Management of Surgical Scars.
This article discusses techniques for prevention and treatment options for unsightly and hypertrophic scars. PMID: 31587770 [PubMed - in process] (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - October 9, 2019 Category: Surgery Authors: Lee Peng G, Kerolus JL Tags: Facial Plast Surg Clin North Am Source Type: research

Management of Surgical Scars
This article discusses techniques for prevention and treatment options for unsightly and hypertrophic scars. (Source: Facial Plastic Surgery Clinics of North America)
Source: Facial Plastic Surgery Clinics of North America - October 4, 2019 Category: Cosmetic Surgery Authors: Grace Lee Peng, Julia L. Kerolus Source Type: research

Sex Differences in Keloidogenesis: An Analysis of 1659 Keloid Patients in Japan
ConclusionThis is the first report to suggest that female sex may drive keloidogenesis because of physiological reasons. Individuals were most likely to seek a medical examination almost 10  years after onset, regardless of sex. These findings provide new insight into the importance of sex in the development and progression of keloids. Future studies should address the influence of sex hormones on the keloid. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 4, 2019 Category: Dermatology Source Type: research

Early Postoperative Application of Botulinum Toxin Type A Prevents Hypertrophic Scarring after Epicanthoplasty: A Split-Face, Double-Blind, Randomized Trial
Conclusions: Early postoperative botulinum toxin type A injection in the medial canthal region efficiently reduces hypertrophic scarring and improves the outcome of epicanthoplasty. Therefore, botulinum toxin type A injection can be used as a routine method to prevent hypertrophic scarring and improve the outcome of epicanthoplasty. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - September 27, 2019 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Geometric modeling and a retrospective cohort study on the usefulness of fascial tensile reductions in severe keloid surgery
Severe keloids are currently treated with surgical resection followed by radiation. Radiotherapy is essential for preventing recurrences. Fascia tensile reduction suturing may also prevent recurrence. We asked whether superficial fascia tensile reduction with or without deep fascia tensile reduction reduced skin mechanical tension and yielded good outcomes. (Source: Surgery)
Source: Surgery - September 24, 2019 Category: Surgery Authors: Takuya Tsuge, Masayo Aoki, Satoshi Akaishi, Teruyuki Dohi, Hiroya Yamamoto, Rei Ogawa Source Type: research

Next-Generation Sequencing in the Diagnosis of Rare Pediatric Sinonasal Tumors.
We report 2 patients with such rare tumors and describe the use of next-generation sequencing in their evaluation. A 3-year-old female had a 4.4-cm midline nasal cavity mass involving the bony septum and extending into the base of the skull bilaterally. The moderate cellular fibroblastic proliferation revealed areas of thick keloid-like collagen bands and other areas with myxoid edematous stroma. Deep targeted sequencing identified a novel G34V mutation in the CTNNB1 gene consistent with desmoid fibromatosis. An 11-month-old male infant presented with a right nasal mass that extended through the cribriform plate into the a...
Source: Ear, Nose and Throat Journal - September 24, 2019 Category: ENT & OMF Authors: Ahmed AA, Vundamati D, Farooqi M, Repnikova E, Zinkus T, Hetherington M, Paulson L Tags: Ear Nose Throat J Source Type: research

CUDC ‑907 reverses pathological phenotype of keloid fibroblasts in vitro and in vivo via dual inhibition of PI3K/Akt/mTOR signaling and HDAC2.
CUDC‑907 reverses pathological phenotype of keloid fibroblasts in vitro and in vivo via dual inhibition of PI3K/Akt/mTOR signaling and HDAC2. Int J Mol Med. 2019 Sep 23;: Authors: Tu T, Huang J, Lin M, Gao Z, Wu X, Zhang W, Zhou G, Wang W, Liu W Abstract Keloids are benign skin tumors with a high recurrence rate following surgical excision. Abnormal intracellular signaling is one of the key mechanisms involved in its pathogenesis. Over‑activated phosphoinositide 3‑kinase/RAC‑alpha serine/threonine‑protein kinase/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway and overproducti...
Source: International Journal of Molecular Medicine - September 23, 2019 Category: Molecular Biology Authors: Tu T, Huang J, Lin M, Gao Z, Wu X, Zhang W, Zhou G, Wang W, Liu W Tags: Int J Mol Med Source Type: research

Battling Neuropathic Scar Pain With Botulinum Toxin
We present a patient with refractory neuropathic pain in a normotrophic spread-scar treated with the injection of BTA. A 47-year-old Caucasian female with a history of invasive melanoma of the left upper arm presented with pain in her excision scar, which she described as a “pins and needles” sensation alternating with a dull, deep ache. She had previously tried topical lidocaine, topical and intralesional steroids, and oral gabapentin without improvement. We treated the patient with 50 U of onabotulinumtoxinA intradermally at 1-1.5 cm intervals within and immediately around the perimeter of the scar. At 1-wee...
Source: Journal of Drugs in Dermatology - September 18, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Are hypertrophic scars and keloids the same?
PMID: 31494925 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Tapking C, Prasai A, Branski LK Tags: Br J Dermatol Source Type: research

The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets
AbstractSkin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet need, underscoring the complex pathophysiologic mechanisms of skin fibrosis. The Th2 cytokines interleukin (IL)-4 and IL-13 have been implicated as key mediators in the pathogenesis of fibroproliferative disorders. The goal of this article is to summarize the current understanding of the role of the IL-4/IL-13 axis in wound healing...
Source: Archives of Dermatological Research - September 6, 2019 Category: Dermatology Source Type: research

657 Induction of IL-11 expression leads to persistent abnormal fibroblast activity in cutaneous wound healing
Injury of the skin can provoke excessive accumulation of extracellular matrix (ECM) leading to a hypertrophic scar or keloid development. However, the mechanism responsible for the persistence of the fibrotic response in a wound healing process is yet not well understood. There is growing evidence that abnormal fibroblast activity mediated by IL-11 signalling plays the pivotal role in systemic organ fibrosis. Therefore, we investigated whether the pathologic activity of myofibroblast-like keloid fibroblast (KFs) are potentiated by hypoxia-induced mesenchymal transition mediated by IL-11. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: J. Kim, B. Kim, S. Kim, Y. Lee, J. Lee Tags: Wound Healing and Tissue Remodelling Source Type: research

637 Hypoxia-Induced Epithelial-to-Mesenchymal Transition Mediates Fibroblast Abnormalities via EKR Activation in Cutaneous Wound Healing
Previous studies described the involvement of extracellular signal-related kinase (ERK) in systemic fibrotic diseases, but the role of ERK in cutaneous scarring is unknown. Although hypoxia drives tissue fibrosis by activating hypoxia-inducible factor-1 α (HIF-1α), the specific roles of hypoxia and associated ERK phosphorylation in abnormal fibroblast activity during cutaneous scarring are unclear. Here, we investigated whether pathologic myofibroblast-like keloid fibroblast activity is promoted by hypoxia-induced epithelial–mesenchymal transit ion mediated by ERK activation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: J. Kim, B. Kim, S. Kim, Y. Lee, J. Lee Tags: Wound Healing and Tissue Remodelling Source Type: research

636 Mechano-sensing and inflammatory signalling in normal and keloid dermal fibroblasts
Keloid scar formation is associated with aberrant inflammatory signalling however the underlying causes remain poorly understood. Additionally, keloid scars have been shown to be 10-50 times stiffer than normal skin and often form in areas of the body where skin tension is high. As a result, it is thought that the formation of keloid scars may be influenced by mechanical forces. The aim of this study was to investigate the direct effects of tissue stiffness on the behaviour of normal (NF) and keloid fibroblasts (KF) and explore the potential cross-talk with inflammatory signalling pathways. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: R. Ross, J. Maxwell, X. Lui, J. Connelly Tags: Wound Healing and Tissue Remodelling Source Type: research

117 Combined therapeutic strategies for keloid treatment
Recent advances in keloid management favor the administration of combination therapy over monotherapy. We evaluated the safety and efficacy of combination therapy to treat keloids using fractional lasers, superficial cryotherapy, and intralesional triamcinolone injections. We performed a retrospective observational study involving 35 Koreans with keloids. Each patient underwent treatment using the 1550 nm non-ablative fractional erbium-glass laser, followed by the 10,600 nm ablative fractional carbon dioxide laser. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: Y. Lee, J. Kim, W. Lee, J. Lee Tags: Clinical Research and Epidemiology Source Type: research

Intralesional Steroids and Compression Devices for Keloids
No abstract available (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - August 27, 2019 Category: Dermatology Tags: Letters and Communications Source Type: research

STAT3 operates as a novel transcription factor that regulates NEDD4 in Keloid.
Abstract Keloid, marked by excessive deposition of extracellular matrix components, usually occurs after cutaneous trauma. The molecular mechanism involved in the etiology of keloid remains largely unknown in spite of extensive studies presented on the mechanism of Keloid. NEDD4 has come to be recognized as a potential mediator implicated in inflammation and keloid that could chronically develop. Despite this, the working mechanism of NEDD4 involved in keloid remains unclear. In our present report, STAT3 was identified as a novel transcriptional factor that can diametrically regulate the transcription of NEDD4 and...
Source: Biochemical and Biophysical Research communications - August 23, 2019 Category: Biochemistry Authors: Wang Y, Yuan B, Qiao L, Yang H, Li X Tags: Biochem Biophys Res Commun Source Type: research

Battling neuropathic scar pain with botulinum toxin
We present a patient with refractory neuropathic pain in a normotrophic spread-scar treated with the injection of BTA. A 47-year-old Caucasian female with a history of invasive melanoma of the left upper arm presented with pain in her excision scar. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Arteriovenous hemangioma masquerading as a dermatofibrosarcoma protuberans
36-year-old African American female presented to the Dermatology clinic with a 10+ year history of enlarging lesion on the left dorsal upper arm that was tender to palpation with pain also elicited by exposure to heat. She denied drainage, bleeding, or other exacerbating factors. She had no history of keloids or similar lesions. On exam, she had four agminated, somewhat firm, skin-colored papules ranging in size from 1 mm to 8x7 mm with smooth surface and some superficial vasculature appreciated on dermoscopy. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Keloid/hypertrophic scars and stretch marks can overlap and together have a greater psychosocial impact
Background: Keloids and hypertrophic scars (raised scars) are an abnormal form of wound healing with excessive connective tissue at the wound site, while striae distensae, also considered a form of scarring, appear as thinned skin. Both can be disfiguring, challenging to treat and can have a major impact on quality of life. While their pathogenesis remains an active area of research, their relationship to each other has not been studied nor the psychosocial impact of having both conditions. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Split-thickness skin grafting and local immunosuppressive therapy to repair a large keloid excision defect following use of a dermal regeneration template
Keloids, resulting from irregular scar formation in response to trauma, can be difficult to treat as excision can result in further keloid formation. A dermal regeneration template is a synthetic skin-regenerating template that has successful applications in reconstructive surgery, including keloid excision. It is a bilayer membrane system in which the dermal replacement layer is made of a porous matrix of fibers of cross-linked bovine tendon collagen and chondroitin-6-sulfate that is manufactured with a controlled porosity and defined degradation rate. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

MiR-152-3p regulates cell proliferation, invasion and extracellular matrix expression through by targeting FOXF1 in keloid fibroblasts
Publication date: Available online 17 August 2019Source: Life SciencesAuthor(s): Rui Wang, Zhuanli Bai, Xiulin Wen, Huicong Du, Lin Zhou, Zhishui Tang, Zhuangqun Yang, Wei MaAbstractEmerging evidence has revealed that microRNAs (miRNAs) play critical roles in keloid pathogenesis. However, potential molecular mechanism of keloid formation remains unclear. In the present study, our findings showed that miR-152-3p mRNA expression level was notably up-regulated in keloid tissues and keloid fibroblasts compared with that of normal skin tissues and normal skin fibroblasts, respectively. Furthermore, miR-152-3p inhibition remarka...
Source: Life Sciences - August 19, 2019 Category: Biology Source Type: research

A review of the pharmacological and therapeutic effects of auraptene
AbstractThere is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the therapeutic benefits of auraptene. Auraptene, also known as auraptene and 7 ‐geranyloxycoumarin, is a bioactive monoterpene coumarin from Rutaceae family, which is isolated fromCitrus aurantium (Seville orange) andAegle marmelos (bael fruit). Auraptene is a highly pleiotropic molecule, which can modulate intracellular signaling pathways that control inflammation, cell g...
Source: BioFactors - August 19, 2019 Category: Biochemistry Authors: Bahram Bibak, Farzaneh Shakeri, George E. Barreto, Zakieh Keshavarzi, Thozhukat Sathyapalan, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Annular scaly plaque confined to presternal keloid treated with intralesional injections
Sanjay Singh, Vishal Gupta, Somesh GuptaIndian Journal of Dermatology, Venereology, and Leprology 2019 85(5):553-554 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - August 16, 2019 Category: Dermatology Authors: Sanjay Singh Vishal Gupta Somesh Gupta Source Type: research

Demographic and clinical characteristics of keloids in an urban center in Sub-Sahara Africa
Conclusion: In view of the burden of keloids, early treatment is advised. Unnecessary trauma and extra piercing should be avoided; elective surgeries that are deferrable should be postponed until when necessary. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - August 14, 2019 Category: Rural Health Authors: O Belie AO Ugburo BO Mofikoya Source Type: research

Long non-coding RNA HOXA11-AS induces Type I Collagen synthesis to keloid formation via sponging miR-124-3p and activating Smad5 Signaling.
CONCLUSIONS: Therefore, our study might offer a new vision for interpreting the mechanism of keloid formation. PMID: 31411918 [PubMed - as supplied by publisher] (Source: Am J Physiol Cell Ph...)
Source: Am J Physiol Cell Ph... - August 14, 2019 Category: Cytology Authors: Jin J, Zhai HF, Jia ZH, Luo XH Tags: Am J Physiol Cell Physiol Source Type: research

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies
Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids display many cancer-like characteristics such as progressive uncontrolled growth, lack of spontaneous regression and extremely high rates of recurrence. Phenotypically, keloids are consistent with non-malignant dermal tumors that are due to the excessive overproduction of collagen which never metastasize. Within the remit of keloid pathobiology, there is increasing evidence for the various interplay of neoplastic-promoting and suppressing fa...
Source: Frontiers in Immunology - August 7, 2019 Category: Allergy & Immunology Source Type: research

Connection between T regulatory cell enrichment and collagen deposition in keloid.
Abstract Keloid is a dermal tumor with high recurrence rate. The immune system plays a critical role in preventing pathogen infiltration, inducing inflammation, initiating downstream processes, and recruiting fibrocytes in keloids. Interestingly, we observed a local, but not systemic, enrichment of Treg cells and Treg-associated gene expression at the keloid lesions compared to non-keloid tissues. Concurrently, keloid tissues presented significantly elevated expression of type I and type III collagen. Moreover, the level of collagen III and the collagen III-to-collagen I ratio were positively correlated with the l...
Source: Experimental Cell Research - August 7, 2019 Category: Cytology Authors: Chen Y, Jin Q, Fu X, Qiao J, Niu F Tags: Exp Cell Res Source Type: research

Association between sphingosine-1-phosphate-induced signal transduction via mitogen-activated protein kinase pathways and keloid formation
AbstractWe conducted this experimental study to analyze the relationship between sphingosine-1-phosphate (S1P)-induced mitogen-activated protein (MAP) kinase pathways and keloid formation. We collected samples of the normal tissue and the keloid tissue from 10 normal healthy individuals and 12 patients with keloid scars, respectively. Then, we compared the level of sphingosine-1-phosphate receptor (S1PR1/S1PR2) mRNA/protein expression between the normal tissue and the keloid tissue. Moreover, we also compared the level of S1PR protein expression, that of S1P-induced COL1A1 (collagen Type I, α-1 chain) expression, tha...
Source: Archives of Dermatological Research - August 5, 2019 Category: Dermatology Source Type: research

Dissolving Triamcinolone-Embedded Microneedles for the Treatment of Keloids: A Single-Blinded Intra-Individual Controlled Clinical Trial
ConclusionsOnce-daily application of dissolving triamcinolone-embedded microneedles significantly reduced the volume of keloids. The treatment was safe, can be self-administered and can serve as an alternative for patients unsuitable for conventional treatments.Trial RegistrationTrial Registry: Health Science Authority (Singapore) Clinical Trials Register Registration number: 2015/00440. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 2, 2019 Category: Dermatology Source Type: research

Pediatric earlobe keloids: Outcomes and patterns of recurrence
This study aims to evaluate the outcomes and patterns of recurrences following treatment of earlobe keloids in a large cohort of pediatric patients to facilitate identification of the optimal treatment strategy. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - August 2, 2019 Category: Surgery Authors: Faraz A. Khan, Natalie A. Drucker, Shawn D. Larson, Janice A. Taylor, Saleem Islam Source Type: research

Pseudofolliculitis barbae; current treatment options.
Authors: Ogunbiyi A Abstract Pseudofolliculitis barbae (PFB) is a chronic inflammatory disorder of follicular and perifollicular skin characterized by papules, pustules, and post-inflammatory hyperpigmentation. It occurs more frequently in men of African and Asian descent. The etiology of PFB is multifactorial. Shaving or plucking the hair precipitates the onset of an inflammatory reaction that results from the penetration of the adjacent skin by the growing sharp tips. The curved shape of the hair follicle allows for the downward curvature and penetration of the growing hair tips into the skin. The onset of the fo...
Source: Clinical, Cosmetic and Investigational Dermatology - July 30, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1 α/PKM2 Signaling Pathway.
Conclusions: Metformin abolishes hypoxia-induced EMT in KFs by inhibiting the HIF-1α/PKM2 signaling pathway. Our study provides a novel mechanistic insight into potential use of metformin for treatment of keloids. PMID: 31341409 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 26, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Expression of Components of the Renin-Angiotensin System by the Embryonic Stem Cell–Like Population within Keloid Lesions
Conclusion: Prorenin receptor, angiotensin-converting enzyme, angiotensin II receptor 1, and angiotensin II receptor 2 were expressed by the embryonic stem cell–like population within the keloid-associated lymphoid tissues, suggesting that this primitive population may be a potential therapeutic target by modulation of the renin-angiotensin system. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - July 26, 2019 Category: Cosmetic Surgery Tags: Experimental Source Type: research

Myths and Knowledge Gaps in the Aesthetic Treatment of Patients With Skin of Color
Conclusions: Knowledge gaps and myths concerning facial aesthetic treatment in individuals with SOC exist. These patients may undergo various facial aesthetic procedures safely and effectively, as long as nuances in treatment approaches are recognized. J Drugs Dermatol. 2019;18(7):616-622. PMID: 31329382 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Major keloids of the scalp successfully treated with intralesional cryotherapy —a case report
We report the case of a patient who suffered from major keloids on the scalp. After multiple sessions of intralesional cryotherapy, a complete eradication of the keloids was achieved.Level of Evidence: Level V, therapeutic study. (Source: European Journal of Plastic Surgery)
Source: European Journal of Plastic Surgery - July 24, 2019 Category: Cosmetic Surgery Source Type: research

Interleukin-6 serum level and gene polymorphism in keloid patients.
In conclusion, there was a great association between IL-6 572 gene polymorphism and its serum level in patients with keloid specifically who have family history. PMID: 31304905 [PubMed - in process] (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - July 17, 2019 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Keloid Excision and Adjuvant Treatments: A Network Meta-analysis
Conclusions According to our results, “excision + radiation” had significantly better outcomes than excision alone. “Excision + pressure” had better outcomes than excision + any other treatment modality, and excision + nonradiation adjuvant therapies were also better than “excision only,” although these findings did not reach statistical significance. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - July 12, 2019 Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research

Knockdown of FOXM1 inhibits activation of keloid fibroblasts and extracellular matrix production via inhibition of TGF-β1/Smad pathway
Publication date: Available online 6 July 2019Source: Life SciencesAuthor(s): Yangang Zhang, Chuantao Cheng, Shuang Wang, Meifeng Xu, Dewu Zhang, Weihui ZengAbstractKeloid is characterized by overactive fibroblasts. Forkhead box M1 (FOXM1) is transcription factor that plays important roles in the progression of fibrosis. However, the role of FOXM1 in keloid has not been elucidated. In the present study, we examined the expression levels of FOXM1 in clinical keloid tissue specimens and primary keloid fibroblasts (KFs). The results showed that FOXM1 levels were significantly increased in both keloid tissues and KFs. To furth...
Source: Life Sciences - July 7, 2019 Category: Biology Source Type: research

The Interplay of Mechanical Stress, Strain, and Stiffness at the Keloid Periphery Correlates with Increased Caveolin-1/ROCK Signaling and Scar Progression
Conclusions: The authors conclude that changes in human position are strongly correlated with mechanical loading of the predilection sites, which leads to increased mechanical strain in the peripheral tissue surrounding keloids. Furthermore, increased mechanical strain in the peripheral tissue, which is the site of keloid progression, was correlated with aberrant expression of caveolin-1/ROCK signaling pathway. These findings suggest a novel mechanism for keloid progression. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - July 1, 2019 Category: Cosmetic Surgery Tags: Experimental Source Type: research

Discussion: The Interplay of Mechanical Stress, Strain, and Stiffness at the Keloid Periphery Correlates with Increased Caveolin-1/ROCK Signaling and Scar Progression
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - July 1, 2019 Category: Cosmetic Surgery Tags: Experimental Source Type: research

Update on the Treatment of Scars
Conclusion: Review of the literature revealed a myriad of options for the treatment of different scar types. Although there is not vast evidence in the literature in regard to combination treatments, these are becoming more popular, and it is the author’s opinion that combination treatments yield better overall results. J Drugs Dermatol. 2019;18(6):550-555. PMID: 31251547 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 30, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

High-resolution ultrasound for keloids and hypertrophic scar assessment
AbstractMost of the widely used scales to evaluate scars are subjective relying on clinical observations. There is a growing need to find out a noninvasive objective tool for this purpose. The study is aimed at evaluating the value of the high-resolution ultrasound in the assessment of the scars when compared with a clinical evaluation scoring system, the Vancouver Scar Scale (VSS). The study included 22 patients with hypertrophic scars or keloids. At baseline, scars were assessed using the Vancouver Scar Scale and high-resolution ultrasound (13-MHz probe). Patients received three Nd:YAG laser sessions (100  J/cm2 flu...
Source: Lasers in Medical Science - June 25, 2019 Category: Laser Surgery Source Type: research

Efficacy of surgical excision and sub-dermal injection of triamcinolone acetonide for treatment of keloid scars after caesarean section: a single blind randomised controlled trial protocol
One of the first-line options to treat keloid scars is corticosteroid injection after excision of the existing scar. A thorough literature search has shown a lack of research on the injection of corticosteroid... (Source: Trials)
Source: Trials - June 18, 2019 Category: General Medicine Authors: Seng Chai Chua, Beata Gidaszewski and Marjan Khajehei Tags: Study protocol Source Type: research

Hypertrophic and keloid scars fail to progress from the CD34-/ α-SMA+ immature scar phenotype and show gradient differences in α-SMA and P16 expression.
CONCLUSIONS: Both abnormal scar types (Hscar and Kscar) showed a unique CD34-/α-SMA+/p16+ scar phenotype, but the differences between Hscar and Kscar observed in this study were of a gradient rather than absolute nature. This suggests that scar progression to the mature normal scar phenotype is, for as yet unknown reasons, hindered in hypertrophic and keloid scars. This article is protected by copyright. All rights reserved. PMID: 31206605 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 17, 2019 Category: Dermatology Authors: Limandjaja GC, Belien JM, Scheper RJ, Niessen FB, Gibbs S Tags: Br J Dermatol Source Type: research

Keloid treatment: what about adjuvant radiotherapy?
Conclusion: Surgical excision combined with immediate PORT is an effective and easy treatment with good esthetic results and an acceptable recurrence rate. It should be considered for patients with persistent keloid formation after failure of other treatments and those at high risk of relapse. PMID: 31190938 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review
Rationale Keloids, dermal fibroproliferative lesions, often occur secondary to skin injury and extend beyond the margins of the original lesion. Aggressive fibromatosis (AF) is a rare condition arising from fibroblasts and is characterized clinically as a nonmetastasizing but locally invasive tumor. In this work, we present the case of a patient who developed AF in the chest 3 years after surgery and postoperative radiotherapy for keloids. Patient Concerns A 15-year-old female patient who underwent surgery and postoperative radiotherapy for keloids presented with AF in the chest 3 years after intervention. Diagnoses ...
Source: Annals of Plastic Surgery - June 14, 2019 Category: Cosmetic Surgery Tags: Review Paper Source Type: research

Comparison of Intralesional Triamcinolone Acetonide, Botulinum toxin type A, and Their Combination for the Treatment of Keloid lesions.
Conclusion: Combined injection of intralesional steroids with BTX-A appears to be superior to either therapy alone and offer the best benefit of safer and more efficacious response with lesser side effects. PMID: 31184533 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of the Role of High-mobility Group Box 1 Protein in Patients With Keloids: A Case Control Study.
CONCLUSIONS: High-mobility group box 1 was found to be elevated in patients with keloids compared with their controls, suggesting its role in excessive scarring and the role of its antagonists in therapy. PMID: 31184592 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - June 13, 2019 Category: General Medicine Tags: Wounds Source Type: research

A Rare Presentation Of Penile Keloids After Traditional Circumcision: Case Report
ConclusionThis case highlights one of the more serious complications of circumcision. Although penile keloids are rare, the techniques involved in traditional circumcision potentially predispose to keloid formation in a genetically prone population. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - June 12, 2019 Category: Surgery Source Type: research