Langerhans Cell Histiocytosis (LCH) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
We examined four cases (one female, three males) of gastric LCH. The affected patients were between 33 and 70 years of age. Endoscopically, three patients presented with a solitary polyp or elevated lesions, whereas one patient showed no abnormalities. Under a microscope, all cases showed abnormal proliferation of histiocytoid cells infiltrating in a nested or sheet-like fashion. The tumor cells were medium-sized, with a slightly eosinophilic cytoplasm, irregular or renal-shaped nuclei, folded nuclear membranes, visible nuclear grooves, and the infiltration of inflammatory cells in the background. Immunohistochemically, al...
Source: Journal of Hematopathology - April 23, 2024 Category: Pathology Source Type: research

Adult Langerhans Cell Histiocytosis Presenting With Skin Lesions, Sclerosing Cholangitis and Pneumothorax
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 23, 2024 Category: Hematology Source Type: research

Adult Langerhans cell histiocytosis in the rib presenting with pathological fracture: Report of 2 cases
Asian J Surg. 2024 Apr 20:S1015-9584(24)00724-3. doi: 10.1016/j.asjsur.2024.04.064. Online ahead of print.NO ABSTRACTPMID:38644126 | DOI:10.1016/j.asjsur.2024.04.064 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 21, 2024 Category: Surgery Authors: Mengjuan Li Ning Ding Source Type: research

Extranodal Rosai-Dorfman disease manifesting as Sj ögren's syndrome combined with panuveitis and hypertrophic pachymeningitis: a case report and review of literature
We present the case of a 28-year-old woman who presented with recurrent blurred vision in her right eye for 3 months. She developed blindness and atrophy in her left eye a decade prior to presentation. She subsequently developed headache, fever, and impaired mental status. Cranial magnetic resonance imaging indicated hypertrophic pachymeningitis (HP), and 18F-fluoro-2-deoxy-2-d-glucose (FDG) positron emission tomography/computed tomography revealed significant FDG uptake in the left dura mater. Autoimmune testing revealed elevated anti-nuclear, anti-SS-A, and anti-SS-B antibody levels. Incisional biopsy of the atrophic eye...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Jing Xu Meihua Huang Binsong Dong Min Jian Jinyu Chen Naiyuan Zhang Chunlian Ou Yongming Wu Dongmei Wang Source Type: research

Honeycomb lung appearance accompanied by pediatric Langerhans cell histiocytosis: changes in imaging findings following chemotherapy
Int J Hematol. 2024 Apr 15. doi: 10.1007/s12185-024-03776-2. Online ahead of print.NO ABSTRACTPMID:38622431 | DOI:10.1007/s12185-024-03776-2 (Source: International Journal of Hematology)
Source: International Journal of Hematology - April 15, 2024 Category: Hematology Authors: Kenichi Sakamoto Osamu Miyazaki Yoko Shioda Source Type: research

Intestinal Langerhans cell histiocytosis presenting with symptoms similar to inflammatory bowel disease: a case report
CONCLUSION: The clinical symptoms of Langerhans cell histiocytosis involving the gastrointestinal tract are not specific and may resemble symptoms observed in inflammatory bowel disease and other primary gastrointestinal tumors. Therefore, in cases of infants presenting with inflammatory gastrointestinal symptoms that do not resolve after treatment, a biopsy is essential to obtain a differential diagnosis.PMID:38605931 | PMC:PMC11007090 | DOI:10.3389/pore.2024.1611705 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - April 12, 2024 Category: Pathology Authors: Yuqing Liu Zhenwei Chen Lu Wang Baizhou Li Source Type: research

Intestinal Langerhans cell histiocytosis presenting with symptoms similar to inflammatory bowel disease: a case report
CONCLUSION: The clinical symptoms of Langerhans cell histiocytosis involving the gastrointestinal tract are not specific and may resemble symptoms observed in inflammatory bowel disease and other primary gastrointestinal tumors. Therefore, in cases of infants presenting with inflammatory gastrointestinal symptoms that do not resolve after treatment, a biopsy is essential to obtain a differential diagnosis.PMID:38605931 | PMC:PMC11007090 | DOI:10.3389/pore.2024.1611705 (Source: Cell Research)
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Yuqing Liu Zhenwei Chen Lu Wang Baizhou Li Source Type: research

Increased AXL < sup > high < /sup > myeloid cells as pathognomonic marker in Langerhans cell histiocytosis and Langerin expression dependence of mTOR inhibition
Clin Immunol. 2024 Apr 2:110203. doi: 10.1016/j.clim.2024.110203. Online ahead of print.ABSTRACTLangerhans cell histiocytosis (LCH) is characterized by an expansion and accumulation of pathological histiocytes expressing langerin (CD207) and CD1a in different organs under an inflammatory milieu. The origin of pathognomonic precursors of LCH is widely debated, but monocytes and pre dendritic cells (pre-DC) play significant role. Remarkable we found an expansion of AXLhigh cells in the CD11c+ subset of patients with active LCH, which also express the pathognomonic CD207 and CD1a. Moreover, we obtained a monocyte-derived LC-l...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Cinthia Mariel Olexen Denise Risnik Mar ía Catalina Lava Guido Luis Dalla Vecchia Diego Alfredo Rosso Andrea Emilse Errasti Eugenio Antonio Carrera Silva Source Type: research

Desquamative interstitial pneumonia: A case report
Exp Ther Med. 2024 Mar 13;27(5):199. doi: 10.3892/etm.2024.12487. eCollection 2024 May.ABSTRACTDiffuse cystic lung diseases (DCLDs) are a group of heterogeneous lung diseases that are characterized by inflated spaces or cysts within the lung parenchyma. They also exhibit similar imaging characteristics and clinical manifestations compared with those of cystic lesions, such as pulmonary cavities, emphysema, bronchiectasis and honeycomb lung. The most common DCLDs encountered in the clinic include lymphangioleiomyomatosis, Birt-Hogg-Dubé syndrome, Langerhans cell histiocytosis and lymphocytic interstitial pneumonia. In part...
Source: Experimental and Therapeutic Medicine - March 28, 2024 Category: General Medicine Authors: Hailong Zhang Guohua Yu Ben Yang Shengyao Ma Yubing Wang Xiaoqi Zhang Yong Zhang Mei-Hua Qu Source Type: research