Langerhans Cell Histiocytosis (LCH) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Letterer-Siwe disease presenting with gastrointestinal and cutaneous manifestations
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662996.ABSTRACTHistiocytosis is a set of distinct proliferative illnesses defined by the proliferation and infiltration of varied numbers of dendritic cells, macrophages, and monocytes in the afflicted tissues. The skin and other organs may be impacted by the inflammatory infiltration. It can occur at any age. The severity of the symptoms can range from mild to severe, depending on the degree and type of organ involvement. Although certain forms of histiocytosis can be fatal, others can be treated successfully without sequelae. Langerhans cell histiocytosis manifests i...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Antonina Sergeevna Stadnikova Walaa Fadhil Abbas Olga Borisovna Tamrazova Ekaterina Andreevna Pristanskova Irina Nikolaevna Zakharova Irina Vladimirovna Berezhnaya Dmitry Alexandrovich Skobeev Lyudmila Viktorovna Goncharova Source Type: research

Multiple juvenile xanthogranulomata
We report a 2-month-old girl with 22 cutaneous papules, clinically and histologically compatible with juvenile xanthogranulomas. Screening of visceral involvement was performed with no evidence of systemic disease. Identifying high-risk factors of systemic disease in patients with multiple juvenile xanthogranuloma is essential to perform an appropriate management of this entity. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Garcia-Sirvent, Lucia Source Type: research

[ < sup > 68 < /sup > Ga]Ga-FAPI versus [ < sup > 18 < /sup > F]FDG PET/CT in the evaluation of Langerhans cell histiocytosis
Eur J Nucl Med Mol Imaging. 2024 Mar 9. doi: 10.1007/s00259-024-06671-4. Online ahead of print.NO ABSTRACTPMID:38459977 | DOI:10.1007/s00259-024-06671-4 (Source: Molecular Medicine)
Source: Molecular Medicine - March 9, 2024 Category: Molecular Biology Authors: Linlin Guo Guohua Shen Source Type: research

[68Ga]Ga-FAPI versus [18F]FDG PET/CT in the evaluation of Langerhans cell histiocytosis
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 9, 2024 Category: Nuclear Medicine Source Type: research

From terminal ileum to terminal diagnosis: The critical role of terminal ileum intubation in diagnosing langerhans cell histiocytosis in a patient with TAR syndrome
Radiol Case Rep. 2024 Mar 2;19(5):2052-2057. doi: 10.1016/j.radcr.2024.02.017. eCollection 2024 May.ABSTRACTThe co-occurrence of Thrombocytopenia with Absent Radius (TAR) syndrome and Langerhans Cell Histiocytosis (LCH) is exceedingly rare, with scant documentation in existing medical literature. This case report aims to shed light on this unique intersection of conditions, emphasizing the diagnostic and therapeutic challenges it presents. A 27-year-old female with a history of TAR syndrome presented with microcytic anemia, hip pain, and gastrointestinal symptoms. Terminal ileum intubation during colonoscopy revealed super...
Source: Pain Physician - March 6, 2024 Category: Anesthesiology Authors: Mena Louis Chad Copper Elaine Lelli Joseph Conway Daniel Sarmiento Hardeep Singh Source Type: research

GSE227984 Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration
Contributors : Matthew D Park ; C M WilkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurodegenerative diseases (ND) are characterized by a progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused by hematopoietic progenitors expressing MAPK activating mutations that differentiate into senescent dendritic cells that drive formation of lesions. Some patients with systemic LCH subsequently develop progressive and...
Source: GEO: Gene Expression Omnibus - March 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

The value of 18F-FDG PET/CT in Langerhans cell histiocytosis
Conclusions18F-FDG PET/CT is an effective way to diagnose and evaluate LCH. PET metabolic parameters were associated with laboratory inflammatory markers, suggesting that 18F-FDG PET/CT may be helpful in evaluating disease activity of LCH. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Source Type: research

Phase 2 study using low dose cytarabine for adult patients with newly diagnosed Langerhans cell histiocytosis
Leukemia, Published online: 22 February 2024; doi:10.1038/s41375-024-02174-1Phase 2 study using low dose cytarabine for adult patients with newly diagnosed Langerhans cell histiocytosis (Source: Leukemia)
Source: Leukemia - February 22, 2024 Category: Hematology Authors: Long Chang Min Lang He Lin Hao Cai Ming-Hui Duan Dao-Bin Zhou Xin-Xin Cao Source Type: research

Panhypopituitarism, Diabetes Insipidus and Bone Pain - Is There a Systemic Disease Behind it?
Praxis (Bern 1994). 2024 Jan;113(1):23-26.ABSTRACTA 27-year-old man presented due to unilateral leg pain. He had a history of diabetes insipidus and panhypopituitarism. Laboratory analysis revealed hormonal undersupply. MRI showed a large contrast medium-absorbing mass in the pituitary gland extending into the hypothalamus. FDG-PET/CT examination revealed a hypermetabolic soft tissue lesion around the left femoral shaft. After biopsy of the lesion, a diagnosis of multisystemic Langerhans cell histiocytosis was made.PMID:38381107 (Source: Nuklearmedizin)
Source: Nuklearmedizin - February 21, 2024 Category: Radiology Authors: Martina Bertschinger Lisa Sze Irene Bosma Corina Dommann-Scherrer Jeroen Goede Source Type: research

Panhypopituitarism, Diabetes Insipidus and Bone Pain - Is There a Systemic Disease Behind it?
Praxis (Bern 1994). 2024 Jan;113(1):23-26.ABSTRACTA 27-year-old man presented due to unilateral leg pain. He had a history of diabetes insipidus and panhypopituitarism. Laboratory analysis revealed hormonal undersupply. MRI showed a large contrast medium-absorbing mass in the pituitary gland extending into the hypothalamus. FDG-PET/CT examination revealed a hypermetabolic soft tissue lesion around the left femoral shaft. After biopsy of the lesion, a diagnosis of multisystemic Langerhans cell histiocytosis was made.PMID:38381107 (Source: Praxis)
Source: Praxis - February 21, 2024 Category: General Medicine Authors: Martina Bertschinger Lisa Sze Irene Bosma Corina Dommann-Scherrer Jeroen Goede Source Type: research