Non-coding RNAs in hypertrophic scars and keloids: Current research and clinical relevance: A review
Int J Biol Macromol. 2023 Nov 23:128334. doi: 10.1016/j.ijbiomac.2023.128334. Online ahead of print.ABSTRACTHypertrophic scars (HS) and keloids (KD) are lesions that develop as a result of excessive fibroblast proliferation and collagen deposition in response to dermal injury, leading to dysregulation of the inflammatory, proliferative, and remodeling phases during wound healing. HS and KD affect up to 90 % of the population and are associated with lower quality of life, physical health, and mental status in patients. Efficient targeted treatment represents a significant challenge, primarily due to our limited understandin...
Source: International Journal of Biological Macromolecules - November 25, 2023 Category: Biochemistry Authors: Linlin Su Juntao Han Source Type: research
Non-coding RNAs in hypertrophic scars and keloids: Current research and clinical relevance: A review
Int J Biol Macromol. 2023 Nov 23:128334. doi: 10.1016/j.ijbiomac.2023.128334. Online ahead of print.ABSTRACTHypertrophic scars (HS) and keloids (KD) are lesions that develop as a result of excessive fibroblast proliferation and collagen deposition in response to dermal injury, leading to dysregulation of the inflammatory, proliferative, and remodeling phases during wound healing. HS and KD affect up to 90 % of the population and are associated with lower quality of life, physical health, and mental status in patients. Efficient targeted treatment represents a significant challenge, primarily due to our limited understandin...
Source: International Journal of Biological Macromolecules - November 25, 2023 Category: Biochemistry Authors: Linlin Su Juntao Han Source Type: research
The upregulation of circFoxp1 influences keloid by promoting cell proliferation
In this study, we explored the function of circFoxp1 on keloid formation. Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) results revealed that circFoxp1 expression was higher in the keloid tissues. Furthermore, RNA-fluorescence in situ hybridization (RNA-FISH) and RNAscope illustrated that circFoxp1 was present in the cytoplasm. Subsequent cellular experiments demonstrated that circFoxp1 overexpression enhanced proliferation, migration, and ECM deposition. In addition, apoptosis was inhibited. Cell proliferation, inflammatory response, and oxidative phosphorylation of fibroblasts were also ...
Source: Aging - November 22, 2023 Category: Biomedical Science Authors: Jing Zhang Qianyi Bao Nan Song Chunming Li Jing Ma Source Type: research
The upregulation of circFoxp1 influences keloid by promoting cell proliferation
In this study, we explored the function of circFoxp1 on keloid formation. Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) results revealed that circFoxp1 expression was higher in the keloid tissues. Furthermore, RNA-fluorescence in situ hybridization (RNA-FISH) and RNAscope illustrated that circFoxp1 was present in the cytoplasm. Subsequent cellular experiments demonstrated that circFoxp1 overexpression enhanced proliferation, migration, and ECM deposition. In addition, apoptosis was inhibited. Cell proliferation, inflammatory response, and oxidative phosphorylation of fibroblasts were also ...
Source: Aging - November 22, 2023 Category: Biomedical Science Authors: Jing Zhang Qianyi Bao Nan Song Chunming Li Jing Ma Source Type: research
The upregulation of circFoxp1 influences keloid by promoting cell proliferation
In this study, we explored the function of circFoxp1 on keloid formation. Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) results revealed that circFoxp1 expression was higher in the keloid tissues. Furthermore, RNA-fluorescence in situ hybridization (RNA-FISH) and RNAscope illustrated that circFoxp1 was present in the cytoplasm. Subsequent cellular experiments demonstrated that circFoxp1 overexpression enhanced proliferation, migration, and ECM deposition. In addition, apoptosis was inhibited. Cell proliferation, inflammatory response, and oxidative phosphorylation of fibroblasts were also ...
Source: Aging - November 22, 2023 Category: Biomedical Science Authors: Jing Zhang Qianyi Bao Nan Song Chunming Li Jing Ma Source Type: research
Joint effect of RRP9 and DDX21 on development of colorectal cancer and keloid via verification of experiment
CONCLUSIONS: The higher the expression of RRP9 and DDX21 in colorectal cancer and keloid, the worse the prognosis.PMID:37988222 | DOI:10.18632/aging.205240 (Source: Aging)
Source: Aging - November 21, 2023 Category: Biomedical Science Authors: Hao Liu Xiaoqian Chi Ning Yang Mengjie Shan Yiding Xiao Mingzi Zhang Yan Hao Shiyang Hou Yabin Liu Youbin Wang Source Type: research
Joint effect of RRP9 and DDX21 on development of colorectal cancer and keloid via verification of experiment
CONCLUSIONS: The higher the expression of RRP9 and DDX21 in colorectal cancer and keloid, the worse the prognosis.PMID:37988222 | DOI:10.18632/aging.205240 (Source: Aging)
Source: Aging - November 21, 2023 Category: Biomedical Science Authors: Hao Liu Xiaoqian Chi Ning Yang Mengjie Shan Yiding Xiao Mingzi Zhang Yan Hao Shiyang Hou Yabin Liu Youbin Wang Source Type: research
