Low Dose Stingless Bee Honey Increases Viability of Human Dermal Fibroblasts That Could Potentially Promote Wound Healing
This study seeks to evaluate the effect of freeze-dried stingless bee honey on the cell viability and proliferative capacity of dermal fibroblast. Dermal fibroblast viability and proliferation will be evaluated via MTT assay, microscopic evaluation and cell cycle analysis. Short-term exposure of dermal fibroblasts to different honey doses revealed a multimodal pattern of increase in cell viability at the honey dose of 0.024, 200, and 6400 µg/ml. Treatment of the selected honey dose to dermal fibroblast proves to be non-toxic under microscopic evaluation and MTT assay. The selected dose of honey improves proliferation an...
Source: Wound Medicine - September 15, 2018 Category: General Medicine Source Type: research
Regenerative effect of epiregulin–loaded hydrogel
Publication date: Available online 14 September 2018Source: Wound MedicineAuthor(s): Mario Migliario, Filippo RenòAbstractRapid and efficient wound healing response is essential to maintain whole organism integrity and homeostasis. Such process could be influenced by a plethora of factors that when interfering with the different healing phases finally result in impaired tissue repair. Furthermore, defective healing process is often associated with chronic and difficult to heal wounds, both conditions deeply affecting patients’ quality of life.Advanced wound management solutions are the new standard in difficult to heal ...
Source: Wound Medicine - September 15, 2018 Category: General Medicine Source Type: research
Optimization of process conditions for chitosan-manuka honey film as wound contact layer for wound dressings
In this study, using solvent evaporation technique, chitosan-honey films were developed and the process parameters like concentration of chitosan, honey and glycerol were optimized using Response Surface Methodology (RSM) against the responses like Water Vapour Transmission Rate (WVTR), swelling ratio, antibacterial activity against Staphylococcus aureus and Escherichia coli, tensile strength and elongation. The effects of individual responses were discussed against all the variables using contour plots. The responses are optimized and the process parameters for achieving optimum responses to be used as a wound contact lay...
Source: Wound Medicine - September 15, 2018 Category: General Medicine Source Type: research
Collagen aids in expediting the healing framework of diabetic ulcers
ConclusionCollagen with its Triple helical structure aids in the healing mechanism by imparting tensile strength to the wound by bridging various processes resulting in fibroplasias and epidermal resurfacing. This could possibly aid in expediting the sequential but overlapping phases by cementing fruitful interactions between cellular and extracellular matrix interfaces. (Source: Wound Medicine)
Source: Wound Medicine - September 15, 2018 Category: General Medicine Source Type: research
Excision wound healing activity of a common biosurfactant produced by Pseudomonas sp.
ConclusionsThe results of this study have expressed that rhamnolipid can be used as a wound healing material for excision wound. Rhamnolipid can provide additional advantage in healing by showing protection from bacterial infection.Graphical abstract (Source: Wound Medicine)
Source: Wound Medicine - September 15, 2018 Category: General Medicine Source Type: research
Disinfection of pseudomonas aeruginosa-infected wounds in diabetic db/db m679d
ConclusionTwelve days of once-daily cleansing of P. aeruginosa-infected wounds on db/db diabetic mice with HOCl solution resulted in significantly decreased P. aeruginosa bioburden, albeit with a minor delay in wound repair. (Source: Wound Medicine)
Source: Wound Medicine - September 15, 2018 Category: General Medicine Source Type: research
Engineered protein hydrogel for open wound management in Canines
In conclusion, PAMG based adhesive hydrogel offers faster wound healing of open wounds of Canines. (Source: Wound Medicine)
Source: Wound Medicine - July 20, 2018 Category: General Medicine Source Type: research
Global Incidence and Prevalence of Pressure Injuries in Public Hospitals: A Systematic Review
ConclusionsA careful and systematic review of all the retrieved citations yielded a rich source of evidence. In this systematic review of the literature, most of the studies employed the skin assessment technique to collate their data. (Source: Wound Medicine)
Source: Wound Medicine - July 10, 2018 Category: General Medicine Source Type: research
Development of antimicrobial colloidal silver incorporated lyophilized biopolymer wafers for wound care
ConclusionLyophilized antimicrobial wafers were developed as a successful wound dressing for combating microbial infections at the site of application with enhanced wound healing activity.Graphical abstract (Source: Wound Medicine)
Source: Wound Medicine - July 10, 2018 Category: General Medicine Source Type: research
Allogeneic fibroblast cell therapy in the treatment of recessive dystrophic epidermolysis bullosa
ConclusionsIntradermal administration of allogeneic fibroblasts is a safe and effective method of treatment of non-healing wounds in recessive dystrophic epidermolysis bullosa. (Source: Wound Medicine)
Source: Wound Medicine - July 10, 2018 Category: General Medicine Source Type: research
Effects of platelet-rich plasma and carbonated hydroxyapatite combination on cranial defect Bone Regeneration: An animal study
ConclusionA combination of PRP and CHA as a bone regeneration scaffold showed a histologically increased bone formation. (Source: Wound Medicine)
Source: Wound Medicine - July 10, 2018 Category: General Medicine Source Type: research
Evaluation of in vivo wound healing and anti-inflammatory activity of crude extract of the fruits of Brucea antidysentrica in mice
ConclusionThe extract supports traditional claims for wound healing and anti-inflammatory activity. (Source: Wound Medicine)
Source: Wound Medicine - July 10, 2018 Category: General Medicine Source Type: research
Effects of hypericum perforatum, clinoptilolite and hydrocolloid dressing on wound healing in diabetic rats
Publication date: September 2018Source: Wound Medicine, Volume 22Author(s): Serap Gokce, Aynur Tureyen, Alpaslan Gokcimen (Source: Wound Medicine)
Source: Wound Medicine - July 10, 2018 Category: General Medicine Source Type: research
Matrix metalloproteinase 9 (MMP9) in wound healing of diabetic foot ulcer: Molecular target and structure-based drug design
Publication date: September 2018Source: Wound Medicine, Volume 22Author(s): Maywan Hariono, Sri H. Yuliani, Enade P. Istyastono, Florentinus D.O. Riswanto, Christophorus F. AdhipanditoAbstractMatrix Metalloproteinase 9 (MMP9) is one of the many zinc-dependent endopeptidases found in the body, which is also involved in delaying wound healing by degrading extracellular matrices associated with normal tissue remodelling processes. In Diabetic Foot Ulcer (DFU), this protein is highly expressed especially at the stage where wound healing is poor. Currently, MMP9 is becoming one of the interesting targets in the discovery and de...
Source: Wound Medicine - July 10, 2018 Category: General Medicine Source Type: research
Global Incidence and Prevalence of Pressure Injuries in Public Hospitals: A Systematic Review
ConclusionsA careful and systematic review of all the retrieved citations yielded a rich source of evidence. In this systematic review of the literature, most of the studies employed the skin assessment technique to collate their data. (Source: Wound Medicine)
Source: Wound Medicine - July 5, 2018 Category: General Medicine Source Type: research
