Size of lymph-node metastases in prostate cancer patients undergoing radical prostatectomy: implication for imaging and oncologic follow-up of 2705 lymph-node positive patients
ConclusionOverall, 26% of LNMs were MM ( ≤ 2mm). Adverse clinical parameters were inversely associated with MM at RP. Consequently, PSMA-PET/CT did not detect a substantial proportion of LNMs. LNM size and count are relevant for prognosis. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Focal radiotherapy boost to MR-visible tumor for prostate cancer: a systematic review
ConclusionsThere is strong evidence that it is possible to improve oncologic outcomes without substantially increasing toxicity through MR-guided focal boost, at least in the setting of a 35-fraction radiotherapy regimen. Barriers to clinical practice implementation are addressable through additional investigation and new technologies. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Analysis of the immunological markers BTLA, TIM-3, and PD-L1 at the invasion front and tumor center in clear cell renal cell carcinoma
ConclusionThe present results show heterogeneous intratumoral and intertumoral expression of the investigated checkpoint receptors PD-L1, BTLA, and TIM-3. In the clinical practice tumor sampling should include different tumor locations, and multiple inhibition of different checkpoint receptors seems reasonable to increase the therapeutic success. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Predictors of elaborated perineal or a combined abdominoperineal approach during repair for pelvic fracture urethral injury
ConclusionsThe need of step 3 or higher during urethroplasty for PFUI can be predicted pre-operatively with conventional imaging (RGU/VCUG). Patients with proximal urethral stump above the lower margin of pubic symphysis were about 66 times more likely to need step 3 or higher during urethroplasty. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Acute and long-term toxicity in primary hypofractionated external photon radiation therapy in patients with localized prostate cancer
ConclusionNevertheless, Hypo-RT has gained ground for patients with localized PCa and further improvements may be achieved by inclusion of genetically assessed radiation sensitivity. Several RCTs in Hypo-RT have shown non-inferior outcome and well-tolerated treatment toxicity by physician-rated scores. In the future, we suggest that toxicity should be measured by patient-reported outcome (PRO) using comparable questionnaires. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula
ConclusionThe SRF-based formula was also able to accurately discriminate all but one patient to an NBGFR of > 45 mL/min/1.73m2. We utilised the newly developed SRF-based formula for predicting NBGFR in a living kidney donor population. Counselling of donor post-operative renal outcomes may then be optimised pre-operatively. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Development and validation of a novel home-made bench-top training model for retrograde intrarenal surgery
ConclusionThe current study presented a valid low-cost easily accessible RIRS bench-top training model which could facilitate skill acquisition and translate to real-life scenario. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Single incision robotic cystectomy and urinary diversion
ConclusionsBy presenting historical context, technical insights, clinical evidence, and strategic foresight, the review aims to provide a comprehensive resource that engages surgeons, researchers, and trainees from diverse perspectives. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Evolution of anxiety management in prostate biopsy under local anesthesia: a narrative review
ConclusionDespite the paucity of available data, VR appears to be a safe and effective technique in reducing anxiety in many procedures, even in frail patients. No studies have evaluated the role of VR in TP-PB. Future research should thus explore the optimal way to implement VR technology and any potential benefits for TP-PB patients. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Radiotherapy in metastatic bladder cancer
ConclusionRadiotherapy is an effective, safe, and accessible treatment modality for palliation as well as disease control in various clinical settings of metastatic bladder cancer. Its role in oligometastatic stage in combination with systemic therapy is expected to expand with emerging evidence. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Advancements in stone classification: unveiling the beauty of urolithiasis
ConclusionsRecognizing that no single classification system can comprehensively cover all aspects, the integration of all classification approaches is essential for tailoring urolithiasis patient-specific management. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Robotic-assisted radical prostatectomy: a multicenter experience with the Senhance Surgical System
ConclusionWe demonstrate progressing safety and efficiency for robotic-assisted radical prostatectomy with the Senhance Surgical System. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Rez ŭm water vaporization therapy versus transurethral resection of the prostate in the management of refractory urine retention: matched pair comparative multicenter experience
ConclusionThis study supports the safety and efficacy of Rez ūm in the management of catheter-dependent patients secondary to BPH, with comparable functional outcomes to TURP. Until a randomized clinical comparison is available, long-term data are crucially recommended to compare the recurrence and reoperation rates. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
The effect of limited english proficiency on prostate-specific antigen screening in American men
ConclusionsLimited English proficiency is associated with significantly lower prevalence of PSA screening among men in the USA. Interventions to mitigate disparities in prostate cancer outcomes should account for limited English proficiency among the barriers to guideline-concordant care. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
Surgical metastasectomy for metastatic renal cell carcinoma in the era of targeted and immune therapy: a narrative review
ConclusionOur work was able to show that SM could be proposed as a consolidation treatment to excise residual lesions that were deemed unresectable prior to a combination of systemic therapies. Contrastingly, it can be proposed as an upfront treatment, leaving systemic therapies as an alternative in case of future relapse. However, patient selection regarding their performance status, metastatic sites, number of lesions and tumorous characteristics is of paramount importance. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2024 Category: Urology & Nephrology Source Type: research
