Structure of V-ATPase from the mammalian brain
In neurons, the loading of neurotransmitters into synaptic vesicles uses energy from proton-pumping vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases). These membrane protein complexes possess numerous subunit isoforms, which complicates their analysis. We isolated homogeneous rat brain V-ATPase through its interaction with SidK, a Legionella pneumophila effector protein. Cryo–electron microscopy allowed the construction of an atomic model, defining the enzyme’s ATP:proton ratio as 3:10 and revealing a homolog of yeast subunit f in the membrane region, which we tentatively identify as RNAseK. The...
Source: ScienceNOW - March 11, 2020 Category: Science Authors: Abbas, Y. M., Wu, D., Bueler, S. A., Robinson, C. V., Rubinstein, J. L. Tags: Biochemistry reports Source Type: news
Report provides road map to improve response to legionnaires' disease outbreaks and conserve water
(NSF International) A new policy report, Electronic Registration Systems for Cooling Towers - Improving Public Health and Sustainability Outcomes, published by the Urban Sustainability Directors Network (USDN) proposes a standardized yet flexible template for cooling tower registries that are designed to improve health outcomes, address disparity in affected populations, and increase water and energy efficiency. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 9, 2020 Category: Infectious Diseases Source Type: news
Fatal Case of Legionnaires' Disease After Home Exposure to Legionella pneumophila Serogroup 3 - Wisconsin, 2018
The case described in this report highlights the potential for people at risk for Legionnaires ' disease to be exposed to Legionella through home water systems containing the bacteria and demonstrates the difficulty of removing the bacteria from residential settings. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - February 27, 2020 Category: American Health Tags: Legionnaires' Disease (Legionellosis) MMWR Morbidity & Mortality Weekly Report Water safety Water-Related Diseases Source Type: news
Legionella Conference 2020 will focus on waterborne pathogens in health care facilities
Discussions at Legionella Conference 2020: Prevention of Disease and Injury From Waterborne Pathogens in Health Care will focus on hazards related to medical devices, cleaning and disinfection in sterile settings and water quality requirements in hospitals and health care facilities. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 14, 2020 Category: International Medicine & Public Health Source Type: news
Cancer drugs unit’s water contaminated by legionella
Legionella and pseudomonas were found in water meant for hand washing in a unit where medicines for cancer patients were prepared, HSJ has learned. (Source: HSJ)
Source: HSJ - February 11, 2020 Category: UK Health Source Type: news
What's in a name? To name an outbreak, a lot
Guidelines now discourage the use of geographic locations (like Zika virus), animals (swine flu) or groups of people (Legionnaires' disease) in naming diseases. (Source: CBC | Health)
Source: CBC | Health - February 4, 2020 Category: Consumer Health News Tags: News/Health Source Type: news
Emerging Role of Pathogen Genomics in Public Health
Source: Centers for Disease Control and Prevention (CDC). Published: 1/21/2020.
This one-hour session of Public Health Grand Rounds addresses the rapid advances in Advanced Molecular Detection (AMD), how these technologies are being applied in public health, and their future uses. The principal objectives of AMD include improving pathogen detection and characterization, and enabling new diagnostic methods to meet public health needs. AMD technologies are now in use across the range of infectious diseases of public health importance, such as bacterial foodborne illness, tuberculosis, influenza, malaria, and Legionnaires â€...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - January 21, 2020 Category: International Medicine & Public Health Source Type: news
Legionellosis in Long-Term Care: An Update
Recently, three cases of Legionnaires ’ disease were reported in three separate nursing centers in my geographic area, the state of New York. Because this was the first time I had seen this occur during my many years of working in long-term care, I felt this would be a good time to discuss the issue. The Centers for Disease Control an d Prevention (CDC) has a tool kit for Legionnaires disease, from which this update has been derived. The website and other resources are included in this article. (Source: Caring for the Ages)
Source: Caring for the Ages - December 25, 2019 Category: Health Management Authors: Nina M. Flanagan Source Type: news
Comparison of Whole-Genome Sequences of L. pneumophila Comparison of Whole-Genome Sequences of L. pneumophila
Using next-generation DNA sequencing, the authors find that multiple L. pneumophila strains were associated with two Legionnaires ' disease outbreaks in Flint, Michigan.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 2, 2019 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Why Is It Called Legionnaire ’s Disease?
The association doesn ’t seem to have done the American Legion any harm, but elsewhere, diseases’ names have done as much harm as the diseases themselves. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - December 1, 2019 Category: Pharmaceuticals Authors: Kiona N. Smith, Contributor Source Type: news
Deadly Legionnaires' outbreak in North Carolina
North Carolina health officials say four people have died from Legionnaires' disease. Officials have confirmed 141 cases involving residents from counties and multiple states. They say that most patients attended the NC Mountain State Fair in Fletcher. CBS affiliate WSPA-TV reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 21, 2019 Category: Consumer Health News Source Type: news
4 dead from Legionnaires' outbreak linked to hot tubs
Officials say those who were diagnosed with the disease may have walked by the hot tub displays at the the NC Mountain State Fair (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 21, 2019 Category: Consumer Health News Source Type: news
Death toll rises after a Legionnaires' disease outbreak in North Carolina
Another person has died from an outbreak of Legionnaires' disease in North Carolina, bringing the death toll to four. (Source: CNN.com - Health)
Source: CNN.com - Health - October 18, 2019 Category: Consumer Health News Source Type: news
A third person has died after a Legionnaires' disease outbreak in North Carolina
A third person has died from an outbreak of Legionnaires' disease in North Carolina, state health officials said. (Source: CNN.com - Health)
Source: CNN.com - Health - October 16, 2019 Category: Consumer Health News Source Type: news
Legionnaire's Outbreak Linked to Hot Tubs Kills One, Sickens Dozens in North Carolina Legionnaire's Outbreak Linked to Hot Tubs Kills One, Sickens Dozens in North Carolina
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 8, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news
