Randomized clinical trial to compare the efficacy of ivermectin versus placebo to negativize nasopharyngeal PCR in patients with early COVID-19 in Peru (SAINT-Peru): a structured summary of a study protocol for randomized controlled trial
AbstractObjectivesThe primary objective is to determine the effect of a daily dose of ivermectin administered in three consecutive days to non-severe COVID-19 patients with no more than 96 hours of symptoms, on the detection of SARS-CoV-2 RNA by PCR from nasopharyngeal swabs at day seven post-treatment initiation.The secondary objectives are:To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab on days 4, 7, 14 and 21 post-treatment initiationTo assess the efficacy of ivermectin on the improvement of symptomsTo assess the proportion of seroconversions at day 21To assess the saf...
Source: Trials - April 9, 2021 Category: Research Source Type: clinical trials
Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial
In this study, the benefit and safety of atorvastatin (statin) and/or aspirin as adjuvant therapy will be compared with the control group receiving usual care for management of COVID-19. Atorvastatin will be prescribed as 40 mg oral tablets once daily for ten days or until discharge, whichever is earlier. The dose of aspirin will be 75 mg once daily for ten days or until discharge, whichever is earlier. All other therapies will be administered according to the institute ’s COVID-19 treatment protocol and the treating physician’s clinical judgment.Main outcomesAll study participants will be prospectively followed up for...
Source: Trials - October 30, 2020 Category: Research Source Type: clinical trials
Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesTo assess the efficacy of local intranasal treatment with budesonide (nasal irrigation), in addition to olfactory rehabilitation, in the management of loss of smell in COVID-19 patients without signs of severity and with persistent hyposmia 30 days after the onset of symptoms.To search for an association between the presence of an obstruction on MRI and the severity of olfactory loss, at inclusion and after 30 days of treatment.Trial designTwo center, open-label, 2-arm (1:1 ratio) parallel group randomized controlled superiority trial.ParticipantsInclusion criteria- Patient over 18 years of age;- Patient ...
Source: Trials - July 19, 2020 Category: Research Source Type: clinical trials
The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial
AbstractObjectivesThe primary objective is to determine the efficacy of a single dose of ivermectin, administered to low risk, non-severe COVID-19 patients in the first 48 hours after symptom onset to reduce the proportion of patients with detectable SARS-CoV-2 RNA by Polymerase Chain Reaction (PCR) test from nasopharyngeal swab at day 7 post-treatment.The secondary objectives are:To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab at day 7 post treatment.To assess the efficacy of ivermectin to improve symptom progression in treated patients.To assess the proportion of seroco...
Source: Trials - June 7, 2020 Category: Research Source Type: clinical trials
Bioavailability of Levoketoconazole and Ketoconazole Tablets
Condition: Healthy Interventions: Drug: Levoketoconazole; Drug: Ketoconazole Sponsor: Cortendo AB Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 26, 2019 Category: Research Source Type: clinical trials
