Recurrence and Complications of Peri-operative Steroid Injection of Keloids: A Systematic Review and Meta-analysis
In conclusion, post-operative steroid injection after surgical excision results in lower keloid recurrence compared to pre- and intra-operative injection.Level of Evidence IV“This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. ” (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - April 1, 2024 Category: Cosmetic Surgery Source Type: research
Natural products - Dawn of keloid treatment
Fitoterapia. 2024 Mar 28:105918. doi: 10.1016/j.fitote.2024.105918. Online ahead of print.ABSTRACTKeloids are prevalent pathological scars, often leading to cosmetic deformities and hindering joint mobility.They cause discomfort, including burning and itching, while gradually expanding and potentially posing a risk of cancer.Developing effective drugs and treatments for keloids has been a persistent challenge in the medical field. Natural products are an important source of innovative drugs and a breakthrough for many knotty disease.Herein, keywords of "natural, plant, compound, extract" were combined with "keloid" and sea...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Zongzhou Song Wenquan Li Qingying He Xin Xie Xurui Wang Jing Guo Source Type: research
Risk factors for local recurrence of keloids and hypertrophic scars after postoperative electron beam radiotherapy
CONCLUSION: This result could be used for follow-up and as a determinant for the optimal dose/fractionation of postoperative radiotherapy.PMID:38554315 | DOI:10.4103/jcrt.jcrt_1861_22 (Source: Cancer Control)
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Atsuto Katano Masanari Minamitani Hideomi Yamashita Source Type: research
Natural products - Dawn of keloid treatment
Fitoterapia. 2024 Mar 28:105918. doi: 10.1016/j.fitote.2024.105918. Online ahead of print.ABSTRACTKeloids are prevalent pathological scars, often leading to cosmetic deformities and hindering joint mobility.They cause discomfort, including burning and itching, while gradually expanding and potentially posing a risk of cancer.Developing effective drugs and treatments for keloids has been a persistent challenge in the medical field. Natural products are an important source of innovative drugs and a breakthrough for many knotty disease.Herein, keywords of "natural, plant, compound, extract" were combined with "keloid" and sea...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Zongzhou Song Wenquan Li Qingying He Xin Xie Xurui Wang Jing Guo Source Type: research
Natural products - Dawn of keloid treatment
Fitoterapia. 2024 Mar 28;175:105918. doi: 10.1016/j.fitote.2024.105918. Online ahead of print.ABSTRACTKeloids are prevalent pathological scars, often leading to cosmetic deformities and hindering joint mobility.They cause discomfort, including burning and itching, while gradually expanding and potentially posing a risk of cancer.Developing effective drugs and treatments for keloids has been a persistent challenge in the medical field. Natural products are an important source of innovative drugs and a breakthrough for many knotty disease.Herein, keywords of "natural, plant, compound, extract" were combined with "keloid" and...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Zongzhou Song Wenquan Li Qingying He Xin Xie Xurui Wang Jing Guo Source Type: research
Surgery and superficial x ‐ray radiotherapy for keloids of the preauricular and contralateral ear lobe: Case report
The combined approach of surgical resection along with superficial x-ray radiotherapy emerges as a superior treatment option for individuals with keloids of the right ear lobe. Key Clinical MessageThe combined approach of surgical resection along with superficial x-ray radiotherapy emerges as a superior treatment option for individuals with keloids, which hold huge potential for enhancing aesthetic outcomes and preventing keloid recurrence. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 30, 2024 Category: General Medicine Authors: Qin Tan,
JinHui Xu,
Wei Xu,
Hao Lu Tags: CASE REPORT Source Type: research
Smart Use of Skin Biopsy Punch in Treating Keloids: A Single-Center Retrospective Study
ConclusionsThis study demonstrated BPCI might be an effective and safe therapy in keloids with a low long-time recurrence rate and well tolerance for patients.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - March 29, 2024 Category: Cosmetic Surgery Source Type: research
Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond
tRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt. The Mitogen-activated protein kinases (MAPK) pathway orchestrates cellular responses, influencing proliferation, differentiation, apoptosis, and transformation. tsRNAs influence the expression of the MAPK signaling pathway by targeting specific proteins within the pathway. Presently, four MAPK-linked tsRNAs have implications in gastric cancer (GC) and high-grade serous ovarian cancer (HGSOC). Notably, tRF-Glu-TTC-027 and tRF-Val-CAC-016 modulate MAPK-related protein expres...
Source: Frontiers in Genetics - March 26, 2024 Category: Genetics & Stem Cells Source Type: research
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms
In this study, we examined the expression of apelin and APJ in scar tissue, normal skin, and fibroblasts derived from these tissues. We investigated the impact of the hypoxic microenvironment in scars on apelin/APJ expression to identify the transcription factors influencing apelin/APJ expression. Through overexpressing or knocking down apelin/APJ expression, we observed their effects on fibroblast secretion of extracellular matrix proteins. We further validated these effects in animal experiments while exploring the underlying mechanisms. Our findings demonstrated that the apelin/APJ axis is expressed in fibroblasts from ...
Source: Biochimica et Biophysica Acta - March 20, 2024 Category: Biochemistry Authors: Nian Shi Yi Wang Zhenyu Xia Jingjuan Zhang Shanshan Jia Ya Jiao Chao Wang Xiaoyang Wang Jie Zhao Jixun Zhang Duyin Jiang Source Type: research
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms
In this study, we examined the expression of apelin and APJ in scar tissue, normal skin, and fibroblasts derived from these tissues. We investigated the impact of the hypoxic microenvironment in scars on apelin/APJ expression to identify the transcription factors influencing apelin/APJ expression. Through overexpressing or knocking down apelin/APJ expression, we observed their effects on fibroblast secretion of extracellular matrix proteins. We further validated these effects in animal experiments while exploring the underlying mechanisms. Our findings demonstrated that the apelin/APJ axis is expressed in fibroblasts from ...
Source: Biochimica et Biophysica Acta - March 20, 2024 Category: Biochemistry Authors: Nian Shi Yi Wang Zhenyu Xia Jingjuan Zhang Shanshan Jia Ya Jiao Chao Wang Xiaoyang Wang Jie Zhao Jixun Zhang Duyin Jiang Source Type: research
A Single Institution Review of the Use of Radiation in the Adjuvant and Definitive Management of Keloids
And purpose: Many individuals suffer from keloids that are refractory to standard treatment modalities, including surgical excision alone. Radiation therapy can be used to reduce the risk of recurrent keloids post-operatively, as well as be used as primary treatment for keloids not amenable to surgical resection. The purpose of this study was to review our institutional experience of radiation therapy for keloid management. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Jason Fernandes, Donna Liao, Archya Dasgupta, May N. Tsao, Elizabeth A. Barnes Tags: Original Article Source Type: research
A Single-Institution Review of the Use of Radiation in the Adjuvant and Definitive Management of Keloids
Many individuals suffer from keloids that are refractory to standard treatment modalities, including surgical excision alone. Radiation therapy can be used to reduce the risk of recurrent keloids post-operatively, as well as be used as primary treatment for keloids not amenable to surgical resection. The purpose of this study was to review our institutional experience of radiation therapy for keloid management. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: J. Fernandes, D. Liao, A. Dasgupta, M.N. Tsao, E.A. Barnes Tags: Original Article Source Type: research
Macrophage phenotype is determinant for fibrosis development in keloid disease
Matrix Biol. 2024 Mar 12:S0945-053X(24)00037-4. doi: 10.1016/j.matbio.2024.03.001. Online ahead of print.ABSTRACTKeloid refers to a fibroproliferative disorder characterized by an accumulation of extracellular matrix (ECM) components at the dermis level, overgrowth beyond initial wound, and formation of tumor-like nodule areas. Treating keloid is still an unmet clinical need and the lack of an efficient therapy is clearly related to limited knowledge about keloid etiology, despite the growing interest of the scientific community in this pathology. In past decades, keloids were often studied in vitro through the sole prism ...
Source: Matrix Biology - March 14, 2024 Category: Molecular Biology Authors: Z élie Dirand M élissa Maraux Marion Tissot Brice Chatelain Dorothy Supp C éline Viennet Sylvain Perruche Gwena ël Rolin Source Type: research
