Diagnosis and Treatment of Keloid: Method Summary and Effect Evaluation
In conclusion, the diagnosis and treatment of keloid require consideration of multiple factors and the implementation of individualized treatment plans. Future research should focus on identifying the molecular mechanisms underlying the occurrence and progression of keloid in order to develop more effective treatment methods.PMID:38170138 | PMC:PMC10759814 | DOI:10.2147/CCID.S446018 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 3, 2024 Category: Dermatology Authors: Yu Liu Xiaoliang Xiong Nan Cao Yinlong Zhao Source Type: research
Drugs targeting TGF- β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion
Mol Cell Biochem. 2023 Dec 29. doi: 10.1007/s11010-023-04912-y. Online ahead of print.ABSTRACTHypertrophic scar (HS) formation is a cutaneous fibroproliferative disease that occurs after skin injuries and results in severe functional and esthetic disability. To date, few drugs have shown satisfactory outcomes for the treatment of HS formation. Transforming growth factor-beta (TGF-β)/Notch interaction via small mothers against decapentaplegic 3 (Smad3) could facilitate HS formation; therefore, targeting TGF-β/ Notch interaction via Smad3 is a potential therapeutic strategy to attenuate HS formation. In addition, optic atr...
Source: Molecular and Cellular Biochemistry - December 29, 2023 Category: Biochemistry Authors: Da Huo Xin-Yu Bi Jun-Ling Zeng Da-Mao Dai Xiang-Lin Dong Source Type: research
Drugs targeting TGF- β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion
Mol Cell Biochem. 2023 Dec 29. doi: 10.1007/s11010-023-04912-y. Online ahead of print.ABSTRACTHypertrophic scar (HS) formation is a cutaneous fibroproliferative disease that occurs after skin injuries and results in severe functional and esthetic disability. To date, few drugs have shown satisfactory outcomes for the treatment of HS formation. Transforming growth factor-beta (TGF-β)/Notch interaction via small mothers against decapentaplegic 3 (Smad3) could facilitate HS formation; therefore, targeting TGF-β/ Notch interaction via Smad3 is a potential therapeutic strategy to attenuate HS formation. In addition, optic atr...
Source: Molecular and Cellular Biochemistry - December 29, 2023 Category: Biochemistry Authors: Da Huo Xin-Yu Bi Jun-Ling Zeng Da-Mao Dai Xiang-Lin Dong Source Type: research
Transcriptome network analysis of inflammation and fibrosis in keloids
Keloid (KL) is a common benign skin tumor. KL is typically characterized by significant fibrosis and an intensive inflammatory response. Therefore, a comprehensive understanding of the interactions between cellular inflammation and fibrotic cells is essential to elucidate the mechanisms driving the progression of KL and to develop therapeutics. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 27, 2023 Category: Dermatology Authors: Jiayi Mao, Lu Chen, Shutong Qian, Yuhuan Wang, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Xiyuan Mao, Peisong Zhai, Yuguang Zhang, Liucheng Zhang, Xiaoming Sun Source Type: research
Keloid Scar Resistance to Intralesional Steroid Injections: Should We Look for Foreign Bodies? A Case Report
Clin Cosmet Investig Dermatol. 2023 Dec 21;16:3693-3697. doi: 10.2147/CCID.S443813. eCollection 2023.ABSTRACTKeloid is a challenging pathological condition characterized by abnormal scarring that extends beyond the boundaries of the original wound. Despite the available treatment options, keloid scars remain difficult to manage. This case report discusses a 10-year-old boy with a keloid scar on his neck following branchial anomaly repair surgery. The patient underwent multiple treatments, including triamcinolone injections, cryotherapy, and a pulsed dye laser session, with limited improvement. Subsequently, an X-ray and ul...
Source: Clinical, Cosmetic and Investigational Dermatology - December 26, 2023 Category: Dermatology Authors: Nuha Alfurayh Reem Alqahtani Mohammed AlFada Source Type: research
A Fully Digital Auricular Splint Workflow for Post-Keloid Excision
Arch Plast Surg. 2023 Aug 31;50(6):563-567. doi: 10.1055/s-0043-1771271. eCollection 2023 Nov.ABSTRACTEar keloids are challenging lesions to treat due to high recurrence rates postexcision. Conservative compression techniques as adjunct treatment have been reported to be effective. An innovative technique of using computer-aided design/computed-aided manufacturing to print a customized auricular splint improves efficiency and comfort level for patients compared with conventional methods. The ear is scanned using an intraoral scanning 2 weeks postsurgery. A two-piece auricular splint is designed on the digital model, incorp...
Source: Archives of Plastic Surgery - December 25, 2023 Category: Cosmetic Surgery Authors: Rahmat Maria Yee Onn Kok Khim Hean Teoh Source Type: research
