Perspective: Efficacy and outcomes for different lumbar interspinous devices (ISD) vs. open surgery to treat lumbar spinal stenosis (LSS)
CONCLUSION: Patients undergoing new generation ISD for LSS exhibited comparable or better outcomes, but greater reductions in OR times, EBL, LOS, ROM, and ASD vs. those receiving original/current ISD or undergoing open surgery.PMID:38344078 | PMC:PMC10858763 | DOI:10.25259/SNI_1007_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - February 12, 2024 Category: Neurosurgery Authors: Nancy E Epstein Marc A Agulnick Source Type: research

Albiflorin Attenuates Neuroinflammation and Improves Functional Recovery After Spinal Cord Injury Through Regulating LSD1-Mediated Microglial Activation and Ferroptosis
AbstractSpinal cord injury (SCI) is a serious, prolonged, and irreversible injury with few therapeutic options. Albiflorin (AF) possesses powerful pharmacodynamic properties and exerts protective effects against neuroinflammation. However, no research has examined the neuroprotective effect of AF following SCI.  Rats were received laminectomy to establish SCI animal model and treated with AF (20 mg/kg and 40 mg/kg). Behavioral experiments were conducted to assess the impacts of AF on motor function after SCI in rats. Hematoxylin–eosin (HE) staining, Nissl staining, and Prussian Blue staining were perf ormed to observe...
Source: Inflammation - February 10, 2024 Category: Allergy & Immunology Source Type: research

Cancers, Vol. 16, Pages 748: Leiomyogenic Tumor of the Spine: A Systematic Review
hmadieh John F. Burke The study cohort consisted of 83 patients with a mean age of 49.55 (SD 13.72) with a female preponderance (60 patients). Here, 32.14% of patients had primary LTS; the remaining were metastases. Clinical presentation included nonspecific back pain (57.83%), weakness (21.69%) and radicular pain (18.07%). History of uterine neoplasia was found in 33.73% of patients. LTS preferentially affected the thoracic spine (51.81%), followed by the lumbar (21.67%) spine. MRI alone was the most common imaging modality (33.33%); in other cases, it was used with CT (22.92%) or X-ray (16.67%); 19.23% of patients ...
Source: Cancers - February 10, 2024 Category: Cancer & Oncology Authors: Abdurrahman F. Kharbat Kishore Balasubramanian Kiran Sankarappan Ryan D. Morgan Khawaja M. Hassan Paolo Palmisciano Panayiotis E. Pelargos Michael Chukwu Othman Bin Alamer Ali S. Haider Tarek Y. El Ahmadieh John F. Burke Tags: Systematic Review Source Type: research

Albiflorin Attenuates Neuroinflammation and Improves Functional Recovery After Spinal Cord Injury Through Regulating LSD1-Mediated Microglial Activation and Ferroptosis
AbstractSpinal cord injury (SCI) is a serious, prolonged, and irreversible injury with few therapeutic options. Albiflorin (AF) possesses powerful pharmacodynamic properties and exerts protective effects against neuroinflammation. However, no research has examined the neuroprotective effect of AF following SCI.  Rats were received laminectomy to establish SCI animal model and treated with AF (20 mg/kg and 40 mg/kg). Behavioral experiments were conducted to assess the impacts of AF on motor function after SCI in rats. Hematoxylin–eosin (HE) staining, Nissl staining, and Prussian Blue staining were perf ormed to observe...
Source: Inflammation - February 10, 2024 Category: Allergy & Immunology Source Type: research

Conus medullaris neuroschistosomiasis mimicking Guillain –Barre syndrome: A case of delayed diagnosis leading to permanent neurological damage
In conclusion, spinal NS should be considered in patients presenting with myeloradicular symptoms in regions endemic for schistosomal infection, as delayed recognition can result in irreversible outcomes. (Source: Clinical Case Reports)
Source: Clinical Case Reports - February 9, 2024 Category: General Medicine Authors: Nabil Aljuma'ai, Saif A. Ghabisha, Faisal Ahmed, Taha Al ‐Mwald, Abdullatif Almohtadi, Mohamed Badheeb Tags: CASE REPORT Source Type: research

Factors Associated With Same Day Discharge Post-Spinal Cord Stimulator Placement
CONCLUSION: These results can be used to help determine hospital bed needs post-SCS surgery. Future research should focus on identifying the specific reasons certain demographic and geographic factors might influence same-day discharge rates. Our study provides important insights into the factors associated with same-day discharge rates post open and percutaneous SCS implant and highlights the need for patient-centered, evidence-based approaches to health care delivery.PMID:38324795 (Source: Pain Physician)
Source: Pain Physician - February 7, 2024 Category: Anesthesiology Authors: Alexander Beletsky Cherry Liu Kim Vickery Natalie Hurlock Nutan Winston Munish Loomba Brittany N Burton Ahish Chitneni Rodney A Gabriel Jeffrey Chen Source Type: research

Risk of Subsequent Fusion After Isolated Decompression of Lumbar Facet Cysts
CONCLUSION: Patients undergoing isolated decompression for lumbar facet cysts undergo subsequent lumbar fusion at a 5-year rate of 6.79%. Risk factors for subsequent decompression include chronic kidney disease, hypertension, and osteoarthritis. This study will assist spine surgeons in appropriately counseling patients on expected postoperative course and potential risks of isolated decompression.PMID:38320287 | DOI:10.5435/JAAOS-D-23-00765 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - February 6, 2024 Category: Orthopaedics Authors: Vincent P Federico Enrico M Forlenza Alexander J Acuna Rajko S Vucicevic William K Conaway James W Nie Alexander J Butler Samy Gabriel Gregory D Lopez Howard S An Matthew W Colman Frank M Phillips Source Type: research

Effects of lercanidipine on traumatic spinal cord injury: an experimental study
CONCLUSION: Lercanidipine, a third-generation calcium channel blocker, is effective against inflammatory responses induced in spinal cord injury. Further studies are required to determine its capability in preventing apoptosis or improving functional recovery. To the best of our knowledge, this study is the first in the literature to examine the neuroprotective effects of lercanidipine on spinal cord injury.PMID:38305651 | DOI:10.14744/tjtes.2024.03660 (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - February 2, 2024 Category: Emergency Medicine Authors: Çağlar Türk Sinan Bahad ır Mahmut Camlar Çevik Gürel Aylin Buhur G ökçe Ceren Kuşçu Source Type: research

Effects of lercanidipine on traumatic spinal cord injury: an experimental study
CONCLUSION: Lercanidipine, a third-generation calcium channel blocker, is effective against inflammatory responses induced in spinal cord injury. Further studies are required to determine its capability in preventing apoptosis or improving functional recovery. To the best of our knowledge, this study is the first in the literature to examine the neuroprotective effects of lercanidipine on spinal cord injury.PMID:38305651 | DOI:10.14744/tjtes.2024.03660 (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - February 2, 2024 Category: Emergency Medicine Authors: Çağlar Türk Sinan Bahad ır Mahmut Camlar Çevik Gürel Aylin Buhur G ökçe Ceren Kuşçu Source Type: research

Effects of lercanidipine on traumatic spinal cord injury: an experimental study
CONCLUSION: Lercanidipine, a third-generation calcium channel blocker, is effective against inflammatory responses induced in spinal cord injury. Further studies are required to determine its capability in preventing apoptosis or improving functional recovery. To the best of our knowledge, this study is the first in the literature to examine the neuroprotective effects of lercanidipine on spinal cord injury.PMID:38305651 | DOI:10.14744/tjtes.2024.03660 (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - February 2, 2024 Category: Emergency Medicine Authors: Çağlar Türk Sinan Bahad ır Mahmut Camlar Çevik Gürel Aylin Buhur G ökçe Ceren Kuşçu Source Type: research

Effects of lercanidipine on traumatic spinal cord injury: an experimental study
CONCLUSION: Lercanidipine, a third-generation calcium channel blocker, is effective against inflammatory responses induced in spinal cord injury. Further studies are required to determine its capability in preventing apoptosis or improving functional recovery. To the best of our knowledge, this study is the first in the literature to examine the neuroprotective effects of lercanidipine on spinal cord injury.PMID:38305651 | DOI:10.14744/tjtes.2024.03660 (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - February 2, 2024 Category: Emergency Medicine Authors: Çağlar Türk Sinan Bahad ır Mahmut Camlar Çevik Gürel Aylin Buhur G ökçe Ceren Kuşçu Source Type: research

Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment
This study aimed to probe into the effects of some commonly used regimens with NSAIDs and opioids on well-being of the rats as well as on the functional outcome of the model. This eight-week study used forty-two female Wistar rats (Crl: WI), randomly and equally divided into 6 treatment groups, viz. I) tramadol (5mg/kg) and buprenorphine (0.05mg/kg); II) carprofen (5mg/kg) and buprenorphine (0.05m g/kg); III) carprofen (5mg/kg); IV) meloxicam (1mg/kg) and buprenorphine (0.05mg/kg); V) meloxicam (1mg/kg); and VI) no analgesia (0.5 ml sterile saline). Buprenorphine was administered twice daily whereas other treatments were g...
Source: PLoS One - January 16, 2024 Category: Biomedical Science Authors: Harikrishnan Vijayakumar Sreelatha Source Type: research

Surgical Treatment of Concha Bullosa: A Comparison of the Short-term Results of Crushing and Lateral Laminectomy with and without Mucosal Preservation
AbstractPneumatized middle turbinate (Concha bullosa) is one of the commonest intranasal anatomical variants. Surgery is the effective method to control symptomatic concha bullosa, however, still no clear definition for the best surgical technique. The aim of our study to assess and compare the short-term outcomes of crushing and lateral laminectomy with and without mucosal preservation in the surgical treatment of symptomatic concha bullosa. Thirty patients who underwent concha bullosa surgery (a total of 42 conchae surgeries) were included in this prospective randomized study. Patients were allocated consecutively and eq...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 8, 2024 Category: ENT & OMF Source Type: research