Clinical characteristics, genomic profiling and outcomes of single system multifocal Langerhans cell histiocytosis in adults with bone involvement
Blood Cancer Journal, Published online: 05 September 2023; doi:10.1038/s41408-023-00913-8Clinical characteristics, genomic profiling and outcomes of single system multifocal Langerhans cell histiocytosis in adults with bone involvement (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - September 5, 2023 Category: Hematology Authors: Hong-xiao Han Long Chang Min Lang He Lin Jian Li Ming-hui Duan Dao-bin Zhou Xin-xin Cao Source Type: research

Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research

Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research

Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research

Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research

Updated AWMF Guideline on the Diagnosis and Treatment of Langerhans cell Histiocytosis in Children and Adolescents
Klin Padiatr. 2023 Sep 4. doi: 10.1055/a-2135-3175. Online ahead of print.ABSTRACTLangerhans cell Histiocytosis is a rare neoplastic disease, which occurs mainly in children and adolescents. The disease may affect any organ, and therefore, the clinical symptoms vary widely. Some patients have a spontaneous remission of the disease, whereas others experience a rapid and potentially lethal clinical course. The therapeutic approach depends on the extent of the disease, and reaches from a watch-and-wait strategy to chemotherapy with the standard drugs vinblastine and prednisone. The identification of mutations in the MAPK-path...
Source: Hamostaseologie - September 4, 2023 Category: Hematology Authors: Thomas Lehrnbecher Martina Ahlmann Michael Albert Anke Elisabeth Barnbrock Karin Beutel Konrad Bochennek Carl Friedrich Classen Susanne Holzhauer Caroline Hutter Karoly Lakatos Roland Meisel Luciana Porto Christian Vokuhl Thomas Vraetz Milen Minkov Source Type: research

Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child
We describe a 10 year-old boy with unifocal (type-3) mixed histiocytosis - Langerhans cell histiocytosis combined with a lesion with features intermediate between Rosai-Dorfman disease and reticulohistiocytosis. Sixty months after excision, the child is disease free.DISCUSSION: Cutaneous type-3 mixed histiocytosis (Langerhans cell histiocytosis with Rosai-Dorfman disease/reticulohistiocytosis) may occur in older childhood, be unifocal, and be cured by surgical excision.PMID:37606204 | DOI:10.1080/15513815.2023.2245489 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 22, 2023 Category: Pathology Authors: Arturo Bonometti Source Type: research

Hepatobiliary involvement in Langerhans cell histiocytosis
AbstractLangerhans cell histiocytosis (LCH) is a rare, proliferative disorder that occurs primarily in children. Periportal lesions were detected on ultrasound at different stages of evolution. In this article, we aim to discuss the sonographic findings in liver involvement of LCH. (Source: Journal of Ultrasound)
Source: Journal of Ultrasound - August 12, 2023 Category: Radiology Source Type: research