Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 18;1870(5):167176. doi: 10.1016/j.bbadis.2024.167176. Online ahead of print.ABSTRACTFerroptosis is a programmed form of cell death regulated by iron and has been linked to the development of asthma. However, the precise mechanisms driving ferroptosis in asthma remain elusive. To gain deeper insights, we conducted an analysis of nasal epithelial and sputum samples from the GEO database using three machine learning methods. Our investigation identified a pivotal gene, Arachidonate 15-lipoxygenase (ALOX15), associated with ferroptosis in asthma. Through both in vitro and in vivo ex...
Source: Biochimica et Biophysica Acta - April 19, 2024 Category: Biochemistry Authors: Weizhen Zhang Fangfang Huang Xuexuan Ding Jingtong Qin Wenjian Wang Lianxiang Luo Source Type: research
Biomarker-based human and animal sperm phenotyping: the good, the bad and the ugly
Biol Reprod. 2024 Apr 19:ioae061. doi: 10.1093/biolre/ioae061. Online ahead of print.ABSTRACTConventional, brightfield-microscopic semen analysis provides important baseline information about sperm quality of an individual; however, it falls short of identifying subtle subcellular and molecular defects in cohorts of "bad", defective human and animal spermatozoa with seemingly normal phenotypes. To bridge this gap, it is desirable to increase the precision of andrological evaluation in humans and livestock animals by pursuing advanced biomarker-based imaging methods. This review, spiced up with occasional classic movie refe...
Source: Reproductive Biology - April 19, 2024 Category: Reproduction Medicine Authors: Peter Sutovsky Lauren E Hamilton Michal Zigo Mayra E Ortiz D'Avila Assump ção Alexis Jones Filip Tirpak Yuksel Agca Karl Kerns Miriam Sutovsky Source Type: research
Prediction of potentially toxic elements in water resources using MLP-NN, RBF-NN, and ANFIS: a comprehensive review
Environ Sci Pollut Res Int. 2024 Apr 20. doi: 10.1007/s11356-024-33350-6. Online ahead of print.ABSTRACTWater resources are constantly threatened by pollution of potentially toxic elements (PTEs). In efforts to monitor and mitigate PTEs pollution in water resources, machine learning (ML) algorithms have been utilized to predict them. However, review studies have not paid attention to the suitability of input variables utilized for PTE prediction. Therefore, the present review analyzed studies that employed three ML algorithms: MLP-NN (multilayer perceptron neural network), RBF-NN (radial basis function neural network), and...
Source: Environmental Science and Pollution Research International - April 19, 2024 Category: Environmental Health Authors: Johnson C Agbasi Johnbosco C Egbueri Source Type: research
Ambient PM < sub > 2.5 < /sub > and specific sources increase inflammatory cytokine responses to stimulators and reduce sensitivity to inhibitors
Environ Res. 2024 Apr 17;252(Pt 2):118964. doi: 10.1016/j.envres.2024.118964. Online ahead of print.ABSTRACTAmbient exposure to fine particulate matter (PM2.5) is associated with increased morbidity and mortality from multiple diseases. Recent observations suggest the hypothesis that trained immunity contributes to these risks, by demonstrating that ambient PM2.5 sensitizes innate immune cells to mount larger inflammatory response to subsequent bacterial stimuli. However, little is known about how general and durable this sensitization phenomenon is, and whether specific sources of PM2.5 are responsible. Here we consider t...
Source: Environmental Research - April 19, 2024 Category: Environmental Health Authors: Gregory E Miller Veronica Passarelli Edith Chen Itai Kloog Rosalind J Wright Heresh Amini Source Type: research
Embedding Bifurcations into Pneumatic Artificial Muscle
This study demonstrates that bifurcations, including periodic and chaotic dynamics, can be embedded into the pneumatic artificial muscle, with the entire bifurcation structure using the framework of physical reservoir computing. These results suggest that dynamics not present in training data can be embedded through bifurcation embedment, implying the capability to incorporate various qualitatively different patterns into pneumatic artificial muscle without the need to design and learn all required patterns explicitly. Thus, this study introduces a novel approach to simplify robotic devices and control training by reducing...
Source: Adv Data - April 19, 2024 Category: Epidemiology Authors: Nozomi Akashi Yasuo Kuniyoshi Taketomo Jo Mitsuhiro Nishida Ryo Sakurai Yasumichi Wakao Kohei Nakajima Source Type: research
Human-level few-shot concept induction through minimax entropy learning
Sci Adv. 2024 Apr 19;10(16):eadg2488. doi: 10.1126/sciadv.adg2488. Epub 2024 Apr 19.ABSTRACTHumans learn concepts both from labeled supervision and by unsupervised observation of patterns, a process machines are being taught to mimic by training on large annotated datasets-a method quite different from the human pathway, wherein few examples with no supervision suffice to induce an unfamiliar relational concept. We introduce a computational model designed to emulate human inductive reasoning on abstract reasoning tasks, such as those in IQ tests, using a minimax entropy approach. This method combines identifying the most e...
Source: Adv Data - April 19, 2024 Category: Epidemiology Authors: Chi Zhang Baoxiong Jia Yixin Zhu Song-Chun Zhu Source Type: research
Sleep-Deep-Learner is taught sleep-wake scoring by the end-user to complete each record in their style
Sleep Adv. 2024 Apr 4;5(1):zpae022. doi: 10.1093/sleepadvances/zpae022. eCollection 2024.ABSTRACTSleep-wake scoring is a time-consuming, tedious but essential component of clinical and preclinical sleep research. Sleep scoring is even more laborious and challenging in rodents due to the smaller EEG amplitude differences between states and the rapid state transitions which necessitate scoring in shorter epochs. Although many automated rodent sleep scoring methods exist, they do not perform as well when scoring new datasets, especially those which involve changes in the EEG/EMG profile. Thus, manual scoring by expert scorers...
Source: Adv Data - April 19, 2024 Category: Epidemiology Authors: Fumi Katsuki Tristan J Spratt Ritchie E Brown Radhika Basheer David S Uygun Source Type: research
Air pollution changes due to COVID-19 lockdowns and attributable mortality changes in four countries
This study underscores the importance of accounting for local characteristics when policymakers adapt successful emission control strategies from other regions.PMID:38640613 | DOI:10.1016/j.envint.2024.108668 (Source: Environment International)
Source: Environment International - April 19, 2024 Category: Environmental Health Authors: Yiqun Ma Federica Nobile Anne Marb Robert Dubrow Patrick L Kinney Annette Peters Massimo Stafoggia Susanne Breitner Kai Chen Source Type: research
Biomarker-based human and animal sperm phenotyping: the good, the bad and the ugly
Biol Reprod. 2024 Apr 19:ioae061. doi: 10.1093/biolre/ioae061. Online ahead of print.ABSTRACTConventional, brightfield-microscopic semen analysis provides important baseline information about sperm quality of an individual; however, it falls short of identifying subtle subcellular and molecular defects in cohorts of "bad", defective human and animal spermatozoa with seemingly normal phenotypes. To bridge this gap, it is desirable to increase the precision of andrological evaluation in humans and livestock animals by pursuing advanced biomarker-based imaging methods. This review, spiced up with occasional classic movie refe...
Source: Biology of Reproduction - April 19, 2024 Category: Reproduction Medicine Authors: Peter Sutovsky Lauren E Hamilton Michal Zigo Mayra E Ortiz D'Avila Assump ção Alexis Jones Filip Tirpak Yuksel Agca Karl Kerns Miriam Sutovsky Source Type: research
Nationally standardized broad consent in practice: initial experiences, current developments, and critical assessment
DISCUSSION: The introduction of the MII consent documents at the university hospitals creates a uniform legal basis for the secondary use of patient data. However, the comprehensive implementation within the sites remains challenging. Therefore, minimum requirements for patient information and supplementary recommendations for best practice must be developed. The further development of the national legal framework for research will not render the participation and transparency mechanisms developed here obsolete.PMID:38639817 | DOI:10.1007/s00103-024-03878-6 (Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - April 19, 2024 Category: International Medicine & Public Health Authors: Sven Zenker Daniel Strech Roland Jahns Gabriele M üller Fabian Prasser Christoph Schickhardt Georg Schmidt Sebastian C Semler Eva Winkler Johannes Drepper Source Type: research
Mismatch between fixed classroom furniture and anthropometric measurements among university students: Relationships to ergonomic risk
CONCLUSIONS: More investigation should be conducted with prospective studies including interventions like adjustable furniture.PMID:38640187 | DOI:10.3233/WOR-230590 (Source: Work)
Source: Work - April 19, 2024 Category: Occupational Health Authors: Özde Depreli Zehra G üçhan Topçu Hayriye Toma ç Source Type: research
Assessing Clinician Utilization of Next-Generation Antibiotics Against Resistant Gram-Negative Infections in U.S. Hospitals : A Retrospective Cohort Study
CONCLUSION: Despite FDA approval of 7 next-generation gram-negative antibiotics between 2014 and 2019, clinicians still frequently treat resistant gram-negative infections with older, generic antibiotics with suboptimal safety-efficacy profiles. Future antibiotics with innovative mechanisms targeting untapped pathogen niches, widely available susceptibility testing, and evidence demonstrating improved outcomes in resistant infections might enhance utilization.PRIMARY FUNDING SOURCE: U.S. Food and Drug Administration; NIH Intramural Research Program.PMID:38639548 | DOI:10.7326/M23-2309 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 19, 2024 Category: Internal Medicine Authors: Jeffrey R Strich Ahmed Mishuk Guoqing Diao Alexander Lawandi Willy Li Cumhur Y Demirkale Ahmed Babiker Alex Mancera Bruce J Swihart Morgan Walker Christina Yek Maniraj Neupane Nathaniel De Jonge Sarah Warner Sameer S Kadri National Institutes of Health An Source Type: research
Role of family medicine physicians in providing nutrition support to older patients admitted to orthopedics departments: a grounded theory approach
CONCLUSIONS: The inclusion of family physicians in nutrition support teams can help with early detection of the rapid deterioration of orthopedic patients' conditions, and comprehensive management can be provided by nutrition support teams. In rural primary care settings, family physicians play a vital role in providing geriatric care in community hospitals in collaboration with specialists. Family medicine in hospitals should be investigated in other settings for better geriatric care and to drive mutual learning among healthcare professionals.PMID:38641569 | PMC:PMC11027398 | DOI:10.1186/s12875-024-02379-4 (Source: Primary Care)
Source: Primary Care - April 19, 2024 Category: Primary Care Authors: Ryuichi Ohta Tachiko Nitta Akiko Shimizu Chiaki Sano Source Type: research
Critical reflections on formal teaching observations
This article provides a personal insight into formal teaching observations, and themes arising from them of motivation, the teacher's voice, the use of abbreviations and acronyms and the use of exemplars, using a critical reflective approach.PMID:38639748 | DOI:10.12968/bjon.2024.33.8.382 (Source: British Journal of Nursing)
Source: British Journal of Nursing - April 19, 2024 Category: Nursing Authors: Shelley O'Connor Source Type: research
Changing the culture around hospital-based nutrition
Br J Nurs. 2024 Apr 18;33(8):S18-S25. doi: 10.12968/bjon.2024.33.8.S18.ABSTRACTFollowing a serious incident and inquest after the death of a patient due to choking at Sheffield Teaching Hospitals NHS Foundation Trust, the Trust put in place an action plan and implemented strategies to reduce the risk of recurrence. Four key actions were identified as essential to try to reduce the risk of a similar event: introduction of a standard operating procedure for mealtimes that included a pre-meal safety 'pause'; use of an electronic communication icon to indicate modified diet/fluid requirements, from emergency department and onw...
Source: British Journal of Nursing - April 19, 2024 Category: Nursing Authors: Jo Sessions Jo Marsden Louise Bringloe Irene Gilsenan Source Type: research
