Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis
AbstractPrevious approaches to acne management have focused on the four main factors implicated in acne, namely, androgen-mediated sebogenesis (considered integral to acne), hyperkeratinization, colonization withCutibacterium acnes, and inflammation related to both innate and adaptive mechanisms. Recent advances have facilitated potential novel approaches to acne management, as the pathophysiology and the immunological aspects related to acne and wound healing have evolved. Particular targets that have been shown to be closely involved in acne pathophysiology and wound healing include interleukin (IL)-1 β, IL-17, IL-2...
Source: Dermatology and Therapy - June 11, 2021 Category: Dermatology Source Type: research

A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis
This study has provided a deeper analysis of the pathogenesis of dermal vascular endothelial cells in keloids. Genes of CXCR4, CXCL9, and Caspase-9 may influence the processes of inflammatory responses and vascular endothelial cell apoptosis to exert crucial effects in the development of keloids. Abbreviations: GEO: gene expression omnibus; DEGs: differentially expressed genes; KVECs: keloid vascular endothelial cells; NVECs: normal skin vascular endothelial cells; GO: gene ontology; KEGG: Kyoto encyclopedia of genes and genomes; PPI: protein protein interaction; BP: biological process; CC: cellular component; MF: molecula...
Source: Hand Surgery - June 10, 2021 Category: Surgery Authors: Xinhang Dong Mingzi Zhang Yuanjing Chen Chengcheng Li Youbin Wang Xiaolei Jin Source Type: research

A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis
This study has provided a deeper analysis of the pathogenesis of dermal vascular endothelial cells in keloids. Genes of CXCR4, CXCL9, and Caspase-9 may influence the processes of inflammatory responses and vascular endothelial cell apoptosis to exert crucial effects in the development of keloids. Abbreviations: GEO: gene expression omnibus; DEGs: differentially expressed genes; KVECs: keloid vascular endothelial cells; NVECs: normal skin vascular endothelial cells; GO: gene ontology; KEGG: Kyoto encyclopedia of genes and genomes; PPI: protein protein interaction; BP: biological process; CC: cellular component; MF: molecula...
Source: Journal of Plastic Surgery and Hand Surgery - June 10, 2021 Category: Surgery Authors: Xinhang Dong Mingzi Zhang Yuanjing Chen Chengcheng Li Youbin Wang Xiaolei Jin Source Type: research

A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis
This study has provided a deeper analysis of the pathogenesis of dermal vascular endothelial cells in keloids. Genes of CXCR4, CXCL9, and Caspase-9 may influence the processes of inflammatory responses and vascular endothelial cell apoptosis to exert crucial effects in the development of keloids. Abbreviations: GEO: gene expression omnibus; DEGs: differentially expressed genes; KVECs: keloid vascular endothelial cells; NVECs: normal skin vascular endothelial cells; GO: gene ontology; KEGG: Kyoto encyclopedia of genes and genomes; PPI: protein protein interaction; BP: biological process; CC: cellular component; MF: molecula...
Source: Hand Surgery - June 10, 2021 Category: Surgery Authors: Xinhang Dong Mingzi Zhang Yuanjing Chen Chengcheng Li Youbin Wang Xiaolei Jin Source Type: research

Multiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease?
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - June 10, 2021 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research

Pressure therapy with a novel compressive device for auricular keloids treatment after surgical excision
Auricular keloids are common in clinic and always lead to cosmetic problems and annoying symptoms such as pruritus and pain. The monotherapy of surgical excision was proved ineffective with recurrence rate between 45% to 100%, and intralesional corticosteroid injection shows recurrence rates of 9% to 50%, as well as side effects such as skin atrophy, pigmentation/depigmentation, and telangiectasias.[1] Here we are introducing our compressive device for auricular keloids prevention postoperatively, which has several advantages over other non-surgery treatments and other compressive devices. (Source: Journal of Plastic, Reco...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - June 8, 2021 Category: Cosmetic Surgery Authors: Mengyan Sun, Yuchong Wang, Chunyu Xue, Ji Zhu Source Type: research

Dipeptidyl Peptidase-4 Inhibitor Reduces the Risk of Developing Hypertrophic Scars and Keloids following Median Sternotomy in Diabetic Patients: A Nationwide Retrospective Cohort Study Using the National Database of Health Insurance Claims of Japan
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - June 1, 2021 Category: Cosmetic Surgery Tags: Letters Source Type: research

Reply: Dipeptidyl Peptidase-4 Inhibitor Reduces the Risk of Developing Hypertrophic Scars and Keloids following Median Sternotomy in Diabetic Patients: A Nationwide Retrospective Cohort Study Using the National Database of Health Insurance Claims of Japan
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - June 1, 2021 Category: Cosmetic Surgery Tags: Letters Source Type: research

GSE175866 Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human skin fibrotic diseases (RNA-seq)
In this study, we performed single-cell RNA-seq in keloid, a paradigm of skin fibrotic diseases, andnormal scardermis tissues.Our results indicate thatkeloid and normal scar fibroblasts could be divided into 4 subpopulations: secretory-papillary, secretory-reticular, mesenchymal and pro-inflammatory.The percentage of mesenchymal fibroblast subpopulationincreased significantly in keloid compared to normal scar. Interestingly, we also found increasing mesenchymal fibroblast subpopulation in scleroderma, another skin fibrotic disease.Function studies showed that the mesenchymal fibroblasts promoted collagen synthesis of the o...
Source: GEO: Gene Expression Omnibus - June 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

LINC01116 regulates proliferation, migration, and apoptosis of keloid fibroblasts by the TGF- β1/SMAD3 signaling via targeting miR-3141
CONCLUSION: Our findings demonstrated a novel mechanism, the miR-3141/TGF-β1/SMAD3 regulatory pathway, at least partially for the oncogenic role of LINC01116 in keloid formation.PMID:34048784 | DOI:10.1016/j.ab.2021.114249 (Source: Analytical Biochemistry)
Source: Analytical Biochemistry - May 28, 2021 Category: Biochemistry Authors: Dan Wu JinJie Zhou Ming Tan Yanshijing Zhou Source Type: research

LINC01116 regulates proliferation, migration, and apoptosis of keloid fibroblasts by the TGF- β1/SMAD3 signaling via targeting miR-3141
CONCLUSION: Our findings demonstrated a novel mechanism, the miR-3141/TGF-β1/SMAD3 regulatory pathway, at least partially for the oncogenic role of LINC01116 in keloid formation.PMID:34048784 | DOI:10.1016/j.ab.2021.114249 (Source: Analytical Biochemistry)
Source: Analytical Biochemistry - May 28, 2021 Category: Biochemistry Authors: Dan Wu JinJie Zhou Ming Tan Yanshijing Zhou Source Type: research

Modified technique of intralesional radiofrequency with drug deposition in keloids using customized i.v. cannulas
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 28, 2021 Category: Dermatology Authors: Neha Taneja, Rhea Ahuja, Somesh Gupta Source Type: research

Individualized surgery combined with radiotherapy and triamcinolone acetonide injection for the treatment of auricular keloids
Although multiple methods have been proposed to treat auricular keloids, low curative effects and high recurrence rates are currently major clinical problems. Thereinto, surgery combined with radiotherapy and ... (Source: BMC Surgery)
Source: BMC Surgery - May 22, 2021 Category: Surgery Authors: Qiang Sun, Er-te Yu, You Zhou, Shuang Tong, Kai-jian Zhou and Shu Guo Tags: Research Source Type: research

Treatment of Keloids by Surgical Excision Combined With 5-Fluorouracil and Betamethasone Injection
No abstract available (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - May 1, 2021 Category: Dermatology Tags: Communications Source Type: research

PP-0167 what about post-operative high-dose-rate brachytherapy in the management of keloids? 5-year outcomes
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - May 1, 2021 Category: Radiology Authors: G.E.F. Noubbigh, S. zarraa, S. yahiaoui, A. mousli, M. mahdouani, R. abidi, A. youssfi, W. gargouri, K. mahjoubi, A. belaid, M. besbes, L. kochbati, C. nasr Tags: Poster presentation: Poster Presentation: Skin Source Type: research

Atypical keloids with an unusual myofibroblastic differentiation in a  patient with acne vulgaris
We present the case of a patient with a discreet acne and multiple keloids in the area of the upper trunk, histologically showing an unusual myofibroblastic differentiation. So far, the clinical course shows a poor response to the treatment, including cryotherapy, intralesional corticosteroid injections, occlusive silicone dressings and dye laser.PMID:33904964 | DOI:10.1007/s00105-021-04815-3 (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - April 27, 2021 Category: Dermatology Authors: N Scheiba W Hartschuh Source Type: research

Peri-areolar double-pedicle technique in the treatment of iatrogenic gynecomastia
CONCLUSION: This technique is feasible. It restores almost normal anatomy structure with minimal scarring and preserves good regional neurovascular supply, with only 60% altered areolar sensation.PMID:33896789 | DOI:10.15537/smj.2021.42.5.20200459 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - April 26, 2021 Category: Middle East Health Authors: Claudio Cannistr à Yousuf Al-Shaqsi Source Type: research

Keloids
This Patient Page describes the symptoms, possible causes, and treatment of keloids. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 21, 2021 Category: Dermatology Source Type: research

Therapeutic Strategies by Regulating Interleukin Family to Suppress Inflammation in Hypertrophic Scar and Keloid
Hypertrophic scar (HS) and keloid are fibroproliferative disorders (FPDs) of the skin due to aberrant wound healing, which cause disfigured appearance, discomfort, dysfunction, psychological stress, and patient frustration. The unclear pathogenesis behind HS and keloid is partially responsible for the clinical treatment stagnancy. However, there are now increasing evidences suggesting that inflammation is the initiator of HS and keloid formation. Interleukins are known to participate in inflammatory and immune responses, and play a critical role in wound healing and scar formation. In this review, we summarize the function...
Source: Frontiers in Pharmacology - April 20, 2021 Category: Drugs & Pharmacology Source Type: research