GSE194125 Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses
Contributors : Rouven Schulz ; Medina Korkut-Demirba ş ; Alessandro Venturino ; Gloria Colombo ; Sandra SiegertSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensG protein-coupled receptors (GPCRs) regulate processes ranging from immune responses to neuronal signaling. However, ligands for many GPCRs remain unknown, suffer from off-target effects or have poor bioavailability. Additionally, dissecting cell type-specific responses is challenging when the same GPCR is expressed on different cells within a tissue. Here, we overcome these limitations by engineering DREADD-based GPCR chi...
Source: GEO: Gene Expression Omnibus - July 6, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Levalbuterol versus albuterol for hospitalized patients with COPD in China: cost-utility and budget impact analysis
CONCLUSION: Levalbuterol is a cost-saving option for treating hospitalized patients with COPD in China.PMID:35786135 | DOI:10.1080/13696998.2022.2096892 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - July 5, 2022 Category: Health Management Authors: Lei Chen Xianqiu Chen Canghong Zhi Xuan Li Yang Hu Source Type: research

Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase.
Abstract Tyrosine hydroxylase (TH) catalyses the (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4)-dependent conversion of l-tyrosine to L-3,4-dihydroxyphenylalanine (l-Dopa), which is the rate-limiting step in the synthesis of dopamine and other catecholamine neurotransmitters and hormones. Dysfunctional mutant TH causes tyrosine hydroxylase deficiency (THD), characterized by symptoms ranging from mild l-Dopa responsive dystonia to severe neuropathy. THD-associated mutations often present misfolding and a propensity to aggregate, characteristics that can also be manifested by dysregulated wild-type TH. TH ...
Source: Biochimie - December 9, 2020 Category: Biochemistry Authors: Flydal MI, Kråkenes TA, Tai MDS, Tran MPA, Teigen K, Martinez A Tags: Biochimie Source Type: research

Comparison Table: Inhaled Short-Acting Bronchodilators for Treatment of COPD (online only)
Date: September 7, 2020 Issue #:  1606Summary:  View the Comparison Table: Inhaled Short-Acting Bronchodilators for Treatment of COPD (Source: The Medical Letter)
Source: The Medical Letter - August 31, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Albuterol Atrovent Combivent COPD Ipratropium Levalbuterol ProAir ProAir RespiClick Proventil Salbutamol Xopenex Source Type: research

Incidence of supraventricular tachycardia after inhaled short-acting beta agonist treatment in children.
Conclusions: SVT is rare during hospital-based treatment for acute asthma using inhaled SABAs and has low morbidity and mortality. PMID: 31902263 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - January 8, 2020 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Case report: Paradoxical responses to short acting beta-agonists in a pediatric patient.
Conclusion: This case highlights the need to include paradoxical response to SABAs in the differential of a patient with poorly controlled asthma. It also provides an example of successful treatment of a pediatric patient with a class of medications previously reserved for adults with chronic obstructive pulmonary disease. PMID: 31573361 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - October 3, 2019 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Short-acting bronchodilators for in-hospital management of acute exacerbation of COPD: Systematic Review
Conclusion: Data from the few studies available suggest that short acting beta agonists at a minimum dose via inhaler or nebuliser is sufficient for managing people admitted to hospital with AECOPD. Superfluous use could be a risk to patients with known and unknown cardiac disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kopsaftis, Z., Sulaiman, N., Carson, K., Mountain, O., Phillips, P., Smith, B. Tags: Clinical Problems Source Type: research

Enantiomeric impurity analysis using circular dichroism spectroscopy with United States Pharmacopeia liquid chromatographic methods
In this study, HPLC-CD was evaluated for enantiomeric purity determinations of 13 drug substances using HPLC methods consistent with assay protocols described in United States Pharmacopeia (USP) monographs. Of these selected substances, three (sitagliptin, timolol, and levalbuterol) showed no CD activity and one other (levofloxacin) could not be analyzed due to incompatibility of the mobile phase with the CD detector. For the remaining 9 substances, method validation was performed to determine the linearity, accuracy, precision and limits of quantitation of enantiomer impurities, which was compared to limits established by...
Source: Journal of Pharmaceutical and Biomedical Analysis - May 11, 2018 Category: Drugs & Pharmacology Source Type: research

Change in Oxygen Consumption Following Inhalation of Albuterol in Comparison with Levalbuterol in Healthy Adult Volunteers
ConclusionAlbuterol and levalbuterol both cause a significant increase in V ’O2 and HR. There was no significant difference between albuterol and levalbuterol regarding the maximum increase in V ’O2. There was a statistically significant but likely clinically insignificant difference in maximum increase in HR in patients with adequate oxygen delivery when comparing albuterol to levalbuterol. (Source: Lung)
Source: Lung - February 15, 2017 Category: Respiratory Medicine Source Type: research