The Efficacy of Surgical Excision Plus Adjuvant Multimodal Therapies in the Treatment of Keloids: A Systematic Review and Meta-Analysis
CONCLUSION Triple therapy using surgery plus radiation and/or TAC as one of the adjuvant treatment modalities may achieve the lowest recurrence rates for keloids. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - July 30, 2020 Category: Dermatology Tags: Review Article Source Type: research

Combination of 1,064-nm Neodymium-doped Yttrium Aluminum Garnet Laser and Steroid Tape Decreases the Total Treatment Time of Hypertrophic Scars: An Analysis of 40 Cases of Cesarean-Section Scars
BACKGROUND The 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (Cutera, Inc., Brisbane, CA) and steroid tape (fludroxycortide tape) have been used to treat keloids and hypertrophic scars. OBJECTIVE To evaluate the efficacy of contact-mode 1,064-nm Nd:YAG laser therapy and steroid tape for hypertrophic cesarean-section scars versus conservative therapy (steroid tape only). MATERIALS AND METHODS A medical record review identified 40 consecutive Japanese patients who had hypertrophic scars (total Japan Scar Workshop Scar Scale [JSS] 2015 evaluation scores of 9 to 12) for more than 1 year after a vertic...
Source: Dermatologic Surgery - July 30, 2020 Category: Dermatology Tags: Original Article Source Type: research

A Review of Vitamin D and Scarring: The Potential for New Therapeutics.
Conclusions: Scars are challenging to treat, and patients are increasingly interested in non-invasive treatment options. Although few human clinical studies have been reported, vitamin D may be beneficial as an adjunct therapy to current treatment options. J Drugs Dermatol. 2020;19(7): doi:10.36849/JDD.2020.4986. PMID: 32721140 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 29, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Subbrow Lift Using Frontalis Sling to Correct Lateral Orbital Laxity
ConclusionsSubbrow lift utilizing the frontalis muscle attachment to the lower flap orbicularis muscle is a novel method of correcting upper eyelid skin hooding. The technique does not rely on periosteal fixation. Therefore, the eyebrow gliding plane is not violated. Thus, the natural eyebrow movement is maintained. There were no cases of injury to the deep branch of the supraorbital nerve, poor wound healing, or other significant complications.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to t...
Source: Aesthetic Plastic Surgery - July 24, 2020 Category: Cosmetic Surgery Source Type: research

Skin Needling in Combination with Antimicrobial Peptides for the Treatment of Keloids: A Novel Perspective Proposal and Approach for Skin Scars
Dermatology (Source: Dermatology)
Source: Dermatology - July 13, 2020 Category: Dermatology Source Type: research

GSE154234 Analysis of mRNA expression between irradiated and non-irradiated keloid-derived primary cells.
This study aims to compare mRNA expression between irradiated and non-irradiated keloid-derived primary cells by RNA-Seq. In this study, keloid-derived primary cells that were isolated from patients, and then divided into three groups and each group had four repeats. The first group of cells was treated without radiation, the second group of cells were received 4 Gy delivered in 2-Gy fractions once per day over 2 days and the third group of cells were received 8 Gy delivered in 2-Gy fractions once per day over 4 days.The last two groups of cells were irradiated at a fixed rate of 1.15 Gy/min using an X-ray linear accelerat...
Source: GEO: Gene Expression Omnibus - July 11, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Alternative Clinical Indications of Botulinum Toxin
AbstractBotulinum toxin type A (BoNTA) is a powerful neurotoxin that inhibits acetylcholine release from presynaptic vesicles. The potency and safety profile of BoNTA grant the toxin vast therapeutic potential. It has been used off-label for a variety of dermatologic conditions. This review aims to analyze published literature regarding the benefits and risks of the off-label use of BoNTA beyond facial lines, including eccrine hidrocystomas, enlarged pores, keloids and hypertrophic scars, hidradenitis suppurativa, hyperhidrosis, masseter muscle hypertrophy, and salivary gland hypertrophy, among others. A MEDLINE search fro...
Source: American Journal of Clinical Dermatology - July 10, 2020 Category: Dermatology Source Type: research

Dipeptidyl Peptidase-4 Inhibitor Reduces the Risk of Developing Hypertrophic Scars and Keloids following Median Sternotomy in Diabetic Patients: A Nationwide Retrospective Cohort Study Using the National Database of Health Insurance Claims of Japan
This study aimed to verify the suppressive effect of dipeptidyl peptidase-4 inhibitors on the formation of hypertrophic scars or keloids using real world data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan. It is a retrospective cohort study, and data were extracted from the National Database between April of 2013 and March of 2015. Patients who underwent median sternotomy were included in the study based on their claimed surgical codes. Subjects who were prescribed dipeptidyl peptidase-4 inhibitors constituted the treatment group; subjects who were not prescribed or administere...
Source: Plastic and Reconstructive Surgery - June 25, 2020 Category: Cosmetic Surgery Tags: Experimental Source Type: research

Use of a smartphone for imaging, modelling, and evaluation of keloids
Publication date: Available online 20 June 2020Source: BurnsAuthor(s): Weiqian Jiang, Lingli Guo, Huan Wu, Jun Ying, Zheng Yang, Baohua Wei, Feng Pan, Yan Han (Source: Burns)
Source: Burns - June 22, 2020 Category: Dermatology Source Type: research

Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression.
Authors: Zhang X, Liu W, Wei S Abstract The current experiment was performed to investigate whether luteolin affects the proliferation and apoptosis of keloid fibroblasts by regulating the expression of FRAT1 gene. Keloid fibroblasts were treated with luteolin at different concentrations. MTT method, western blot, flow cytometry, and real-time quantitative PCR (qPCR) were used to detect cell proliferation, cyclin D1 (CyclinD1), p21, B-cell lymphoma / leukemia-2 (Bcl-2), Bcl-2 related X protein (Bax), FRAT1 protein expression, apoptosis and ARHI mRNA expression. Keloid fibroblasts were transfected with si-FRAT1, or ...
Source: Cellular and Molecular Biology - June 18, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

743 Midkine and pleiotrophin are expressed in keloids
Midkine (MDK) is a 15.5kDa heparin-binding growth factor induced by retinoids and inhibited by corticosteroids. It is closely related in structure to another low molecular weight protein, Pleiotrophin (PTN, 18.9kDa). Both MDK and PTN are involved in many important biological pathways including embryogenesis, tumorigenesis, and wound healing. They bind to a number of different receptors, including Protein-Tyrosine Phosphatase, Receptor-Type Zeta-1 (PTZPRZ1), which is known to play a key role in regulating cell growth, differentiation and transformation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: V. Cantu, A. Tran, I. Dougherty, D. Glass Tags: Skin of Color Source Type: research

733 SFRP2-expressing, COL11A1-expressing fibroblasts are the major fibroblast population within keloids
Fibroblasts perform a multitude of processes within skin: extracellular matrix (ECM) production, regulation of inflammation, facilitate cutaneous repair after injury, and serve as pluripotent mesenchymal cells. Recent evidence suggests that there are two main major fibroblast populations in human skin: SFRP2-expressing fibroblasts and FMO1-expressing fibroblasts, and five minor populations, each expressing discrete genes: CRABP1, COL11A1, FMO2, PRG4, or C2ORF40. Keloids are benign fibroproliferative tumors that result from an exaggerated response to cutaneous wound healing. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: I. Dougherty, V. Cantu, D. Glass Tags: Skin of Color Source Type: research

727 Keloids are associated with Th2, JAK3, and CCR9/CCL25 inflammation
Keloids occur due to disturbed wound healing and abnormal collagen production, often affecting African American (AA) and Asian populations. An increased prevalence of atopic conditions, particularly asthma, has been described in keloid patients. However, its immune pathomechanism has not been studied, inhibiting therapeutic development. To evaluate the inflammatory signature of keloids in skin we obtained lesional and nonlesional biopsies from 3 AA patients with new onset keloids and 5 AA healthy controls. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: J. Wu, E. Del Duca, M. Espino, A. Diaz, N. Zhang, A. Gontzes, Y. Estrada, J.G. Krueger, A. Pavel, E. Guttman-Yassky Tags: Skin of Color Source Type: research

Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Tao Zhang, Xiao-Feng Wang, Zheng-Cai Wang, Dong Lou, Qing-Qing Fang, Yan-Yan Hu, Wan-Yi Zhao, Li-Yun Zhang, Li-Hong Wu, Wei-Qiang Tan (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 14, 2020 Category: Drugs & Pharmacology Source Type: research

Current potential therapeutic strategies targeting the TGF- β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation.
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation. Biomed Pharmacother. 2020 Jun 12;129:110287 Authors: Zhang T, Wang XF, Wang ZC, Lou D, Fang QQ, Hu YY, Zhao WY, Zhang LY, Wu LH, Tan WQ Abstract Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process with chronic inflammation. The TGF-β/Smad signaling pathway is the most canonical pathway through which the formation of collagen in the fibroblasts and myofibroblasts is regul...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 12, 2020 Category: Drugs & Pharmacology Authors: Zhang T, Wang XF, Wang ZC, Lou D, Fang QQ, Hu YY, Zhao WY, Zhang LY, Wu LH, Tan WQ Tags: Biomed Pharmacother Source Type: research

Treatment of keloids with a single dose of low energy superficial X-ray radiation to prevent recurrence after surgical excision: an in vitro and in vivo study
• Evidence-based radiation parameters for preventing post-surgical keloid recurrence are unavailable. • Based on radiation parameters determined in vitro, a single dose of 8Gy,50kV X-rays delivered an average of 34 days after keloid excision blocked recurrence in 13 of 14 keloids, although 4 pat ients with 6 keloids were lost to follow up. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 11, 2020 Category: Dermatology Authors: Yuna Son, Ernest Owen Nicandro Phillips, Kristin Magrini Price, Laurence Zalmon Rosenberg, Branko Stefanovic, Christopher Michael Wolfe, Tarek Samir Shaath, Amit Om, George Franklin Cohen, Akash Gunjan Source Type: research

Invited Discussion On: Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-Analysis
Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - June 9, 2020 Category: Cosmetic Surgery Source Type: research

Resveratrol inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting HIF-1 α.
In this study, keloid-derived fibroblasts were cultured under hypoxia environment and was treated by resveratrol. CCK-8 assay and Annexin V-FITC were used to evaluate cell activity and apoptosis level. Western blot and RT-qPCR were also used to assess the expression of HIF-α, Collagen I and Collagen III. Besides, siRNA was also used to explore the mechanisms of resveratrol's effect. In this study, hypoxia promotes proliferation and inhibits apoptosis of keloid fibroblasts. These findings highlight the potential obstacle in treating keloids. Furthermore, we demonstrated that resveratrol could reverse the effect of hyp...
Source: Journal of Plastic Surgery and Hand Surgery - June 6, 2020 Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research

Low-Grade Myofibroblastic Sarcoma Arising from Keloid Scar on the Chest Wall after Thoracic Surgery
Publication date: Available online 4 June 2020Source: The Annals of Thoracic SurgeryAuthor(s): Yur-Ren Kuo, Chih-Kai Yang, Austin Chen, Savitha Ramachandran, Sin-Daw Lin (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 6, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research

Modified injection technique for improving the treatment of keloids.
PMID: 32515920 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - June 5, 2020 Category: General Medicine Authors: Xiao HT, Deng K, Liu XX, Xu XW, Zhang YG Tags: Chin Med J (Engl) Source Type: research

Low-Grade Myofibroblastic Sarcoma Arising from Keloid Scar on the Chest Wall after Thoracic Surgery.
Abstract Keloids are considered as benign fibroproliferative skin tumors and rare case of malignancies has been reported. Hereby, we present a case of low-grade myofibroblastic sarcoma arising from a recurrent painful keloid scar on the right chest wall after video-assisted thoracic surgery for pneumothorax in a 77-year-old man. Wide composite excision of the keloid and surrounding ribs, and partial diaphragm were performed. The chest wall pleural defect was reconstructed with Teflon, and soft tissue was reconstructed with a transverse rectus abdominis myocutaneous flap. This case highlights that refractory keloid...
Source: The Annals of Thoracic Surgery - June 4, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Kuo YR, Yang CK, Chen A, Ramachandran S, Lin SD Tags: Ann Thorac Surg Source Type: research

Fibroblast Heterogeneity in and Its Implications for Plastic and Reconstructive Surgery: A Basic Science Review
Source: Plastic and Reconstructive Surgery Global Open - June 1, 2020 Category: Cosmetic Surgery Tags: Plastic Surgery Focus: Special Topic Source Type: research

Sumoylation enhances the activity of the TGF-β/SMAD and HIF-1 signaling pathways in keloids
Publication date: Available online 29 May 2020Source: Life SciencesAuthor(s): Xiaohu Lin, Yuming Wang, Yan Jiang, Mingyuan Xu, Qianqian Pang, Jiaqi Sun, Yijia Yu, Zeren Shen, Rui Lei, Jinghong Xu (Source: Life Sciences)
Source: Life Sciences - May 29, 2020 Category: Biology Source Type: research

Risk factors of recurrence after postoperative electron beam radiation therapy for keloid: Comparison of long-term local control rate
Publication date: Available online 19 May 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Hitoshi Maemoto, Shiro Iraha, Ken Arashiroc, Kousei Ishigami, Fumikiyo Ganaha, Sadayuki Murayama (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - May 20, 2020 Category: Cancer & Oncology Source Type: research

The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars.
Conclusion: Topical FTY720 induces M2 predominance and impairs angiogenesis. Therefore, its local immunosuppressive mechanisms differ from those of conventional immunosuppressive agents. Topical FTY720 can be a novel therapeutic option for abnormal scars that are difficult to control with corticosteroids. Its lymphocytopenic effects may be limited by careful optimization of the treatment regimen. PMID: 32377536 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - May 8, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders
Conclusions: This review condenses evidence for the active interaction between keratinocytes and fibroblasts in maintaining skin homeostasis and the altered homeostatic interplay between keratinocytes and dermal fibroblasts in scleroderma and scleroderma-like disorders. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 6, 2020 Category: Allergy & Immunology Source Type: research

IJERPH, Vol. 17, Pages 3229: Effect of Kelulut Honey on the Cellular Dynamics of TGF β-Induced Epithelial to Mesenchymal Transition in Primary Human Keratinocytes
IJERPH, Vol. 17, Pages 3229: Effect of Kelulut Honey on the Cellular Dynamics of TGFβ-Induced Epithelial to Mesenchymal Transition in Primary Human Keratinocytes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17093229 Authors: Abid Nordin Shiplu Roy Chowdhury Aminuddin Bin Saim Ruszymah Bt Hj Idrus Over-induction of epithelial to mesenchymal transition (EMT) by tumor growth factor beta (TGFβ) in keratinocytes is a key feature in keloid scar. The present work seeks to investigate the effect of Kelulut honey (KH) on TGFβ-induced EMT in human p...
Source: International Journal of Environmental Research and Public Health - May 6, 2020 Category: Environmental Health Authors: Abid Nordin Shiplu Roy Chowdhury Aminuddin Bin Saim Ruszymah Bt Hj Idrus Tags: Article Source Type: research

TM4SF1 involves in miR-1-3p/miR-214-5p-mediated inhibition of the migration and proliferation in keloid by regulating AKT/ERK signaling
Publication date: Available online 3 May 2020Source: Life SciencesAuthor(s): Mingyuan Xu, Jiaqi Sun, Yijia Yu, Qianqian Pang, Xiaohu Lin, May Barakat, Rui Lei, Jinghong Xu (Source: Life Sciences)
Source: Life Sciences - May 5, 2020 Category: Biology Source Type: research

miR-4417 suppresses keloid fibrosis growth by inhibiting CyclinD1.
In conclusion, miR-4417 and CyclinD1 may be potential therapeutic targets for the treatment of keloid. PMID: 32345773 [PubMed - in process] (Source: Journal of Biosciences)
Source: Journal of Biosciences - May 2, 2020 Category: Biomedical Science Authors: Liu P, Hu Y, Xia L, DU M, Hu Z Tags: J Biosci Source Type: research

5-Fluorouracil Management of Oculofacial Scars: A Systematic Literature Review
Conclusions: High-quality randomized controlled trials are currently lacking, and the existing literature is predominately not specific to use of 5-FU on the face. These studies, however, suggest that intralesional 5-FU is safe and probably more effective than other options in the management of cutaneous scars in the oculofacial region. The delivery methods, timing, dosing, and concomitant therapies were highly variable. Further high-quality controlled studies specific to oculofacial scars may be indicated to assess the efficacy of 5-FU and to establish the best protocols for administering this medication. (Source: Ophth...
Source: Ophthalmic Plastic and Reconstructive Surgery - May 1, 2020 Category: Opthalmology Tags: Major Reviews Source Type: research

The JAK2/STAT3 pathway inhibitor, AG490, suppresses the abnormal behavior of keloid fibroblasts in  vitro.
The JAK2/STAT3 pathway inhibitor, AG490, suppresses the abnormal behavior of keloid fibroblasts in vitro. Int J Mol Med. 2020 Apr 29;: Authors: Zhou Y, Sun Y, Hou W, Ma L, Tao Y, Li D, Xu C, Bao J, Fan W Abstract AG490 is a selective inhibitor of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. The present study examined its effects on the abnormal behavior of human keloid fibroblasts (HKFs) and evaluated its potential use in the treatment of keloids. Human normal fibroblasts (HNFs) and HKFs were treated with increasing concentrations of...
Source: International Journal of Molecular Medicine - April 29, 2020 Category: Molecular Biology Authors: Zhou Y, Sun Y, Hou W, Ma L, Tao Y, Li D, Xu C, Bao J, Fan W Tags: Int J Mol Med Source Type: research

Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis
AbstractBackgroundAlthough keloids and hypertrophic scars are common benign hyperproliferative growths of dermal fibroblasts, the clinical problems including physical and psychological problems are significant and impairing, with few proven treatments. Intralesional triamcinolone acetonide (TAC) and combination of TAC with 5-fluorouracil (5-FU) are widely used to treat keloids and hypertrophic scars, but their efficacy and safety remain controversial.MethodsWe systematically searched MEDLINE, EMBASE, Cochrane Library, and CNKI for relevant trials.ResultsThe mean scar height and the erythema score in the TAC  +&thins...
Source: Aesthetic Plastic Surgery - April 27, 2020 Category: Cosmetic Surgery Source Type: research

3d printed custom made pressure clips for ear keloid treatment after surgical excision
Publication date: Available online 25 April 2020Source: American Journal of OtolaryngologyAuthor(s): Haidong Li, Tao Song (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - April 25, 2020 Category: Endocrinology Source Type: research

Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization
Acta Pharmacologica Sinica, Published online: 23 April 2020; doi:10.1038/s41401-020-0381-yNintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 23, 2020 Category: Drugs & Pharmacology Authors: Bo-ya Zhou Wen-bo Wang Xiao-li Wu Wen-jie Zhang Guang-dong Zhou Zhen Gao Wei Liu Source Type: research

Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization.
In this study, we investigated the effects of nintedanib on keloid fibroblasts in both in vitro and ex vivo models. Keloid fibroblasts were prepared from 54 keloid scar samples in active stages collected from 49 patients. We found that nintedanib (1-4 μM) dose-dependently suppressed cell proliferation, induced G0/G1 cell cycle arrest, and inhibited migration and invasion of keloid fibroblasts. The drug also significantly inhibited the gene and protein expression of collagen I (COL-1) and III (COL-3), fibronectin (FN), and connective growth factor (CTGF), as well as the gene expression of other pathological factor...
Source: Acta Pharmacologica Sinica - April 23, 2020 Category: Drugs & Pharmacology Authors: Zhou BY, Wang WB, Wu XL, Zhang WJ, Zhou GD, Gao Z, Liu W Tags: Acta Pharmacol Sin Source Type: research

Hypoxia and HIF-1 α Regulate Collagen Production in Keloids
Keloids are reactive or spontaneous fibroproliferative dermal tumors characterized by the exaggerated and uncontrolled accumulation of extracellular collagen. Current approaches to mitigate keloidogenesis are largely procedural in nature. However, a better understanding of its biological drivers may lead to novel targeted treatments for keloids. Through whole-genome expression analysis, we found that a HIF-1 α transcriptional footprint is preferentially upregulated (activation score=2.024; p=1.05E-19) in keloid fibroblasts (KFs) compared to normal dermal fibroblasts (NFs). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 18, 2020 Category: Dermatology Authors: Yuanyuan Kang, Mi Ryung Roh, Suvi Rajadurai, Anpuchchelvi Rajadurai, Raj Kumar, Ching-Ni Njauw, Zhenlong Zheng, Hensin Tsao Tags: Original Article Source Type: research

Knockdown of fibronectin extra domain B suppresses TGF- β1-mediated cell proliferation and collagen deposition in keloid fibroblasts via AKT/ERK signaling pathway.
We examined expression of EDB and the effects of EDB on fibroblast proliferation, apoptosis and the expression of the related proteins and genes. The level of phosphorylation of Smad, ERK, and AKT was estimated to elucidate the signaling pathways. The results showed that EDB in human keloid tissues and fibroblasts was overexpressed. EDB knockdown suppressed the cell proliferation of keloid fibroblasts (KFs) treated by transforming growth factor-β1 (TGF-β1). Also, the phosphorylation of Smad, ERK, and AKT in TGF-β1-induced KFs was inhibited In addition, the low expression of pro-collagen-I (Col-I) and Col-III...
Source: Biochemical and Biophysical Research communications - April 18, 2020 Category: Biochemistry Authors: Cui J, Li Z, Jin C, Jin Z Tags: Biochem Biophys Res Commun Source Type: research

Are Prophylactic Measures Necessary to Prevent Recurrence of Penile Keloids?
In this report, we present penile keloids complicating neonatal circumcision in twin brothers. Risk of recurrence in previous reports and measures to guard against it are also discussed. (Source: Urology)
Source: Urology - April 15, 2020 Category: Urology & Nephrology Authors: Ahmed Abdelhalim, Ahmed M. Atwa, Mohamed A. Soltan, Mohamed Edwan, Tamer E. Helmy, Ashraf T. Hafez, Mohamed E. Dawaba Source Type: research

Effects of hyperbaric oxygen therapy on the expression levels of the inflammatory factors interleukin-12p40, macrophage inflammatory protein-1β, platelet-derived growth factor-BB, and interleukin-1 receptor antagonist in keloids
Conclusion : Significantly altered levels of inflammatory factors in the samples from keloid patients were observed, suggesting that formation of a keloid is potentially related to inflammatory responses. HBO therapy could significantly affect the expression levels of IL-12p40, MIP-1β, PDGF-BB, and IL-1Ra, indicating that the effects of HBO therapy are associated with the attenuation of inflammatory responses. (Source: Medicine)
Source: Medicine - April 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Angioleiomyoma of the lumbo-sacral region with unusual keloid-like collagen fibers.
We present a rare case of lumbo-sacral angioleiomyoma in a 54-year-old man. Apart from this unusual site, the most striking morphological feature was the presence of numerous keloid-like collagen fibers interspersed among the fascicles of the neoplastic cells. Radiological, morphological and immunohistochemical features are presented, and differential diagnosis with its potential morphological mimickers is discussed. PMID: 32202538 [PubMed - as supplied by publisher] (Source: Pathologica)
Source: Pathologica - March 24, 2020 Category: Pathology Tags: Pathologica Source Type: research

Hyperbaric oxygen therapy relieved pruritus and pain of keloid patients.
Conclusion: TPH1, Cx43 and TRPV1 were overexpressed in the samples of keloid patients, indicating that the pruritus and pain of keloid might be related to these factors. Furthermore, TPH1, Cx43 and TRPV1 were expressed highest in keloid patients without HBO therapy, indicating that HBO therapy might relief pruritus of keloid patients by regulating these factors. PMID: 32194905 [PubMed] (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 22, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathway
Publication date: Available online 20 March 2020Source: Molecular and Cellular ProbesAuthor(s): Yong Huang, Yuting Wang, Lixin Lin, Peng Wang, Lei Jiang, Jian Liu, Xueming Wang (Source: Molecular and Cellular Probes)
Source: Molecular and Cellular Probes - March 21, 2020 Category: Molecular Biology Source Type: research

The Safety and Efficacy of Intralesional Verapamil Versus Intralesional Triamcinolone Acetonide for Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis
BACKGROUND Keloids and hypertrophic scars often result after skin trauma. Currently, intralesional triamcinolone acetonide (TAC) is the criterion standard in nonsurgical management of keloids and hypertrophic scars. Intralesional verapamil may be an effective alternative modality, but it has been insufficiently studied. Accordingly, the study authors conducted a systematic review and meta-analysis of randomized controlled trials to compare the efficacy and safety of the two drugs. METHODS The study authors systematically searched the MEDLINE, EMBASE, Cochrane Library, and China National Knowledge Infrastructure databa...
Source: Advances in Skin and Wound Care - March 20, 2020 Category: Dermatology Tags: ONLINE EXCLUSIVES Source Type: research

Two-step treatment of bulky keloids on the cheeks after deep chemical peeling: intralesional cryosurgery followed by pulsed dye and ablative fractional CO2 laser
AbstractScarring of the face following chemical peeling is an uncommon and devastating complication. This case report describes the successful treatment of bulky mature keloids on both cheeks following deep chemical peeling by using a combined approach of intralesional cryosurgery followed by pulsed dye and ablative fractional CO2 laser therapy.Level of evidence: Level V, therapeutic study. (Source: European Journal of Plastic Surgery)
Source: European Journal of Plastic Surgery - March 20, 2020 Category: Cosmetic Surgery Source Type: research

Analysis of Scars and Keloids by Focused Ion Beam/Scanning Electron Microscopy: Distinguishing Between Hypertrophic Scars and Keloids
Conclusions These histopathologic findings suggest that FIB/SEM tomography is useful for distinguishing between HSs and keloids and can provide important knowledge for understanding the pathogenesis of keloids. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - March 10, 2020 Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research

Role of Homeodomain-Interacting Protein Kinase 2 in the Pathogenesis of Tissue Fibrosis in Keloid-Derived Keratinocytes: Corrigendum
No abstract available (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - March 10, 2020 Category: Cosmetic Surgery Tags: Corrigendum Source Type: research

Letter to the Editor Regarding: Bao Y, Xu S, Pan Z, et al. Comparative Efficacy and Safety of Common Therapies in Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis. Aesth Plast Surg, 2019
(Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - March 4, 2020 Category: Cosmetic Surgery Source Type: research

Normal Expression of SRY-related HMG-BOX Gene 10 (SOX-10) in Recent and Old Cutaneous Scars is a Potential Mimicker of Desmoplastic Malignant Melanoma
Desmoplastic malignant melanoma (DMM) is an amelanotic spindle cell proliferation that can be mistaken for a cutaneous scar. The distinction can be difficult in reexcisions because DMM is negative for conventional melanoma markers such as HMB-45 and Melan-A, and scars may be positive for S-100 protein and SOX-10. We compare a total of 12 DMM cases with 8 reexcision and 35 old non–reexcision cutaneous scars using SOX-10 immunohistochemical stains. Cell quantification was performed on captured images using ImageJ 1.51t. SOX-10 was expressed in DMM (100%, 12/12), and reexcision (75%, 6/8), atrophic (88%, 22/25), hypertr...
Source: Applied Immunohistochemistry and Molecular Morphology - March 1, 2020 Category: Chemistry Tags: Research Articles Source Type: research

Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification
Source: Plastic and Reconstructive Surgery Global Open - March 1, 2020 Category: Cosmetic Surgery Tags: Original Articles Source Type: research

Keloid and Hypertrophic Scar Formation, Prevention, and Management: Standard Review of Abnormal Scarring in Orthopaedic Surgery.
Authors: Grabowski G, Pacana MJ, Chen E Abstract Keloid and hypertrophic scar formation after orthopaedic surgical closure is a complex issue. The nature and location of procedures maximize wound tension, leave foreign bodies, and diminish dermal supply, all potentiating keloid formation. There is little discussion regarding the pathophysiology and management of this recurrent problem in orthopaedic literature. Keloid formation is a fibroproliferative disorder resulting in extensive production of extracellular matrix and collagen, but prevention and treatment is poorly understood. Patient and surgical factors contr...
Source: The Journal of the American Academy of Orthopaedic Surgeons - February 29, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research