Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort
Curr Issues Mol Biol. 2024 Mar 17;46(3):2553-2565. doi: 10.3390/cimb46030162.ABSTRACTThe interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD), which can be classified as Graves' disease (GD) or Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which, in the form of selenoproteins, strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine release and autoantibody production. The aim of this study was to a...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sabine Upmale-Engela Ieva Vaivode Raitis Peculis Helena Litvina Tatjana Zake Andrejs Skesters Deniss Gogins Vita Rovite Ilze Konrade Source Type: research

WSV2023 - The second meeting of the world society for virology: One health - One world - One virology
Discussions further explored SARS-CoV-2 RNA replicons as vaccine candidates, SARS-CoV-2 in humans and animals, and the significance of plant viruses in the 'One Health' paradigm. The presence of the presidents from three virology societies, namely the American, Indian, and Korean Societies for Virology, highlighted the event's significance. Additionally, past president of the American Society for Virology (ASV), formally declared the partnership between ASV and WSV during the conference.PMID:38527382 | DOI:10.1016/j.virol.2024.110049 (Source: Virology)
Source: Virology - March 25, 2024 Category: Virology Authors: Ahmed S Abdel-Moneim Modra Murovska Maria S öderlund-Venermo Vikram N Vakharia William C Wilson Douglas P Gladue Matthew D Moore Covadonga Alonso Sayed F Abdelwahab Marietjie Venter Yashpal S Malik Shi Zhengli Shailendra K Saxena Anupam Varma Richard J K Source Type: research

Heart failure care in the Central and Eastern Europe and Baltic region: status, barriers, and routes to improvement
AbstractDespite improvements over recent years, morbidity and mortality associated with heart failure (HF) are higher in countries in the Central and Eastern Europe and Baltic region than in Western Europe. With the goal of improving the standard of HF care and patient outcomes in the Central and Eastern Europe and Baltic region, this review aimed to identify the main barriers to optimal HF care and potential areas for improvement. This information was used to suggest methods to improve HF management and decrease the burden of HF in the region that can be implemented at the national and regional levels. We performed a lite...
Source: ESC Heart Failure - March 23, 2024 Category: Cardiology Authors: Ovidiu Chioncel, Jelena Čelutkienė, Jan Bělohlávek, Ginta Kamzola, Mitja Lainscak, Béla Merkely, Davor Miličić, Jadwiga Nessler, Arsen D. Ristić, Lidia Sawiełajc, Izabella Uchmanowicz, Tiina Uuetoa, Eva Turgonyi, Yoto Yotov, Piotr P Tags: Review Source Type: research

Effect of NAT2, GSTM1 and CYP2E1 genetic polymorphisms on plasma concentration of isoniazid and its metabolites in patients with tuberculosis, and the assessment of exposure-response relationships
Conclusion: Our findings suggest that CYP2E1, but not GSTM1, significantly affects the INH pharmacokinetics along with NAT2. AcINH plasma level could serve as a biomarker for INH-related hepatotoxicity, and the inclusion of INH metabolite screening in TB therapeutic drug monitoring could be beneficial in clinical studies for determination of optimal dosing strategies. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 22, 2024 Category: Drugs & Pharmacology Source Type: research

Moving forward after the COVID-19 pandemic: Lessons learned in primary care from the multi-country PRICOV-19 study
CONCLUSION: Policymakers, primary care associations, and the broader healthcare system are urged to collaboratively take responsibility and increase support for GP practices to enhance their resilience, adaptability, and capacity to deliver safe and equitable healthcare during future crises.PMID:38511848 | DOI:10.1080/13814788.2024.2328716 (Source: European Journal of General Practice)
Source: European Journal of General Practice - March 21, 2024 Category: Primary Care Authors: Sara Willems Pierre Vanden Bussche Esther Van Poel Claire Collins Zalika Klemenc-Ketis Source Type: research

Volatilomic profiles of gastric juice in gastric cancer patients
Volatilomics is a powerful tool capable of providing novel biomarkers for the diagnosis of gastric cancer. The main objective of this study was to characterize the volatilomic signatures of gastric juice in order to identify potential alterations induced by gastric cancer. Gas chromatography with mass spectrometric detection, coupled with headspace solid phase microextraction as the pre-concentration technique, was used to identify volatile organic compounds (VOCs) released by gastric juice samples collected from 78 gastric cancer patients and two cohorts of controls (80 and 96 subjects) from four different locations (Latv...
Source: Journal of Breath Research - March 21, 2024 Category: Respiratory Medicine Authors: Linda Mezmale, Daria Ślefarska-Wolak, Manohar Prasad Bhandari, Clemens Ager, Viktors Veliks, Veronika Patsko, Andrii Lukashenko, Emmanuel Dias-Neto, Diana Noronha Nunes, Thais Fernanda Bartelli, Adriane Graicer Pelosof, Claudia Zitron Sztokfisz, Raúl Mu Source Type: research

The effect of yin yoga intervention on state and trait anxiety during the COVID-19 pandemic
ConclusionThe positive effects of yin yoga on state anxiety indicate the potential of yin yoga intervention as a first-line treatment to control and reduce state anxiety, with possible additional effects on trait anxiety. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 14, 2024 Category: Psychiatry Source Type: research

Psychometric properties and normative data of the Latvian and Russian language versions of the strengths and difficulties questionnaire (SDQ) in the Latvian general adolescent population
CONCLUSIONS: This study suggests that the self-report SDQ must be used cautiously in Latvian adolescents because some SDQ subscales lack reliability. When used in population research, the internalising subscales seem more reliable than the externalising ones. More research is needed regarding the reliability of the SDQ in clinical adolescent populations.PMID:38421351 | DOI:10.1080/08039488.2024.2319662 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - February 29, 2024 Category: Psychiatry Authors: Ņikita Bezborodovs R ūdolfs Krēgers Lelde V ētra Elm ārs Rancāns Anita Villeru ša Source Type: research