Debates in Allergy Medicine: Does oral immunotherapy shorten the duration of milk and egg allergy? The pro argument
AbstractThe development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default immune response in the gut. A food allergy occurs when this process fails and a pathologic Th2 response is activated. Oral food immunotherapy (OIT) aims to restore immune tolerance in food-allergic individuals. The stimulation of Tregs production seems to represent a crucial step in inducing long-term tolerance, but other mechanisms (e.g., the suppression of mast cell and basophil reactivity, changes in aller...
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research
Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument
AbstractOral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow ’s milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy. While it has been shown that children who tolerate baked forms of egg and milk are more likely to deve...
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research
High burden of atopy in immigrant families in substandard apartments in Sweden – on the contribution of bad housing to poor health in vulnerable populations
ConclusionsThe atopic burden in this selected immigrant population was high, and results point to unmet medical needs. Health care systems caring for such populations need to be aware of their specific health needs; comprehensive asthma and allergy care should include consideration of harmful environmental exposures, adhering to the precautionary principle. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - May 15, 2018 Category: Allergy & Immunology Source Type: research
The importance of allergic disease in public health: an iCAALL statement
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - April 27, 2018 Category: Allergy & Immunology Source Type: research
Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis
ConclusionBased on our findings, ALEX is a novel tool for describing the IgE profile in a PM setting, where the IgE assay must be performed on many allergens and components. In particular, polysensitized patients and patients with pollen-food syndrome will have a real advantage due the combination of the second and third levels of allergy diagnostics in the same chip. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - April 26, 2018 Category: Allergy & Immunology Source Type: research
Smoking, environmental tobacco smoke and occupational irritants increase the risk of chronic rhinitis
ConclusionsSmoking, environmental tobacco smoke, and occupational irritants are significant risk factors for nasal symptoms with an additive pattern. The findings suggest that these factors should be systematically inquired in patients with nasal symptoms for appropriate preventive measures. (192 words). (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - March 14, 2018 Category: Allergy & Immunology Source Type: research
The international WAO/EAACI guideline for the management of hereditary angioedema – the 2017 revision and update
This article is co-published with permission in Allergy and the World Allergy Organization Journal. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - February 27, 2018 Category: Allergy & Immunology Source Type: research
Food protein-induced enterocolitis syndrome: a review of the new guidelines
This article summarizes the guidelines and adds recent updates. FPIES is gaining recognition, however there continues to be delays in diagnosis and misdiagnosis due to overlap of symptoms with over conditions, lack of a diagnostic test, and because some of the common trigger foods are not thought of as allergenic. More research into disease mechanisms and factors influencing differences between populations is needed. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - February 7, 2018 Category: Allergy & Immunology Source Type: research
Vespa crabro immunotherapy versus Vespula -venom immunotherapy in Vespa crabro allergy: a comparison study in field re-stings
ConclusionThis observation suggests that in patients with ascertained VC-induced allergic reactions a specific VC VIT, where available, would be more adequate, at least concerning the safety profile. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - February 2, 2018 Category: Allergy & Immunology Source Type: research
