PDX Data Commons and Coordinating Center (PDCCC) for the PDX Development and Trial Centers Research Network (PDXNet) (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-22-013 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to establish a PDXNet Data Commons and Coordinating Center (PDCCC). PDCCC will interact with and coordinate with the PDX (Patient-Derived Xenograft) Development and Trial Centers Research Network (PDXNet) comprised of five PDX Development and Trial Centers (PDTCs, to be supported by companion FOA, RFA-CA-22-012) in a collaborative network. The PDXNet is a National Cancer Institute (NCI) program established to coordinate collaborative, large-scale development and pre-clinical testin...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 25, 2022 Category: Research Source Type: funding
Patient Derived Xenograft (PDX) Development and Trial Centers (PDTCs) Network (U54 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-22-012 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) requests applications for PDX (patient-derived xenografts) Development and Trial Centers (PDTCs) to serve as the laboratory research units of the PDX Development and Trial Centers Research Network (PDXNet). The PDXNet is a National Cancer Institute (NCI) program established to coordinate collaborative, large-scale development and pre-clinical testing of targeted therapeutic agents in patient-derived models (PDMs) to advance the vision of cancer precision medicine. The main goals for PDTCs include: d...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 25, 2022 Category: Research Source Type: funding
National Centers for Translational Research in Reproduction and Infertility (NCTRI) (P50) (Clinical Trial Optional)
Funding Opportunity RFA-HD-23-011 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to announce the re-competition of the National Centers for Translational Research in Reproduction and Infertility (NCTRI). The NCTRI will be administered through the Specialized Research Center (P50) award mechanism. These centers will form a national network that facilitates and accelerates bidirectional knowledge transfer between the laboratory and clinic with the ultimate goal of improving human reproductive health through research excellence and innovation. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 17, 2022 Category: Research Source Type: funding
Are COVID-19 Flexibilities Related to Animal Care and Use Still in Effect?
Yes. The flexibilities allowed by the NIH Office of Laboratory Animal Welfare are continuing due to the recent surges in the COVID-19 pandemic throughout the country and the impact on institutions’ operations. Of note:
Assured institutions with existing approved waivers do not need to request new waivers and may continue to use their waivers if unable to conduct semiannual facility inspections on schedule due to COVID-19 restrictions.
New requests for waivers to conduct semiannual inspections will be considered on a case-by-case basis. See OLAW’s COVID-19 FAQ VIII.11 for instructions for requesting waivers.
Additio...
Source: NIH Extramural Nexus - February 14, 2022 Category: Research Authors: NIH Staff Tags: You Ask, We Answer Animal Welfare OLAW Source Type: funding
Ship-based Science Technical Support in the Arctic (STARC)
Full Proposal Deadline Date: March 1, 2022 Program Guidelines: NSF 22-528This solicitation is for proposals to enhance marine science and technical services provided to NSF-supported research cruises on U.S. Coast Guard cutter (USCGC) Healy. U.S. Coast Guard (USCG) provides basic services that will be augmented by the awardee to the level provided by the University-National Oceanographic Laboratory System (UNOLS) for supporting academic research. This solicitation is for an awardee to perform two primary functions: 1) to plan, coordinate, and ...More at https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503383&WT.mc_id=...
Source: NSF Upcoming Due Dates - January 30, 2022 Category: Science Source Type: funding
Notice of Special Interest (NOSI): Administrative Supplements to Enhance Laboratory Safety Curriculum and a Culture of Safety in Biomedical Research Training Environments
Notice NOT-GM-22-010 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 18, 2022 Category: Research Source Type: funding
Webinar Available on Searches for Alternatives to Animals
The NIH Office of Laboratory Animal Welfare hosted a live webinar in December 2021 entitled, “Best Practices for Conducting a Search for Alternatives and Finding Animal Model/Model Organism Information.” The panelists included Jessie Kull from the U.S. Department of Agriculture Animal Welfare Information Center and Joelle Mornini from the NIH Library. View this recording to learn how to find:
3Rs methods (replacement, reduction, and refinement) and animal use alternative information in bibliographic databases
Journal articles, patents, NIH-funded research projects, and genetic information related to animal models and ...
Source: NIH Extramural Nexus - January 6, 2022 Category: Research Authors: NIH Staff Tags: New Resources Alternatives to Animals Animal Welfare webinar Source Type: funding
Clinical Trial Readiness for Functional Neurological Disorders (U01 Clinical Trial Optional)
Funding Opportunity PAR-22-053 from the NIH Guide for Grants and Contracts. Functional Neurological Disorders (FNDs) are characterized by symptoms of altered voluntary motor or sensory function with clinical findings providing evidence of incompatibility between the symptoms and recognized neurological or medical conditions. FNDs are highly prevalent and associated with significant morbidity, health care costs, and even mortality. In some respects, this group of conditions sits at the intersection of neurology and psychiatry, but the majority of cases first come to the attention of neurologists. Management is complex an...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 2, 2021 Category: Research Source Type: funding
Animal Welfare Assurance Annual Reports to OLAW Due by December 1, 2021
Recipient institutions with an Animal Welfare Assurance must submit their Annual Reports to the NIH Office of Laboratory Animal Welfare by December 1, 2021 (NOT-OD-22-002). These reports cover the October 1, 2020, through September 30, 2021, reporting period, as required by the Public Health Service Policy on Humane Care and Use of Laboratory Animals.
The following information must be reported:
Changes in the institution’s AAALAC International accreditation status, animal care and use program, Institutional Official, and/or Institutional Animal Care and Use Committee (IACUC) membership
Dates for the program and facility...
Source: NIH Extramural Nexus - October 13, 2021 Category: Research Authors: NIH Staff Tags: Top Stories Animal Welfare Assurances Source Type: funding
Reminder: Annual Reports to the Office of Laboratory Animal Welfare due December 1, 2021
Notice NOT-OD-22-002 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 13, 2021 Category: Research Source Type: funding
Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)
Funding Opportunity PAR-21-321 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-designated Cancer Centers. CCSGs support three types of Cancer Centers: 1) Comprehensive Cancer Centers, which demonstrate reasonable depth and breadth of research activities in each of three major areas: basic laboratory; clinical; and prevention, control and population-based research, and which have substantial transdisciplinary research that bridges these scientific areas; and 2) Clinical Cancer Centers, which are prima...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 12, 2021 Category: Research Source Type: funding
An Intergenerational Precision Medicine Research Program for the Study of Factor VIII Immunogenicity in Severe Hemophilia A: Hemophilia A Analytical Cohort Research Program (UG3/UH3 Clinical Trial Not Allowed)
Funding Opportunity RFA-HL-22-004 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support applications that propose the establishment of a Hemophilia A Analytical Cohort Research Program (HARP) that will: 1) collaborate with an established consortium of clinical centers to support the recruitment, enrollment, and follow-up of an antenatal/ neonatal/ pediatric cohort in severe hemophilia A; 2) provide data management, laboratory, and biospecimen support necessary for the establishment of a unique and sharable biospecimen resource annotated with robust intergenerational clinical and demographic ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 9, 2021 Category: Research Source Type: funding
NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genetic Research Centers (GRCs) (U01 Clinical Trial Optional)
Funding Opportunity RFA-DK-21-022 from the NIH Guide for Grants and Contracts. The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July 2002 for the purpose of identifying genetic variation predisposing to Inflammatory Bowel Disease (IBD). Since its establishment and in collaboration with the International IBD Genetics Consortium, the NIDDK IBDGC has identified over 250 IBD susceptibility loci. However, for the great majority of these loci, the specific causal variants and effector genes have not yet been identified, and the biological mechanisms through which these variants influence IBD...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 1, 2021 Category: Research Source Type: funding
Checklist to Help with Semiannual Animal Facility Inspections
We recently released a Guide Notice discussing various flexibilities for conducting semiannual animal facility inspections. This Notice highlights an optional checklist based on the Guide for the Care and Use of Laboratory Animals (Guide), designed to help Institutional Animal Care and Use Committees (IACUCs) conduct thorough animal facility inspections. Both the Notice and the checklist strive to reduce the administrative burden on IACUCs while also ensuring that all the requirements for the Guide are met.
Here are some highlights for those new to the checklist:
Addressing major topics of the Guide, such as Institutional...
Source: NIH Extramural Nexus - August 18, 2021 Category: Research Authors: NIH Staff Tags: Animal Welfare New Resources 21st century cures Source Type: funding
Canine Cancer Immunotherapy Network (K9CIN; U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-21-050 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support canine clinical studies using immunotherapeutic agents and novel drug combinations together with laboratory correlative studies that seek to characterize and understand the cellular and molecular mechanisms that determine anti-tumor responses (or non-responses) in pet dogs with spontaneous tumors. The goal is to create a network of laboratories and canine clinical trial sites. The proposed clinical studies must include therapeutic modulation ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 27, 2021 Category: Research Source Type: funding
