternative medicine Homeopathy Naturopathy Pseudoscience Quackery Skepticism/critical thinking antibiotics Borrelia burgdorferi catheter-associated sepsis CDC chronic lyme disease Clostridium diff Source Type: blogs

Irresponsible reporting on "poop doping" from the Washington Post
Went on a bit of a Twitter tirade last night. See more below[View the story "Irresponsible reporting on "poop doping" from The Washington Post #microbiomania" on Storify]The Washington Post story, by Marissa Payne, requires a log in but the article is now in other papers that are free onlineincluding the Denver Post here.It is just really bad reporting because the claims of one scientist are presented as facts without any scrutiny and these claims need lots of scrutiny.Recently this story was covered in Bicycling Magazine and Igave them an "overselling the microbiome" award for their reporting...
Source: The Tree of Life - June 21, 2017 Category: Microbiology Authors: Jonathan Eisen Source Type: blogs