Safety of Biological Therapies for Severe Asthma: An Analysis of Suspected Adverse Reactions Reported in the WHO Pharmacovigilance Database
CONCLUSIONS: The most frequently reported suspected ADRs of asthma biologics in VigiBase confirmed the presence of well-known adverse effects such as general disorders, injection-site reactions, nasopharyngitis, headache and hypersensitivity, while some others (e.g. asthma reactivation or therapeutic failure) could be ascribed to the indication of use. Moreover, the analysis of signals of disproportionate reporting suggests the presence of malignancies, effects on the cardiovascular system, alopecia and autoimmune conditions, requiring further assessment and investigation.PMID:38489062 | DOI:10.1007/s40259-024-00653-6 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Paola Maria Cutroneo Elena Arzenton Fabiana Furci Fabio Scapini Maria Bulzom ì Nicoletta Luxi Marco Caminati Gianenrico Senna Ugo Moretti Gianluca Trifir ò Source Type: research
Safety of Biological Therapies for Severe Asthma: An Analysis of Suspected Adverse Reactions Reported in the WHO Pharmacovigilance Database
CONCLUSIONS: The most frequently reported suspected ADRs of asthma biologics in VigiBase confirmed the presence of well-known adverse effects such as general disorders, injection-site reactions, nasopharyngitis, headache and hypersensitivity, while some others (e.g. asthma reactivation or therapeutic failure) could be ascribed to the indication of use. Moreover, the analysis of signals of disproportionate reporting suggests the presence of malignancies, effects on the cardiovascular system, alopecia and autoimmune conditions, requiring further assessment and investigation.PMID:38489062 | DOI:10.1007/s40259-024-00653-6 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Paola Maria Cutroneo Elena Arzenton Fabiana Furci Fabio Scapini Maria Bulzom ì Nicoletta Luxi Marco Caminati Gianenrico Senna Ugo Moretti Gianluca Trifir ò Source Type: research
Pathological changes in oral epithelium and the expression of SARS-CoV-2 entry receptors, ACE2 and furin
by Osnat Grinstein-Koren, Michal Lusthaus, Hilla Tabibian-Keissar, Ilana Kaplan, Amos Buchner, Ron Ilatov, Marilena Vered, Ayelet Zlotogorski-Hurvitz
BackgroundExpression of angiotensin-converting enzyme (ACE)-2 and co-factors like furin, play key-roles in entry of SARS-CoV-2 into host cells. Furin is also involved in oral carcinogenesis. We investigated their expression in oral pre-malignant/malignant epithelial pathologies to evaluate whether ACE2 and furin expression might increase susceptibility of patients with these lesions for SARS-CoV-2 infection. MethodsStudy included normal oral mucosa (N = 14), epithelial hyperp...
Source: PLoS One - March 15, 2024 Category: Biomedical Science Authors: Osnat Grinstein-Koren Source Type: research
Safety of Biological Therapies for Severe Asthma: An Analysis of Suspected Adverse Reactions Reported in the WHO Pharmacovigilance Database
ConclusionsThe most frequently reported suspected ADRs of asthma biologics in VigiBase confirmed the presence of well-known adverse effects such as general disorders, injection-site reactions, nasopharyngitis, headache and hypersensitivity, while some others (e.g. asthma reactivation or therapeutic failure) could be ascribed to the indication of use. Moreover, the analysis of signals of disproportionate reporting suggests the presence of malignancies, effects on the cardiovascular system, alopecia and autoimmune conditions, requiring further assessment and investigation. (Source: BioDrugs)
Source: BioDrugs - March 15, 2024 Category: Drugs & Pharmacology Source Type: research
Downregulation of salivary miR-3928 as a potential biomarker in patients with oral squamous cell carcinoma and oral lichen planus
CONCLUSIONS: The salivary miR-3928 can play a tumor suppressive role in the pathobiology of OSCC, and it is significantly downregulated in patients. According to the potential tumor suppressive role of miR-3928 in the OSCC process, we can consider this microRNA as a biomarker for future early diagnosis, screening, and potential target therapy.PMID:38481355 | DOI:10.1002/cre2.877 (Source: Cell Research)
Source: Cell Research - March 14, 2024 Category: Cytology Authors: Alieh Farshbaf Farnaz Mohajertehran Seyed Hamid Aghaee-Bakhtiari Hossein Ayatollahi Katayoun Douzandeh Atessa Pakfetrat Nooshin Mohtasham Source Type: research
Lichen planus triggered by COVID-19 vaccination: A case series
We present a case series of lichen planus that appeared after receiving the COVISHIELD vaccine from Oxford-AstraZeneca. In order to rule out any further potential triggers, like recent infections, prior drug use, smoking, dental treatments, etc., a thorough history was collected in each instance. Skin biopsies were used to confirm each case's diagnosis. In nearly all of the cases, skin biopsies revealed typical dermatopathological features of lichen planus.PMID:38482327 | PMC:PMC10931865 | DOI:10.4103/jfmpc.jfmpc_664_23 (Source: Primary Care)
Source: Primary Care - March 14, 2024 Category: Primary Care Authors: Murali Narasimhan Ramachandran Ramakrishnan Divya Sree Varri Muthubharathi Sivasubramanian Source Type: research
Association between Vitamin D Receptor Polymorphism and Susceptibility to Oral Lichen Planus and Oral Squamous Cell Carcinoma
CONCLUSION: There was a positive association between rs7975232 VDR polymorphism and susceptibility to OSCC. More experimental evidence must reveal the possible association between rs7975232 and the risk of OLP in a larger cohort.PMID:38476562 | PMC:PMC10925961 | DOI:10.22038/IJORL.2024.73925.3489 (Source: Cancer Control)
Source: Cancer Control - March 13, 2024 Category: Cancer & Oncology Authors: Nooshin Mohtasham Farnaz Mohajertehran Fahimeh Afzaljavan Alieh Farshbaf Kiumars Maraqehmoqadam Maryam Tavakoliroodi Majid Mirhashemi Source Type: research
The efficacy and safety of deucravacitinib compared to methotrexate, in patients with vulvar lichen planus who have failed topical therapy with potent corticosteroids: a study protocol for a single-centre double-blinded randomised controlled trial
Vulvar lichen planus (VLP) is a chronic vulvar dermatosis that is difficult to treat and can severely impair quality of life in the absence of adequate treatment. There is a lack of high-quality evidence to di... (Source: Trials)
Source: Trials - March 12, 2024 Category: General Medicine Authors: Marlene Wijaya, Gayle Fischer and Rebecca Bronwyn Saunderson Tags: Study protocol Source Type: research
Lichen Planus Follicularis Tumidus of the Vulva
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 8, 2024 Category: OBGYN Authors: Denali E. TERMIN, Kathryn C. WELCH, Hope K. HAEFNER, Lynette J. MARGESSON, Maxwell D. WANG, Natalie A. SAUNDERS, Ebony C. PARKER-FEATHERSTONE Tags: Images in Gynecology Source Type: research
Immunophenotypic and Gene Expression Analyses of the Inflammatory Microenvironment in High-Grade Oral Epithelial Dysplasia and Oral Lichen Planus
ConclusionsThe immune microenvironment distinguishes OED and OLP, suggesting diagnostic potential. Upregulated genes indicate cytotoxic immune response in OED. Downregulation ofTRADD,CX3CL1, andILI24 implies dysregulation inTNFR1 signaling, immune recruitment, and tumor suppression. This study contributes to the foundation for understanding immune interactions in OED and OLP, offering insights into future objective diagnostic avenues. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 8, 2024 Category: Pathology Source Type: research
Highlighting the Link Between Lichen Planus Pigmentosus and Frontal Fibrosing Alopecia
J Drugs Dermatol. 2024 Mar 1;23(3):196-198. doi: 10.36849/jdd.0324.NO ABSTRACTPMID:38443129 | DOI:10.36849/jdd.0324 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - March 5, 2024 Category: Dermatology Authors: Sara Abdel Azim Cleo Whiting Adam Friedman Source Type: research
