Dexamethasone solution and dexamethasone in Mucolox for the treatment of oral lichen planus: a preliminary study
Publication date: Available online 25 March 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Alessandro Villa, Vidya Sankar, Gus Bassani, Lisa Bennett Johnson, Herve Sroussi (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - March 25, 2020 Category: ENT & OMF Source Type: research

HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus
Publication date: Available online 20 March 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Fang Wang, Jing Zhang, Gang Zhou (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - March 20, 2020 Category: Biochemistry Source Type: research

Validity, reliability and optimisation of the TOPICOP questionnaire for oral lichen planus.
Conclusions: The optimised TOPICOP scale proved valuable as a PROM in OLP. TCs phobia can be a real consideration in OLP, nonetheless, it does not appear to be an impediment to treatment adherence. PMID: 32189543 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - March 19, 2020 Category: Dentistry Authors: Lorenzo-Pouso AI, Rodríguez-González F, Blanco-Carrión A, García-García A, Chamorro-Petronacci C, López-Jornet P, Pérez-Sayáns M Tags: Acta Odontol Scand Source Type: research

Evaluation of synuclein- γ levels by novel monoclonal antibody in saliva and cancer tissues from oral squamous cell carcinoma patients.
Evaluation of synuclein-γ levels by novel monoclonal antibody in saliva and cancer tissues from oral squamous cell carcinoma patients. Neoplasma. 2020 Mar 18;: Authors: Wang K, Shen Y, Xu J, Li Z, Liu Y, Yu C, Peng L, Zheng J, Zeng Y Abstract The clinical value of synuclein-γ (SNCG) in oral squamous cell carcinoma (OSCC) was evaluated by detecting the expression of SNCG in saliva and tissues and its correlation with clinicopathological parameters (age, gender, ethnicity, degree of differentiation, clinical stage and lymph node metastasis). Salivary samples were collected from 79 patients w...
Source: Neoplasma - March 18, 2020 Category: Cancer & Oncology Authors: Wang K, Shen Y, Xu J, Li Z, Liu Y, Yu C, Peng L, Zheng J, Zeng Y Tags: Neoplasma Source Type: research

Erosive Lichen Planus on the Extremities During Combination Therapy with Nivolumab and Radiation: A Second Case Report.
PMID: 32176308 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 16, 2020 Category: Dermatology Authors: Katsuo K, Honda T, Komori T, Kaku Y, Kabashima K Tags: Acta Derm Venereol Source Type: research

A pilot study: a possible implication of Candida as an etiologically endogenous pathogen for oral lichen planus
The aim of this study was to investigate the prevalence and genotypic profiles of Candida albicans in patients with oral lichen planus (OLP). (Source: BMC Oral Health)
Source: BMC Oral Health - March 14, 2020 Category: Dentistry Authors: Hong He, Xinyu Xia, Haiping Yang, Qiao Peng and Jiaoer Zheng Tags: Research article Source Type: research

[Successful combination of topical corticosteroids and trichloroacetic acid for the treatment of verrucous lichen planus].
CONCLUSION: The combination of TCA and topical steroids offers a good alternative for the treatment of hypertrophic lichen planus. PMID: 32164922 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 9, 2020 Category: Dermatology Authors: Lahlou F, El Fatoiki F, Hali F, Chiheb S Tags: Ann Dermatol Venereol Source Type: research

Role of interleukin-4 in pathogenesis of oral lichen planus: A systematic review.
CONCLUSIONS: This review study shows that IL-4 plays a key role in the development of OLP. According to the past studies, there are several factors contributing to the production of this cytokine. Identification of the routes of production of IL-4 and its role in OLP might be useful for development of new preventive and therapeutic methods in management of patients with OLP. PMID: 32134902 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - March 7, 2020 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Successful treatment of recalcitrant lichen planus pemphigoides with tildrakizumab.
PMID: 32141608 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - March 6, 2020 Category: Dermatology Authors: Kerkemeyer KL, Pinczewski J, Sinclair R Tags: Australas J Dermatol Source Type: research

Koebnerization of Eruptive Keratoacanthoma Into Lesions of Classic Lichen Planus Treated With Oral Acitretin
No abstract available (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - March 1, 2020 Category: Dermatology Tags: Letters and Communications Source Type: research

Inverse Psoriasis: From Diagnosis to Current Treatment Options.
Authors: Micali G, Verzì AE, Giuffrida G, Panebianco E, Musumeci ML, Lacarrubba F Abstract Inverse psoriasis represents a clinical variant of psoriasis that is sometimes difficult to diagnose due to its clinical similarity with other skin disorders involving the folds, mainly including mechanical intertrigo, fungal and bacterial infections, contact dermatitis, seborrheic dermatitis, and lichen planus. Dermoscopy represents a useful tool for an enhanced non-invasive diagnosis. The treatment of inverse psoriasis may be challenging and include topical corticosteroids, topical calcineurin inhibitors, vitamin D a...
Source: Clinical, Cosmetic and Investigational Dermatology - February 28, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Oral lichen planus in an 8-year-old child: A case report with a brief literature review
Shamimul Hasan, Shahnaz Mansoori, Mohd Irfan Ansari, Safia SiddiquiJournal of Oral and Maxillofacial Pathology 2020 24(4):128-134 Lichen planus (LP) is a chronic autoimmune condition of uncertain etiopathogenesis and usually affects the skin, oro-genital mucosa, nail and scalp appendages. LP is primarily seen in middle-aged individuals, and oral lesions of LP in children are relatively uncommon. Herewith, we report a case of oral LP in an 8-year-old boy, which regressed well with the treatment modality. (Source: Journal of Oral and Maxillofacial Pathology)
Source: Journal of Oral and Maxillofacial Pathology - February 28, 2020 Category: ENT & OMF Authors: Shamimul Hasan Shahnaz Mansoori Mohd Irfan Ansari Safia Siddiqui Source Type: research

Interventions for treating oral lichen planus: corticosteroid therapies.
CONCLUSIONS: Corticosteroids have been first line for the treatment of OLP. This review found that these drugs, delivered topically as adhesive gels or similar preparations, may be more effective than placebo for reducing the pain of symptomatic OLP; however, with the small number of studies and participants, our confidence in the reliability of this finding is low. The results for clinical response were inconclusive, and we are uncertain about adverse effects. Very low-certainty evidence suggests that calcineurin inhibitors, specifically tacrolimus, may be more effective at resolving pain than corticosteroids, although th...
Source: Cochrane Database of Systematic Reviews - February 28, 2020 Category: General Medicine Authors: Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M Tags: Cochrane Database Syst Rev Source Type: research

Isolated Nail Lichen Planus – an expert consensus on treatment of the classical form
Lichen planus is a benign inflammatory disorder of unknown etiology that may affect the skin, mucosae, scalp and nails. When the nails are affected, it may lead to permanent destruction with severe functional and psychosocial consequences. Therefore, prompt diagnosis and early treatment are essential, even in mild cases. There are currently no guidelines for the management of nail lichen planus and the published literature on treatment is limited. The aim of this paper is then to provide practical management recommendations for the classical form of nail lichen planus, especially when restricted to the nails. (Source: Jour...
Source: Journal of the American Academy of Dermatology - February 26, 2020 Category: Dermatology Authors: Matilde Iorizzo, Antonella Tosti, Michela Starace, Robert Baran, C. Ralph Daniel, Nilton Di Chiacchio, Sophie Goettmann, Chander Grover, Eckart Haneke, Shari R. Lipner, Phoebe Rich, Bertrand Richert, Dimitris Rigopoulos, Adam I. Rubin, Martin Zaiac, Bianc Source Type: research

Urticaria due to acitretin in a patient with lichen planus
Hilal Kaya Erdogan, Tuba Erdogan, Ersoy Acer, Zeynep N SaracogluIndian Journal of Dermatology 2020 65(2):160-162 (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - February 25, 2020 Category: Dermatology Authors: Hilal Kaya Erdogan Tuba Erdogan Ersoy Acer Zeynep N Saracoglu Source Type: research

A Rare Case of Lichen Planus–Like Atopic Dermatitis Involving the Hands
We report a case of a 55-year-old African American woman who developed intensely pruritic papules and plaques on bilateral hands. Histological examination demonstrated acute spongiotic dermatitis with lymphocyte exocytosis into the epidermis. Taken together, a diagnosis of lichen planus–like atopic dermatitis was made. This case serves to highlight that lichen planus–like atopic dermatitis can develop on hands and that it presents as spongiotic dermatitis with lymphocyte exocytosis into the epidermis. Correlating the clinical presentation with histopathological findings will assist in establishing the diagnosis...
Source: The American Journal of Dermatopathology - February 21, 2020 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Lichen Planus Severity Index: A new, valid scoring system to assess the severity of cutaneous lichen planus
Conclusion: Lichen Planus Severity Index is a new reproducible tool to grade the severity of lichen planus. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - February 20, 2020 Category: Dermatology Authors: Harsimran Kaur Balkrishna P Nikam Varsha P Jamale Mohan S Kale Source Type: research

Dermoscopic features of various stages of lichen planus
Meena Makhecha, Tishya Singh, Nitya Malladi, Kinjal RambhiaIndian Journal of Dermatology, Venereology, and Leprology 2020 86(2):191-194 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - February 20, 2020 Category: Dermatology Authors: Meena Makhecha Tishya Singh Nitya Malladi Kinjal Rambhia Source Type: research

Hypertrophic Lichen Planus with Histological Features of Squamous Cell Carcinoma Associated with Immune Checkpoint Blockade Therapy.
The objective of this article is to highlight hypertrophic lichen planus (HLP) with histological features diagnosed as squamous cell carcinoma (SCC), which is a potential cutaneous reaction to ICB. Two patients (75 and 69 years) presented with lesions diagnosed as SCC on biopsy, which developed after 3-9 months on ICB therapy. Biopsies demonstrated endophytic, atypical, or cystic squamous proliferations consistent with cutaneous SCC. However, the clinical presentation including monomorphic nature of the lesions and lichenoid inflammation in the background were consistent with HLP. Patients initially received topical...
Source: The Oncologist - February 19, 2020 Category: Cancer & Oncology Authors: Ameri AH, Foreman RK, Vedak P, Chen S, Miller DM, Demehri S Tags: Oncologist Source Type: research

Immune-mediated Skin Disorders and their Oral Manifestations in the Omani Population: A Hospital-based Study.
Conclusions: Several IMDs have considerable oral involvement. These oral manifestations of the diseases may be overlooked by other specialists leading to a delay in the diagnosis and its management. In order to circumvent this delay, the analysis and evaluation of a disease need to be done by a team comprising of a dental surgeon, dermatologist, and an oral medicine specialist. PMID: 32042465 [PubMed] (Source: Oman Medical Journal)
Source: Oman Medical Journal - February 13, 2020 Category: Middle East Health Tags: Oman Med J Source Type: research

Multimorbidity and mortality risk in hospitalized adults with chronic inflammatory skin disease in the United States
AbstractChronic inflammatory skin diseases (CISD) represent a significant burden of skin disease in the United States, and a growing number of studies demonstrate that CISD are associated with multiple comorbidities. However, few studies examined multimorbidity in adults with CISD. We sought to determine whether hospitalized US adults with chronic inflammatory skin disorders have increased multi-morbidity and mortality risk. Data from the 2002 –2012 Nationwide Inpatient Sample were analyzed, including a representative 20% sample of US hospitalizations. Charlson comorbidity index (CCI) and mean estimated 10-year survi...
Source: Archives of Dermatological Research - February 11, 2020 Category: Dermatology Source Type: research

Expression profile of salivary micro RNA-21 and 31 in oral potentially malignant disorders
Abstract Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as controls and in 36 patients who were newly diagnosed as OPMD having four different lesions including leucoplakia, oral sub mucous fibrosis (OSMF) 궱 , oral lichen planus, and (OSMF) 궱 with leucoplakia. The samples were also classified as non-dysplastic, or with mild, moderate, and severe dysplasia according to their hist...
Source: Brazilian Oral Research - February 10, 2020 Category: Dentistry Source Type: research

Comparing the Frequency of Some Oral Lesions in Prediabetic and Healthy Individuals: Is There Any Difference?
This study aimed to compare some oral complications between prediabetic andhealthy control groups.Methods:The   present two‑group cross‑sectional study was carried outon 302 prediabetic and non ‑diabetic (healthy) 20‑ to 60‑year‑old subjects. In this study, dataon age, gender, educational level, medications use, smoking, and some other variables wereextracted through history taking. In addition, orodental examination was carried out by an oralmedicine specialist to diagnose oral lesions including candidiasis, lichen planus, periodontitis,gingivitis, xerostomia, delayed wound healing, geographic tongue, fissur...
Source: International Journal of Preventive Medicine - February 9, 2020 Category: International Medicine & Public Health Source Type: research

Predictors of symptomatic oral lichen planus
ConclusionsMost patients with OLP in the present cohort were symptomatic at the initial visit, with location, type, sex, steroid use and medical conditions being predictors of symptomatic OLP. Despite improvement in OLP symptoms in most patients over time, 25% of patients who are asymptomatic at the initial visit present with symptomatic OLP at a future visit. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 8, 2020 Category: ENT & OMF Source Type: research

Predictors of symptomatic oral lichen planus
The aim of this study was to determine the prevalence and the factors associated with symptomatic oral lichen planus (OLP). (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - February 7, 2020 Category: ENT & OMF Authors: Anna Osipoff, Michael D. Carpenter, Jenene L. Noll, J. Amadeo Valdez, Martin Gormsen, Michael T. Brennan Tags: Original Article Source Type: research

No detection of TSH or TSHR in oral lichen planus lesions in patients with or without hypothyroidism.
Conclusions: These results suggest that TSH and TSHR may not be commonly involved in the pathogenetic mechanism that could explain the association between OLP and hypothyroidism. PMID: 32031461 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - February 7, 2020 Category: Dentistry Authors: Vehviläinen M, Salem A, Asghar MY, Salo T, Siponen M Tags: Acta Odontol Scand Source Type: research

Oral lichen planus-associated oral cavity squamous cell carcinoma is associated with improved survival and increased risk of recurrence
To investigate overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) among patients with oral lichen planus-associated oral cavity squamous cell carcinoma (OLP-OCSCC). The secondary objective was to assess yearly risk of tumor recurrence or second primary tumor (SPT). (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - February 5, 2020 Category: ENT & OMF Authors: David L. Best, Curtis Herzog, Corey Powell, Thomas Braun, Brent B. Ward, Justine Moe Source Type: research

Study on the Role of Salivary Flora and NF- κB Inflammatory Signal Pathway in Oral Lichen Planus
AbstractOral lichen planus (OLP) is an inflammatory disease. It is believed that infection and immune dysfunction play a key role in its pathogenesis, but the specific mechanism of action remains unclear. The 16s rRNA high-throughput sequencing technique was used to analyze the microbial flora structure in the saliva of OLP patients and healthy controls. The relative abundance ofDerxia,Haemophilus, andPseudomonas in the saliva of the OLP group was lower than that of the healthy control group, but there was no significant difference in the overall structure of the microbial population. In addition, we measured the protein e...
Source: Inflammation - February 3, 2020 Category: Allergy & Immunology Source Type: research

Comparison of topical clobetasol propionate 0.05% and topical tacrolimus 0.1% in the treatment of cutaneous lichen planus.
Authors: Özkur E, Aksu EK, Gürel MS, Savaş S Abstract Introduction: The effectiveness of topical tacrolimus in the treatment of oral and genital lichen planus has been verified in many randomized studies; however, there are only few case reports in treatment of cutaneous lichen planus (CLP). Aim: We sought to compare the safety and efficacy of topical clobetasol propionate and tacrolimus ointment in the treatment of CLP. Material and methods: Retrospective analysis of patient files was performed. We enrolled patients who were diagnosed with CLP and treated with topical tacrolimus 0.1% or topical ...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Treatment of severe lichen planus with the JAK inhibitor tofacitinib
Lichen planus (LP) is frequently difficult to treat. Here we show that JAK-STAT signaling is activated in LP and that treatment with a JAK inhibitor, tofacitinib, was effective in 3 patients with recalcitrant erosive LP. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: William Damsky, Alice Wang, Brianna Olamiju, Danielle Peterson, Anjela Galan, Brett King Source Type: research

Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population
This study investigated the association between VDR gene polymorphisms and the risk of OLP. (Source: BMC Oral Health)
Source: BMC Oral Health - January 30, 2020 Category: Dentistry Authors: Hong Shen, Qinglan Liu, Peng Huang, Haozhi Fan, Feng Zang, Mei Liu, Lingyun Zhuo, Jingjing Wu, Guoying Wu, Rongbin Yu and Jianrong Yang Tags: Research article Source Type: research

Comparison of serum lipid parameters between patients with classic cutaneous lichen planus and oral lichen planus
ConclusionsPatients with OLP have a more impaired lipid metabolism and significantly higher atherogenic indexes compared with patients with CCLP. The differences in the molecular inflammatory pathways between OLP and CCLP and the longer disease duration of OLP leading to long-lasting inflammation may elucidate this distinction.Clinical relevanceWe recommend to pay close attention to the early recognition of coexisting atherogenic dyslipidemia and to apply the early protective measures against the development of cardiovascular disease in OLP patients. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 27, 2020 Category: Dentistry Source Type: research

Dental Implants in Patients with Oral Lichen Planus: A Systematic Review.
Conclusions: When the results of the one study with a very high failure rate and of the cases that developed OSCC are not considered, the dental implant failure rate in OLP patients was 2.7% after a follow-up of approximately five years. Recommendations are given when treating OLP patients with dental implants. PMID: 32012782 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - January 27, 2020 Category: Universities & Medical Training Authors: Chrcanovic BR, Cruz AF, Trindade R, Gomez RS Tags: Medicina (Kaunas) Source Type: research

A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China
Objective: To investigate the prevalence of thyroid diseases in patients with oral lichen planus (OLP) and to explore the correlation between the two diseases.Methods: A cross-sectional study was conducted to investigate the history of thyroid disease in 585 patients with oral lichen planus diagnosed in the Department of Oral Mucosal Diseases of the Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine from June 2017 to April 2018 and in 10,441 normal people in an epidemiological survey conducted by endocrinology department of Ninth People's Hospitalin eastern China from 2014 to 2015. Personal medical h...
Source: Frontiers in Endocrinology - January 24, 2020 Category: Endocrinology Source Type: research

Bullous lichen planus and anti-programmed cell death-1 therapy: Case report and literature review.
DISCUSSION: Bullous lichen planus has been reported only rarely in the context of nivolumab therapy. The timeline for development of cutaneous adverse reactions under anti-PD1 immunotherapy may last weeks or months and regular monitoring is required. Withdrawal of immunotherapy should only be considered where the outcome under systemic corticosteroids is unfavourable. PMID: 31982173 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - January 22, 2020 Category: Dermatology Authors: de Lorenzi C, André R, Vuilleumier A, Kaya G, Abosaleh M Tags: Ann Dermatol Venereol Source Type: research

Expression of nucleotide-binding oligomerization domain 1 and 2 in oral lichen planus
ConclusionThese findings suggest that NOD2 may play an important role in the pathogenesis of OLP and represents a new diagnostic and treatment target. (Source: Journal of Dental Sciences)
Source: Journal of Dental Sciences - January 19, 2020 Category: Dentistry Source Type: research

Oral lichen planus and lichenoid lesions: what's new?
This article presents therapies for dental practitioners who do not focus on treating patients with oral mucosa diseases. Oral lichenoid lesions, which are clinically and histologically similar, must be distinguished from oral lichen planus. Before starting therapy, it is necessary to differentiate between drug- and contact-related variants. Both clinical features have in common that according to the World Health Organization (2017) they belong to the class of potentially malignant disorders. Accordingly, these patients must be referred to a regular, and in oral lichen planus patients, lifelong, recall. (Source: Quintessence International)
Source: Quintessence International - January 16, 2020 Category: Dentistry Source Type: research

Lymphocyte-predominant Esophagitis: A Distinct and Likely Immune-mediated Disorder Encompassing Lymphocytic and Lichenoid Esophagitis
Lymphocytic esophagitis is a well-known manifestation of Crohn disease among children but is not considered to be an immune-mediated mucositis in adults. We hypothesize that adult-onset lymphocyte-predominant esophagitis is also an immune-mediated inflammatory pattern, the nature of which has been masked by other conditions that feature esophageal lymphocytosis and occur in older patients. We performed this study to consolidate diagnostic criteria for lymphocyte-predominant esophagitis and determine its clinical significance. We identified 61 patients with lymphocyte-rich inflammation in the mid or proximal esophagus, none...
Source: The American Journal of Surgical Pathology - January 11, 2020 Category: Pathology Tags: Original Articles Source Type: research

MicroRNA-26a/b have protective roles in oral lichen planus
Cell Death & Disease, Published online: 06 January 2020; doi:10.1038/s41419-019-2207-8MicroRNA-26a/b have protective roles in oral lichen planus (Source: Cell death and disease)
Source: Cell death and disease - January 6, 2020 Category: Internal Medicine Authors: Jie Du Ruifang Gao Yimei Wang Tivoli Nguyen Fang Yang Yongyan Shi Tianjing Liu Wang Liao Ran Li Fang Zhang Xuejun Ge Bin Zhao Source Type: research

Global Prevalence and Incidence Estimates of Oral Lichen Planus
This systematic review and meta-analysis identifies the global prevalence and incidence of oral lichen planus in the overall population and among subgroups. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 2, 2020 Category: Dermatology Source Type: research

Methotrexate for the Treatment of Recalcitrant Erosive Lichen Planus of the Vulva
This retrospective medical record review evaluates the efficacy of methotrexate for treatment of recalcitrant erosive lichen planus of the vulva in women treated at a vulvar clinic. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 2, 2020 Category: Dermatology Source Type: research

Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature
In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Following IRB approval, all cases diagnosed as VX found in the archives of the University of Florida Oral Pathology Biopsy Service (1994 –2018) were included. Patient age, gender, location, clinical appearance, clinical impression, and duration of each lesion was collected. A total of 212 cases were included in our database with a mean age of 61 years (range of 9–94...
Source: Head and Neck Pathology - January 2, 2020 Category: Pathology Source Type: research

Research trends and characteristics of oral lichen planus: A bibliometric study of the top-100 cited articles
Conclusions: The results of this first citation analysis of the 100 most cited articles on OLP provide a historical perspective on scientific evolution, and suggest further research trends and clinical practice in the field of OLP. (Source: Medicine)
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

There is probably a low risk of experiencing a malignant transformation of oral lichen planus.
Authors: Brignardello-Petersen R PMID: 31882124 [PubMed - as supplied by publisher] (Source: Journal of the American Dental Association)
Source: Journal of the American Dental Association - December 30, 2019 Category: Dentistry Tags: J Am Dent Assoc Source Type: research

Masturbation-induced painless hemorrhagic bulla on scarring penile lichen planus
Anurag Verma, Saurabh Singh, Aasma NalwaIndian Journal of Dermatology, Venereology, and Leprology 2020 86(1):96-97 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - December 20, 2019 Category: Dermatology Authors: Anurag Verma Saurabh Singh Aasma Nalwa Source Type: research

Immunohistochemical and clinical significance of matrix metalloproteinase-2 and its inhibitor in oral lichen planus
Conclusion: The expression of MMP-2 and TIMP-2 was observed in all cases of OLP. However, a clinical 5-year follow-up of the lesion revealed no progression of the disease except for chronic exacerbation and regression of these lesions. Although our study considers MMP-2 and TIMP-2 as mediators in the pathogenesis of OLP, it still remains debatable whether they have a direct role to play in the disease process or whether they are suitable biomarkers to assess the disease progression. (Source: Journal of Oral and Maxillofacial Pathology)
Source: Journal of Oral and Maxillofacial Pathology - December 19, 2019 Category: ENT & OMF Authors: Neha Agarwal Sunitha Carnelio Gabriel Rodrigues Source Type: research

Neutrophil extracellular traps (NETs) formation induced by TGF- β in oral lichen planus - Possible implications for the development of oral cancer.
Neutrophil extracellular traps (NETs) formation induced by TGF-β in oral lichen planus - Possible implications for the development of oral cancer. Immunobiology. 2019 Dec 19;:151901 Authors: Jablonska E, Garley M, Surazynski A, Grubczak K, Iwaniuk A, Borys J, Moniuszko M, Ratajczak-Wrona W Abstract Oral Potentially Malignant Disorders (OPMDs) including Oral Lichen Planus (OLP) are associated with risk of transformation to oral squamous cell carcinoma (OSCC). Available data show that innate immune cells involving polymorphonuclear neutrophils (PMNs) with their ability to neutrophil extracellular t...
Source: Immunobiology - December 19, 2019 Category: Allergy & Immunology Authors: Jablonska E, Garley M, Surazynski A, Grubczak K, Iwaniuk A, Borys J, Moniuszko M, Ratajczak-Wrona W Tags: Immunobiology Source Type: research

A comparative study between oral zinc therapy with or without steroid application in symptomatic oral lichen planus: a randomized controlled trial
ConclusionsOral zinc therapy was found to be an adjunct in reducing burning sensation and lesion size in symptomatic OLP. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Overexpressed interleukin-6 functionally impaired CD4+CD25+ regulatory T cells in patients with oral lichen planus: an in vitro study
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Qianqian Sun, Wei Wei, Guanhuan Du, Yufeng Wang, Guoyao TangObjectivesOur previous studies have shown that interleukin-6 (IL-6) is overexpressed in the saliva of patients with oral lichen planus (OLP) and is positively correlated with severity of disease. IL-6 may be associated with immune imbalance in patients with OLP. The purpose of the present study was to investigate the inhibitory effect of IL-6 on regulatory T cells (Treg) derived from patients with OLP.Study DesignThe diagnosis of OLP ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Dexamethasone solution and dexamethasone in Mucolox for the treatment of oral lichen planus: a preliminary report on findings
The objective of this single-center, open-label, randomized, phase II study was to evaluate the safety and efficacy of dexamethasone solution (standard of care) in Mucolox (group A) compared with dexamethasone solution alone (group B) for the treatment of OLP. The primary outcome measure was to detect changes in each subject's sensitivity scores (0–10) evaluated at baseline and after 4 weeks of treatment.Study DesignPatients with clinical OLP and a visual analogue scale (VAS) sensitivity score of 7 or greater were randomized to group A or group B. REU (Reticulation/keratosis, erythema, and ulceration) scoring, VAS fo...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research