Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
Lovastatin has widespread applications thanks to its multiple pharmacological effects. Fermentation by filamentous fungi represents the major way of lovastatin production. However, the current lovastatin produ... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - May 9, 2024 Category: Microbiology Authors: Han Na, Yao-yao Zheng, Yaoning Jia, Jingzhao Feng, Jizi Huang, Jihao Huang, Chang-Yun Wang and Guangshan Yao Tags: Research Source Type: research

Estrogen induces LCAT to maintain cholesterol homeostasis and suppress hepatocellular carcinoma development
Cancer Res. 2024 May 8. doi: 10.1158/0008-5472.CAN-23-3966. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is an aggressive disease that occurs predominantly in men. Estrogen elicits protective effects against HCC development. Elucidation of the estrogen-regulated biological processes that suppress HCC could lead to improved prevention and treatment strategies. Here, we performed transcriptomic analyses on mouse and human liver cancer and identified LCAT as the most highly estrogen-upregulated gene and a biomarker of favorable prognosis. LCAT upregulation inhibited HCC in vitro and in vivo and mediated estrog...
Source: Cell Research - May 8, 2024 Category: Cytology Authors: Wenzhi He Min Wang Xuechun Zhang Yilan Wang Dongli Zhao Wenhua Li Fang Lei Min Peng Zhonglin Zhang Yufeng Yuan Zan Huang Source Type: research

A Novel Combination Therapy Targets Sonic Hedgehog Signaling by the Dual Inhibition of HMG-CoA Reductase and HSP90 in Rats with Non-Alcoholic Steatohepatitis
In conclusion, exploring the applicability of this combination contributes to a more comprehensive understanding and improved management of NASH and other fibrotic disorders.PMID:38714237 | DOI:10.1016/j.ejps.2024.106792 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - May 7, 2024 Category: Drugs & Pharmacology Authors: Osama A Mohammed Mahmoud E Youssef Ahmed S Doghish Rabab S Hamad Mustafa Ahmed Abdel-Reheim Mushabab Alghamdi Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Abdullah Hassan Alhalafi Emad Bahashwan Assad Ali Rezigalla Daad Source Type: research

A Novel Combination Therapy Targets Sonic Hedgehog Signaling by the Dual Inhibition of HMG-CoA Reductase and HSP90 in Rats with Non-Alcoholic Steatohepatitis
In conclusion, exploring the applicability of this combination contributes to a more comprehensive understanding and improved management of NASH and other fibrotic disorders.PMID:38714237 | DOI:10.1016/j.ejps.2024.106792 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - May 7, 2024 Category: Drugs & Pharmacology Authors: Osama A Mohammed Mahmoud E Youssef Ahmed S Doghish Rabab S Hamad Mustafa Ahmed Abdel-Reheim Mushabab Alghamdi Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Abdullah Hassan Alhalafi Emad Bahashwan Assad Ali Rezigalla Daad Source Type: research

A novel combination therapy targets sonic hedgehog signaling by the dual inhibition of HMG-CoA reductase and HSP90 in rats with non-alcoholic steatohepatitis
In conclusion, exploring the applicability of this combination contributes to a more comprehensive understanding and improved management of NASH and other fibrotic disorders.PMID:38714237 | DOI:10.1016/j.ejps.2024.106792 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - May 7, 2024 Category: Drugs & Pharmacology Authors: Osama A Mohammed Mahmoud E Youssef Ahmed S Doghish Rabab S Hamad Mustafa Ahmed Abdel-Reheim Mushabab Alghamdi Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Abdullah Hassan Alhalafi Emad Bahashwan Assad Ali Rezigalla Daad Source Type: research

Study of active components and mechanisms mediating the hypolipidemic effect of < em > Inonotus obliquus < /em > polysaccharides
Food Sci Nutr. 2024 Feb 6;12(4):2833-2845. doi: 10.1002/fsn3.3964. eCollection 2024 Apr.ABSTRACTHyperlipidemia is a multifaceted metabolic disease, which is the major risk factor for atherosclerosis and cardiovascular diseases. Traditional Chinese medicine provides valuable therapeutic strategies in the treatment of hyperlipidemia. Inonotus obliquus has been used in traditional medicine to treat numerous diseases for a long time. To screen and isolate the fractions of I. obliquus polysaccharides (IOP) that can reduce blood lipid in the hyperlipemia animals and cell models, and investigate its mechanisms. The active compone...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Guanwen Ding Xiao Guo Xiao Li Liping An Huawen Shi Source Type: research

Study of active components and mechanisms mediating the hypolipidemic effect of < em > Inonotus obliquus < /em > polysaccharides
Food Sci Nutr. 2024 Feb 6;12(4):2833-2845. doi: 10.1002/fsn3.3964. eCollection 2024 Apr.ABSTRACTHyperlipidemia is a multifaceted metabolic disease, which is the major risk factor for atherosclerosis and cardiovascular diseases. Traditional Chinese medicine provides valuable therapeutic strategies in the treatment of hyperlipidemia. Inonotus obliquus has been used in traditional medicine to treat numerous diseases for a long time. To screen and isolate the fractions of I. obliquus polysaccharides (IOP) that can reduce blood lipid in the hyperlipemia animals and cell models, and investigate its mechanisms. The active compone...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Guanwen Ding Xiao Guo Xiao Li Liping An Huawen Shi Source Type: research

Retracted: "Lovastatin Inhibits RhoA to Suppress Canonical Wnt/ β-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer"
Cell Transplant. 2024 Jan-Dec;33:9636897241246903. doi: 10.1177/09636897241246903.NO ABSTRACTPMID:38581246 | DOI:10.1177/09636897241246903 (Source: Cell Transplantation)
Source: Cell Transplantation - April 6, 2024 Category: Cytology Source Type: research

Retracted: "Lovastatin Inhibits RhoA to Suppress Canonical Wnt/ β-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer"
Cell Transplant. 2024 Jan-Dec;33:9636897241246903. doi: 10.1177/09636897241246903.NO ABSTRACTPMID:38581246 | PMC:PMC10999123 | DOI:10.1177/09636897241246903 (Source: Cell Transplantation)
Source: Cell Transplantation - April 6, 2024 Category: Cytology Source Type: research

Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42
Pharmacol Res. 2024 Mar 30:107165. doi: 10.1016/j.phrs.2024.107165. Online ahead of print.ABSTRACTThe clinical use of the DNA damaging anticancer drug doxorubicin (DOX) is limited by irreversible cardiotoxicity, which depends on the cumulative dose applied. The RAS-homologous (RHO) small GTPase RAC1 contributes to DOX-induced DNA damage formation and cardiotoxicity. However, the pathophysiological relevance of other RHO GTPases than RAC1 and different cardiac cell types (i.e., cardiomyocytes, non-cardiomyocytes) for DOX-triggered cardiac damage is unclear. Employing diverse in vitro and in vivo models, we comparatively inv...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Pelin K ücük Lena Abbey Joachim Schmitt Christian Henninger Gerhard Fritz Source Type: research

The serine/threonine protein kinase MpSTE1 directly governs hyphal branching in Monascus spp
Appl Microbiol Biotechnol. 2024 Mar 6;108(1):255. doi: 10.1007/s00253-024-13093-7.ABSTRACTMonascus spp. are commercially important fungi due to their ability to produce beneficial secondary metabolites such as the cholesterol-lowering agent lovastatin and natural food colorants azaphilone pigments. Although hyphal branching intensively influenced the production of these secondary metabolites, the pivotal regulators of hyphal development in Monascus spp. remain unclear. To identify these important regulators, we developed an artificial intelligence (AI)-assisted image analysis tool for quantification of hyphae-branching and...
Source: Applied Microbiology and Biotechnology - March 6, 2024 Category: Microbiology Authors: Yali Duan Xizhu Chen Tingya Wang Mu Li Source Type: research

The serine/threonine protein kinase MpSTE1 directly governs hyphal branching in Monascus spp
Appl Microbiol Biotechnol. 2024 Mar 6;108(1):255. doi: 10.1007/s00253-024-13093-7.ABSTRACTMonascus spp. are commercially important fungi due to their ability to produce beneficial secondary metabolites such as the cholesterol-lowering agent lovastatin and natural food colorants azaphilone pigments. Although hyphal branching intensively influenced the production of these secondary metabolites, the pivotal regulators of hyphal development in Monascus spp. remain unclear. To identify these important regulators, we developed an artificial intelligence (AI)-assisted image analysis tool for quantification of hyphae-branching and...
Source: Applied Microbiology and Biotechnology - March 6, 2024 Category: Microbiology Authors: Yali Duan Xizhu Chen Tingya Wang Mu Li Source Type: research

Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
CONCLUSION: Lovastatin impairs cellular proliferation but enhances HA production in human FLSs.PMID:38432573 | DOI:10.1016/j.tiv.2024.105806 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 3, 2024 Category: Toxicology Authors: Wen-Tien Wu Chen-Chie Wang Dai-Hua Lu Kuan-Jung Lu Yu-Chia Chang Kai-Chiang Yang Source Type: research

Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
CONCLUSION: Lovastatin impairs cellular proliferation but enhances HA production in human FLSs.PMID:38432573 | DOI:10.1016/j.tiv.2024.105806 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 3, 2024 Category: Toxicology Authors: Wen-Tien Wu Chen-Chie Wang Dai-Hua Lu Kuan-Jung Lu Yu-Chia Chang Kai-Chiang Yang Source Type: research

Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
CONCLUSION: Lovastatin impairs cellular proliferation but enhances HA production in human FLSs.PMID:38432573 | DOI:10.1016/j.tiv.2024.105806 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - March 3, 2024 Category: Toxicology Authors: Wen-Tien Wu Chen-Chie Wang Dai-Hua Lu Kuan-Jung Lu Yu-Chia Chang Kai-Chiang Yang Source Type: research