Langerhans Cell Histiocytosis (LCH) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

PM2.5, vegetation density, and childhood cancer: a case-control registry-based study from Texas 1995-2011
DISCUSSION: Increasing early life exposure to PM2.5 increased the risk of childhood cancers. NDVI decreased risk of two cancers yet increased risk of others. These findings highlight the complexity between PM2.5 and NDVI in cancer etiology.PMID:38366656 | DOI:10.1093/jnci/djae035 (Source: Cancer Control)
Source: Cancer Control - February 17, 2024 Category: Cancer & Oncology Authors: Lindsay A Williams David Haynes Jeannette M Sample Zhanni Lu Ali Hossaini Laura A McGuinn Thanh T Hoang Philip J Lupo Michael E Scheurer Source Type: research

Langerhans cell histiocytosis of the skull in 23 children
CONCLUSION: Personalized treatment plans according to different clinical types. Regular outpatient follow-up is crucial to monitor disease recurrence and late effects.PMID:38368348 | PMC:PMC10874530 | DOI:10.1186/s40001-024-01727-5 (Source: Cell Research)
Source: Cell Research - February 17, 2024 Category: Cytology Authors: Min Wei Wenbin Jiang Rui Wang Bo Xiao Qijia Zhan Source Type: research

Langerhans cell histiocytosis of the skull in 23 children
ConclusionPersonalized treatment plans according to different clinical types. Regular outpatient follow-up is crucial to monitor disease recurrence and late effects. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 17, 2024 Category: Research Source Type: research

Chronic health conditions after childhood Langerhans cell histiocytosis: Results from the Swiss Childhood Cancer Survivor Study
ConclusionsMore than half of long-term LCH survivors suffered from one or more CHC and were affected considerably more than siblings.Implications for Cancer SurvivorsLCH survivors in follow-up care should be screened especially for cardiovascular, endocrine, musculoskeletal, and digestive conditions. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - February 14, 2024 Category: Cancer & Oncology Source Type: research

Case report: Exploring the utility of whole-body bone scintigraphy for pediatric Langerhans cell histiocytosis: insights from clinical practice
ConclusionPediatric LCH can present with a wide range of clinical and radiologic features. By amalgamating our cases with extant literature, we stress the necessity of a multimodal strategy. 99mTc-MDP scintigraphy emerged as an indispensable tool for accurate staging and soft tissue detection. Our findings collectively advocate for a holistic approach to managing LCH, ensuring informed therapeutic decisions for optimal patient outcomes. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 9, 2024 Category: Cancer & Oncology Source Type: research

Safety and clinical contribution of computed tomography-guided biopsy for cervical spine lesion
CONCLUSION: CT-guided percutaneous needle biopsies for cervical spine lesions were safe and clinically beneficial.PMID:38315057 | DOI:10.1080/13645706.2024.2311720 (Source: Minimally Invasive Therapy and Allied Technologies)
Source: Minimally Invasive Therapy and Allied Technologies - February 5, 2024 Category: Surgery Authors: Daisuke Okamoto Yasuhiro Ushijima Nobuhiro Fujita Keisuke Ishimatsu Ryo Murayama Masahiro Itoyama Kousei Ishigami Source Type: research

Isolated eyelid neonatal Langerhans cell histiocytosis
Orbit. 2024 Jan 30:1-5. doi: 10.1080/01676830.2023.2300802. Online ahead of print.ABSTRACTLangerhans cell histiocytosis (LCH) is a condition characterized by clonal proliferation of the phagocytic cells derived from the bone marrow. In this article, we present an exceedingly rare case of congenital/neonatal LCH in a 3-week-old girl who initially presented with an isolated swelling of the eyelid, initially misdiagnosed as a chalazion. Subsequently, a biopsy was performed, and histopathological evaluation confirmed the diagnosis of LCH. A staging work-up revealed no evidence of multisystem involvement, and thus, local steroi...
Source: Orbit - January 30, 2024 Category: Opthalmology Authors: Abdelrahman M Elhusseiny Jamal O Azhari Tom Kornhauser David A Kilgore David K Wilson Kevin J Bielamowicz Kandi A Stallings-Archer John D Pemberton Source Type: research

Ocular and Orbital Tumors in Childhood
Pediatric tumors of the eye and orbit can be benign or malignant as well as congenital or acquired and are usually distinctively different than those seen in adults.1 Although most of these neoplasms are benign (e.g. dermoid cyst, chalazion or molluscum), their location near and within a vital organ can result in serious dermatologic and ophthalmologic sequelae. Lesions discussed include vascular lesions, retinoblastomas (the most common primary pediatric intraocular malignancy), rhabdomyosarcoma (the most common primary pediatric orbital malignancy), Langerhans cell histiocytosis, and metastatic lesions to the orbit (neur...
Source: Clinics in Dermatology - January 30, 2024 Category: Dermatology Authors: Kathryn Bentivegna, Nicholas J. Saba, Roman Shinder, Jane M. Grant-Kels Source Type: research

An unusual manifestation of Langerhans cell histiocytosis in the gastrointestinal tract
We present the case of a 49-year-old woman with a previous diagnosis of LCH in 2018 with only cutaneous involvement, managed with topical corticosteroids. After developing hypertransaminasemia, a PET-CT scan was performed, showing dissemination of the disease with bone, hepatosplenic and gynecological involvement. In addition, hypermetabolic lesions were described in the cecum with ileocecal adenopathies. A colonoscopy was performed showing in the cecum and ascending colon multiple sessile polyps of 5-10mm with central fibrin-coated erosions, from which biopsies were obtained. Histology revealed typical features of LCH wit...
Source: Revista Espanola de Enfermedades Digestivas - January 29, 2024 Category: Gastroenterology Authors: Laura Ray ón Moreno Alberto P érez Garvin Bruno Bernardo Beatriz Merino Source Type: research

Highlights from the literature
Langerhans cell histiocytosis (LCH) It’s rare, but it is there, and will need to be considered in your differential diagnoses on a few occasions in a general paediatrician’s career. Lucina’s most recent experience has been with the common presentation of polydipsia and polyuria and an ultimate diagnosis of central diabetes insipidus (CDI) caused by LCH. Alexander A and Zacharin M [J Paediatr and Child Health 2023 https://doi.org/10.1111/jpc.16521] have documented the incidence of endocrine features in paediatric patients with LCH from one tertiary endocrine centre in Victoria, Australia. Using a simple re...
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Tags: Miscellanea Source Type: research

Langerhans cell histiocytosis of the thyroid mimicking thyroiditis in a boy: a case report and literature review
Langerhans cell histiocytosis affecting the thyroid commonly presents with nonspecific clinical and radiological manifestations. Thyroid Langerhans cell histiocytosis is typically characterized by non-enhancin... (Source: BMC Pediatrics)
Source: BMC Pediatrics - January 20, 2024 Category: Pediatrics Authors: Yu Fan Cheng, Ching Che Wang, Pei Shan Tsai, Dao Chen Lin and Wen Hui Huang Tags: Case Report Source Type: research

Letterer-Siwe disease presenting with gastrointestinal and cutaneous manifestations
Histiocytosis is a set of distinct proliferative illnesses defined by the proliferation and infiltration of varied numbers of dendritic cells, macrophages, and monocytes in the afflicted tissues. The skin and other organs may be impacted by the inflammatory infiltration. It can occur at any age. The severity of the symptoms can range from mild to severe, depending on the degree and type of organ involvement. Although certain forms of histiocytosis can be fatal, others can be treated successfully without sequelae. Langerhans cell histiocytosis manifests itself clinically in both children and adults. A combination of clinica...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Stadnikova, Antonina Sergeevna Source Type: research

Vemurafenib combined with chemotherapy achieved sustained remission in pediatric LCH: a multi-center observational study
ConclusionOur data suggest that the combination of vemurafenib and chemotherapy can achieve sustained clinical and molecular level relief in children with LCH, and side effects are tolerable. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 17, 2024 Category: Cancer & Oncology Source Type: research

The value of 18F-FDG PET/CT in Langerhans cell histiocytosis
Conclusions18F-FDG PET/CT is an effective way to diagnose and evaluate LCH. PET metabolic parameters were associated with laboratory inflammatory markers, suggesting that 18F-FDG PET/CT may be helpful in evaluating disease activity of LCH. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 13, 2024 Category: Nuclear Medicine Source Type: research

Isolated liver involvement in Langerhans cell histiocytosis: A case report
We report here a case of LCH with solitary hepatic involvement in a 74 year-old patient. This case demonstrated molecular anomaly of the MAPK pathway, BRAF N486_P490del. Through this observation, we precise the epidemiological and histological aspects and diagnostic criteria of this rare disease.PMID:38216436 | DOI:10.1016/j.annpat.2023.12.001 (Source: Annales de Pathologie)
Source: Annales de Pathologie - January 12, 2024 Category: Pathology Authors: Pierre Allaume Eric Meneyrol Gontran Bernard Pauline Houssel-Debry Jean-Fran çois Emile Bruno Turlin Source Type: research