Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis
Bone Marrow Transplantation, Published online: 24 April 2024; doi:10.1038/s41409-024-02292-5Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 24, 2024 Category: Hematology Authors: Weiwei Xu Wencui Chen Jinzhou Guo Liang Zhao Guisheng Ren Xianghua Huang Source Type: research
Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Mohammad Khani Amir Moradi Erfan Ghadirzadeh Seyed Pooria Salehi Mashhad Sari Tooba Akbari Source Type: research
Apparent Mineralocorticoid Excess in Israel: A Case Series and Literature Review
CONCLUSIONS: In this 11-year follow-up report of two Israeli families with AME, patients who presented early maintained long-term normal kidney function, while those who presented late progressed to ESKD. Nevertheless, despite early diagnosis and management, AME is commonly associated with serious complications of the disease or its treatment.PMID:38652803 | DOI:10.1093/ejendo/lvae049 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Asaf Lebel Efrat Ben Shalom Rozan Mokatern Raphael Halevy Yoav Zehavi Daniela Magen Source Type: research
Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: The International Journal of Cardiovascular Imaging - April 23, 2024 Category: Radiology Source Type: research
Mesenchymal stem cells promote ovarian reconstruction in mice
CONCLUSIONS: The presence of BM-MSCs in the artificial ovary was found to promote the survival of ovarian cells, as well as facilitate follicle formation and development. Since the cells didn't proliferate in the reconstituted ovary, this discovery suggests a potential new and safe method for the application of MSCs in clinical fertility preservation by enhancing the success rate of cryo-thawed ovarian tissues after transplantation.PMID:38650029 | DOI:10.1186/s13287-024-03718-z (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Jiazhao Li Haonan Fan Wei Liu Jing Zhang Yue Xiao Yue Peng Weijie Yang Wenwen Liu Yuanlin He Lianju Qin Xiang Ma Jing Li Source Type: research
Impaired kidney function: supporting the safe use of medicines for patients
This article provides an overview of the effects of impaired kidney function on pharmacokinetics and the importance of accurate drug dose adjustments for patients with related conditions. It also discusses various aspects of medicines use in patients with AKI, the pharmacological management of patients with CKD and the use of immunosuppressive therapy in patients who have had a kidney transplant. The authors consider the role of the nurse in ensuring safe medicines use for patients with impaired kidney function throughout the article.PMID:38646689 | DOI:10.7748/ns.2024.e12075 (Source: Nursing Standard)
Source: Nursing Standard - April 22, 2024 Category: Nursing Authors: Kathrine Parker Janette Chu Source Type: research
Drug-drug interaction between tacrolimus and caspofungin in Chinese kidney transplant patients with different < em > CYP3A5 < /em > genotypes
CONCLUSION: Co-administration of caspofungin reduced tacrolimus blood levels and elevated the required daily dose of tacrolimus. In CYP3A5 non-expressers, co-administration of caspofungin had a significant effect on tacrolimus C0/D values. An approximate 10% increase in the weight-adjusted daily dose of tacrolimus in CYP3A5 non-expressers is recommended to ensure the safety of tacrolimus administration.PMID:38646424 | PMC:PMC11027596 | DOI:10.1177/20420986241243165 (Source: Adv Data)
Source: Adv Data - April 22, 2024 Category: Epidemiology Authors: Yundi Zhang Bowen Shen Yue Li Huiying Zong Xiaoming Zhang Xiaohong Cao Fengxi Liu Yan Li Source Type: research
Comparison of skin cancer risk between renal transplant recipients and patients with glomerular diseases in rural Queensland
CONCLUSION: In patients with a high risk of NMSC, reducing skin cancer risk should be considered in conjunction with the optimisation of treatment.PMID:38646861 | DOI:10.1111/ajr.13081 (Source: The Australian Journal of Rural Health)
Source: The Australian Journal of Rural Health - April 22, 2024 Category: Rural Health Authors: Zaw Thet Alfred King-Yin Lam Shu-Kay Ng Soe Yu Aung Thin Han Dwarakanathan Ranganathan Stephanie Newsham Jennifer Borg Christine Pepito Tien K Khoo Source Type: research
From the Clinical to the Bench: Exploring the Insulin Modulation Effects of Tacrolimus and Belatacept
This study investigates whether the observed effects on PTD stem solely from CNI withdrawal or if belatacept influences PTD independently. The study assessed the impact of tacrolimus and belatacept on insulin secretion in MIN6 cells (a beta cell line) and rat islets. Tacrolimus and belatacept were administered to the cells and islets, followed by assessments of cell viability and insulin secretion. Tacrolimus impaired insulin secretion without affecting cell viability, while belatacept showed no detrimental effects on either parameter. These findings support clinical observations of improved HbA1c upon switching from tacro...
Source: Cell Transplantation - April 22, 2024 Category: Cytology Authors: Quentin Perrier C écile Cottet-Rouselle Marine de-Beaumont Johan Noble Sandrine Lablanche Source Type: research
Percutaneous Nephrolithotomy for De Novo Urolithiasis After Kidney Transplantation: A Systematic Review of the Literature
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - April 22, 2024 Category: Urology & Nephrology Authors: Clara Cerrato Victoria Jahrreiss Carlotta Nedbal Francesco Ripa Vincenzo De Marco Manoj Monga B.M.Z. Hameed Peter Kronenberg Amelia Pietropaolo Nithesh Naik Bhaskar K. Somani Source Type: research
Role of nutritional therapy on dietary habits and glycemic control in insulin-treated kidney transplant patients with diabetes
To evaluate the effect of nutritional therapy on glycemic compensation and key cardio-renal risk markers in patients with diabetes and kidney transplant, on insulin treatment by Multiple Daily Injection (MDI) or Continuous Subcutaneous Insulin Infusion (CSII). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 22, 2024 Category: Endocrinology Authors: G. Clemente, N. Della Pia, A. Bramanti, L. Cerbara, G. Russo, P. De Rosa, V. Marotta, A. Tortora, M. Riccio, M. Vitale Source Type: research
Disrupting B and T cell Collaboration in Autoimmune Disease: T cell engagers versus CAR T cell therapy?
Clin Exp Immunol. 2024 Apr 20:uxae031. doi: 10.1093/cei/uxae031. Online ahead of print.ABSTRACTB and T cells collaborate to drive autoimmune disease (AID). Historically, B and T cell (B-T cell) co-interaction was targeted through different pathways such as alemtuzumab, abatacept, and dapirolizumab with variable impact on B cell depletion (BCD), whereas the majority of patients with AID including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and organ transplantation benefit from targeted BCD with anti-CD20 monoclonal antibodies such as rituximab, ocrelizumab or ofatumumab. Refractory AID is a signi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Kavina Shah Maria Leandro Mark Cragg Florian Kollert Franz Schuler Christian Klein Venkat Reddy Source Type: research
Extramedullary relapsed acute lymphoblastic leukemia presenting as asymptomatic acute kidney injury after hematopoietic stem cell transplantation
AbstractAcute kidney injury (AKI) is a common complication in children with hematological malignancies. Although AKI due to infiltration of tumor cells in children is rare, it negatively impacts treatment outcomes and increases the risk of mortality. We introduce a case of a child with acute lymphoblastic leukemia (ALL) who experienced kidney relapse resulting in asymptomatic AKI after remission from treatment, to remind clinicians not to overlook the primary disease in clinical judgment. In cases of unexplained AKI, kidney biopsy should be performed when feasible to get an accurate diagnosis and scientific treatment. In b...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
A 6-year review of acute post-streptococcal glomerulonephritis at a public children ’s hospital in Cape Town, South Africa
ConclusionsChildhood APSGN remains an important health problem in South Africa (SA) with favourable outcomes in most, apart from those with crescentic glomerulonephritis who progressed to kidney failure.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Use of a donor kidney with known autosomal dominant polycystic kidney disease in a highly sensitised paediatric recipient
We report the use of an autosomal-dominant polycystic kidney disease (ADPKD) donor kidney in a paediatric recipient. A 14-year-old boy on haemodialysis for 4 years following loss of a first kidney transplant, highly sensitised, and with limited vascular options for ongoing dialysis access, was offered a deceased brain death donor transplant from a mid-30s donor with known ADPKD but normal kidney function and negligible proteinuria. After extensive discussion with the patient and family, discussing all alternative options and review of available literature, the kidney was accepted and implanted. Graft function was immediate...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
