Catastrophic Antiphospholipid Syndrome: Skin, Eye and Brain Involvement.
CONCLUSION: CAPS causes multiple organ thrombosis and is associated with high rate of mortality. PMID: 33186069 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - November 18, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

In Vitro Study of Synergic Effect of Cisplatin and Low Molecular Weight Heparin on Oral Squamous Cell Carcinoma
ConclusionsA combination of cisplatin and enoxaparin sodium shows a synergic effect that reduces cell viability and cell migration capacity and increases the apoptosis of human OSCC cells.Clinical relevanceEnoxaparin may be beneficial in chemotherapy for patients with OSCC; this finding requires further clinical and laboratory investigation. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 18, 2020 Category: Cancer & Oncology Source Type: research

The use of enoxaparin as bridge to therapeutic INR after LVAD implantation
Left ventricular assist devices (LVAD) have been increasingly used in the treatment of end-stage heart failure. While warfarin has been uniformly recommended in the long-term as anticoagulation strategy, no cl... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - November 14, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Zubair Shah, Ioannis Mastoris, Prakash Acharya, Aniket S. Rali, Moghni Mohammed, Sami Farhad, Sagar Ranka, Savahanna Wagner, Giorgio Zanotti, Christopher T. Salerno, Nicholas A. Haglund, Andrew J. Sauer, Ashwin K. Ravichandran and Travis Abicht Tags: Research article Source Type: research

PREvention of VENous Thromboembolism in Hemorrhagic Stroke Patients – PREVENTIHS Study: A Randomized Controlled Trial and a Systematic Review and Meta-Analysis
Conclusions: In patients with acute ICH, the use of anticoagulants to prevent VTE was safe but the overall level of evidence was low due to the low number of patients included in randomized clinical trials.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 13, 2020 Category: Neurology Source Type: research

Anticoagulation in COVID-19: Effect of Enoxaparin, Heparin, and Apixaban on Mortality.
Abstract BACKGROUND:  Mortality in coronavirus disease of 2019 (COVID-19) is associated with increases in prothrombotic parameters, particularly D-dimer levels. Anticoagulation has been proposed as therapy to decrease mortality, often adjusted for illness severity. OBJECTIVE:  We wanted to investigate whether anticoagulation improves survival in COVID-19 and if this improvement in survival is associated with disease severity. METHODS:  This is a cohort study simulating an intention-to-treat clinical trial, by analyzing the effect on mortality of anticoagulation therapy chosen in the first ...
Source: Thrombosis and Haemostasis - November 13, 2020 Category: Hematology Authors: Billett HH, Reyes-Gil M, Szymanski J, Ikemura K, Stahl LR, Lo Y, Rahman S, Gonzalez-Lugo JD, Kushnir M, Barouqa M, Golestaneh L, Bellin E Tags: Thromb Haemost Source Type: research

Aminotransferases disorders associated with venous thromboembolic events in patients infected with COVID-19.
CONCLUSIONS: the incidence of aminotransferases disorders associated with acute VTE events in patients infected with COVID-19 is significantThe use of DOACs appear pertinent in these patients. Monitoring of the liver balance should therefore be considered at a distance from the acute episode in the perspective of DOACs relay. PMID: 33130333 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 11, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study.
CONCLUSIONS: Most characteristics of the present MIS-C patients were similar to that of other cohorts. The present results may contribute to a broader understanding of SARS-CoV-2 infection in children and its short-term consequences. Long-term multidisciplinary follow-up is needed, since it is not known whether these patients will have chronic cardiac impairment or other sequelae. PMID: 33186512 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 9, 2020 Category: Pediatrics Authors: Lima-Setta F, Magalhães-Barbosa MC, Rodrigues-Santos G, Figueiredo EADN, Jacques ML, Zeitel RS, Sapolnik R, Borges CTDS, Lanziotti VS, Castro REV, Bellinat APN, Silva TPD, Oliveira FRC, Reis BCSD, Castro NAASR, Macedo JHGC, Scarlato ACCP, Riveiro PM, Mot Tags: J Pediatr (Rio J) Source Type: research

Anticoagulant drug utilization pattern and their cost analysis: a retrospective study from Saudi Arabia
ConclusionApixaban was the preferred oral anticoagulant among all the studied anticoagulants, although Warfarin is the cheapest. Therapeutic drug monitoring was recommended for Warfarin. The study highlights the importance of more studies to measure the advantages and disadvantages of all types of anticoagulants. (Source: Journal of Pharmaceutical Health Services Research)
Source: Journal of Pharmaceutical Health Services Research - November 9, 2020 Category: Drugs & Pharmacology Authors: Mohammad Daud Ali, Ayaz Ahmad, Nuzhat Banu, Munfis Patel, Sherihan Ahmad Ghosn, Zainab Eltrafi Tags: Short Communication Source Type: research

Primary care physicians comprehensively manage acute pulmonary embolism without higher-level-of-care transfer: A report of two cases
This report sets the stage for investigating the public health implications of comprehensive primary care-based PE management, including cost-savings as well as enhanced patient follow-up and patient satisfaction. (Source: Medicine)
Source: Medicine - November 6, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Which Trauma Patients Require Lower Enoxaparin Dosing for Venous Thromboembolism Prophylaxis?
Abstract Trauma patients have a high risk for venous thromboembolism (VTE) such that an increased enoxaparin dose is necessary to reduce related complications. Given that most trauma patients require an enoxaparin dose of at least 40 mg every 12 hours for VTE prophylaxis, we sought to identify which patients require enoxaparin 30 mg every 12 hours and hypothesized that both weight and low creatinine clearance (CrCl) would more likely determine enoxaparin dosing than age, body mass index (BMI), or body surface area (BSA). Single institution data were collected on trauma patients between August 2...
Source: The American Surgeon - November 6, 2020 Category: Surgery Authors: Veatch J, Hashim Y, Dhillon NK, Toscano S, Mason R, Lin TL, Barmparas G, Ley EJ Tags: Am Surg Source Type: research

Primary care physicians comprehensively manage acute pulmonary embolism without higher-level-of-care transfer: A report of two cases.
This report sets the stage for investigating the public health implications of comprehensive primary care-based PE management, including cost-savings as well as enhanced patient follow-up and patient satisfaction. PMID: 33157953 [PubMed - in process] (Source: Pain Physician)
Source: Pain Physician - November 6, 2020 Category: Anesthesiology Authors: Isaacs DJ, Johnson EJ, Hofmann ER, Rangarajan S, Vinson DR Tags: Medicine (Baltimore) Source Type: research

Biclonal gammopathay in a case of severe COVID-19.
Abstract COVID-19 is a disease caused by a coronavirus named as SARS-CoV-2. It has become pandemic due to its contagious nature. Majority of the patients are asymptomatic or having mild flu like symptoms. Few need hospitalisation due to severe acute respiratory infection (SARI). Co-morbidity like diabetes, hypertension, renal failure etc. are associated with severe COVID-19 that often causes death. There have been only two published case reports of monoclonal gammopathy of unknown significance (MGUS) in patients with COVID-19 disease. Cytokine storm is often observed in severe COVID-19 and various cytokines includ...
Source: International Journal of Clinical Chemistry - November 4, 2020 Category: Chemistry Authors: Vashistha P, Gupta A, Arya M, Kumar Singh V, Dubey A, Chandra Koner B Tags: Clin Chim Acta Source Type: research

Antiplatelets/enoxaparin-sodium
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2020 Category: Drugs & Pharmacology Source Type: research

Kawasaki-like disease in children with COVID-19
In this study, we investigated children with typical and atypical Kawasaki disease (KD) likely to be associated with COVID-19. We have reported four children with Kawasaki-like disease probably associated with COVID-19. The clinical features were consistent with incomplete KD in three patients. SARS-CoV-2 RT-PCR was positive in one and the serology was positive in one patient with negative RT-PCR. Corticosteroids, anakinra, intravenous immunoglobulin (IVIG), and acetylsalicylic acid were used in the treatment. Three patients recovered after the treatment while one patient died. The literature review revealed 36 articles de...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Comparision of side effects between thrombolytic and anticoagulation therapy in patients with Pulmonary Embolism
Conclusion: According to our results; major hemorrhage observed similar in thrombolytic, enoxaparin and warfarin therapy. Study results about the rate of cerebral hemorrhage related to thrombolytic therapy was low in contrast to the results reported in some literature before. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kilic, H., Hasanoglu, H. C., Karalezli, A., Hezer, H., Babaoglu, E., Er, M., Parlak, E. S., Abuzaina, O., Oztuna, D., Arguder, E. Tags: Pulmonary embolism Source Type: research

Safety and effectiveness of biosimilar enoxaparin (Inhixa) for the prevention of thromboembolism in medical and surgical inpatients
AbstractIn 2016, biosimilar enoxaparin (Inhixa®, Techdow) was introduced in European markets with the same indications as branded enoxaparin (Clexane®, Sanofi). Its use is constantly increasing in clinical practice, however, little information from post-marketing clinical trials is available on its safety and effectiveness. We conducted an observational, retrospective study to assess the safety and effectiveness of Inhixa in preventing venous thromboembolism (VTE) in medically ill patients and in patients undergoing major abdominal surgery. We then compared our results with the incidence of symptomatic VTE and blee...
Source: Internal and Emergency Medicine - October 27, 2020 Category: Emergency Medicine Source Type: research

Rectus sheath hematoma in patients receiving subcutaneous enoxaparin: A case series of five patients
Physicians must acknowledge the potential risk of RSH with enoxaparin. Switching home anticoagulation by enoxaparin upon hospital admission is common, but it may put patients at higher risk for RSH. Management guidelines are needed in this setting. AbstractPhysicians must acknowledge the potential risk of RSH with enoxaparin. Switching home anticoagulation by enoxaparin upon hospital admission is common, but it may put patients at higher risk for RSH. Management guidelines are needed in this setting. (Source: Clinical Case Reports)
Source: Clinical Case Reports - October 27, 2020 Category: General Medicine Authors: Diogo Mendes, Ana Penedones, Michele Martins, Susana Cavadas, Carlos Alves, Francisco Batel ‐Marques Tags: CASE REPORT Source Type: research

Thrombocytopenia-Related Problems in Patients with Concomitant Atrial Fibrillation Requiring Antithrombotic Prevention: A Retrospective Cohort Study
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorr&eci...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Temporal Evolution of the iFR (Instantaneous Wave-Free Ratio) Employment Results Analysis
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorr&eci...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Update of the Brazilian Guidelines for Valvular Heart Disease – 2020
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorr&eci...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Statement – Protocol for the Reconnection of Cardiology Services with Patients During the COVID-19 Pandemic – 2020
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorr&eci...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Erratum
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorr&eci...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Enoxaparin related spontaneous fatal retroperitoneal hemorrhage in a patient with atrial fibrillation.
Authors: Oh TH, Jung H, Lee Y Abstract Spontaneous retroperitoneal hemorrhage (SRH) is a potentially lethal complication of anticoagulation therapy. The signs and symptoms vary from clinical silence to abdominal pain or hemorrhagic shock. The diagnosis of SRH may be difficult, especially in its early clinical course, due to its varied symptoms. Physicians need to have a high degree of suspicion for its early diagnosis. Delayed diagnosis of SRH can lead to serious complications or death. Bleeding complications in anticoagulated patients are well known; however, reports about SRH with fatal outcomes are sporadic. Her...
Source: Reviews in Cardiovascular Medicine - October 21, 2020 Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research

Venous thromboembolism and COVID-19: a case report and  review of the literature
ConclusionAs COVID-19 continues to lead to significant mortality, more data is emerging that is exposing its perplexing pathogenicity. Meanwhile, the presentation of venous thromboembolism in patients with COVID-19 remains an unusual finding. It is imperative for health care providers to be mindful of this unique association to make necessary diagnostic evaluations and provide appropriate treatment for the patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - October 15, 2020 Category: General Medicine Source Type: research

Higher Intensity Thromboprophylaxis Regimens and Pulmonary Embolism in Critically Ill Coronavirus Disease 2019 Patients
Conclusions: In this study, one third of coronavirus disease 2019 mechanically ventilated patients have a pulmonary embolism visible on CT pulmonary angiography. High regimen thromboprophylaxis may decrease the occurrence of such complication. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 14, 2020 Category: Emergency Medicine Tags: Online Brief Reports Source Type: research

Superior ophthalmic vein thrombosis post manual carotid compression for indirect carotid-cavernous fistula.
CONCLUSION: SOVT is a rare but possible complication in patients on IMCC for indirect CCF, and hence warrants close follow up. Early diagnosis and prompt management will help in preventing complications like permanent vision loss. PMID: 33032482 [PubMed - as supplied by publisher] (Source: Orbit)
Source: Orbit - October 9, 2020 Category: Opthalmology Authors: Salim S, Koka K, Halbe S, Nisar SP, Singh P, Mukherjee B Tags: Orbit Source Type: research

Incidence of Silent Deep Venous Thrombosis after Laparoscopic Bariatric Surgery in Patients Who Received Combined Mechanical and Chemical Thromboprophylaxis Compared to Patients Who Received Mechanical Thromboprophylaxis Only.
Conclusion. Combined mechanical and mechanical thromboprophylaxis is effective and safe in the prevention of silent DVT after laparoscopic bariatric surgery. Trial registration: The trial was registered in the Thai Clinical Trials Registry (TCTR20200127002) on January 20, 2020 retrospectively. PMID: 33035103 [PubMed - as supplied by publisher] (Source: Surgical Innovation)
Source: Surgical Innovation - October 9, 2020 Category: Surgery Authors: Ahmad KS, Zayed ME, Faheem MH, Essa MS Tags: Surg Innov Source Type: research

Elevated eosinophil count is related with lower anti-factor Xa activity in COVID-19 patients
This study aimed to evaluate the factors influencing anti-factor Xa activity in COVID-19 patients receiving low molecular weight heparin (LMWH). We prospectively evaluated 80 COVID-19 patients, diagnosed using polymerase chain reaction test, who were admitted to our clinic and administered LMWH; LMWH (enoxaparin) was applied according to the weight, D-dimer levels, and clinical condition of patients. Anti-factor Xa activity in blood, drawn 4  h after the 3rd dose of LMWH, was measured and an activity of  4%, 6 were in group 1 ((6/13) 46.2%), while 8 were in group 2 ((8/63) 11.9%); (p = 0.009), and...
Source: Journal of Hematopathology - October 8, 2020 Category: Pathology Source Type: research

Acute Kidney Injury During Hospitalization Increases the Risk for Venous Thromboembolism.
Abstract BACKGROUND: Kidney disease has been linked to risk for hospitalization related venous thromboembolism (HR-VTE), but the effect size and differences across types of kidney disease are poorly described. RESEARCH QUESTION: We sought to quantify the risk for HR-VTE among patients with acute kidney injury (AKI) and chronic kidney disease (CKD). STUDY DESIGN AND METHODS: We prospectively collected data on hospitalized adult patients and documented HR-VTE events. We recorded creatinine clearance (CrCl) daily throughout hospitalization, and modeled the effects that admission CrCl, peak CrCl, average CrC...
Source: Chest - October 5, 2020 Category: Respiratory Medicine Authors: McMahon MJ, Collen JF, Chung KK, Stewart IJ, Al-Eid H, Moores LK, Holley AB Tags: Chest Source Type: research

Fondaparinux Use in Patients With COVID-19: A Preliminary Multicenter Real-World Experience
Abstract: The use of heparin has been shown to decrease the mortality in hospitalized patients with severe COVID-19. The aim of our study was to evaluate the clinical impact of venous thromboembolism prophylaxis with fondaparinux versus enoxaparin among 100 hospitalized COVID-19 patients. The incidence of pulmonary embolism, deep venous thrombosis, major bleeding (MB), clinically relevant non-MB, acute respiratory distress syndrome, and in-hospital mortality was compared between patients on fondaparinux versus enoxaparin therapy. The 2 groups were homogeneous for demographic, laboratory, and clinical characteristics. In ...
Source: Journal of Cardiovascular Pharmacology - October 1, 2020 Category: Cardiology Tags: Rapid Communication Source Type: research

Is Weight-Based Enoxaparin Dosing Safe to Use in the Setting of Traumatic Brain Injury?
Enoxaparin is the established treatment modality for deep vein thrombosis (DVT) chemoprophylaxis in trauma patients. Current literature suggests that weight-based dosing is superior to standard dosing for adequate chemoprophylaxis. While Brain Trauma Foundation supports the need for chemoprophylaxis, it does not have a specific recommendation for drug of choice or dosing. Additionally, there is limited literature regarding the use of weight-based enoxaparin in the setting of traumatic brain injury (TBI). (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - September 30, 2020 Category: Surgery Authors: Cassandra Q. White Tags: Trauma Source Type: research

Society for Maternal-Fetal Medicine Consult Series #51: thromboembolism prophylaxis for cesarean delivery
We appreciate the detailed, evidenced-based review of thromboprophylaxis for cesarean delivery in “The Society for Maternal Medicine Consult Series #51: thromboembolism prophylaxis for cesarean delivery.” In their recommendations, the authors state, “Compared with UFH [unfractionated heparin], enoxaparin has the advantage of better bioavailability, longer half-life, more predictable antico agulation effect, less bleeding risks, and less risk of heparin-induced thrombocytopenia and osteopenia. We recommend the use of LMWH [low molecular weight heparin] as the preferred thromboprophylactic agent in pregnanc...
Source: American Journal of Obstetrics and Gynecology - September 23, 2020 Category: OBGYN Authors: Alexander M. Friedman, Mary D ’Alton Tags: Letter to the Editors Source Type: research

Rationale and Design of the H-REPLACE Study: Safety and Efficacy of LMWH Versus Rivaroxaban in ChinEse Patients HospitaLized with Acute Coronary SyndromE
ConclusionsThe H-REPLACE trial offers an opportunity to assess clinical outcomes of rivaroxaban versus enoxaparin during the acute phase of ACS and may provide an alternative anticoagulation strategy for ACS patients, who missed the primary reperfusion therapy window and before selective revascularization.Trial RegistrationClinicalTrials.gov; NCT03363035. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 22, 2020 Category: Cardiology Source Type: research

The hazard of fondaparinux in non-critically ill patients with COVID-19: Retrospective controlled study versus enoxaparin
COVID-19 (acronym of COronaVIrus Disease 2019) is an infectious respiratory disease, responsible for a worldwide pandemic, with a high rate of venous and arterial thrombotic complications. These complications have recently been reported to occur in patients with COVID-19 disease regardless of the use of prophylactic doses of low-molecular-weight heparin (LMWH) [1,2]. Although their incidence is higher in the most severe patients, it has been reported to be substantial also in those with less severe disease [1,3,4]. (Source: Thrombosis Research)
Source: Thrombosis Research - September 16, 2020 Category: Hematology Authors: Paolo Prandoni, Anna Maria Cattelan, Laura Carrozzi, Lucia Leone, Lucia Filippi, Egidio De Gaudenzi, Sabina Villalta, Raffaele Pesavento, for the FONDACOVIT Investigators [all in Italy] Tags: Letter to the Editors-in-Chief Source Type: research

Use of Enoxaparin to Counteract COVID-19 Infection and Reduce Thromboembolic Venous Complications: A Review of the Current Evidence
The impact of the COVID-19 pandemic has been dramatic worldwide, with China, Italy, and now US at its epicenter. Researchers and clinicians are studying and testing different approaches in the attempt to prevent the infection and minimize its severity. Major efforts are focused on optimizing mechanical ventilation, antiviral, and supportive treatment; however, the role of heparin and low molecular weight (LMW) heparin in this setting has been largely overlooked. This review summarizes the available evidence about the role of heparan sulfate as a key entry mechanism for SARS-CoV-2; the efficacy of heparin and LMW heparin in...
Source: Frontiers in Pharmacology - September 15, 2020 Category: Drugs & Pharmacology Source Type: research

Practical Considerations for the Management of Cushing's Disease and COVID-19: A Case Report
Conclusion: Adrenal insufficiency might be a clinical challenge that needs a prompt treatment also in CS patients during COVID-19 infection. We should consider the possibility to titrate or temporary halt medical therapies of CS in the context of COVID-19 infection. Unexpected hyperkalemia in CS patients under treatment with heparin might be the signal of aldosterone suppression. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - September 10, 2020 Category: Endocrinology Source Type: research

Weight-Based Enoxaparin Achieves Adequate Anti-Xa Levels More Often in Trauma Patients: A Prospective Study.
Abstract BACKGROUND: Previous research demonstrates that twice-daily enoxaparin is inadequate for venous thromboembolic (VTE) prophylaxis in critically ill trauma patients prompting dose adjustment based on anti-Xa levels. Most studies evaluate peak anti-Xa levels; however, data suggest that trough levels are associated with decreased VTE. We evaluated trough anti-Xa levels in noncritically ill trauma patients receiving fixed or weight-based enoxaparin. METHODS: Peak and trough anti-Xa levels were prospectively collected from patients receiving at least 3 consecutive doses of enoxaparin (PRE). A performance i...
Source: The American Surgeon - September 10, 2020 Category: Surgery Authors: Stutsrim AE, Eady JM, Collum M, Rebo GJ, Rebo KA, Miller PR, Nunn AM Tags: Am Surg Source Type: research

Anticoagulation Strategies in the Management of Lemierre Syndrome: A Systematic Review of the Literature.
CONCLUSIONS: Anticoagulation is both efficacious and safe in LS, including treatment using a DOAC. Although further studies are needed, clinicians should consider a duration of anticoagulation of 6 to 12 weeks. PMID: 32909436 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 9, 2020 Category: Drugs & Pharmacology Authors: Adedeji A, Chukwura O, Obafemi T, McNulty SB, Reinert JP Tags: Ann Pharmacother Source Type: research

Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial
The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral di... (Source: Trials)
Source: Trials - September 9, 2020 Category: General Medicine Authors: Stefano Barco, Roland Bingisser, Giuseppe Colucci, Andr é Frenk, Bernhard Gerber, Ulrike Held, Francois Mach, Lucia Mazzolai, Marc Righini, Thomas Rosemann, Tim Sebastian, Rebecca Spescha, Stefan Stortecky, Stephan Windecker and Nils Kucher Tags: Letter Source Type: research

Liver Injury Among Japanese Patients Treated Using Prophylactic Enoxaparin After Colorectal Surgery
This study aimed to clarify the relationship between prophylactic enoxaparin and  liver injury after colorectal surgery, and characterize the injury profile.MethodsWe retrospectively reviewed 732 Japanese patients who underwent elective resection of the colorectum, and compared their clinicopathological background, details of surgery, postoperative complications, including liver injury, and the type of liver injury according to prophylactic use of enoxaparin. Univariate and multivariate analyses were performed to identify risk factors for liver injury during the postoperative period.ResultsThe rate of liver injury was...
Source: Digestive Diseases and Sciences - September 4, 2020 Category: Gastroenterology Source Type: research

Effect of 3 different anticoagulants on hidden blood loss during total hip arthroplasty after tranexamic acid
Comparison of different anticoagulants in blood management and complications with tranexamic acid (TXA) in total hip arthroplasty (THA) is unclear. Our aim was to compare the efficacy and safety among receiving nadroparin calcium, enoxaparin sodium or rivaroxaban after TXA in THA. 150 patients undergoing primary unilateral THA were received 15 mg/kg intravenous TXA (IV-TXA) before skin incision, followed by 1 of nadroparin calcium (Group A), enoxaparin sodium (Group B), or rivaroxaban (Group C) randomly during hospitalization. The primary outcome was hidden blood loss (HBL). Other outcomes such as the maximum hemoglobin...
Source: Medicine - September 4, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Anticoagulant drug utilization pattern and their cost analysis: a retrospective study from Saudi Arabia
ConclusionApixaban was the preferred oral anticoagulant among all the studied anticoagulants, although Warfarin is the cheapest. Therapeutic drug monitoring was recommended for Warfarin. The study highlights the importance of more studies to measure the advantages and disadvantages of all types of anticoagulants. (Source: Journal of Pharmaceutical Health Services Research)
Source: Journal of Pharmaceutical Health Services Research - September 1, 2020 Category: Drugs & Pharmacology Authors: Mohammad Daud Ali, Ayaz Ahmad, Nuzhat Banu, Munfis Patel, Sherihan Ahmad Ghosn, Zainab Eltrafi Tags: Short Communication Source Type: research

Incidence of Venous Thromboembolism following Knee Arthroscopy: Effectiveness of a Risk-Based Stratified Chemoprophylaxis Protocol
This study found that a chemoprophylaxis protocol with preferential use of aspirin or low–molecular weight heparin based on risk factors reduced the VTE incidence below to 2.0%, which is lower than most historical controls. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Knee Surgery)
Source: Journal of Knee Surgery - August 30, 2020 Category: Orthopaedics Authors: Reynolds, Alan W. Garay, Mariano Lynch, Scott Black, Kevin P. Gallo, Robert A. Tags: Original Article Source Type: research

Once-daily vs. twice-daily dosing of enoxaparin for the management of venous thromboembolism: A systematic review and meta-analysis.
Authors: Niu J, Song Y, Li C, Ren H, Zhang W Abstract The present study aimed to determine whether there is any difference in the efficacy and safety of once-daily vs. twice-daily enoxaparin when used for the initial treatment of venous thromboembolism (VTE). The PubMed, Embase, Cochrane Central Register of Controlled Trials, Science Direct and Google Scholar databases were searched for studies comparing once-daily and twice-daily enoxaparin for the initial treatment of VTE added from inception up to 1st October 2019. Studies utilizing any other low-molecular-weight heparin and using enoxaparin for VTE prophylaxis ...
Source: Experimental and Therapeutic Medicine - August 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Low-Molecular-Weight Heparin and Fondaparinux Use in Pediatric Patients With Obesity.
CONCLUSION: Pediatric patients with obesity may benefit from proactively adjusting enoxaparin dosing on initiation of therapy. Further studies are needed for dalteparin and fondaparinux in these populations. Clinical controversy exists with the relevance of monitoring these high-risk medications for therapeutic and prophylactic indications. Thrombotic and hemorrhagic events were similar to reported adult outcomes. PMID: 32864984 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 29, 2020 Category: Drugs & Pharmacology Authors: Garner MP, Onuoha CP, Fenn NE Tags: Ann Pharmacother Source Type: research

SARS-CoV-2 Trasmission and Outcome in Neuro-rehabilitation patients hospitalized at Neuroscience Hospital in Italy
Conclusions:  In 13 out of 14 patients, the infection was asymptomatic; this is particularly intriguing considering their severe neurological clinical profile. According to the pivotal role played by inflammation and activation of blood coagulation in the pathogenesis of COVID-19, the anti-inflammatory and anticoagulant properties of enoxaparin, administered much earlier and during infection, could have favored an extremely benign disease course in these patients at high risk of poor outcome.Keywords: SARS CoV 2, neurological patients, neurological damage, Infection, Coronavirus   (Source: Mediterranean Jour...
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2020 Category: Hematology Authors: Francesco Di Gennaro Source Type: research

SARS-CoV-2 Transmission and Outcome in Neuro-rehabilitation patients hospitalized at Neuroscience Hospital in Italy
Conclusions:  In 13 out of 14 patients, the infection was asymptomatic; this is particularly intriguing considering their severe neurological clinical profile. According to the pivotal role played by inflammation and activation of blood coagulation in the pathogenesis of COVID-19, the anti-inflammatory and anticoagulant properties of enoxaparin, administered much earlier and during infection, could have favored an extremely benign disease course in these patients at high risk of poor outcome.Keywords: SARS CoV 2, neurological patients, neurological damage, Infection, Coronavirus   (Source: Mediterranean Jour...
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2020 Category: Hematology Authors: Francesco Di Gennaro Source Type: research

Coronavirus disease 2019 (COVID-19) in a patient with ankylosing spondylitis treated with secukinumab: a case-based review
AbstractSevere acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potential risks of SARS-CoV-2 for this particular patient group. However, less is known with regard to the course of COVID-19 among patients receiving IL-17 inhibitors. The aim of the current article is to review the growing body of knowledge on the course/management of COVID-19 in patients with inflammatory ...
Source: Rheumatology International - August 28, 2020 Category: Rheumatology Source Type: research

One Size Does Not Fit All: Venous Thromboembolism Prophylaxis in Colorectal Cancer.
Conclusions: Patients with similar pre-operative comorbidities have various venous thromboembolism perioperative prophylaxis regimens prescribed. Despite prescription variations, VTE rates remain negligible. Patients with different comorbid conditions may require alterations to the traditionally prescribed 40 mg enoxaparin daily. Upon discharge, aspirin 81 mg with 40 mg of enoxaparin daily for high-risk patients shows benefits, but requires further investigation. PMID: 32831542 [PubMed - in process] (Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons)
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - August 26, 2020 Category: Surgery Tags: JSLS Source Type: research